scholarly journals Modulation of Iron Metabolism in Response to Infection: Twists for All Tastes

2018 ◽  
Vol 11 (3) ◽  
pp. 84 ◽  
Author(s):  
Ana Gomes ◽  
Ana Moreira ◽  
Gonçalo Mesquita ◽  
Maria Gomes
Keyword(s):  
Iron Metabolism ◽  
Recent Literature ◽  
Therapeutic Strategies ◽  
Therapeutic Approaches ◽  
Different Types ◽  
Essential Nutrient ◽  
Living Organisms ◽  
Almost All ◽  
And Control ◽  
Ongoing Infection

Iron is an essential nutrient for almost all living organisms, but is not easily made available. Hosts and pathogens engage in a fight for the metal during an infection, leading to major alterations in the host’s iron metabolism. Important pathological consequences can emerge from the mentioned interaction, including anemia. Several recent reports have highlighted the alterations in iron metabolism caused by different types of infection, and several possible therapeutic strategies emerge, based on the targeting of the host’s iron metabolism. Here, we review the most recent literature on iron metabolism alterations that are induced by infection, the consequent development of anemia, and the potential therapeutic approaches to modulate iron metabolism in order to correct iron-related pathologies and control the ongoing infection.

scholarly journals Adeno-Associated Viral Vectors as Versatile Tools for Parkinson’s Research, Both for Disease Modeling Purposes and for Therapeutic Uses

2021 ◽  
Vol 22 (12) ◽  
pp. 6389
Author(s):  
Ana Fajardo-Serrano ◽  
Alberto J. Rico ◽  
Elvira Roda ◽  
Adriana Honrubia ◽  
Sandra Arrieta ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurodegenerative Disorders ◽  
Viral Vectors ◽  
Disease Modeling ◽  
Therapeutic Strategies ◽  
Therapeutic Approaches ◽  
Therapeutic Uses ◽  
Different Types ◽  
Experimental Challenge

It is without any doubt that precision medicine therapeutic strategies targeting neurodegenerative disorders are currently witnessing the spectacular rise of newly designed approaches based on the use of viral vectors as Trojan horses for the controlled release of a given genetic payload. Among the different types of viral vectors, adeno-associated viruses (AAVs) rank as the ones most commonly used for the purposes of either disease modeling or for therapeutic strategies. Here, we reviewed the current literature dealing with the use of AAVs within the field of Parkinson’s disease with the aim to provide neuroscientists with the advice and background required when facing a choice on which AAV might be best suited for addressing a given experimental challenge. Accordingly, here we will be summarizing some insights on different AAV serotypes, and which would be the most appropriate AAV delivery route. Next, the use of AAVs for modeling synucleinopathies is highlighted, providing potential readers with a landscape view of ongoing pre-clinical and clinical initiatives pushing forward AAV-based therapeutic approaches for Parkinson’s disease and related synucleinopathies.

scholarly journals Iron and Chelation in Biochemistry and Medicine: New Approaches to Controlling Iron Metabolism and Treating Related Diseases

Cells ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 1456 ◽  
Author(s):  
George Kontoghiorghes ◽  
Christina Kontoghiorghe
Keyword(s):  
Free Radical ◽  
Iron Metabolism ◽  
Metabolic Pathways ◽  
Physiological Activity ◽  
Genetic Disorders ◽  
Iron Complex ◽  
Idiopathic Hemochromatosis ◽  
Living Organisms ◽  
Almost All ◽  
And Function

Iron is essential for all living organisms. Many iron-containing proteins and metabolic pathways play a key role in almost all cellular and physiological functions. The diversity of the activity and function of iron and its associated pathologies is based on bond formation with adjacent ligands and the overall structure of the iron complex in proteins or with other biomolecules. The control of the metabolic pathways of iron absorption, utilization, recycling and excretion by iron-containing proteins ensures normal biologic and physiological activity. Abnormalities in iron-containing proteins, iron metabolic pathways and also other associated processes can lead to an array of diseases. These include iron deficiency, which affects more than a quarter of the world’s population; hemoglobinopathies, which are the most common of the genetic disorders and idiopathic hemochromatosis. Iron is the most common catalyst of free radical production and oxidative stress which are implicated in tissue damage in most pathologic conditions, cancer initiation and progression, neurodegeneration and many other diseases. The interaction of iron and iron-containing proteins with dietary and xenobiotic molecules, including drugs, may affect iron metabolic and disease processes. Deferiprone, deferoxamine, deferasirox and other chelating drugs can offer therapeutic solutions for most diseases associated with iron metabolism including iron overload and deficiency, neurodegeneration and cancer, the detoxification of xenobiotic metals and most diseases associated with free radical pathology.

scholarly journals iDEF-PseRAAC: Identifying the Defensin Peptide by Using Reduced Amino Acid Composition Descriptor

