scholarly journals Preparation, Characterization, Swelling Potential and In-Vitro Evaluation of Sodium Poly(Styrene Sulfonate)-Based Hydrogels for Controlled Delivery of Ketorolac Tromethamine

2021 ◽  
Vol 14 (4) ◽  
pp. 350
Author(s):  
Muhammad Suhail ◽  
Chih-Wun Fang ◽  
Muhammad Usman Minhas ◽  
Pao-Chu Wu
Keyword(s):  
Acrylic Acid ◽  
Drug Loading ◽  
Controlled Delivery ◽  
Potential Candidate ◽  
Ketorolac Tromethamine ◽  
Scanning Calorimetry ◽  
Styrene Sulfonate ◽  
Dynamic Swelling ◽  
Cross Linker ◽  
Poly Styrene Sulfonate

The objective of the current study work was to fabricate sodium poly(styrene sulfonate-co-poly acrylic acid) (SPSPAA) hydrogels by using a free radical co-polymerization method for controlled delivery of ketorolac tromethamine (KT). Polymer (sodium poly(styrene sulfonate) (SPS) polymerized with monomer acrylic acid (AA) in the presence of initiator ammonium peroxodisulfate (APS) and cross-linker N′,N′-Methylene bisacrylamide (MBA). Different combinations of polymer, cross-linker and monomer, were employed for development of polymeric hydrogels. Various studies such as sol-gel, drug loading, dynamic swelling, and drug release studies were carried out to know the sol and gel portion of SPSPAA, swelling behavior of hydrogels at different pH media (1.2 and 7.4), quantification of drug loaded by fabricated hydrogels, and amount release of KT at pH 1.2 and 7.4. Higher dynamic swelling was found at pH 7.4 compared to pH 1.2, and as a result, greater percent release of drug was perceived at pH 7.4. Thermal stability, crystallinity, confirmation of functional groups and development of a new polymeric system, and surface morphology were evaluated via Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC), Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) respectively. The results showed that the present work could be used as a potential candidate for controlled delivery of KT.

scholarly journals Hydroxypropyl Methylcellulose-Based Hydrogel Copolymeric for Controlled Delivery of Galantamine Hydrobromide in Dementia

Processes ◽  
2020 ◽  
Vol 8 (11) ◽  
pp. 1350
Author(s):  
Sidra Bashir ◽  
Nadiah Zafar ◽  
Noureddine Lebaz ◽  
Asif Mahmood ◽  
Abdelhamid Elaissari
Keyword(s):  
Acrylic Acid ◽  
Release Kinetics ◽  
Drug Loading ◽  
Hydroxypropyl Methylcellulose ◽  
Controlled Delivery ◽  
Release Mechanism ◽  
Release Kinetic ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Gel Fraction

The study aims to prepare a smart copolymeric for controlled delivery of Galantamine hydrobromide. The synthesis of the hydrogel was executed through free radical polymerization using HPMC (Hydroxypropyl methylcellulose) and pectin as polymers and acrylic acid as monomer. Cross-linking was performed by methylene bisacrylamide (MBA). HPMC-pectin-co-acrylic acid hydrogel was loaded with Galantamine hydrobromide (antidementia drug) as a model drug for treatment of Alzheimer based dementia. Formulated hydrogels (SN1–SN9) were characterized for Fourier transform-infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, X-ray diffraction, and energy dispersive X-ray. Drug loading efficiency, gel fraction, measurements of porosity, and tensile strength were reported. Swelling and release studies were performed at pH 1.2 and 7.4. Drug liberation mechanism was evaluated by applying different release kinetic models. Galantamine hydrobromide was released from prepared hydrogels by Fickian release mechanism. Swelling, gel fraction, porosity, and drug release percentages were found to be dependent on hydroxypropyl methylcellulose, pectin, acrylic acid, and methylene bisacrylamide concentrations. By increasing HPMC amount, swelling was increased from 76.7% to 95.9%. Toxicity studies were conducted on albino male rabbits for a period of 14 days. Hematological and histopathological studies were carried out to evaluate safety level of hydrogel. Successfully prepared HPMC-pectin-co-acrylic acid hydrogel showed good swelling and release kinetics, which may help greatly in providing controlled release drug effect leading to enhanced patient compliance for dementia patients.

