scholarly journals Design, Synthesis, In Vitro, and Initial In Vivo Evaluation of Heterobivalent Peptidic Ligands Targeting Both NPY(Y1)- and GRP-Receptors—An Improvement for Breast Cancer Imaging?

2018 ◽  
Vol 11 (3) ◽  
pp. 65
Author(s):  
Alicia Vall-Sagarra ◽  
Shanna Litau ◽  
Clemens Decristoforo ◽  
Björn Wängler ◽  
Ralf Schirrmacher ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Imaging ◽  
Breast Cancer Imaging ◽  
In Vivo Evaluation ◽  
Design Synthesis ◽  
Grp Receptors

scholarly journals Synthesis and Evaluation of Amino Acid-Based Radiotracer99mTc-N4-AMT for Breast Cancer Imaging

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Fan-Lin Kong ◽  
Mohammad S. Ali ◽  
Yinhan Zhang ◽  
Chang-Sok Oh ◽  
Dong-Fang Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Amino Acid ◽  
Cellular Uptake ◽  
Mammary Tumor ◽  
Cancer Imaging ◽  
High Yield ◽  
Planar Imaging ◽  
Breast Cancer Imaging

Purpose. This study was to develop an efficient synthesis of99mTc-O-[3-(1,4,8,11-tetraazabicyclohexadecane)-propyl]-α-methyl tyrosine (99mTc-N4-AMT) and evaluate its potential in cancer imaging.Methods. N4-AMT was synthesized by reacting N4-oxalate and 3-bromopropyl AMT (N-BOC, ethyl ester).In vitrocellular uptake kinetics of99mTc-N4-AMT was assessed in rat mammary tumor cells. Tissue distribution of the radiotracer was determined in normal rats at 0.5–4 h, while planar imaging was performed in mammary tumor-bearing rats at 30–120 min.Results. The total synthesis yield of N4-AMT was 14%. Cellular uptake of99mTc-N4-AMT was significantly higher than that of99mTc-N4. Planar imaging revealed that99mTc-N4-AMT rendered greater tumor/muscle ratios than99mTc-N4.Conclusions. N4-AMT could be synthesized with a considerably high yield. Ourin vitroandin vivodata suggest that99mTc-N4-AMT, a novel amino acid-based radiotracer, efficiently enters breast cancer cells, effectively distinguishes mammary tumors from normal tissues, and thus holds the promise for breast cancer imaging.

N-pyridin-2-yl benzamide analogues as allosteric activators of glucokinase: Design, synthesis, in vitro,in silico and in vivo evaluation

2018 ◽  
Vol 93 (3) ◽  
pp. 364-372 ◽  
Author(s):  
Ajmer Singh Grewal ◽  
Rajeev Kharb ◽  
Deo Nandan Prasad ◽  
Jagdeep Singh Dua ◽  
Viney Lather
Keyword(s):  
In Silico ◽  
In Vivo Evaluation ◽  
Design Synthesis

scholarly journals 99mTc Radiolabeled HA/TPGS-Based Curcumin-Loaded Nanoparticle for Breast Cancer Synergistic Theranostics: Design, in vitro and in vivo Evaluation

2020 ◽  
Vol Volume 15 ◽  
pp. 2987-2998
Author(s):  
Chong Huang ◽  
Fen Chen ◽  
Ling Zhang ◽  
Yue Yang ◽  
Xinggang Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
In Vivo Evaluation

scholarly journals Design, Synthesis, and Preliminary in Vitro and in Vivo Evaluation ofN-(2-diethylaminoethyl)-4-[18F]fluorobenzamide ([18F]-DAFBA): A Novel Potential PET Probe to Image Melanoma Tumors

2009 ◽  
Vol 20 (3) ◽  
pp. 583-590 ◽  
Author(s):  
Sudha Garg ◽  
Kanchan Kothari ◽  
Shankar R. Thopate ◽  
Aniruddha K. Doke ◽  
Pradeep K. Garg
Keyword(s):  
In Vivo Evaluation ◽  
Design Synthesis

Novel folate-targeted docetaxel-loaded nanoparticles for tumour targeting: in vitro and in vivo evaluation

RSC Advances ◽  
2016 ◽  
Vol 6 (69) ◽  
pp. 64306-64314 ◽  
Author(s):  
M. H. Han ◽  
Z. T. Li ◽  
D. D. Bi ◽  
Y. F. Guo ◽  
H. X. Kuang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Folic Acid ◽  
Cancer Therapy ◽  
Targeted Delivery ◽  
Tumour Targeting ◽  
Breast Cancer Therapy ◽  
In Vivo Evaluation ◽  
Targeted Delivery System

Cholesterol-PEG1000-FA (folic acid) was synthesized as a stabilizer to encapsulate DTX, for the construction of a promising targeted delivery system for breast cancer therapy.

scholarly journals The anticancer efficacy of paclitaxel liposomes modified with low-toxicity hydrophobic cell-penetrating peptides in breast cancer: an in vitro and in vivo evaluation

RSC Advances ◽  
2018 ◽  
Vol 8 (43) ◽  
pp. 24084-24093 ◽  
Author(s):  
Qi Zhang ◽  
Jing Wang ◽  
Hao Zhang ◽  
Dan Liu ◽  
Linlin Ming ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Delivery ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating Peptide ◽  
In Vivo Evaluation ◽  
Anticancer Efficacy ◽  
Cell Penetrating ◽  
Low Toxicity

Hydrophobic cell penetrating peptide PFVYLI-modified liposomes have been developed for the targeted delivery of PTX into tumors.

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