scholarly journals Interactions of Some Chemotherapeutic Agents as Epirubicin, Gemcitabine and Paclitaxel in Multicomponent Systems Based on Orange Essential Oil

2021 ◽  
Vol 14 (7) ◽  
pp. 619
Author(s):  
Adriana Samide ◽  
Bogdan Tutunaru ◽  
Renata-Maria Varut ◽  
Bogdan Oprea ◽  
Simona Iordache
Keyword(s):  
Essential Oil ◽  
Half Life ◽  
Hydrophobic Interactions ◽  
Volume Ratio ◽  
Orange Peel ◽  
Decomposition Reaction ◽  
Chemotherapeutic Agents ◽  
Alcohol Water ◽  
Orange Essential Oil ◽  
Over Time

In order to anticipate the effect induced by a natural product on the chemical activity of medicines simultaneously administered, spontaneous interactions of certain cancer treatment drugs such as, epirubicin (EPR), gemcitabine (GCT), and paclitaxel (PTX) with limonene (LIM)—a natural compound extracted from orange peel and known as an anticancer agent—were investigated. To estimate the stability of the drugs over time, a current density of 50 mA cm−2 was applied as an external stimulus between two platinum electrodes immersed in hydrochloric acid solution containing ethyl alcohol/water in the volume ratio of 2/3, in the absence and presence of orange essential oil (limonene concentration of 95%). The concentration variation of chemotherapeutic agents over time was evaluated by UV-Vis spectrophotometry. Kinetic studies have shown a delay in the decomposition reaction of epirubicin and gemcitabine and a paclitaxel activity stimulation. Thus, in the presence of limonene, the epirubicin half-life increased from 46.2 min to 63 min, and from 6.2 min to 8.6 min in gemcitabine case, while for paclitaxel a decrease of half-life from 35.9 min to 25.8 min was determined. Therefore, certain drug-limonene interactions took place, leading to the emergence of molecular micro-assemblies impacting decomposition reaction of chemotherapeutics. To predict drug–limonene interactions, the Autodock 4.2.6 system was employed. Thus, two hydrophobic interactions and five π-alkyl interactions were established between EPR-LIM, the GCT-LIM connection involves four π-alkyl interactions, and the PTX-LIM bridges take place through three hydrophobic interactions and the one π-alkyl. Finally, the decomposition reaction mechanism of drugs was proposed.

scholarly journals Orange Peel Essential Oil Nanoemulsions Supported by Nanosilver for Antibacterial Application

2020 ◽  
Vol 20 (2) ◽  
pp. 430
Author(s):  
Doan Van Dat ◽  
Nguyen Van Cuong ◽  
Pham Hoang Ai Le ◽  
Tran Thi Lan Anh ◽  
Pham Tan Viet ◽  
...  
Keyword(s):  
Essential Oil ◽  
Ultrasonic Method ◽  
Average Particle Size ◽  
Orange Peel ◽  
Gas Chromatography Mass Spectrometry ◽  
Diffusion Method ◽  
Average Particle ◽  
Antibacterial Ability ◽  
Mechanical Stirring ◽  
Orange Essential Oil

This study is devoted to the synthesis of King Orange peel essential oil in water nanoemulsions combined with nanosilver by ultrasonic method supported by mechanical stirring for antibacterial application. The samples were characterized by Gas chromatography-mass spectrometry (GC-MS), Ultraviolet–visible (UV-Vis), Transmission electron microscopy (TEM), and Dynamic light scattering (DLS) methods. According to the above-experimental results, it was found that the emulsions based on orange essential oil (without nanosilver) and the ones combined with nanosilver have the average particle size from 66.2 nm and 42.9 nm, respectively. The obtained nanoemulsions were also tested to examine their antibacterial ability against Escherichia coli (E. coli) by the disc diffusion method. It has been also found that nanoemulsions based on orange essential oil supported by nanosilver have the superior antibacterial ability, compared with individual components of the materials.

