scholarly journals TRP Channels as Therapeutic Targets in Diabetes and Obesity

2016 ◽  
Vol 9 (3) ◽  
pp. 50 ◽  
Author(s):  
Andrea Zsombok ◽  
Andrei Derbenev
Keyword(s):  
Trp Channels ◽  
Therapeutic Targets ◽  
Diabetes And Obesity

TRP channels: diagnostic markers and therapeutic targets for breast cancer?

2013 ◽  
Vol 19 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Halima Ouadid-Ahidouch ◽  
Isabelle Dhennin-Duthille ◽  
Mathieu Gautier ◽  
Henri Sevestre ◽  
Ahmed Ahidouch
Keyword(s):  
Breast Cancer ◽  
Trp Channels ◽  
Therapeutic Targets ◽  
Diagnostic Markers

TRP channels as therapeutic targets in airway disorders: a patent review

2012 ◽  
Vol 22 (6) ◽  
pp. 663-695 ◽  
Author(s):  
Delia Preti ◽  
Arpad Szallasi ◽  
Riccardo Patacchini
Keyword(s):  
Trp Channels ◽  
Therapeutic Targets ◽  
Patent Review

scholarly journals Vascular Dysfunction in Diabetes and Obesity: Focus on TRP Channels

2021 ◽  
Vol 12 ◽  
Author(s):  
Raiana dos Anjos Moraes ◽  
R. Clinton Webb ◽  
Darízy Flávia Silva
Keyword(s):  
Molecular Mechanisms ◽  
Transient Receptor Potential ◽  
Metabolic Diseases ◽  
Trp Channels ◽  
Vascular Dysfunction ◽  
Vascular Complications ◽  
Sensory Nerves ◽  
Perivascular Adipose Tissue ◽  
Cardiometabolic Diseases ◽  
Diabetes And Obesity

Transient receptor potential (TRP) superfamily consists of a diverse group of non-selective cation channels that has a wide tissue distribution and is involved in many physiological processes including sensory perception, secretion of hormones, vasoconstriction/vasorelaxation, and cell cycle modulation. In the blood vessels, TRP channels are present in endothelial cells, vascular smooth muscle cells, perivascular adipose tissue (PVAT) and perivascular sensory nerves, and these channels have been implicated in the regulation of vascular tone, vascular cell proliferation, vascular wall permeability and angiogenesis. Additionally, dysfunction of TRP channels is associated with cardiometabolic diseases, such as diabetes and obesity. Unfortunately, the prevalence of diabetes and obesity is rising worldwide, becoming an important public health problems. These conditions have been associated, highlighting that obesity is a risk factor for type 2 diabetes. As well, both cardiometabolic diseases have been linked to a common disorder, vascular dysfunction. In this review, we briefly consider general aspects of TRP channels, and we focus the attention on TRPC (canonical or classical), TRPV (vanilloid), TRPM (melastatin), and TRPML (mucolipin), which were shown to be involved in vascular alterations of diabetes and obesity or are potentially linked to vascular dysfunction. Therefore, elucidation of the functional and molecular mechanisms underlying the role of TRP channels in vascular dysfunction in diabetes and obesity is important for the prevention of vascular complications and end-organ damage, providing a further therapeutic target in the treatment of these metabolic diseases.

TRP Channels as Therapeutic Targets in Kidney Disease and Hypertension

2013 ◽  
Vol 13 (3) ◽  
pp. 386-397 ◽  
Author(s):  
Paolo Mene ◽  
Giorgio Punzo ◽  
Nicola Pirozzi
Keyword(s):  
Kidney Disease ◽  
Trp Channels ◽  
Therapeutic Targets

Editorial: TRP Channels as Therapeutic Targets

2013 ◽  
Vol 999 (999) ◽  
pp. 8-14
Author(s):  
Yosuke Kaneko ◽  
Arpad Szallasi
Keyword(s):  
Trp Channels ◽  
Therapeutic Targets
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