scholarly journals Comparison of Salbutamol Delivery Efficiency for Jet versus Mesh Nebulizer Using Mice

Pharmaceutics ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 192 ◽  
Author(s):  
Chang ◽  
Moon ◽  
Oh ◽  
Yoon ◽  
Gu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Aerosol Particles ◽  
Clinical Validation ◽  
Output Rate ◽  
Medication Delivery ◽  
Jet Nebulizer ◽  
Jet Nebulizers ◽  
Effective Medication ◽  
Delivery Efficiency ◽  
Better Than

Recent reports using a breathing simulator system have suggested that mesh nebulizers provide more effective medication delivery than jet nebulizers. In this study, the performances of jet and mesh nebulizers were evaluated by comparing their aerosol drug delivery efficiencies in mice. We compared four home nebulizers: two jet nebulizers (PARI BOY SX with red and blue nozzles), a static mesh nebulizer (NE-U22), and a vibrating mesh nebulizer (NE-SM1). After mice were exposed to salbutamol aerosol, the levels of salbutamol in serum and lung were estimated by ELISA. The residual volume of salbutamol was the largest at 34.6% in PARI BOY SX, while the values for NE-U22 and NE-SM1 mesh nebulizers were each less than 1%. The salbutamol delivery efficiencies of NE-U22 and NE-SM1 were higher than that of PARI BOY SX, as the total delivered amounts of lung and serum were 39.9% and 141.7% as compared to PARI BOY SX, respectively. The delivery efficiency of the mesh nebulizer was better than that of the jet nebulizer. Although the jet nebulizer can generate smaller aerosol particles than the mesh nebulizer used in this study, the output rate of the jet nebulizer is low, resulting in lower salbutamol delivery efficiency. Therefore, clinical validation of the drug delivery efficiency according to nebulizer type is necessary to avoid overdose and reduced drug wastage.

scholarly journals Aerosol Delivery of Dornase Alfa Generated by Jet and Mesh Nebulizers

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 721 ◽  
Author(s):  
Kyung Hwa Chang ◽  
Sang-Hyub Moon ◽  
Sun Kook Yoo ◽  
Bong Joo Park ◽  
Ki Chang Nam
Keyword(s):  
Enzymatic Activity ◽  
Drug Stability ◽  
Aerosol Delivery ◽  
Clinical Safety ◽  
Dornase Alfa ◽  
Jet Nebulizer ◽  
Jet Nebulizers ◽  
In Vitro Performance ◽  
Delivery Efficiency

Recent reports on mesh nebulizers suggest the possibility of stable nebulization of various therapeutic protein drugs. In this study, the in vitro performance and drug stability of jet and mesh nebulizers were examined for dornase alfa and compared with respect to their lung delivery efficiency in BALB/c mice. We compared four nebulizers: two jet nebulizers (PARI BOY SX with red and blue nozzles), a static mesh nebulizer (NE-U150), and a vibrating mesh nebulizer (NE-SM1). The enzymatic activity of dornase alfa was assessed using a kinetic fluorometric DNase activity assay. Both jet nebulizers had large residual volumes between 24% and 27%, while the volume of the NE-SM1 nebulizer was less than 2%. Evaluation of dornase alfa aerosols produced by the four nebulizers showed no overall loss of enzymatic activity or protein content and no increase in aggregation or degradation. The amount of dornase alfa delivered to the lungs was highest for the PARI BOY SX-red jet nebulizer. This result confirmed that aerosol droplet size is an important factor in determining the efficiency of dornase alfa delivery to the lungs. Further clinical studies and analysis are required before any conclusions can be drawn regarding the clinical safety and efficacy of these nebulizers.

Influence of Divalent Cation on Morphology and Drug Delivery Efficiency of Mixed Polymer Nanoparticles

2018 ◽  
Vol 15 (5) ◽  
pp. 652-657 ◽  
Author(s):  
Ramachandran Deepika ◽  
Koyeli Girigoswami ◽  
Ramachandran Murugesan ◽  
Agnishwar Girigoswami
Keyword(s):  
Drug Delivery ◽  
Divalent Cation ◽  
Polymer Nanoparticles ◽  
Delivery Efficiency

Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications

2020 ◽  
Vol 20 (4) ◽  
pp. 271-287 ◽  
Author(s):  
Kuldeep Rajpoot
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Targeted Drug Delivery ◽  
Tumor Therapy ◽  
Cancer Therapies ◽  
Medication Delivery ◽  
Lipid Nanocarriers ◽  
Targeted Drug ◽  
Drug Nanocarriers

Though modern available cancer therapies are effective, they possess major adverse effects, causing non-compliance to patients. Furthermore, the majority of the polymeric-based medication platforms are certainly not universally acceptable, due to their several restrictions. With this juxtaposition, lipid-based medication delivery systems have appeared as promising drug nanocarriers to replace the majority of the polymer-based products because they are in a position to reverse polymer as well as, drug-associated restrictions. Furthermore, the amalgamation of the basic principle of nanotechnology in designing lipid nanocarriers, which are the latest form of lipid carriers, has tremendous chemotherapeutic possibilities as tumor-targeted drug-delivery pertaining to tumor therapy. Apart from this, it is reported that nearly 40% of the modern medication entities are lipophilic. Moreover, research continues to be efficient in attaining a significant understanding of the absorption and bioavailability of the developed lipids systems.