scholarly journals Edible Films from Carrageenan/Orange Essential Oil/Trehalose—Structure, Optical Properties, and Antimicrobial Activity

Polymers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 332
Author(s):  
Jancikova Simona ◽  
Dordevic Dani ◽  
Sedlacek Petr ◽  
Nejezchlebova Marcela ◽  
Treml Jakub ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oil ◽  
Antibacterial Properties ◽  
Edible Films ◽  
Attenuated Total Reflectance ◽  
Practical Application ◽  
Film Properties ◽  
Gram Positive Bacteria ◽  
Edible Packaging ◽  
Orange Essential Oil

The research aim was to use orange essential oil and trehalose in a carrageenan matrix to form edible packaging. The edible packaging experimentally produced by casting from an aqueous solution were evaluated by the following analysis: UV-Vis spectrum, transparency value, transmittance, attenuated total reflectance Fourier-Transform spectroscopy (FTIR), scanning electron microscopy (SEM) and antimicrobial activity. The obtained results showed that the combination of orange essential oil with trehalose decreases the transmittance value in the UV and Vis regions (up to 0.14% ± 0.02% at 356 nm), meaning that produced films can act as a UV protector. Most produced films in the research were resistant to Gram-positive bacteria (Staphylococcus aureus subsp. aureus), though most films did not show antibacterial properties against Gram-negative bacteria and yeasts. FTIR and SEM confirmed that both the amount of carrageenan used and the combination with orange essential oil influenced the compatibility of trehalose with the film matrix. The research showed how different combinations of trehalose, orange essential oils and carrageenan can affect edible film properties. These changes represent important information for further research and the possible practical application of these edible matrices.

Effect of aromatherapy massage with orange essential oil on postoperative pain after cesarean section: a randomized controlled trial

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Seyedmohammad Mirhosseini ◽  
Ali Abbasi ◽  
Nastaran Norouzi ◽  
Fatemeh Mobaraki ◽  
Mohammad Hasan Basirinezhad ◽  
...  
Keyword(s):  
Side Effects ◽  
Essential Oil ◽  
Cesarean Section ◽  
Statistical Tests ◽  
Intervention Group ◽  
Nursing Intervention ◽  
Anxiety Score ◽  
Control Group ◽  
And Control ◽  
Orange Essential Oil

Abstract Objectives Many women in recent years have been willing to undergo puncture surgery for childbirth, which, like other surgeries, has physical and psychological side effects such as incision, infertility, chronic pain, and anxiety. Therefore, it is important to reduce and improve these side effects. The aim of this study was to determine the effect of foot massage with orange essential oil on pain and anxiety in women undergoing cesarean section. Methods This randomized clinical trial study was conducted in 2019 on 80 women referred to Bahar Shahroud Hospital after cesarean section surgery. The samples were divided into two groups by intervention (foot massage with orange essential oil) and control (foot massage without orange essential oil). The Spielberger scale was used to determine anxiety scores after cesarean section. In the intervention group, the feet were massaged with orange essential oil, and in the control group, the orange essential oil massage was performed without oil. Anxiety before, immediately after, and 60 min after the intervention was measured and evaluated in both groups. Data analysis was performed using descriptive and inferential statistics. Significant levels were considered for all statistical tests (p<0.05). Results The anxiety score before the intervention in the two groups of intervention and control was 57.12 ± 3.12 and 57.07 ± 3.54, respectively, which were not significantly different, but immediately after the intervention, the anxiety scores in both groups decreased significantly so that there was a further decrease in the intervention group (52.10 ± 4.75 and 56.02 ± 3.77), 1 h after the intervention, the anxiety score in the intervention group decreased compared to the previous stage and increased in the control group (50.40 ± 3.74 and 56.85 ± 4.27). Conclusions Foot massage with orange essential oil can probably be effective as a proper nursing intervention in reducing anxiety after cesarean section surgery.

