scholarly journals Comparison of the Clinico-Microbiological Characteristics of Culture-Positive and Culture-Negative Septic Pulmonary Embolism: A 10-Year Retrospective Study

Pathogens ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 995
Author(s):  
Yoshito Nishimura ◽  
Hideharu Hagiya ◽  
Mikako Obika ◽  
Fumio Otsuka
Keyword(s):  
Pulmonary Embolism ◽  
Blood Culture ◽  
Positive Blood Culture ◽  
Elevated Serum ◽  
Clinical Findings ◽  
Positive Group ◽  
Odontogenic Infections ◽  
Septic Pulmonary Embolism ◽  
Culture Positive ◽  
Culture Negative

Septic pulmonary embolism (SPE) is a rare yet serious infectious disorder with nonspecific clinical findings due to microorganism-containing emboli disseminating from extrapulmonary infectious foci. It is unknown whether a positive blood culture correlates with a worse clinical outcome. We compared the clinical and microbiologic characteristics of patients with SPE divided into the culture-positive group and the culture-negative one. This study was a retrospective observational study of the patients diagnosed with SPE and treated in an academic hospital from April 2010 to May 2020. We identified six culture-positive and four culture-negative patients with SPE during the study period. The culture-positive group had significantly longer periods of hospitalization (median: 75 days, range: 45–125 days) than the culture-negative group (median: 14.5 days, range: 3–43 days) (p < 0.05), as well as significantly elevated serum C-reactive protein and procalcitonin. Patients with culture-negative SPE more commonly had odontogenic infections as the primary infectious foci. Our study highlights the importance of giving extra attention to SPE patients who have a positive blood culture, as they may have worse clinical outcomes. Physicians need to collaborate with dentists when faced with patients with culture-negative SPE, since they may have primary odontogenic infections.

scholarly journals Predictive and prognostic factors in patients with blood-culture-positive community-acquired pneumococcal pneumonia

2016 ◽  
Vol 48 (3) ◽  
pp. 797-807 ◽  
Author(s):  
Rosanel Amaro ◽  
Adamantia Liapikou ◽  
Catia Cilloniz ◽  
Albert Gabarrus ◽  
Francesc Marco ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Blood Culture ◽  
Conjugate Vaccine ◽  
Pneumococcal Conjugate Vaccine ◽  
Pneumococcal Pneumonia ◽  
Protective Factor ◽  
Severe Pneumonia ◽  
Increased Risk ◽  
Culture Positive ◽  
Culture Negative

In patients with pneumococcal community-acquired pneumonia (CAP), the risk factors for bacteraemia and its impact on outcomes are not fully elucidated. We aimed to compare characteristics of patients with blood-culture-positiveversusblood-culture-negative pneumococcal CAP, and to characterise bacteraemic serotypes.We describe a prospective, observational study on nonimmunocompromised patients with pneumococcal CAP, from 1996 to 2013. We define severe pneumonia according to American Thoracic Society/Infectious Diseases Society of America guidelines.Of a total of 917 patients with pneumococcal CAP, 362 had blood-culture-positive pneumococcal pneumonia (BCPPP; 39%). High C-reactive protein (CRP) (≥20 mg·dL−1) (odds ratio (OR) 2.36, 95% CI 1.45–3.85), pleural effusion (OR 2.03, 95% CI 1.13–3.65) and multilobar involvement (OR 1.69, 95% CI 1.02–2.79) were independently associated with bacteraemic CAP, while nursing home resident (OR 0.12, 95% CI 0.01–1.00) was found as a protective factor. Despite the clinical differences, BCPPP showed similar outcomes to blood-culture-negative pneumococcal pneumonia (BCNPP). 14% of the serotypes (period 2006–2013) causing bacteraemia are included in pneumococcal conjugate vaccine PVC7, 74% in pneumococcal conjugate vaccine PVC13 and 83% in pneumococcal polysaccharide vaccine PPSV23.Pleural effusion, a high level of CRP and multilobar involvement predicted an increased risk of BCPPP. Although BCPPP patients were more severely ill at admission, mortality was not significantly greater than in BCNPP patients.