2019 ◽  
Vol 15 ◽  
pp. 117693431986708 ◽  
Author(s):  
Yongchun Zuo ◽  
Yu Chang ◽  
Shenghui Huang ◽  
Lei Zheng ◽  
Lei Yang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Host Defense ◽  
Feature Subset ◽  
Host Defense Peptides ◽  
Function Annotation ◽  
Different Types ◽  
Living Organisms ◽  
Almost All ◽  
Amino Acid Alphabet ◽  
Acid Reduction

Defensins as 1 of major classes of host defense peptides play a significant role in the innate immunity, which are extremely evolved in almost all living organisms. Developing high-throughput computational methods can accurately help in designing drugs or medical means to defense against pathogens. To take up such a challenge, an up-to-date server based on rigorous benchmark dataset, referred to as iDEF-PseRAAC, was designed for predicting the defensin family in this study. By extracting primary sequence compositions based on different types of reduced amino acid alphabet, it was calculated that the best overall accuracy of the selected feature subset was achieved to 92.38%. Therefore, we can conclude that the information provided by abundant types of amino acid reduction will provide efficient and rational methodology for defensin identification. And, a free online server is freely available for academic users at http://bioinfor.imu.edu.cn/idpf . We hold expectations that iDEF-PseRAAC may be a promising weapon for the function annotation about the defensins protein.

scholarly journals Xenograft Zebrafish Models for the Development of Novel Anti-Hepatocellular Carcinoma Molecules

2021 ◽  
Vol 14 (8) ◽  
pp. 803
Author(s):  
Federica Tonon ◽  
Rossella Farra ◽  
Cristina Zennaro ◽  
Gabriele Pozzato ◽  
Nhung Truong ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Animal Husbandry ◽  
Therapeutic Strategies ◽  
Common Type ◽  
Transgenic Zebrafish ◽  
Therapeutic Approaches ◽  
Predisposing Factor ◽  
Different Types ◽  
Xenograft Models ◽  
Tumor Related Death

Hepatocellular carcinoma (HCC) is the sixth most common type of tumor and the second leading cause of tumor-related death worldwide. Liver cirrhosis is the most important predisposing factor for HCC. Available therapeutic approaches are not very effective, especially for advanced HCC, which is the most common form of the disease at diagnosis. New therapeutic strategies are therefore urgently needed. The use of animal models represents a relevant tool for preclinical screening of new molecules/strategies against HCC. However, several issues, including animal husbandry, limit the use of current models (rodent/pig). One animal model that has attracted the attention of the scientific community in the last 15 years is the zebrafish. This freshwater fish has several attractive features, such as short reproductive time, limited space and cost requirements for husbandry, body transparency and the fact that embryos do not show immune response to transplanted cells. To date, two different types of zebrafish models for HCC have been developed: the transgenic zebrafish and the zebrafish xenograft models. Since transgenic zebrafish models for HCC have been described elsewhere, in this review, we focus on the description of zebrafish xenograft models that have been used in the last five years to test new molecules/strategies against HCC.

scholarly journals Recent Advances in Nanotechnology for the Treatment of Melanoma

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 785
Author(s):  
Roberta Cassano ◽  
Massimo Cuconato ◽  
Gabriella Calviello ◽  
Simona Serini ◽  
Sonia Trombino
Keyword(s):  
Carbon Nanotubes ◽  
Drug Resistance ◽  
Targeted Therapy ◽  
Therapeutic Strategies ◽  
Multi Drug Resistance ◽  
Therapeutic Approaches ◽  
Innovative Strategy ◽  
Different Types ◽  
Specific Alternative ◽  
Melanoma Patients

Melanoma is one of the most aggressive forms of skin cancer, with few possibilities for therapeutic approaches, due to its multi-drug resistance and, consequently, low survival rate for patients. Conventional therapies for treatment melanoma include radiotherapy, chemotherapy, targeted therapy, and immunotherapy, which have various side effects. For this reason, in recent years, pharmaceutical and biomedical research has focused on new sito-specific alternative therapeutic strategies. In this regard, nanotechnology offers numerous benefits which could improve the life expectancy of melanoma patients with very low adverse effects. This review aims to examine the latest advances in nanotechnology as an innovative strategy for treating melanoma. In particular, the use of different types of nanoparticles, such as vesicles, polymers, metal-based, carbon nanotubes, dendrimers, solid lipid, microneedles, and their combination with immunotherapies and vaccines will be discussed.

Knowledge and Awareness of Dengue Fever

2018 ◽  
pp. 219-222
Author(s):  
Y. Arockia Suganthi ◽  
Chitra K. ◽  
J. Magelin Mary
Keyword(s):  
Dengue Fever ◽  
Prevention And Control ◽  
Control Measures ◽  
Infection Transmission ◽  
Standard Guideline ◽  
The World ◽  
Different Types ◽  
Prevention And Control Measures ◽  
Dengue Prevention ◽  
And Control

Dengue fever is a painful mosquito-borne infection caused by different types of virus in various localities of the world. There is no particular medicine or vaccine to treat person suffering from dengue fever. Dengue viruses are transmitted by the bite of female Aedes (Ae) mosquitoes. Dengue fever viruses are mainly transmitted by Aedes which can be active in tropical or subtropical climates. Aedes Aegypti is the key step to avoid infection transmission to save millions of people in all over the world. This paper provides a standard guideline in the planning of dengue prevention and control measures. At the same time gives the priorities including clinical management and hospitalized dengue patients have to address essentially.