In vivo drug delivery efficiency of albumin-encapsulated liposomes as hydrophobic drug carriers

2018 ◽  
Vol 47 ◽  
pp. 62-66 ◽  
Author(s):  
Yuko Okamoto ◽  
Kazuaki Taguchi ◽  
Mina Sakuragi ◽  
Shuhei Imoto ◽  
Keishi Yamasaki ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Carriers ◽  
Hydrophobic Drug ◽  
Delivery Efficiency

Review on Nanotechnology and its utilization in Pharmaceuticals

2021 ◽  
pp. 319-322
Author(s):  
Kiran Patole ◽  
Anil Danane ◽  
Amit Nikam ◽  
Anuja Patil
Keyword(s):  
Drug Delivery ◽  
Pharmaceutical Industry ◽  
Molecular Biology ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Medication Delivery ◽  
Traditional Drug ◽  
Pharmaceutical Nanotechnology

Nanotechnology is the study of tiny structures ranging in size from 0.1 to 100 nanometers. It includes biophysics, molecular biology, and bioengineering, as well as medical subspecialties such as cardiology, ophthalmology, endocrinology, oncology, and immunology. Pharmaceutical Nanotechnology combines the methods and ideas of nanoscience and nanomedicine with pharmacy to create novel medication delivery systems that transcend the limitations of traditional drug delivery systems. The purpose of this article is to provide an overview of nanotechnology and its uses in the pharmaceutical industry.

Biocompatibility and drug delivery efficiency of PEG-b-PCL/hydroxyapatite bilayer coatings on Nitinol superelastic alloy

2020 ◽  
Vol 46 (8) ◽  
pp. 12711-12717
Author(s):  
M.R. Etminanfar ◽  
S.O.R. Sheykholeslami ◽  
V. Khalili ◽  
S. Mahdavi
Keyword(s):  
Drug Delivery ◽  
Delivery Efficiency ◽  
Bilayer Coatings

Study on the Application of Magnetic Nanoparticles as Drug Delivery Particles on the Atopic Dermatitis

2013 ◽  
Vol 750 ◽  
pp. 180-183
Author(s):  
Gang An ◽  
Ping Ma ◽  
Dong Ying Ju ◽  
Takashi Kumazawa
Keyword(s):  
Drug Delivery ◽  
Atopic Dermatitis ◽  
Magnetic Nanoparticles ◽  
Medical Treatment ◽  
Magnetite Nanoparticles ◽  
Treatment Technique ◽  
Mice Model ◽  
Target Region ◽  
Better Than

It is well known that the advances in the biomedicinal applications of magnetite nanoparticles were studied recently. As a drug delivery tools, it only affects on the target region of illness. We investigated the application of magnetic nanoparticles as drug delivery tools by the mice model of atopic dermatitis. The results involve that after magnetic nanoparticles are applied to the skin, the condition of atopic dermatitis becomes much better than the former one of atopic mice model. It only affects on the illness region and healthy regions almost have no influence. It is suitable for the medical treatment technique usage on the atopic dermatitis.

scholarly journals Albumin-based nanosystems in medicine

2018 ◽  
Vol 72 ◽  
pp. 1004-1017
Author(s):  
Bogusława Konopska ◽  
Krzysztof Gołąb ◽  
Katarzyna Juszczyńska ◽  
Jakub Gburek
Keyword(s):  
Drug Delivery ◽  
The United States ◽  
Delivery Systems ◽  
Anti Cancer ◽  
United States Food ◽  
Poorly Soluble ◽  
States Food ◽  
The Common ◽  
Low Cytotoxicity ◽  
Delivery Efficiency

Proteins are natural and safe substitutes of the synthetic polymers for the development of drug delivery systems (DDS). Few of proteins have been approved for drug delivery purposes by the United States Food and Drug Administration (FDA). Among them, albumin is the most explored carrier for synthesis of therapeutic nanoparticles. Its usefulness was determined by the common accessibility, biocompatibility and the feasibility of accumulation in tissues with increased metabolism. Albumin with its properties is particularly attractive carrier for anti-arthritis and anti-cancer drugs. It is mainly used to design delivery systems for poorly soluble substances with low permeability through biological membranes. The albumin nanoparticles are characterized by favourable pharmacokinetics, high drug delivery efficiency and low cytotoxicity. In addition, they are biodegradable, relatively easy to prepare and non-immunogenic. Interest in the exploration of clinical applications of albumin-based drug delivery carriers, especially for those at the nanoscale, has increased in recent years. A lot of research have been done to design multifunctional theranostic nanosystems that could be used for both imaging and cancer therapy. This article aims at providing an overview of already commercialized and just emerging applications of albumin-based nanosystems as drug delivery carriers.

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