scholarly journals Exploring Polymeric Micelles for Improved Delivery of Anticancer Agents: Recent Developments in Preclinical Studies

Pharmaceutics ◽  
2013 ◽  
Vol 5 (4) ◽  
pp. 201-219 ◽  
Author(s):  
Chalet Tan ◽  
Yingzhe Wang ◽  
Wei Fan
Keyword(s):  
Anticancer Agents ◽  
Polymeric Micelles ◽  
Preclinical Studies ◽  
Recent Developments

scholarly journals Advances in Engineered Polymer Nanoparticle Tracking Platforms towards Cancer Immunotherapy—Current Status and Future Perspectives

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 935
Author(s):  
Ramar Thangam ◽  
Kapil D. Patel ◽  
Heemin Kang ◽  
Ramasamy Paulmurugan
Keyword(s):  
Cancer Immunotherapy ◽  
Anticancer Agents ◽  
Polymeric Nanoparticles ◽  
Current Status ◽  
Polymeric Nanocarriers ◽  
Therapeutic Drugs ◽  
Small Molecule Ligands ◽  
Recent Developments ◽  
Cancer Immunotherapies

Engineering polymeric nanoparticles for their shape, size, surface chemistry, and functionalization using various targeting molecules has shown improved biomedical applications for nanoparticles. Polymeric nanoparticles have created tremendous therapeutic platforms, particularly applications related to chemo- and immunotherapies in cancer. Recently advancements in immunotherapies have broadened this field in immunology and biomedical engineering, where “immunoengineering” creates solutions to target translational science. In this regard, the nanoengineering field has offered the various techniques necessary to manufacture and assemble multifunctional polymeric nanomaterial systems. These include nanoparticles functionalized using antibodies, small molecule ligands, targeted peptides, proteins, and other novel agents that trigger and encourage biological systems to accept the engineered materials as immune enhancers or as vaccines to elevate therapeutic functions. Strategies to engineer polymeric nanoparticles with therapeutic and targeting molecules can provide solutions for developing immune vaccines via maintaining the receptor storage in T- and B cells. Furthermore, cancer immunotherapy using polymeric nanomaterials can serve as a gold standard approach for treating primary and metastasized tumors. The current status of the limited availability of immuno-therapeutic drugs highlights the importance of polymeric nanomaterial platforms to improve the outcomes via delivering anticancer agents at localized sites, thereby enhancing the host immune response in cancer therapy. This review mainly focuses on the potential scientific enhancements and recent developments in cancer immunotherapies by explicitly discussing the role of polymeric nanocarriers as nano-vaccines. We also briefly discuss the role of multifunctional nanomaterials for their therapeutic impacts on translational clinical applications.

scholarly journals NEW PHARMACEUTICAL DOSAGE FORMS USED IN THE TREATMENT OF BREAST CANCER. POLYMERIC MICELLES

2021 ◽  
Vol 1 (1) ◽  
pp. 38-52
Author(s):  
Alexandru Oprita ◽  
Ani-Simona Sevastre
Keyword(s):  
Breast Cancer ◽  
Anticancer Agents ◽  
Polymeric Micelles ◽  
Screening Methods ◽  
Preparation Methods ◽  
Pharmaceutical Dosage Forms ◽  
High Performing ◽  
Current State ◽  
Pharmaceutical Form ◽  
New Treatment

Among all types of cancer encountered in women, breast cancer is the most prevalent, with the highest mortality rate. An increased survival rate is closely related to early diagnosis, the use of high performing screening methods and of selective and adequate treatments. By using the nanotechnologies, the therapeutic effectiveness of the drugs may be improved by a controlled release of the active substances to the tumoral site. The aim of this review is to present the current state of knowledge and to mention the new treatment trends in breast cancer, focusing on a pharmaceutical form that, thanks to its advantages, is already used in the therapy of this disease – the polymeric micelles. Several examples of anticancer agents loaded polymeric micelles are mentioned, illustrating the preparation methods and the current state of clinical studies in which polymeric micelles are used.

scholarly journals Toward Understanding the Sex Differences in the Biological Mechanism of Social Stress in Mouse Models

2021 ◽  
Vol 12 ◽  
Author(s):  
Aki Takahashi
Keyword(s):  
Sex Differences ◽  
Social Stress ◽  
Social Defeat ◽  
Preclinical Studies ◽  
Biological Mechanism ◽  
Depression And Anxiety ◽  
Social Defeat Stress ◽  
Pharmacological Interventions ◽  
Recent Developments ◽  
Stress Models

Significant sex differences in terms of prevalence, symptomatic profiles, severity, and comorbidities of psychiatric disorders are quite common. Women have been shown to be more vulnerable to stress and are nearly twice as likely as men to develop stress-related disorders such as depression and anxiety. Therefore, understanding sex differences with respect to the neurobiological mechanisms underlying stress-related disorders is important for developing more efficient pharmacological interventions for women. However, most preclinical studies on stress-related disorders have focused heavily on male rodents. Here, recent developments in the study of repeated social defeat stress models in female mice are summarized. Our findings suggest that a variety of factors need to be considered when employing this model.