Convergence in norming and control of modern wireless technologies electromagnetic fields

2020 ◽  
Vol 60 (9) ◽  
pp. 610-613
Author(s):  
Michail Yu. Maslov ◽  
Yuri M. Spodobaev
Keyword(s):  
Wireless Communication ◽  
Electromagnetic Fields ◽  
Communication Systems ◽  
Communication Technologies ◽  
Telecommunications Industry ◽  
High Tech ◽  
Wireless Technologies ◽  
Almost All ◽  
Network Technologies ◽  
And Control

Telecommunications industry evolution shows the highest rates of transition to high-tech systems and is accompanied by a trend of deep mutual penetration of technologies - convergence. The dominant telecommunication technologies have become wireless communication systems. The widespread use of modern wireless technologies has led to the saturation of the environment with technological electromagnetic fields and the actualization of the problems of protecting the population from them. This fundamental restructuring has led to a uniform dense placement of radiating fragments of network technologies in the mudflow areas. The changed parameters of the emitted fields became the reason for the revision of the regulatory and methodological support of electromagnetic safety. A fragmented structural, functional and parametric analysis of the problem of protecting the population from the technological fields of network technologies revealed uncertainty in the interpretation of real situations, vulnerability, weakness and groundlessness of the methodological basis of sanitary-hygienic approaches. It is shown that this applies to all stages of the electromagnetic examination of the emitting fragments of network technologies. Distrust arises on the part of specialists and the population in not only the system of sanitary-hygienic control, but also the safety of modern network technologies is being called into question. Growing social tensions and radio phobia are everywhere accompanying the development of wireless communication technologies. The basis for solving almost all problems of protecting the population can be the transfer of subjective methods and means of monitoring and sanitary-hygienic control of electromagnetic fields into the field of IT.

Types of refractive errors and methods for their diagnosis

2020 ◽  
pp. 30-36
Author(s):  
Olga Lemzyakova
Keyword(s):  
Optical System ◽  
Contact Lenses ◽  
Vision Impairment ◽  
Refractive Errors ◽  
Vision Correction ◽  
Light Rays ◽  
Different Types ◽  
Almost All ◽  
Degrees Of Severity ◽  
The Brain

Refraction of the eye means its ability to bend (refract) light in its own optical system. In a normal state, which is called emmetropia, light rays passing through the optical system of the eye focus on the retina, from where the impulse is transmitted to the visual cortex of the brain and is analyzed there. A person sees equally well both in the distance and near in this situation. However, very often, refractive errors develop as a result of various types of influences. Myopia, or short-sightedness, occurs when the light rays are focused in front of the retina as a result of passing through the optical system of the eye. In this case, a person will clearly distinguish close objects and have difficulties in seeing distant objects. On the opposite side is development of farsightedness (hypermetropia), in which the focusing of light rays occurs behind the retina — such a person sees distant objects clearly, but outlines of closer objects are out of focus. Near vision impairment in old age is a natural process called presbyopia, it develops due to the lens thickening. Both myopia and hypermetropia can have different degrees of severity. The variant, when different refractive errors are observed in different eyes, is called anisometropia. In the same case, if different types of refraction are observed in the same eye, it is astigmatism, and most often it is a congenital pathology. Almost all of the above mentioned refractive errors require correction with spectacles or use of contact lenses. Recently, people are increasingly resorting to the methods of surgical vision correction.

Drug policy and control at the international level

2018 ◽  
Author(s):  
Thomas F. Babor ◽  
Jonathan Caulkins ◽  
Benedikt Fischer ◽  
David Foxcroft ◽  
Keith Humphreys ◽  
...  
Keyword(s):  
Low Income ◽  
Low Income Countries ◽  
Drug Control ◽  
Prescription Medications ◽  
Access To Treatment ◽  
Illicit Markets ◽  
Pain Medications ◽  
Almost All ◽  
And Control ◽  
Illicit Trafficking

International drug control efforts are designed to coordinate domestic laws with international activities that regulate or limit the supply of psychoactive substances. These efforts are organized around three main drug control treaties that almost all countries have ratified in order to prevent illicit trafficking and other drug-related crime, while at the same time allowing access to prescription medications. The effects of the system have been evaluated mostly in terms of the ability to eliminate illicit markets and supply. The gross imbalance in world consumption of legal opiates is a pointer to the limited availability of effective pain medications in many low-income countries, with 80% of the world’s population having either no or inadequate access to treatment for moderate or severe pain.

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