scholarly journals Fabrication and In Vitro Evaluation of pH-Sensitive Polymeric Hydrogels as Controlled Release Carriers

Gels ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 110
Author(s):  
Muhammad Suhail ◽  
Chih-Wun Fang ◽  
Arshad Khan ◽  
Muhammad Usman Minhas ◽  
Pao-Chu Wu
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Acrylic Acid ◽  
Chondroitin Sulfate ◽  
Diclofenac Sodium ◽  
Research Work ◽  
Controlled Delivery ◽  
Scanning Calorimetry ◽  
Release Studies

The purpose of the current investigation was to develop chondroitin sulfate/carbopol-co-poly(acrylic acid) (CS/CBP-co-PAA) hydrogels for controlled delivery of diclofenac sodium (DS). Different concentrations of polymers chondroitin sulfate (CS), carbopol 934 (CBP), and monomer acrylic acid (AA) were cross-linked by ethylene glycol dimethylacrylate (EGDMA) in the presence of ammonium peroxodisulfate (APS) (initiator). The fabricated hydrogels were characterized for further experiments. Characterizations such as Scanning electron microscopy (SEM), Thermogravimetric analysis (TGA), Differential scanning calorimetry (DSC), Powder X-ray diffractometry (PXRD), and Fourier transform infrared spectroscopy (FTIR) were conducted to understand the surface morphology, thermodynamic stability, crystallinity of the drug, ingredients, and developed hydrogels. The swelling and drug release studies were conducted at two different pH mediums (pH 1.2 and 7.4), and pH-dependent swelling and drug release was shown due to the presence of functional groups of both polymers and monomers; hence, greater swelling and drug release was observed at the higher pH (pH 7.4). The percent drug release of the developed system and commercially available product cataflam was compared and high controlled release of the drug from the developed system was observed at both low and high pH. The mechanism of drug release from the hydrogels followed Korsmeyer–Peppas model. Conclusively, the current research work demonstrated that the prepared hydrogel could be considered as a suitable candidate for controlled delivery of diclofenac sodium.

Morphology and properties of PEDOT:PSS/soft polymer blends through hydrogen bonding interaction and their pressure sensor application

2020 ◽  
Vol 8 (18) ◽  
pp. 6013-6024
Author(s):  
Yin-Tse Tseng ◽  
Yan-Cheng Lin ◽  
Chien-Chung Shih ◽  
Hui-Ching Hsieh ◽  
Wen-Ya Lee ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Acrylic Acid ◽  
Polymer Blends ◽  
Pressure Sensor ◽  
Pressure Sensors ◽  
Hydrogen Bonding Interaction ◽  
Styrene Sulfonate ◽  
Bonding Interaction ◽  
Soft Polymer ◽  
Poly Styrene Sulfonate

The effects of the composition on the stretchability and conductivity of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) polymer blends with soft polymers poly(acrylic acid) (PAA) and their application in pressure sensors. 

