scholarly journals Functional Polymer Nanocarriers for Photodynamic Therapy

2018 ◽  
Vol 11 (4) ◽  
pp. 133 ◽  
Author(s):  
Tuanwei Li ◽  
Lifeng Yan
Keyword(s):  
Photodynamic Therapy ◽  
Penetration Depth ◽  
Polymer Nanoparticles ◽  
Therapeutic Modality ◽  
Cancer Treatments ◽  
Functional Polymer ◽  
Tumor Tissues ◽  
Therapy Effect ◽  
Minimal Invasion ◽  
Polymer Nanocarriers

Photodynamic therapy (PDT) is an appealing therapeutic modality in management of some solid tumors and other diseases for its minimal invasion and non-systemic toxicity. However, the hydrophobicity and non-selectivity of the photosensitizers, inherent serious hypoxia of tumor tissues and limited penetration depth of light restrict PDT further applications in clinic. Functional polymer nanoparticles can be used as a nanocarrier for accurate PDT. Here, we elucidate the mechanism and application of PDT in cancer treatments, and then review some strategies to administer the biodistribution and activation of photosensitizers (PSs) to ameliorate or utilize the tumor hypoxic microenvironment to enhance the photodynamic therapy effect.

Role of Exosomes in Photodynamic Anticancer Therapy

2020 ◽  
Vol 27 (40) ◽  
pp. 6815-6824 ◽  
Author(s):  
Yuan Jiang ◽  
Chuanshan Xu ◽  
Wingnang Leung ◽  
Mei Lin ◽  
Xiaowen Cai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Basic Principle ◽  
Photochemical Reaction ◽  
Cell Communication ◽  
Anticancer Therapy ◽  
Bioactive Molecules ◽  
Promising Alternative ◽  
Tumor Tissues ◽  
Significant Attention

Photodynamic Therapy (PDT) is a promising alternative treatment for malignancies based on photochemical reaction induced by Photosensitizers (PS) under light irradiation. Recent studies show that PDT caused the abundant release of exosomes from tumor tissues. It is well-known that exosomes as carriers play an important role in cell-cell communication through transporting many kinds of bioactive molecules (e.g. lipids, proteins, mRNA, miRNA and lncRNA). Therefore, to explore the role of exosomes in photodynamic anticancer therapy has been attracting significant attention. In the present paper, we will briefly introduce the basic principle of PDT and exosomes, and focus on discussing the role of exosomes in photodynamic anticancer therapy, to further enrich and boost the development of PDT.

Nanocarriers for Photodynamic Therapy Intended to Cutaneous Tumors

2021 ◽  
Vol 22 ◽  
Author(s):  
Maria Bernadete Riemma Pierre
Keyword(s):  
Photodynamic Therapy ◽  
Drug Delivery Systems ◽  
Active Agent ◽  
Therapeutic Modality ◽  
Tissue Penetration ◽  
Promising Tool ◽  
Skin Cancers ◽  
Superficial Basal Cell Carcinoma ◽  
The Stability ◽  
Disor Ders

Abstract: Photodynamic Therapy (PDT) is a therapeutic modality used for several malignant and premalignant skin disor-ders, including Bowen's disease skin cancers and Superficial Basal Cell Carcinoma (BCC). Several photosensitizers (PSs) have been explored for tumor destruction of skin cancers, after their activation by a light source of appropriate wavelength. Topical release of PSs avoids prolonged photosensitization reactions associated with systemic administration; however, its clinical usefulness is influenced by its poor tissue penetration and the stability of the active agent. Nanotechnology-based drug delivery systems are promising tool to enhance the efficiency for PDT of cancer. This review focuses on PSs encap-sulated in nanocarriers explored for PDT of skin tumors.

scholarly journals Nanomedicine-Based Strategies Assisting Photodynamic Therapy for Hypoxic Tumors: State-of-the-Art Approaches and Emerging Trends

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 137
Author(s):  
Chun-Yan Shih ◽  
Pei-Ting Wang ◽  
Wu-Chou Su ◽  
Hsisheng Teng ◽  
Wei-Lun Huang
Keyword(s):  
Photodynamic Therapy ◽  
State Of The Art ◽  
Metal Organic Framework ◽  
Basic Knowledge ◽  
Future Perspectives ◽  
Effective Strategies ◽  
Emerging Trends ◽  
Tumor Tissues ◽  
Metal Organic ◽  
Manipulating Hypoxia

