scholarly journals Organic Nitrate Maintains Bone Marrow Blood Perfusion in Ovariectomized Female Rats: A Dynamic, Contrast-Enhanced Magnetic Resonance Imaging (MRI) Study

Pharmaceutics ◽  
2012 ◽  
Vol 5 (4) ◽  
pp. 23-35 ◽  
Author(s):  
Yi-Xiang Wang ◽  
Chun Ko ◽  
James Griffith ◽  
Min Deng ◽  
Hing Wong ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Perfusion ◽  
Female Rats ◽  
Organic Nitrate ◽  
Resonance Imaging ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Magnetic Resonance Imaging Mri ◽  
Mri Study ◽  
Bone Marrow Blood

scholarly journals Dynamic contrast-enhanced magnetic resonance imaging for monitoring neovascularization during bone regeneration—a randomized in vivo study in rabbits

2021 ◽  
Author(s):  
L. A. R. Righesso ◽  
M. Terekhov ◽  
H. Götz ◽  
M. Ackermann ◽  
T. Emrich ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Bone Regeneration ◽  
Blood Perfusion ◽  
Autogenous Bone ◽  
Resonance Imaging ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

Abstract Objectives Micro-computed tomography (μ-CT) and histology, the current gold standard methods for assessing the formation of new bone and blood vessels, are invasive and/or destructive. With that in mind, a more conservative tool, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), was tested for its accuracy and reproducibility in monitoring neovascularization during bone regeneration. Additionally, the suitability of blood perfusion as a surrogate of the efficacy of osteoplastic materials was evaluated. Materials and methods Sixteen rabbits were used and equally divided into four groups, according to the time of euthanasia (2, 3, 4, and 6 weeks after surgery). The animals were submitted to two 8-mm craniotomies that were filled with blood or autogenous bone. Neovascularization was assessed in vivo through DCE-MRI, and bone regeneration, ex vivo, through μ-CT and histology. Results The defects could be consistently identified, and their blood perfusion measured through DCE-MRI, there being statistically significant differences within the blood clot group between 3 and 6 weeks (p = 0.029), and between the former and autogenous bone at six weeks (p = 0.017). Nonetheless, no significant correlations between DCE-MRI findings on neovascularization and μ-CT (r =−0.101, 95% CI [−0.445; 0.268]) or histology (r = 0.305, 95% CI [−0.133; 0.644]) findings on bone regeneration were observed. Conclusions These results support the hypothesis that DCE-MRI can be used to monitor neovascularization but contradict the premise that it could predict bone regeneration as well.

scholarly journals Proximal femur bone marrow blood perfusion indices are reduced in hypertensive rats: A dynamic contrast-enhanced MRI study

2009 ◽  
Vol 30 (5) ◽  
pp. 1139-1144 ◽  
Author(s):  
Ya-Feng Zhang ◽  
Yi-Xiang J. Wang ◽  
James F. Griffith ◽  
William K.M. Kwong ◽  
Heather T. Ma ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Proximal Femur ◽  
Blood Perfusion ◽  
Hypertensive Rats ◽  
Dynamic Contrast Enhanced ◽  
Femur Bone ◽  
Contrast Enhanced ◽  
Mri Study ◽  
Bone Marrow Blood ◽  
Contrast Enhanced Mri

scholarly journals Masquerading Hypervascular Exophytic Liver Nodule

2020 ◽  
Author(s):  
Kevin Kim-Jun Teh ◽  
Albert Su-Chong Low ◽  
Jason Pik-Eu Chang ◽  
Chee-Kiat Tan
Keyword(s):  
Magnetic Resonance Imaging ◽  
Ct Imaging ◽  
Liver Lesions ◽  
Resonance Imaging ◽  
Dynamic Contrast Enhanced ◽  
Routine Surveillance ◽  
Contrast Enhanced ◽  
Increased Risk ◽  
Magnetic Resonance Imaging Mri ◽  
Contrast Enhanced Mri

Patients with liver cirrhosis are at increased risk of developing hepatocellular carcinoma (HCC) and are placed on routine surveillance for HCC. Diagnosis algorithms are in place to guide clinicians in the evaluation of liver lesions detected during surveillance. Radiological assessments are critical with diagnostic criteria based on identification of typical hallmarks of HCCs on multiphasic computed tomography (CT) and dynamic contrast-enhanced magnetic resonance imaging (MRI). We report a patient with a hypervascular exophytic lesion indeterminate for HCC on CT imaging. While the detection of an exophytic arterially-enhancing lesion in an at-risk patient on CT imaging may prompt clinicians to treat the lesion as HCC without further evaluation, the patient underwent contrast-enhanced MRI with the lesion being eventually diagnosed as an exophytic haemangioma. Thus, no further action was necessary and the patient was continued on routine HCC surveillance.

scholarly journals Measurement of Blood Perfusion in Spinal Metastases With Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Spine ◽  
2013 ◽  
Vol 38 (22) ◽  
pp. E1418-E1424 ◽  
Author(s):  
Stacy Chu ◽  
Sasan Karimi ◽  
Kyung K. Peck ◽  
Yoshiya Yamada ◽  
Eric Lis ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Spinal Metastases ◽  
Blood Perfusion ◽  
Resonance Imaging ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced
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