scholarly journals Usage of Synthetic Peptides in Cosmetics for Sensitive Skin

2021 ◽  
Vol 14 (8) ◽  
pp. 702
Author(s):  
Diana I. S. P. Resende ◽  
Marta Salvador Ferreira ◽  
José Manuel Sousa-Lobo ◽  
Emília Sousa ◽  
Isabel Filipa Almeida
Keyword(s):  
Clinical Study ◽  
Synthetic Peptides ◽  
Scientific Evidence ◽  
Signal Peptides ◽  
Active Ingredients ◽  
High Potency ◽  
Sensitive Skin ◽  
Present Evidence ◽  
Skin Cells ◽  
Low Dosage

Sensitive skin is characterized by symptoms of discomfort when exposed to environmental factors. Peptides are used in cosmetics for sensitive skin and stand out as active ingredients for their ability to interact with skin cells by multiple mechanisms, high potency at low dosage and the ability to penetrate the stratum corneum. This study aimed to analyze the composition of 88 facial cosmetics for sensitive skin from multinational brands regarding usage of peptides, reviewing their synthetic pathways and the scientific evidence that supports their efficacy. Peptides were found in 17% of the products analyzed, namely: acetyl dipeptide-1 cetyl ester, palmitoyl tripeptide-8, acetyl tetrapeptide-15, palmitoyl tripeptide-5, acetyl hexapeptide-49, palmitoyl tetrapeptide-7 and palmitoyl oligopeptide. Three out of seven peptides have a neurotransmitter-inhibiting mechanism of action, while another three are signal peptides. Only five peptides present evidence supporting their use in sensitive skin, with only one clinical study including volunteers having this condition. Noteworthy, the available data is mostly found in patents and supplier brochures, and not in randomized placebo-controlled studies. Peptides are useful active ingredients in cosmetics for sensitive skin. Knowing their efficacy and synthetic pathways provides meaningful insight for the development of new and more effective ingredients.

scholarly journals Effects of a complex mixture prepared from agrimonia, houttuynia, licorice, peony, and phellodendron on human skin cells

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kyung-Ha Lee ◽  
Jeong Pyo Lee ◽  
Wanil Kim
Keyword(s):  
Human Skin ◽  
Complex Mixture ◽  
Skin Barrier ◽  
Aging Effect ◽  
Human Keratinocytes ◽  
Skin Barrier Function ◽  
Active Ingredients ◽  
Γ Irradiation ◽  
Skin Cells ◽  
Human Skin Cells

AbstractActive ingredients derived from natural sources are widely utilized in many industries. Cosmetic active ingredients are largely derived from various plants. In this study, we examined whether a mixture of plant extracts obtained from agrimonia, houttuynia, licorice, peony, and phellodendron (hereafter AHLPP), which are well-known for their effects on skin, could affect skin barrier function, inflammation, and aging in human skin cells. We also determined whether AHLPP extracts sterilized using γ-irradiation (to avoid preservatives) retained their skin cell regulating activity. The AHLPP mixture could downregulate representative pro-inflammatory cytokines including IL 1-β and IL 7. Procollagen peptide synthesis was also increased by AHLPP treatment along with mRNA upregulation of barrier proteins such as filaggrin and desmoplakin. The AHLPP mixture showed an anti-aging effect by significantly upregulating telomerase activity in human keratinocytes. We further observed TERT upregulation and CDKN1B downregulation, implying a weakening of pro-aging signal transduction. Co-cultivation of a hydrogel polymer containing the AHLPP mixture with human skin cells showed an alteration in skin-significant genes such as FLG, which encodes filaggrin. Thus, the AHLPP mixture with or without γ-irradiation can be utilized for skin protection as it alters the expression of some significant genes in human skin cells.

scholarly journals Interaction of wild-type signal sequences and their charged variants with model and natural membranes

1993 ◽  
Vol 293 (1) ◽  
pp. 43-49 ◽  
Author(s):  
N M Rao ◽  
R Nagaraj
Keyword(s):  
Amino Acids ◽  
Synthetic Peptides ◽  
Model Membranes ◽  
Signal Peptides ◽  
Wild Type ◽  
Signal Sequences ◽  
Hydrophobic Region ◽  
Phospholipases A2 ◽  
Charged Amino Acids