Diagnosis of blood culture-negative endocarditis and clinical comparison between blood culture-negative and blood culture-positive cases

Infection ◽  
2015 ◽  
Vol 44 (4) ◽  
pp. 459-466 ◽  
Author(s):  
Cristiane C. Lamas ◽  
Pierre-Edouard Fournier ◽  
Monica Zappa ◽  
Tatiana J. D. Brandão ◽  
Carolina A. Januário-da-Silva ◽  
...  
Keyword(s):  
Blood Culture ◽  
Clinical Comparison ◽  
Culture Positive ◽  
Culture Negative

Reassessment of Blood Culture-Negative Endocarditis: Its Profile Is Similar to That of Blood Culture-Positive Endocarditis

2012 ◽  
Vol 65 (10) ◽  
pp. 891-900 ◽  
Author(s):  
Carlos Ferrera ◽  
Isidre Vilacosta ◽  
Cristina Fernández ◽  
Javier López ◽  
Carmen Olmos ◽  
...  
Keyword(s):  
Blood Culture ◽  
Culture Positive ◽  
Culture Negative

scholarly journals Gastric aspirate cytology as a screening tool for neonatal sepsis: a prospective study from a tertiary care centre

2018 ◽  
Vol 5 (4) ◽  
pp. 1662
Author(s):  
Ranjith Kumar ◽  
Bhaskar Reddy ◽  
Chapay Soren ◽  
Venkataramana Reddy ◽  
Raheemunisa .
Keyword(s):  
Blood Culture ◽  
Positive Blood Culture ◽  
Neonatal Sepsis ◽  
Screening Tool ◽  
Tertiary Care ◽  
Neonatal Infection ◽  
Gastric Aspirate ◽  
Tertiary Care Centre ◽  
High Power Field ◽  
Culture Negative

Background: Neonatal sepsis is a clinical syndrome of bacteremia characterized by systemic signs and symptoms of infection in the first 28 days of life. It is responsible for 30-50% of the total neonatal deaths each year in developing countries. Gastric aspirate cytology has been used for neonatal infection. The presence of more than five polymorphs per high power field co-relate with neonatal infection. The objective of the present study was to evaluate the utility of gastric aspirate cytology as a screening tool for neonatal sepsis and to determine the polymorphonuclear leukocytes count in smear of gastric aspirate and correlating it with culture proven sepsis.Methods: This prospective observational study was conducted from February 2017 to January 2018 at level III Neonatal intensive care Unit of Sri Venkata Sai Medical College and Hospital, Mahabubnagar, Telangana. A total of 108 neonates with risk factor and / or clinical features of sepsis were included in the study.Results: Out of 108 neonates, 40 were blood culture positive   and 68 were culture negative. Gastric aspirate smear showed ≥5 polymorphs in 30 and <5 polymorphs in 10 neonates with positive blood culture. Among blood culture negative cases, 20 had ≥5 polymorphs and 48 had <5 polymorphs in gastric aspirate smear. Gastric aspirate culture was positive in 48 neonates and negative in 60 neonates. Of the 48 gastric aspirate positive neonates, 45 had ≥5 polymorphs and 3 had <5 polymorphs in gastric aspirate smear. Similarly, among 60 gastric aspirate culture negative neonates, 55 had ≥5 polymorphs and 3 had <5 polymorphs in gastric aspirate smear. This was statistically significant (P<0.000001). Of 48 neonates with positive gastric aspirate culture, 30 had positive blood culture and 18 had negative blood culture.Conclusions: Gastric aspirate cytology is a good screening tool for neonatal sepsis added to a detailed perinatal history and clinical examination but does not completely substitute the present day available screening parameters.

scholarly journals Comparing mortality between positive and negative blood culture results: an inverse probability of treatment weighting analysis of a multicenter cohort