Swelling behavior of poly (N-hydroxymethylacrylamide-co-acrylic acid) hydrogels and release of potassium nitrate as fertilizer

2018 ◽  
Vol 38 (5) ◽  
pp. 437-447 ◽  
Author(s):  
Fatma Louzri ◽  
Sadjia Bennour
Keyword(s):  
Ionic Strength ◽  
Acrylic Acid ◽  
Release Kinetics ◽  
Potassium Nitrate ◽  
Swelling Behavior ◽  
Scanning Calorimetry ◽  
Ph Values ◽  
Dynamic Swelling ◽  
Kinetics Of ◽  
And Diffusion

Abstract Poly (N-hydroxymethylacrylamide-co-acrylic acid) [P(NHMA-AAx)] hydrogels were prepared by free-radical polymerization in aqueous solution at 56°C, using N,N′-methylenebisacrylamide as the cross-linking agent. The synthesized hydrogels were subsequently investigated by a series of characterization techniques including Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis and differential scanning calorimetry analysis. The effects of comonomer composition in the feed, pH, temperature and ionic strength on the swelling behavior were studied. Results indicated that the swelling capabilities of P(NHMA-AAx) hydrogels decreased with the increase in N-hydroxymethylacrylamide (NHMA) content in the polymeric matrix and ionic strength of the medium. Additionally, the hydrogels showed both temperature and pH responses. The dynamic swelling behaviors of hydrogels at different pH values followed a non-Fickian type. The P(NHMA-AAx) hydrogels were also loaded with potassium nitrate (KNO3) as a model agrochemical, and the release kinetics of fertilizer from the hydrogels was studied as a function of KNO3 and NHMA concentrations. Moreover, various kinetic parameters, such as release exponents and diffusion coefficients, were calculated.

scholarly journals 3-Dimensional stable polyelectrolyte hollow capsules: preparation and spontaneous encapsulation

RSC Advances ◽  
2017 ◽  
Vol 7 (3) ◽  
pp. 1260-1265 ◽  
Author(s):  
Y. D. Chen ◽  
J. J. Xu ◽  
Y. Wang ◽  
H. Chen ◽  
Q. J. Luo ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
3 Dimensional ◽  
Styrene Sulfonate ◽  
Allylamine Hydrochloride ◽  
Poly Styrene Sulfonate ◽  
Size Controlled ◽  
Poly Acrylic Acid

By alternatively depositing poly(styrene)-co-poly(acrylic acid) and poly(allylamine hydrochloride) on poly(styrene sulfonate sodium) hybrid CaCO3 microparticles, a series of size-controlled 3-dimensional stable capsules were obtained after the removal of hybrid templates.

One-Pot Fabrication of Hollow Porphyrinic MOF Nanoparticles with Ultrahigh Drug Loading toward Controlled Delivery and Synergistic Cancer Therapy

2021 ◽  
Vol 13 (3) ◽  
pp. 3679-3693
Author(s):  
Xin Sun ◽  
Guihua He ◽  
Chuxiao Xiong ◽  
Chenyuan Wang ◽  
Xiang Lian ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Loading ◽  
Controlled Delivery ◽  
One Pot

scholarly journals A review of nanotechnology with an emphasis on Nanoplex

2015 ◽  
Vol 51 (2) ◽  
pp. 255-263
Author(s):  
Rupali Nanasaheb Kadam ◽  
Raosaheb Sopanrao Shendge ◽  
Vishal Vijay Pande
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Conventional Drug ◽  
Anionic Drugs ◽  
Oppositely Charged ◽  
The Brain

<p>The use of nanotechnology based on the development and fabrication of nanostructures is one approach that has been employed to overcome the challenges involved with conventional drug delivery systems. Formulating Nanoplex is the new trend in nanotechnology. A nanoplex is a complex formed by a drug nanoparticle with an oppositely charged polyelectrolyte. Both cationic and anionic drugs form complexes with oppositely charged polyelectrolytes. Compared with other nanostructures, the yield of Nanoplex is greater and the complexation efficiency is better. Nanoplex are also easier to prepare. Nanoplex formulation is characterized through the production yield, complexation efficiency, drug loading, particle size and zeta potential using scanning electron microscopy, differential scanning calorimetry, X-ray diffraction and dialysis studies. Nanoplex have wide-ranging applications in different fields such as cancer therapy, gene drug delivery, drug delivery to the brain and protein and peptide drug delivery.</p>

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