Since the first clinical cancer treatment in 1978, photodynamic therapy (PDT) technologies have been largely improved and approved for clinical usage in various cancers. Due to the oxygen-dependent nature, the application of PDT is still limited by hypoxia in tumor tissues. Thus, the development of effective strategies for manipulating hypoxia and improving the effectiveness of PDT is one of the most important area in PDT field. Recently, emerging nanotechnology has benefitted progress in many areas, including PDT. In this review, after briefly introducing the mechanisms of PDT and hypoxia, as well as basic knowledge about nanomedicines, we will discuss the state of the art of nanomedicine-based approaches for assisting PDT for treating hypoxic tumors, mainly based on oxygen replenishing strategies and the oxygen dependency diminishing strategies. Among these strategies, we will emphasize emerging trends about the use of nanoscale metal–organic framework (nMOF) materials and the combination of PDT with immunotherapy. We further discuss future perspectives and challenges associated with these trends in both the aspects of mechanism and clinical translation.

Rational fabrication of two-photon responsive metal-organic framework for enhanced photodynamic therapy

2021 ◽  
Author(s):  
Xin Yao ◽  
Xinxin Pei ◽  
Bo Li ◽  
Mengqi Lv ◽  
Wen Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Rational Design ◽  
Metal Organic Framework ◽  
Cancer Treatments ◽  
Two Photon ◽  
Metal Organic ◽  
Organic Framework

Rational design of specific platform which can address the unavoidable side effects of traditional cancer treatments is of great interest. In this sense, herein, an intelligent nanoplatform (ZnL1@MOF-199@FA) with efficient...

Current phthalocyanines delivery systems in photodynamic therapy: an updated review

2021 ◽  
Vol 28 ◽  
Author(s):  
Mariana Miretti ◽  
Cesar German Prucca ◽  
Tomas Cristian Tempesti ◽  
Maria Teresa Baumgartner
Keyword(s):  
Photodynamic Therapy ◽  
Polymeric Micelles ◽  
Polymeric Nanoparticles ◽  
Aqueous Media ◽  
Delivery Systems ◽  
Current Status ◽  
Oxygen Species ◽  
Cancer Treatments ◽  
Therapy Efficacy ◽  
Cellular Components

: Photodynamic therapy has emerged as an effective therapeutic alternative to treat oncological, cardiovascular, dermatological, infectious, and ophthalmic diseases. Photodynamic therapy combines the action of a photosensitizer with light in the presence of oxygen to generate reactive oxygen species capable of reacting with cellular components resulting in injury and, consequently, inducing cellular death. Phthalocyanines are considered good photosensitizers, although most of them are lipophilic, difficulting their administration for clinical use. A strategy to overcome the lack of solubility of phthalocyanines in aqueous media is to incorporate them into different delivery systems. The present review aimed to summarize the current status of the main drug delivery systems used for Zn and Al phthalocyanines and their effect in photodynamic therapy, reported in the last five years. Liposomes, polymeric micelles, polymeric nanoparticles, and gold-nanoparticles constituted some of the most used carriers and were discussed in this review. The latest studies reported strongly suggests that the application of nanotechnologies as delivery systems allow an increase in photodynamic therapy efficacy and reduce side-effects associated with the phthalocyanine administration, which represents a promise for cancer treatments.

scholarly journals Photodynamic therapy effect of m-THPC (Foscan®) in vivo: correlation with pharmacokinetics

2003 ◽  
Vol 89 (2) ◽  
pp. 398-404 ◽  
Author(s):  
H J Jones ◽  
D I Vernon ◽  
S B Brown
Keyword(s):  
Photodynamic Therapy ◽  
Therapy Effect

The investigation of in vitro dark cytotoxicity and photodynamic therapy effect of a 2,6-dibromo-3,5-distyryl BODIPY dye encapsulated in Pluronic® F-127 micelles

2018 ◽  
Vol 71 (21) ◽  
pp. 3444-3457 ◽  
Author(s):  
Nthabeleng Molupe ◽  
Balaji Babu ◽  
David O. Oluwole ◽  
Earl Prinsloo ◽  
John Mack ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Therapy Effect
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