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Aibo Liu ◽  
Chia-Hung Yo ◽  
Lu Nie ◽  
Hua Yu ◽  
Kuihai Wu ◽  
...  
Keyword(s):  
Propensity Score ◽  
Blood Culture ◽  
Early Mortality ◽  
Negative Blood Culture ◽  
Late Mortality ◽  
Inverse Probability ◽  
Propensity Score Model ◽  
Significant Difference ◽  
Culture Positive ◽  
Culture Negative

Abstract Background The association between blood culture status and mortality among sepsis patients remains controversial hence we conducted a tri-center retrospective cohort study to compare the early and late mortality of culture-negative versus culture-positive sepsis using the inverse probability of treatment weighting (IPTW) method. Methods Adult patients with suspected sepsis who completed the blood culture and procalcitonin tests in the emergency department or hospital floor were eligible for inclusion. Early mortality was defined as 30-day mortality, and late mortality was defined as 30- to 90-day mortality. IPTW was calculated from propensity score and was employed to create two equal-sized hypothetical cohorts with similar covariates for outcome comparison. Results A total of 1405 patients met the inclusion criteria, of which 216 (15.4%) yielded positive culture results and 46 (21.3%) died before hospital discharge. The propensity score model showed that diabetes mellitus, urinary tract infection, and hepatobiliary infection were independently associated with positive blood culture results. There was no significant difference in early mortality between patients with positive or negative blood culture results. However, culture-positive patients had increased late mortality as compared with culture-negative patients in the full cohort (IPTW-OR, 1.95, 95%CI: 1.14–3.32) and in patients with severe sepsis or septic shock (IPTW-OR, 1.92, 95%CI: 1.10–3.33). After excluding Staphylococcal bacteremia patients, late mortality difference became nonsignificant (IPTW-OR, 1.78, 95%CI: 0.87–3.62). Conclusions Culture-positive sepsis patients had comparable early mortality but worse late mortality than culture-negative sepsis patients in this cohort. Persistent Staphylococcal bacteremia may have contributed to the increased late mortality.

scholarly journals Neonatal Sepsis-Culture Positive Sepsis Vs Clinical Sepsis

2017 ◽  
Vol 6 (1) ◽  
pp. 1362
Author(s):  
Purbasha Ghosh ◽  
Rabindra Nath Misra ◽  
Retina Paul
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Blood Culture ◽  
Neonatal Sepsis ◽  
Gold Standard ◽  
Methicillin Resistance ◽  
High Morbidity ◽  
Sepsis Screen ◽  
Culture Positive ◽  
Culture Negative

<p><strong>Background</strong>: The incidence of sepsis is increasing globally, with high morbidity and mortality. Diagnosis of neonatal sepsis is still a clinical and laboratory challenge. Though blood culture is gold standard, it sometimes gives false negative result. So, judgement of clinical condition along with various investigations is important.</p><p><strong>Objectives</strong>: To find out the risk factors associated with neonatal sepsis, to isolate&amp;amp;identify the pathogens from various clinical specimens and to find out antimicrobial susceptibility of the pathogens.</p><p><strong>Material and methods</strong>: Blood culture, sepsis screen, haematological&amp;amp;biochemical markers, cerebrospinal fluid (CSF) study, radiology, MRSA (methicillin resistance Staphylococcus aureus) surveillance were carried out in this study. Some samples were processed in BacT/ALERT-3D system (BioMerieux ) and identified by VITEK-2 (BioMerieux). Epi Info Software system was used to calculate statistics.</p><p><strong>Results</strong>: One seventy (65.9%) were culture positive and 88 (34.1%) were culture negative out of 258 clinically suspected cases. Methicillin sensitive Staphylococcus aureus (MSSA) 66 (38.82%) was the commonest organism. Among 88 culture negative cases, 38(43.2%) babies were two or more sepsis screen tests positive, 40(45.5%) culture negative babies were with risk factors and 5(5.7%) had radiological evidence of pneumonia.</p><p><strong>Conclusion</strong>: The clinical diagnosis of it remains difficult as the symptoms are nonspecific. So, blood culture is mandatory. Other diagnostic tests also help in this situation. Blood culture is still the "Gold standard" for the diagnosis of septicaemia in neonates, but culture negativity cannot exclude the sepsis as a whole.</p>

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