The interaction of synthetic peptides corresponding to wild-type signal sequences, and their mutants having charged amino acids in the hydrophobic region, with model and natural membranes has been studied. At high peptide concentrations, i.e. low lipid/peptide ratios, the signal peptides cause release of carboxyfluorescein (CF) from model membranes with lipid compositions corresponding to those of translocation-competent as well as translocation-incompetent membranes. Interestingly, mutant sequences, which were non-functional in vivo, caused considerable release of CF compared with the wild-type sequences. Both wild-type and mutant signal sequences perturb model membranes even at lipid/peptide ratios of 1000:1, as indicated by the activities of phospholipases A2, C and D. These studies indicate that such mutant signals are non-functional not because of their inability to interact with membranes, but due to defective targeting to the membrane. The signal peptides inhibit phospholipase C activity in microsomes, uncouple oxidative phosphorylation in mitochondria and increase K+ efflux from erythrocytes, and one of the mutant sequences is a potent degranulator of the mast cells. Both wild-type and mutant signal sequences have the ability to perturb vesicles of various lipid compositions. With respect to natural membranes, the peptides do not show any bias towards translocation-competent membranes.

scholarly journals Effects of Gene-Eden-VIR and Novirin on SARS-CoV: Implications for COVID-19

2020 ◽  
Vol 25 ◽  
pp. 2515690X2093252
Author(s):  
Hanan Polansky ◽  
Gillad Lori
Keyword(s):  
Clinical Study ◽  
Severe Acute Respiratory Syndrome ◽  
Broad Spectrum ◽  
Clinical Studies ◽  
Government Agencies ◽  
Pharmaceutical Companies ◽  
Sars Coronavirus ◽  
Present Evidence ◽  
Virus Gene ◽  
Need For Treatment

The coronavirus (SARS-CoV-2), which causes COVID-19, is a betacoronavirus closely related to the human severe acute respiratory syndrome (SARS)-coronavirus (SARS-CoV). The recent COVID-19 outbreak created an urgent need for treatment. To expedite the development of such treatment, pharmaceutical companies and government agencies are currently testing several existing drugs for their effect on the virus. Gene-Eden-VIR and Novirin are natural, broad-spectrum, antiviral treatments proven to be safe and effective in several clinical studies. In this article, we present evidence indicating that the 5 Gene-Eden-VIR/Novirin ingredients have anti-betacoronavirus, and specifically, anti-SARS-CoV effects. We consider this evidence as a first indication of the anti-coronavirus effects of Gene-Eden-VIR/Novirin. Next, we are planning to conduct a clinical study with users of the treatments to test the effects of Gene-Eden-VIR/Novirin on individuals at risk and those infected with the virus.

Marijuana legalization in Colorado: Increasing Potency, Changing Risk Perceptions, and Emerging Public Health Concerns for Youth

2021 ◽  
Vol 11 ◽  
Author(s):  
Jesse D. Hinckley ◽  
Christian Hopfer
Keyword(s):  
Risk Perceptions ◽  
Scientific Evidence ◽  
Marijuana Use ◽  
High Potency ◽  
Product Availability ◽  
Political Processes ◽  
Use Patterns ◽  
Marijuana Legalization ◽  
Treatment Considerations ◽  
History Of

Background: Marijuana legalization occurred gradually in Colorado through political processes. Objectives: This study aimed to describe the history of marijuana legalization and correlated shifts in product availability, use patterns, and risk perceptions and describe associated emerging concerns with this process for adolescents and young adults. Methods: This review focuses on the history of marijuana legalization and correlated shifts in product availability, use patterns, and risk perceptions. Results: Along with the legalization of marijuana, there has been strong commercialization characterized by the widespread development of dispensaries, new products including edibles and concentrates, and an overall lowering of the “price per serving” of marijuana. While the frequency of marijuana use among adolescents does not appear to have shifted substantially, young adult patterns of use have demonstrated an increase in usage. A substantial shift has occurred in the increasing use of concentrates and high potency products. Emerging concerns related to high potency products include increased acute care visits, prevalence and outcomes of comorbid mental health disorders, cannabis-induced psychosis, driving while high, marijuana-related lung injuries, and increased use during pregnancy. Yet, there are also potential medical uses of marijuana. Conclusion: To date, scientific evidence of the mental or physical effects of high potency products is currently very limited. Clinical issues related to the treatment of marijuana use and comorbid psychiatric disorders in youth are discussed, focusing on how low-risk perceptions influence treatment considerations.

scholarly journals The Use of Narrow Diameter Implants in the Molar Area

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
M. Saad ◽  
A. Assaf ◽  
E. Gerges
Keyword(s):  
Clinical Trials ◽  
Clinical Study ◽  
Bone Resorption ◽  
Gold Standard ◽  
Scientific Evidence ◽  
Bone Augmentation ◽  
Narrow Diameter Implants ◽  
Bone Height

