scholarly journals Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Progress in Small Molecule Drug Development

2010 ◽  
Vol 3 (5) ◽  
pp. 1530-1549 ◽  
Author(s):  
Praveen P. N. Rao ◽  
Saad N. Kabir ◽  
Tarek Mohamed
Keyword(s):  
Drug Development ◽  
Small Molecule ◽  
Small Molecule Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Towards Academic Drug Development Guidelines

2019 ◽  
Author(s):  
Christopher Southan
Keyword(s):  
Drug Development ◽  
Success Rate ◽  
Case Studies ◽  
Small Molecule ◽  
Research Productivity ◽  
Medicinal Chemistry ◽  
Academic Development ◽  
Commercial Development ◽  
Small Molecule Drug

This report covers academic small-molecule drug development with a view to distilling guidelines. The first section covers research productivity feeding into commercial development before reviewing the literature on statistics of academic development It then considers differences between probes and drugs before discussing the role of author guidelines in medicinal chemistry and pharmacology journals. Resources for comprehensive compound and target cross-checking are then covered followed by comparisons between public and commercial databases including case studies of selected compounds. It concludes with an outline of new scientific developments that could increase the success rate of academic drug development.

scholarly journals Towards Academic Drug Development Guidelines

2019 ◽  
Author(s):  
Christopher Southan
Keyword(s):  
Drug Development ◽  
Success Rate ◽  
Case Studies ◽  
Small Molecule ◽  
Research Productivity ◽  
Medicinal Chemistry ◽  
Academic Development ◽  
Commercial Development ◽  
Small Molecule Drug

This report covers academic small-molecule drug development with a view to distilling guidelines. The first section covers research productivity feeding into commercial development before reviewing the literature on statistics of academic development It then considers differences between probes and drugs before discussing the role of author guidelines in medicinal chemistry and pharmacology journals. Resources for comprehensive compound and target cross-checking are then covered followed by comparisons between public and commercial databases including case studies of selected compounds. It concludes with an outline of new scientific developments that could increase the success rate of academic drug development.

scholarly journals A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0226661 ◽  
Author(s):  
Teresa L. Burgess ◽  
Joshua D. Amason ◽  
Jeffrey S. Rubin ◽  
Damien Y. Duveau ◽  
Laurence Lamy ◽  
...  
Keyword(s):  
Drug Development ◽  
Ligand Binding ◽  
Small Molecule ◽  
Binding Assay ◽  
Ligand Binding Assay ◽  
Small Molecule Drug

scholarly journals Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals

2019 ◽  
Vol 20 (18) ◽  
pp. 4367 ◽  
Author(s):  
Kalpesh R. Patil ◽  
Umesh B. Mahajan ◽  
Banappa S. Unger ◽  
Sameer N. Goyal ◽  
Sateesh Belemkar ◽  
...  
Keyword(s):  
Animal Models ◽  
Adverse Effects ◽  
Drug Development ◽  
Drug Screening ◽  
Current Therapy ◽  
Natural Sources ◽  
Inflammatory Drug ◽  
Screening Programs ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Inflammation is one of the common events in the majority of acute as well as chronic debilitating diseases and represent a chief cause of morbidity in today’s era of modern lifestyle. If unchecked, inflammation leads to development of rheumatoid arthritis, diabetes, cancer, Alzheimer’s disease, and atherosclerosis along with pulmonary, autoimmune and cardiovascular diseases. Inflammation involves a complex network of many mediators, a variety of cells, and execution of multiple pathways. Current therapy for inflammatory diseases is limited to the steroidal and non-steroidal anti-inflammatory agents. The chronic use of these drugs is reported to cause severe adverse effects like gastrointestinal, cardiovascular, and renal abnormalities. There is a massive need to explore new anti-inflammatory agents with selective action and lesser toxicity. Plants and isolated phytoconstituents are promising and interesting sources of new anti-inflammatories. However, drug development from natural sources has been linked with hurdles like the complex nature of extracts, difficulties in isolation of pure phytoconstituents, and the yield of isolated compounds in minute quantities that is insufficient for subsequent lead development. Although various in-vivo and in-vitro models for anti-inflammatory drug development are available, judicious selection of appropriate animal models is a vital step in the early phase of drug development. Systematic evaluation of phytoconstituents can facilitate the identification and development of potential anti-inflammatory leads from natural sources. The present review describes various techniques of anti-inflammatory drug screening with its advantages and limitations, elaboration on biological targets of phytoconstituents in inflammation and biomarkers for the prediction of adverse effects of anti-inflammatory drugs. The systematic approach proposed through present article for anti-inflammatory drug screening can rationalize the identification of novel phytoconstituents at the initial stage of drug screening programs.

Associating Histopathological Findings with Drug-Induced Kidney Injury Rat Biomarkers in Small Molecule Drug Development—A Case Study

2017 ◽  
Vol 88 ◽  
pp. 213
Author(s):  
Andre Nogueira da Costa ◽  
Marcia Santos ◽  
Pierrette De Ron ◽  
Jean-Pierre Valentin ◽  
Renaud Fleurance ◽  
...  
Keyword(s):  
Drug Development ◽  
Small Molecule ◽  
Kidney Injury ◽  
Drug Induced ◽  
Histopathological Findings ◽  
Small Molecule Drug

scholarly journals Towards Academic Drug Development Guidelines

2019 ◽  
Author(s):  
Christopher Southan
Keyword(s):  
Drug Development ◽  
Success Rate ◽  
Case Studies ◽  
Small Molecule ◽  
Research Productivity ◽  
Medicinal Chemistry ◽  
Academic Development ◽  
Commercial Development ◽  
Small Molecule Drug

This report covers academic small-molecule drug development with a view to distilling guidelines. The first section covers research productivity feeding into commercial development before reviewing the literature on statistics of academic development It then considers differences between probes and drugs before discussing the role of author guidelines in medicinal chemistry and pharmacology journals. Resources for comprehensive compound and target cross-checking are then covered followed by comparisons between public and commercial databases including case studies of selected compounds. It concludes with an outline of new scientific developments that could increase the success rate of academic drug development.

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