Toward a predictive theoretical model for osmolality rise with non-humidified incubation: a randomized, multivariate response-surface study

2021 ◽  
Author(s):  
Steven F Mullen
Keyword(s):  
Mathematical Model ◽  
Response Surface ◽  
Surface Area ◽  
Embryo Culture ◽  
Culture Medium ◽  
Conflicts Of Interest ◽  
Volume Ratio ◽  
P Value ◽  
Cook Medical ◽  
Over Time

Abstract STUDY QUESTION What factors associated with embryo culture techniques contribute to the rate of medium osmolality change over time in an embryo culture incubator without added humidity? SUMMARY ANSWER The surface area-to-volume ratio of culture medium (surface area of the medium exposed to an oil overlay), as well as the density and height of the overlaying oil, all interact in a quantitative way to affect the osmolality rise over time. WHAT IS KNOWN ALREADY Factors such as medium volume, different oil types, and associated properties, individually, can affect osmolality change during non-humidified incubation. STUDY DESIGN, SIZE, DURATION Several experimental designs were used, including simple single-factor completely randomized designs, as well as a multi-factor response surface design. Randomization was performed at one or more levels for each experiment. Osmolality measurements were performed over 7 days, with up to 8 independent osmolality measurements performed per treatment group over that time. For the multi-factor study, 107 independent combinations of factor levels were assessed to develop the mathematical model. PARTICIPANTS/MATERIALS, SETTING, METHODS This study was conducted in a research laboratory setting. Commercially available embryo culture medium and oil was used. A MINC incubator without water for humidification was used for the incubation. Osmolality was measured with a vapor pressure osmometer after calibration. Viscometry and density were conducted using a rheometer, and volumetric flasks with an analytical balance, respectively. Data analyses were conducted with several commercially available software programs. MAIN RESULTS AND THE ROLE OF CHANCE Preliminary experiments showed that the surface area-to-volume ratio of the culture medium, oil density, and oil thickness above the medium all contributed significantly (P &lt; 0.05) to the rise in osmolality. A multi-factor experiment showed that a combination of these variables, in the form of a truncated cubic polynomial, was able to predict the rise in osmolality, with these three variables interacting in the model (P &lt; 0.05). Repeatability, as measured by the response of identical treatments performed independently, was high, with osmolality values being ± 2 of the average in most instances. In the final mathematical model, the terms of the equation were significant predictors of the outcome, with all P-values being significant, and only one P-value &gt; 0.0001. LIMITATIONS, REASONS FOR CAUTION Although the range of values for the variables were selected to encompass values that are expected to be encountered in usual embryo culture conditions, variables outside of the range used may not result in accurate model predictions. Although the use of a single incubator type and medium type is not expected to affect the conclusions, that remains an uncertainty. WIDER IMPLICATIONS OF THE FINDINGS Using this predictive model will help to determine if one should be cautious in using a specific system and will provide guidance on how a system may be modified to provide improved stability during embryo culture. STUDY FUNDING/COMPETING INTEREST(S) This study was funded by Cook Medical. The author is a Team Lead and Senior Scientist at Cook Medical. The author has no other conflicts of interest to declare TRIAL REGISTRATION NUMBER N/A.

scholarly journals Orange essential oil as antimicrobial additives in poly(vinyl chloride) films

Polímeros ◽  
2018 ◽  
Vol 28 (4) ◽  
pp. 332-338 ◽  
Author(s):  
Carla Fabiana da Silva ◽  
Flávia Suellen Melo de Oliveira ◽  
Viviane Fonseca Caetano ◽  
Glória Maria Vinhas ◽  
Samara Alvachian Cardoso
Keyword(s):  
Essential Oil ◽  
Vinyl Chloride ◽  
Poly Vinyl Chloride ◽  
Orange Essential Oil

Extraction and Characterization of Orange Peel Essential Oil from Mexico and United States of America