Drug Delivery and Targeting to the Brain Through Nasal Route: Mechanisms, Applications and Challenges

2019 ◽  
Vol 16 (10) ◽  
pp. 887-901 ◽  
Author(s):  
Kanchan Kashyap ◽  
Rahul Shukla
Keyword(s):  
Drug Delivery ◽  
Nasal Cavity ◽  
Polymeric Micelles ◽  
Polymeric Nanoparticles ◽  
Complex Structure ◽  
Nasal Drug Delivery ◽  
Nasal Route ◽  
Recent Developments ◽  
Systemic Side Effects ◽  
The Brain

: Blood-brain barrier (BBB) provides restrictions for the transportation of various therapeutic agents to the brain. Efforts to directly target the brain by olfactory as well as trigeminal nerve pathway, bypassing BBB, have grown significantly in recent times. The intranasal route of transportation of the drug encompasses ability for the delivery of drug directly to the brain, improves site-specificity in the brain and avoids systemic side effects. In the current era, novel drug delivery systems are useful tools for targeting the brain without providing any harmful effects in nasal mucosa as well as the central nervous system. The complex structure of nasal cavity, mucociliary clearance, degradation by the enzymes present in nasal cavity and pathological conditions like rhinitis, common cold, etc. are the major disputes for nasal drug delivery. The use of nanotechnological approaches like solid lipid nanoparticles, polymeric nanoparticles, nanoemulsions, liposomes and polymeric micelles provides the ability to overcome these barriers. There are several emerging nasal drug delivery technologies produced by various pharmaceutical companies to conquer these hurdles. This review tries to address the recent developments in the area of direct drug delivery to the brain through the nasal route.

Recent Advancements in Nanotechnology for Oral Cancer: A Review

2020 ◽  
Vol 15 ◽  
Author(s):  
Dipali R. Talele ◽  
Deepa H. Patel
Keyword(s):  
Drug Delivery ◽  
Oral Cancer ◽  
Anticancer Agents ◽  
Polymeric Micelles ◽  
Polymeric Nanoparticles ◽  
Inorganic Nanoparticles ◽  
Safe Delivery ◽  
Main Challenge ◽  
Therapeutic Outcomes ◽  
Life Threatening

Background: Oral cancer is the life threatening disease causing mortality. The majority of chemotherapeutic anticancer agents are toxic to healthy tissues, have poor bioavailability and affects the quality of life of the patients. Objective: The main challenge in the treatment of oral cancer is the effective and safe delivery of chemotherapeutic anticancer drugs. This present review deals with the recent advancement in the nanotechnologies and its probable applications in the oral cancer treatment. Methods: This review includes a gist of suitable literature. Results: Nanotechnology brings novel methodologies or modifications in current anticancer therapies to improve individual wellbeing and survival. Conclusion: Nanotechnology put forward the potential of increasing the efficacy of the therapy and targeted drug delivery, which in turn increase drug absorption and bioavailability at the site of tumour. Different nanocarriers include liposomes, polymeric nanoparticles, inorganic nanoparticles, combinational (polymeric- inorganic) nanoparticles, magnetic nanoparticles, nanolipids, hydrogels, dendrimers and polymeric micelles. This review confers development of new drug delivery approaches for effective therapeutic outcomes and abating the toxicity to healthy tissues.

Recent developments in selenium-containing polymeric micelles: prospective stimuli, drug-release behaviors, and intrinsic anticancer activity

2021 ◽  
Author(s):  
Yihenew Simegniew Birhan ◽  
Hsieh-Chih Tsai
Keyword(s):  
Drug Release ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Polymeric Micelles ◽  
Recent Developments

Selenium-containing nanocarriers can respond to different stimuli to release payloads in the vicinity of cancer cells.

A Review on Recent Developments in the Anticancer Potential of Oleanolic acid and its analogs (2017-2020)

2021 ◽  
Vol 21 ◽  
Author(s):  
Nidhi Gupta
Keyword(s):  
Clinical Trials ◽  
Natural Product ◽  
Oleanolic Acid ◽  
Anticancer Agents ◽  
Biological Activities ◽  
Pentacyclic Triterpenoid ◽  
Recent Developments ◽  
Anti Inflammatory ◽  
Pharmaceutical Properties

: Oleanolic acid (OA) is a pentacyclic triterpenoid class of natural product known to possess a broad range of biological activities, specifically, anticancer. Considering the anticancer potential of OA, a large number of analogs have been prepared by several researchers through modifications at C-3, C-12 and C-28 –COOH to develop the potent anticancer agents with improved cytotoxicity and pharmaceutical properties. Some of the synthesized derivatives have been assessed in clinical trials also. This review summarizes the most recent synthetic and biological efforts in the development of oleanolic acid and its analogs during the period 2017-2020. Reports published during this period revealed that both OA and its analogs possess a remarkable potential for the development of effective anticancer agents along with several others such as anti-inflammatory, anti-viral, anti-microbial and anti-diabetic agents.

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