scholarly journals Multiple Routes to Oestrogen Antagonism

2010 ◽  
Vol 3 (11) ◽  
pp. 3417-3434 ◽  
Author(s):  
Hilary R. Glover ◽  
Stewart Barker ◽  
Sylvanie D. M. Malouitre ◽  
John R. Puddefoot ◽  
Gavin P. Vinson
Keyword(s):  
Multiple Routes ◽  
Oestrogen Antagonism

Dictators and Democrats

2016 ◽  
Author(s):  
Stephan Haggard ◽  
Robert R. Kaufman
Keyword(s):  
First Century ◽  
Organizational Capabilities ◽  
Mass Mobilization ◽  
Democratic Transitions ◽  
Authoritarian Rule ◽  
Emerging Democracies ◽  
Regime Changes ◽  
Political Landscape ◽  
Transitions To Democracy ◽  
Multiple Routes

From the 1980s through the first decade of the twenty-first century, the spread of democracy across the developing and postcommunist worlds transformed the global political landscape. What drove these changes and what determined whether the emerging democracies would stabilize or revert to authoritarian rule? This book takes a comprehensive look at the transitions to and from democracy in recent decades. Deploying both statistical and qualitative analysis, the book engages with theories of democratic change and advocates approaches that emphasize political and institutional factors. While inequality has been a prominent explanation for democratic transitions, the book argues that its role has been limited, and elites as well as masses can drive regime change. Examining seventy-eight cases of democratic transition and twenty-five cases of reversion to autocracy since 1980, the book shows how differences in authoritarian regimes and organizational capabilities shape popular protest and elite initiatives in transitions to democracy, and how institutional weaknesses cause some democracies to fail. The determinants of democracy lie in the strength of existing institutions and the public's capacity to engage in collective action. There are multiple routes to democracy, but those growing out of mass mobilization may provide more checks on incumbents than those emerging from intra-elite bargains. Moving beyond well-known beliefs regarding regime changes, this book explores the conditions under which transitions to democracy are likely to arise.

scholarly journals Vaccination against Canine Distemper Virus Infection in Infant Ferrets with and without Maternal Antibody Protection, Using Recombinant Attenuated Poxvirus Vaccines

2000 ◽  
Vol 74 (14) ◽  
pp. 6358-6367 ◽  
Author(s):  
Janet Welter ◽  
Jill Taylor ◽  
James Tartaglia ◽  
Enzo Paoletti ◽  
Charles B. Stephensen
Keyword(s):  
Canine Distemper Virus ◽  
Clinical Signs ◽  
Neutralizing Antibody ◽  
Maternal Antibody ◽  
Canine Distemper ◽  
Parenteral Immunization ◽  
Multiple Routes ◽  
Antibody Titers ◽  
Group 3 ◽  
Rabies Glycoprotein

ABSTRACT Canine distemper virus (CDV) infection of ferrets is clinically and immunologically similar to measles, making this a useful model for the human disease. The model was used to determine if parenteral or mucosal immunization of infant ferrets at 3 and 6 weeks of age with attenuated vaccinia virus (NYVAC) or canarypox virus (ALVAC) vaccine strains expressing the CDV hemagglutinin (H) and fusion (F) protein genes (NYVAC-HF and ALVAC-HF) would induce serum neutralizing antibody and protect against challenge infection at 12 weeks of age. Ferrets without maternal antibody that were vaccinated parenterally with NYVAC-HF (n = 5) or ALVAC-HF (n = 4) developed significant neutralizing titers (log10 inverse mean titer ± standard deviation of 2.30 ± 0.12 and 2.20 ± 0.34, respectively) by the day of challenge, and all survived with no clinical or virologic evidence of infection. Ferrets without maternal antibody that were vaccinated intranasally (i.n.) developed lower neutralizing titers, with NYVAC-HF producing higher titers at challenge (1.11 ± 0.57 versus 0.40 ± 0.37, P = 0.02) and a better survival rate (6/7 versus 0/5, P = 0.008) than ALVAC-HF. Ferrets with maternal antibody that were vaccinated parenterally with NYVAC-HF (n = 7) and ALVAC-HF (n = 7) developed significantly higher antibody titers (1.64 ± 0.54 and 1.28 ± 0.40, respectively) than did ferrets immunized with an attenuated CDV vaccine (0.46 ± 0.59;n = 7) or the recombinant vectors expressing rabies glycoprotein (RG) (0.19 ± 0.32; n = 8,P = 7 × 10−6). The NYVAC vaccine also protected against weight loss, and both the NYVAC and attenuated CDV vaccines protected against the development of some clinical signs of infection, although survival in each of the three vaccine groups was low (one of seven) and not significantly different from the RG controls (none of eight). Combined i.n.-parenteral immunization of ferrets with maternal antibody using NYVAC-HF (n = 9) produced higher titers (1.63 ± 0.25) than did i.n. immunization with NYVAC-HF (0.88 ± 0.36; n = 9) and ALVAC-HF (0.61 ± 0.43; n = 9, P = 3 × 10−7), and survival was also significantly better in the i.n.-parenteral group (3 of 9) than in the other HF-vaccinated animals (none of 18) or in controls immunized with RG (none of 5) (P = 0.0374). Multiple routes were not tested with the ALVAC vaccine. The results suggest that infant ferrets are less responsive to i.n. vaccination than are older ferrets and raises questions about the appropriateness of this route of immunization in infant ferrets or infants of other species.

scholarly journals Multiple Routes from Occipital to Temporal Cortices during Reading

2011 ◽  
Vol 31 (22) ◽  
pp. 8239-8247 ◽  
Author(s):  
F. M. Richardson ◽  
M. L. Seghier ◽  
A. P. Leff ◽  
M. S. C. Thomas ◽  
C. J. Price
Keyword(s):  
Multiple Routes

scholarly journals Multiple routes lead to the native state in the energy landscape of the beta-trefoil family

2006 ◽  
Vol 103 (27) ◽  
pp. 10254-10258 ◽  
Author(s):  
L. L. Chavez ◽  
S. Gosavi ◽  
P. A. Jennings ◽  
J. N. Onuchic
Keyword(s):  
Energy Landscape ◽  
Native State ◽  
Multiple Routes

Multiple routes to mind wandering: Predicting mind wandering with resource theories

2019 ◽  
Vol 67 ◽  
pp. 26-43 ◽  
Author(s):  
Jason G. Randall ◽  
Margaret E. Beier ◽  
Anton J. Villado
Keyword(s):  
Mind Wandering ◽  
Multiple Routes

Sensor Operation Deployment with Multiple Routes per Asset

2018 ◽  
Author(s):  
Jennifer Sander ◽  
Roland Rodenbeck ◽  
Frank Reinert ◽  
Wilmuth Muller ◽  
Kim Berude
Keyword(s):  
Multiple Routes
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