scholarly journals Micellisation Mechanism and Behaviour of Soluplus®–Furosemide Micelles: Preformulation Studies of an Oral Nanocarrier-Based System

2019 ◽  
Vol 12 (1) ◽  
pp. 15 ◽  
Author(s):  
Julia F. Alopaeus ◽  
Ellen Hagesæther ◽  
Ingunn Tho
Keyword(s):  
Oral Drug Delivery ◽  
Solution Temperature ◽  
Oral Drug ◽  
Calorimetric Analysis ◽  
Micellar Size ◽  
Self Assembling ◽  
Size And Morphology ◽  
Semi Solid ◽  
Preformulation Studies ◽  
Solid Form

: In this study, self-assembling Soluplus® micelles were examined for inherent properties. Through calorimetric analysis, the critical micelle concentration (CMC) could be determined at 25 and 37 °C, and the influence of three media (Milli-Q water, phosphate-buffered saline (PBS) with a pH of 7.4 and 0.1 M HCl) on the lower critical solution temperature (LCST) was detected. Furthermore, the solubilisation of a poorly soluble drug, furosemide, into the Soluplus® micelles was studied. The concentration-dependent properties of the micellar system were assessed through an examination of the micellar size, polydispersity, morphology, viscosity and solubilising properties, which were all found to be affected by the concentration, but temperature, pH and the composition of the test medium were also found to have an effect. Homogeneity in the estimated micellar size and morphology was shown for monophasic micelle dispersions in lower concentrations and with a shift towards more complex structures or aggregates in higher concentrations. The micelles were further investigated in terms of drug release and biocompatibility with mucus-producing HT29-MTX cells, where no biocompatibility issues were found. In this research, the implications for oral drug delivery are discussed and valuable preformulation information is provided on the micellar properties of a Soluplus® drug system in a liquid or semi-solid form.

Natural Superdisintegrant: Opportunity in Oral Drug Delivery System

2021 ◽  
pp. 135-140
Author(s):  
Rina G. Maskare ◽  
Nitin H. Indurwade ◽  
Aparna O. Yadav ◽  
Ajita S. Kesharwani ◽  
Aishwarya A. Jain ◽  
...  
Keyword(s):  
Oral Drug Delivery ◽  
Stability Study ◽  
In Vitro Dissolution ◽  
Oral Drug ◽  
Plantago Ovata ◽  
Disintegration Time ◽  
Weight Variation ◽  
Complete Disintegration ◽  
Preformulation Studies

The present work concerned with formulation and evaluation of fast disintegrating tablet of Topiramate by using natural superdisintegrants like Trigonellafoenum graceum (fenugreek) powder, Plantago ovata powder, dehydrated banana powder, soy polysaccharide, linseed powder. Topiramate is an antiepileptic drug and also used in migraine. Preformulation studies like solubility, melting point were studied. Five formulations were prepared using different natural superdisintegrant with same concentrations by using direct compression method. All the formulations were evaluated for precompression parameters and all the parameters were found to be within the pharmacopoeial limits. Post compression parameters like hardness of the tablet, thickness of the tablet, friability test, weight variation, disintegration test, in-vitro dissolution test, drug content were performed. The formulation F-5 containing Trigonellafoenum-graceum (fenugreek) powder shown disintegration time of 12sec. Rapid disintegration of the Trigonellafoenum-graceum due to its rapid water absorbency swells in water to the extent of 200–300% disintegrates rapidly for quick and complete disintegration of the tablet. An accelerated stability study on optimized formulation was performed and it was found to be stable. It can be concluded that Trigonellafoenum-graceum (fenugreek) powder as Superdisintegrant showed better release than soy polysaccharide, plantago ovata powder, dehydrated banana powder and linseed powder.

