scholarly journals Opioid Antagonists May Reverse Endogenous Opiate “Dependence” in the Treatment of Self-Injurious Behavior

2011 ◽  
Vol 4 (2) ◽  
pp. 366-381 ◽  
Author(s):  
Curt A. Sandman ◽  
Aaron S. Kemp
Keyword(s):  
Opiate Dependence ◽  
Opioid Antagonists ◽  
Endogenous Opiate

Classical conditioning in opiate dependence.

1984 ◽  
Author(s):  
Charles P. O'Brien ◽  
Ronald N. Ehrman ◽  
Joseph W. Ternes
Keyword(s):  
Classical Conditioning ◽  
Opiate Dependence

Opioid Peptide Receptor Studies. 13. Characterization of Opioid Antagonists With the [35S]GTP-γ-S Binding Assay

Analgesia ◽  
1999 ◽  
Vol 4 (1) ◽  
pp. 27-32 ◽  
Author(s):  
John S. Partilla ◽  
F. Ivy Carrol ◽  
James B. Thomas ◽  
Kenner C. Rice ◽  
Dennis M. Zimmerman ◽  
...  
Keyword(s):  
Binding Assay ◽  
Opioid Peptide ◽  
Opioid Antagonists ◽  
Peptide Receptor

Synthesis oftrans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Opioid Antagonists:  Application of theCis-Thermal Elimination of Carbonates to Alkaloid Synthesis

1996 ◽  
Vol 61 (2) ◽  
pp. 587-597 ◽  
Author(s):  
John A. Werner ◽  
Louis R. Cerbone ◽  
Scott A. Frank ◽  
Jeffrey A. Ward ◽  
Parviz Labib ◽  
...  
Keyword(s):  
Opioid Antagonists ◽  
Alkaloid Synthesis ◽  
Thermal Elimination

Interaction between methadone and clarithromycin as the suspected cause of an opioid toxidrome

2021 ◽  
Vol 14 (5) ◽  
pp. e240647
Author(s):  
Blair Wallace ◽  
Daniel Edwardes ◽  
Christian Subbe ◽  
Muhammed Murtaza
Keyword(s):  
Respiratory Failure ◽  
Community Acquired Pneumonia ◽  
Opiate Dependence ◽  
Pleuritic Chest Pain ◽  
Once Daily ◽  
High Importance ◽  
Level Of Consciousness ◽  
The World ◽  
History Of

A 40-year-old patient was admitted through the acute medical take with pleuritic chest pain and rigours. He had a medical history of opiate dependence and was receiving 60 mg of methadone once daily. He was diagnosed with a community-acquired pneumonia and treated with amoxicillin and clarithromycin. After administration of only two concomitant doses of methadone and oral clarithromycin, he developed an opioid toxidrome with type-2 respiratory failure, a decreased level of consciousness and pinpoint pupils. The patient was treated with naloxone and his symptoms improved. Retrospectively, it was suspected that an interaction between clarithromycin and methadone might have contributed to the toxidrome. Respiratory failure has not been previously prescribed for this combination of medication and is of high importance for physicians and pharmacists around the world.

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