scholarly journals Profiles of Extrapulmonary Nontuberculous Mycobacteria Infections and Predictors for Species: A Multicenter Retrospective Study

Pathogens ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 949
Author(s):  
Jung Ho Kim ◽  
In Young Jung ◽  
Je Eun Song ◽  
Eun Jin Kim ◽  
Jun Hyoung Kim ◽  
...  
Keyword(s):  
Nontuberculous Mycobacteria ◽  
Tertiary Care ◽  
Treatment Regimens ◽  
Female Sex ◽  
Joint Infections ◽  
Bone And Joint Infections ◽  
Male Sex ◽  
The Difference ◽  
Tertiary Care Centers ◽  
Post Hoc

Extrapulmonary nontuberculous mycobacteria (NTM) infections contribute to morbidity and mortality worldwide. However, studies about extrapulmonary NTM infections have been limited. Therefore, we aim to describe the diversity of extrapulmonary NTM infections and identify predictors for species. Information regarding diversity of NTM isolates, antimicrobial susceptibility testing, treatment regimens, and outcomes were collected from four tertiary care centers in South Korea. Comparisons were made between patients with rapidly growing mycobacteria (RGM) and slowly growing mycobacteria (SGM) infections. A total of 117 patients (46 males vs. 71 females) were included. Skin and soft tissue infections (SSTIs) predominated (34.2%), followed by bone and joint infections (28.2%). In SSTIs, RGM species were predominantly identified (26/28, 92.9%), whereas SGM species were mainly identified in bone and joint infections (18/26, 69.2%), and the difference of isolated sites was verified by a post hoc test (p < 0.001). Multivariable regression analysis revealed that male sex (vs. female sex; OR 5.30, CI 1.35–24.26, p = 0.020) and bone and joint infections (vs. SSTIs; OR 18.10, CI 3.28–157.07, p = 0.002) were predictors of SGM infections, whereas the opposite was observed for RGM infections. Bone and joint infections and male sex were predictors for SGM infections, whereas SSTIs and female sex were predictors for RGM infections.

scholarly journals 1365. Profiling Extrapulmonary Nontuberculous Mycobacteria Infections and Predictors for rapid-growing Species: A Multi-Center Retrospective Study

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S494-S494
Author(s):  
Jung Ho Kim ◽  
Woon Ji Lee ◽  
Hye Seong ◽  
In Young Jung ◽  
Eun Jin Kim ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Antimicrobial Susceptibility ◽  
Susceptibility Testing ◽  
Nontuberculous Mycobacteria ◽  
Joint Infection ◽  
Tertiary Care ◽  
Antimicrobial Susceptibility Testing ◽  
Soft Tissue Infections ◽  
Joint Infections ◽  
Bone And Joint Infections

Abstract Background Nontuberculous mycobacteria (NTM) disease is increasing worldwide and is an important cause of morbidity and mortality. It is found that 20 to 30% of NTM isolates are of extrapulmonary origin. However, Studies about extrapulmonary NTM infections have been limited. Thus, we aim to describe the diversity of NTM infections and correlate these observations with clinical data. Methods We analyzed all symptomatic patients with positive NTM cultures in sterile extrapulmonary sites at three tertiary care centers in South Korea between January 2006 and June 2018. We collected patient information including predisposing factors, diversity of NTM isolates, antimicrobial susceptibility testing, treatment regimens, and outcomes. Results A total of 117 patients (46 males vs. 71 females) were included. The median age of the patients was 54 years. There are a lot of infections associated with medical procedures like surgery, but about half of cases (54.7%) are unknown origin. Skin and soft-tissue infections predominated (34.2%), followed by bone and joint infections (28.2%). Of 117 NTM isolates, 66 NTM subspecies were identified. Mycobacterium intracellulare (34.8%) was the most common species identified, followed rapid-growing NTM (RGM) species such as M. fortuitum complex (21.2%), M. abscessus (15.2%), M. massiliense (10.6%), and M. chelonae (9.1%). In skin and soft-tissue infections, RGM species were predominantly identified (26/28, 92.9%), whereas slow-growing NTM (SGM) species were mainly identified in bone and joint infections (18/26, 69.2%). The difference of isolated sites was verified by post hoc test and female sex (OR 4.72; P < 0.001) and skin and soft-tissue infections (OR 25.33; P < 0.001) were identified as predictors of RGM by logistic regression analysis. Based on antimicrobial susceptibility testing, fluoroquinolone and macrolide were mainly used for RGM treatment, and rifamycin-ethambutol-macrolide-based regimen was predominantly used for SGM treatment. Conclusion Skin and soft-tissue infection were predominantly caused by RGM, whereas bone and joint infection is mainly caused by SGM. Species-specific and region-specific data that integrate clinical and microbiologic information is crucial in determining treatment direction. Disclosures All authors: No reported disclosures.