2017 ◽  
Vol 20 (4) ◽  
pp. 897-914 ◽  
Author(s):  
José R. Ayala ◽  
Gisela Montero ◽  
Héctor E. Campbell ◽  
Conrado García ◽  
Marcos A. Coronado ◽  
...  
Keyword(s):  
United States ◽  
Essential Oil ◽  
United States Of America ◽  
Orange Peel

scholarly journals PERBANDINGAN METODE MICROWAVE HYDRODISTILLATION (MH) DAN MICROWAVE HYDRODIFFUSION AND GRAVITY (MHG) UNTUK MENGEKSTRAK MINYAK ATSIRI DARI KULIT JERUK

2017 ◽  
Vol 2 (1) ◽  
pp. 82
Author(s):  
Ayu Chandra Kartika Fitri ◽  
Fikka Kartika Widyastuti
Keyword(s):  
Essential Oil ◽  
Microwave Power ◽  
Citrus Fruit ◽  
Orange Peel ◽  
Quality Standard ◽  
Extraction Methods ◽  
Oil Composition ◽  
Citrus Peel ◽  
Oxygenated Compounds ◽  
Earth Gravity

One source of essential oil that has long been popular is a citrus fruit (Citrus aurantium). Results waste citrus peel around 500,000 tonnes per year. So the prospects for the utilization of waste orange peel are big enough to extract the essential oil. However, conventional extraction methods have drawbacks in terms of product quality, so to find solutions to these shortcomings, it is necessary to use the extraction method by Microwave Hydrodiffusion and Gravity (MHG). This method combines the use of microwave heating and physical phenomena (hydrodiffusi and earth gravity) at atmospheric pressure, without addition of organic solvents or water. In this study used fresh orange peel material 400 and 500 grams, two variable microwave power of 100 and 300 Watt and the extraction time for 15, 30, 45 and 60 minutes. To know the processing time and the microwave power effective method of MHG, oil composition was analyzed by GCMS to determine the amount of the fraction of oxygenated compounds. The larger of installed microwave power, the higher of operating temperature, so the %yield increases in a shorter time. From the comparison of energy consumed, the MHG method is give 30% more energy efficient than the Microwave Hydrodistillation (MHD) method. The use of microwaves does not change the physical properties of oil. The oil produced from the MHG method has a good quality because it has specific gravity and refractive index values that meet the EOA quality standard and has a greater oxygenated compounds content than the MHD method

scholarly journals COMBINED EFFECT OF STREPTOMYCIN AND SWEET ORANGE ESSENTIAL OIL TO MEMBRANE AND ACROSOME INTEGRITY BOER GOAT FROZEN SEMEN

2019 ◽  
Vol 3 (2) ◽  
pp. 89
Author(s):  
Sukma Aditya Sitepu ◽  
Julia Marisa
Keyword(s):  
Essential Oil ◽  
Sweet Orange ◽  
Membrane Integrity ◽  
Boer Goat ◽  
Randomized Design ◽  
Frozen Semen ◽  
Acrosome Integrity ◽  
Completely Randomized Design ◽  
Orange Essential Oil

One of factors that cause a bad quality of Boer Goat frozen semen is the growth of bacterial. This can be overcome by adding antibiotics such as streptomycin. To further suppress the growth of bacteria can be added other ingredients that contain antibacterials such as sweet orange essential oil. The purpose of this research is to know the percentage value of Membrane Integrity and Acrosome Integrity on Boer Goat frozen semen with addition sweet orange essential oil and streptomycin. The method used was experimental using Completely Randomized Design with 5 treatments and 5 replications. The treatment in this research is addition 0%, 0,25%; 0.5%; 0.75% and 1% sweet orange essential oil on tris yolk and streptomycin extender. The results showed the best treatment addition combination streptomycin and sweet orange essential oil to percentage Membrane Integrity and Acrosome Integrity is increase 1% sweet orange essential oil.Keywords: Boer Goat, essential oil, frozen semen, streptomycin, sweet orange.

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