Implant rehabilitations in the posterior jaw are influenced by many factors such as the condition of the remaining teeth, the force factors related to the patient, the quality of the bone, the maintenance of the hygiene, the limited bone height, the type and extent of edentulism, and the nature of the opposing arch. The gold standard is to place a regular diameter implant (>3.7 mm) or a wide one to replace every missing molar. Unfortunately, due to horizontal bone resorption, this option is not possible without lateral bone augmentation. In this situation, narrow diameter implant (NDI < 3.5 mm) could be the alternative to lateral bone augmentation procedures. This paper presents a clinical study where NDIs were used for the replacement of missing molars. They were followed up to 11 years. Special considerations were observed and many parameters were evaluated. NDI could be used to replace missing molar in case of moderate horizontal bone resorption if strict guidelines are respected. Yet, future controlled prospective clinical trials are required to admit their use as scientific evidence.

scholarly journals Marine Ingredients for Sensitive Skin: Market Overview

Marine Drugs ◽  
2021 ◽  
Vol 19 (8) ◽  
pp. 464
Author(s):  
Marta Salvador Ferreira ◽  
Diana I. S. P. Resende ◽  
José M. Sousa Lobo ◽  
Emília Sousa ◽  
Isabel F. Almeida
Keyword(s):  
Scientific Evidence ◽  
Skin Inflammation ◽  
Ascophyllum Nodosum ◽  
Cosmetic Products ◽  
Brown Macroalgae ◽  
Sensitive Skin ◽  
Great Opportunity ◽  
Red Macroalgae ◽  
Cosmetic Industry ◽  
Asparagopsis Armata

Marine ingredients are a source of new chemical entities with biological action, which is the reason why they have gained relevance in the cosmetic industry. The facial care category is the most relevant in this industry, and within it, the sensitive skin segment occupies a prominent position. This work analyzed the use of marine ingredients in 88 facial cosmetics for sensitive skin from multinational brands, as well as their composition and the scientific evidence that supports their efficacy. Marine ingredients were used in 27% of the cosmetic products for sensitive skin and included the species Laminaria ochroleuca, Ascophyllum nodosum (brown macroalgae), Asparagopsis armata (red macroalgae), and Chlorella vulgaris (microalgae). Carotenoids, polysaccharides, and lipids are the chemical classes highlighted in these preparations. Two ingredients, namely the Ascophyllum nodosum extract and Asparagopsis armata extracts, present clinical evidence supporting their use for sensitive skin. Overall, marine ingredients used in cosmetics for sensitive skin are proposed to reduce skin inflammation and improve the barrier function. Marine-derived preparations constitute promising active ingredients for sensitive skin cosmetic products. Their in-depth study, focusing on the extracted metabolites, randomized placebo-controlled studies including volunteers with sensitive skin, and the use of extraction methods that are more profitable may provide a great opportunity for the cosmetic industry.

scholarly journals Trending Anti-Aging Peptides

Cosmetics ◽  
2020 ◽  
Vol 7 (4) ◽  
pp. 91
Author(s):  
Marta Salvador Ferreira ◽  
Maria Catarina Magalhães ◽  
José Manuel Sousa-Lobo ◽  
Isabel Filipa Almeida
Keyword(s):  
Synthetic Peptides ◽  
Skin Care ◽  
Active Ingredients ◽  
Technical Data ◽  
Dominant Source ◽  
Scientific Databases ◽  
Cosmetic Industry ◽  
Cosmetic Formulations ◽  
Market Trends ◽  
Meaningful Data

The development of synthetic peptides for skin care dates to the 1980s. The cosmetic industry periodically launches new peptides, as they are promising and appealing active ingredients in the growing and innovative cosmetics market. In this study, trends in the use of peptides in anti-aging products were analyzed by comparing the composition of the products marketed in 2011 with products launched or reformulated in 2018. The scientific and marketing evidence for their application as active ingredients in anti-aging cosmetics was also compiled from products’ labels, suppliers’ technical data forms and online scientific databases. The use of peptides in anti-aging cosmetics increased by 7.2%, while the variety and the number of peptide combinations in products have increased by 88.5%. The most used peptides in antiaging cosmetic formulations are, in descending order, Palmitoyl Tetrapeptide-7, Palmitoyl Oligopeptide and Acetyl Hexapeptide-8. In 2011, the majority of peptides were obtained from synthesis, while in 2018, biotechnology processing was the dominant source. This study provides an overview of the market trends regarding the use of peptides in anti-aging products, providing meaningful data for scientists involved in the development of new peptides to identify opportunities for innovation in this area.

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