scholarly journals Prevalence of Nontuberculous Mycobacteria among Extrapulmonary Tuberculosis Cases in Tertiary Care Centers in Northern India

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
A. K. Maurya ◽  
V. L. Nag ◽  
S. Kant ◽  
R. A. S. Kushwaha ◽  
M. Kumar ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Nontuberculous Mycobacteria ◽  
Extrapulmonary Tuberculosis ◽  
Tertiary Care ◽  
Rapid Identification ◽  
Northern India ◽  
Tertiary Care Centers ◽  
Tertiary Care Hospitals ◽  
Culture Positive ◽  
Final Confirmation

The reports of nontuberculous mycobacteria (NTM) associated with extrapulmonary diseases are increasing in tertiary care hospitals. Despite a significant increase in knowledge about NTM infections, they still represent a diagnostic and therapeutic challenge. The aim of this study is to know the prevalence of NTN among extrapulmonary tuberculosis cases in tertiary care centers in Northern India. A total of 227 culture positive isolates from 756 cases were tested for niacin production and catalase assay. BIO-LINE SD Ag MPT64 TB test and final identification and differentiation between MTBC and different species of NTM were further confirmed by GenoType Mycobacterium CM/AS assay. 71 cases (9.3%) were positive for AFB by ZN staining and 227 cases (30.1%) were positive for mycobacteria by culture. Niacin production and catalase activity were negative in 62/227 (27.4%) strains and after using a panel of different biochemicals and final confirmation by GenoType Mycobacterium CM assay. Out of 227 cultures tested, 165 (72.6%) strains were confirmed asM. tuberculosiscomplex, and 62 (27.4%) were confirmed as NTM. The most common NTM species identified wereM. fortuitum17 (27.5%) andM. intracellulare13 (20.9%). The rapid identification of NTM species may help in targeted therapy and management of the diseases.

scholarly journals ASPEK BIOLOGI REPRODUKSI IKAN LAYANG (Decapterus russelli) DAN IKAN BANYAR (Rastrelliger kanagurta) YANG DIDARATKAN DI REMBANG, JAWA TENGAH

2017 ◽  
Vol 3 (1) ◽  
pp. 17
Author(s):  
Wiwiet An Pralampita ◽  
Umi Chodriyah
Keyword(s):  
Purse Seine ◽  
Maturity Level ◽  
Gonad Maturity ◽  
Female Sex ◽  
Gonad Size ◽  
Biological Aspects ◽  
Male Sex ◽  
Rastrelliger Kanagurta ◽  
The Difference ◽  
First Time

Ikan layang (Decapterus russelli) dan banyar (Rastrelliger kanagurta) merupakan dua jenis ikan hasil tangkapan dominan kapal mini purse seine yang didaratkan di Rembang. Aspek biologi ikan layang dan banyar yang diteliti, meliputi sebaran ukuran panjang, perbandingan jenis kelamin, tingkat kematangan gonad dan ukuran pertama kali matang gonad pada tahun 2007. Ukuran yang dominan tertangkap untuk ikan layang 18-18,9 cm, sedangkan untuk ikan banyar 21-21,9 cm. Ikan layang dan banyar yang berkelamin jantan lebih banyak tertangkap pada ukuran lebih kecil daripada ikan yang berkelamin betina. Spesies ikan layang menunjukan bahwa ikan yang dalam kondisi matang (mature) lebih banyak ditemukan pada ikan yang berjenis kelamin betina, sedangkan spesies ikan banyar yang mempunyai tingkat kematangan gonad I, II, III, dan IV lebih banyak ditemukan pada spesies ikanyang berjenis kelamin jantan. Spesies ikan banyar yang mempunyai tingkat kematangan gonad V lebih banyak ditemukan pada spesies yang berjenis kelamin betina. Ukuran pertama kali matang gonad untuk ikan layang betina 18,97 cm dan untuk yang jantan 21,2 cm. Jenis ikan banyar berkelaminbetina ukuran pertama kali matang gonad 20,37 cm, sedangkan yang jantan 20,87 cm. Scad fish (Decapterus russelli) and mackerel (Rastrelliger kanagurta) are two species of dominant caught by boat mini purse seine landed in Rembang. Biological aspects of and mackerel examined are the size of the length, the difference in sex, level of maturity, and gonad size of first time The dominant size caught for scad was 18-18.9 cm, while for mackerel was 21-21.9 cm. Male fishes of scad and mackerel were mostly caught in the smaller size compared to the size of female. Matured of gonad was mostly found in the female of scad fish. While in the female mackerel species having gonad maturity level of 1, 2, 3, and 4 was mostly found in male sex. Mackerel species having 5th stage of gonad maturity was mostly found in the female sex. First time of gonad matured in female scad was in size of 18.97 cm and for a male was 21.2 cm. While in female mackerel, the first time of gonad matured was 20.37 cm and for a male one was 21.2 cm.

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