Bioactive Self-Assembling Lipid-Like Peptides as Permeation Enhancers for Oral Drug Delivery

2015 ◽  
Vol 104 (7) ◽  
pp. 2304-2311 ◽  
Author(s):  
Christina Karavasili ◽  
Marios Spanakis ◽  
Dionysia Papagiannopoulou ◽  
Ioannis S. Vizirianakis ◽  
Dimitrios G. Fatouros ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Permeation Enhancers ◽  
Self Assembling

scholarly journals Preformulation Studies and Bioavailability Enhancement of Curcumin with a ‘Two in One’ PEG-β-Cyclodextrin Polymer

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1710
Author(s):  
Ádám Haimhoffer ◽  
Eleftheria Dossi ◽  
Monika Béresová ◽  
Ildikó Bácskay ◽  
Judit Váradi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Oral Drug Delivery ◽  
Porous Matrix ◽  
Water Soluble ◽  
Oral Drug ◽  
Phase Solubility ◽  
Bioavailability Enhancement ◽  
Preformulation Studies ◽  
Biopharmaceutical Properties

Drug delivery systems are used to improve the biopharmaceutical properties of curcumin. Our aim was to investigate the effect of a water-soluble ‘two in one’ polymer containing covalently bonded PEG and βCD moieties (βCPCD) on the solubility and bioavailability of curcumin and compare it to a polymeric β-cyclodextrin (βCDP) cross-linked with epichlorohydrin. Phase-solubility and dynamic light scattering (DLS) experiments showed that the solubility of curcumin increased significantly in 10 m/m % βCPCD and βCDP solutions, but βCPCD–curcumin particles had higher hydrodynamic volume. The formation of the βCPCD–curcumin complex in solution and sedimented phase was confirmed by NMR spectroscopy. Biocompatibility and permeability experiments were performed on Caco-2 cells. Polymers did not show cytotoxicity up to 10 m/m % and βCPCD significantly increased the permeability of curcumin. DLS measurements revealed that among the interaction of polymers with mucin, βCPCD formed bigger aggregates compared to βCDP. Curcumin complexes were lyophilized into capsules and structurally characterized by micro-CT spectroscopy. Drug release was tested in a pH 1.2 medium. Lyophilized complexes had a solid porous matrix and both βCPCD and βCDP showed rapid drug release. βCPCD provides an opportunity to create a swellable, mucoadhesive matrix system for oral drug delivery.

Applications of Ion Exchange Resin in Oral Drug Delivery Systems

2017 ◽  
Vol 7 (03) ◽  
Author(s):  
Kathpalia Harsha ◽  
Das Sukanya
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Drug Delivery Systems ◽  
Oral Drug Delivery ◽  
Physical Stability ◽  
Delivery Systems ◽  
Oral Drug ◽  
Ion Exchange Resins ◽  
Exchange Resins ◽  
Oral Drug Delivery Systems

Ion Exchange Resins (IER) are insoluble polymers having styrene divinylbenzene copolymer backbone that contain acidic or basic functional groups and have the ability to exchange counter ions with the surrounding aqueous solutions. From the past many years they have been widely used for purification and softening of water and in chromatographic columns, however recently their use in pharmaceutical industry has gained considerable importance. Due to the physical stability and inert nature of the resins, they can be used as a versatile vehicle to design several modified release dosage forms The ionizable drug is complexed with the resin owing to the property of ion exchange. This resin complex dissociatesin vivo to release the drug. Based on the dissociation strength of the drug from the drug resin complex, various release patterns can be achieved. Many formulation glitches can be circumvented using ion exchange resins such as bitter taste and deliquescence. These resins also aid in enhancing disintegrationand stability of formulation. This review focuses on different types of ion exchange resins, their preparation methods, chemistry, properties, incompatibilities and their application in various oral drug delivery systems as well as highlighting their use as therapeutic agents.

Implication of Nanofibers in Oral Drug Delivery

2015 ◽  
Vol 21 (15) ◽  
pp. 2021-2036 ◽  
Author(s):  
Himani Kapahi ◽  
Nikhat Khan ◽  
Ankur Bhardwaj ◽  
Neeraj Mishra
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Oral Drug

Fat-Soluble Vitamins Release Based on Clinoptilolite Zeolite as an Oral Drug Delivery System

2012 ◽  
Vol 9 (2) ◽  
pp. 213-217 ◽  
Author(s):  
Mehdi Rahimi ◽  
Hamid Mobedi ◽  
Aliasghar Behnamghader ◽  
Alireza Nateghi Baygi ◽  
Houri Mivehchi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Oral Drug ◽  
Oral Drug Delivery System ◽  
Clinoptilolite Zeolite ◽  
Fat Soluble Vitamins
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