scholarly journals Naturally Acquired Humoral Immunity against Malaria Parasites in Non-Human Primates from the Brazilian Amazon, Cerrado and Atlantic Forest

Pathogens ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 525 ◽  
Author(s):  
Eliana Ferreira Monteiro ◽  
Carmen Fernandez-Becerra ◽  
Maisa da Silva Araujo ◽  
Mariluce Rezende Messias ◽  
Luiz Shozo Ozaki ◽  
...  
Keyword(s):  
Atlantic Forest ◽  
Parasite Species ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Surveillance Program ◽  
Malaria Surveillance ◽  
Genus Plasmodium ◽  
Malaria Vaccine Candidate ◽  
Potential Risks ◽  
Plasmodium Brasilianum

Non-human primates (NHPs) have been shown to be infected by parasites of the genus Plasmodium, the etiological agent of malaria in humans, creating potential risks of zoonotic transmission. Plasmodium brasilianum, a parasite species similar to P. malariae of humans, have been described in NHPs from Central and South America, including Brazil. The merozoite surface protein 1 (MSP1), besides being a malaria vaccine candidate, is highly immunogenic. Due to such properties, we tested this protein for the diagnosis of parasite infection. We used recombinant proteins of P. malariae MSP1, as well as of P. falciparum and P. vivax, for the detection of antibodies anti-MSP1 of these parasite species, in the sera of NHPs collected in different regions of Brazil. About 40% of the NHP sera were confirmed as reactive to the proteins of one or more parasite species. A relatively higher number of reactive sera was found in animals from the Atlantic Forest than those from the Amazon region, possibly reflecting the former more intense parasite circulation among NHPs due to their proximity to humans at a higher populational density. The presence of Plasmodium positive NHPs in the surveyed areas, being therefore potential parasite reservoirs, needs to be considered in any malaria surveillance program.

scholarly journals Effect of Plasmodium yoelii Exposure on Vaccination with the 19-Kilodalton Carboxyl Terminus of Merozoite Surface Protein 1 and Vice Versa and Implications for the Application of a Human Malaria Vaccine

2008 ◽  
Vol 77 (2) ◽  
pp. 817-824 ◽  
Author(s):  
Jiraprapa Wipasa ◽  
Huji Xu ◽  
Xueqin Liu ◽  
Chakrit Hirunpetcharat ◽  
Anthony Stowers ◽  
...  
Keyword(s):  
Malaria Vaccine ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Plasmodium Yoelii ◽  
Natural Immunity ◽  
Vaccine Response ◽  
Malaria Vaccine Candidate ◽  
Current Infection ◽  
Antibody Specificities ◽  
Original Antigenic Sin

ABSTRACT It is well known that exposure to one antigen can modulate the immune responses that develop following exposure to closely related antigens. It is also known that the composition of the repertoire can be skewed to favor epitopes shared between a current infection and a preceding one, a phenomenon referred to as “original antigenic sin.” It was of interest, therefore, to investigate the antibody response that develops following exposure to the malaria vaccine candidate homologue Plasmodium yoelii MSP119 in mice that had previously experienced malaria infection and vice versa. In this study, preexposure of mice to Plasmodium yoelii elicited native anti-MSP119 antibody responses, which could be boosted by vaccination with recombinant MSP119. Likewise, infection of MSP119-primed mice with P. yoelii led to an increase of anti-MSP119 antibodies. However, this increase was at the expense of antibodies to parasite determinants other than MSP119. This change in the balance of antibody specificities significantly affected the ability of mice to withstand a subsequent infection. These data have particular relevance to the possible outcome of malaria vaccination for those situations where the vaccine response is suboptimal and suggest that suboptimal vaccination may in fact render the ultimate acquisition of natural immunity more difficult.

scholarly journals Immunoglobulin G3 Antibodies Specific for the 19-Kilodalton Carboxyl-Terminal Fragment of Plasmodium yoelii Merozoite Surface Protein 1 Transfer Protection to Mice Deficient in Fc-γRI Receptors

2000 ◽  
Vol 68 (5) ◽  
pp. 3019-3022 ◽  
Author(s):  
Peter Vukovic ◽  
P. Mark Hogarth ◽  
Nadine Barnes ◽  
David C. Kaslow ◽  
Michael F. Good
Keyword(s):  
Malaria Vaccine ◽  
Vaccine Candidate ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Plasmodium Yoelii ◽  
Merozoite Surface Protein 1 ◽  
Specific Immunoglobulin ◽  
Malaria Vaccine Candidate ◽  
Main Action ◽  
Carboxyl Terminal

ABSTRACT Merozoite surface protein 1 (MSP-119) is a leading malaria vaccine candidate. Specific antibodies contribute to immunity; binding to macrophages is believed to represent the main action of malaria antibodies. We show that an MSP-119-specific immunoglobulin G3 (IgG3) monoclonal antibody can passively transfer protection to mice deficient in the α chain of Fc-γRI whose macrophages cannot bind IgG3.

scholarly journals Humoral Responses to Plasmodium falciparum Blood-Stage Antigens and Association with Incidence of Clinical Malaria in Children Living in an Area of Seasonal Malaria Transmission in Burkina Faso, West Africa

2007 ◽  
Vol 76 (2) ◽  
pp. 759-766 ◽  
Author(s):  
Issa Nebie ◽  
Amidou Diarra ◽  
Alphonse Ouedraogo ◽  
Issiaka Soulama ◽  
Edith C. Bougouma ◽  
...  
Keyword(s):  
Malaria Transmission ◽  
Malaria Vaccine ◽  
Vaccine Development ◽  
Malaria Incidence ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
Clinical Malaria ◽  
Blood Stage ◽  
Igg Subclass ◽  
Malaria Surveillance

ABSTRACT There is longstanding evidence that immunoglobulin G (IgG) has a role in protection against clinical malaria, and human antibodies of the cytophilic subclasses are thought to be particularly critical in this respect. In this cohort study, 286 Burkinabè children 6 months to 15 years old were kept under malaria surveillance in order to assess the protective role of antibody responses against four antigens which are currently being evaluated as vaccine candidates: apical membrane antigen 1 (AMA1), merozoite surface protein 1-19 (MSP1-19), MSP3, and glutamate-rich protein (GLURP). Total IgG, IgM, and IgG subclass responses were measured just before the malaria transmission season. The incidence of malaria was 2.4 episodes per child year of risk. After adjusting for the confounding effects of age, the level of total IgG to GLURP was strongly associated with reduced malaria incidence (incidence rate ratio associated with a doubling of total IgG, 0.79; 95% confidence interval, 0.66 to 0.94; P = 0.009.); there was a borderline statistically significant association between the level of total IgG to MSP3 and malaria incidence and no evidence of an association for total IgG to AMA1 and to MSP1-19. Of the IgG subclass responses studied, only IgG3 and IgG4 against GLURP and IgG1 against AMA1 were associated with reduced risk of clinical malaria. There was no evidence of an interaction between responses to AMA1 and baseline parasitemia in their effects on malaria incidence. Currently included in malaria vaccine formulations for clinical trials in humans, these blood-stage antigens, AMA1 and GLURP, offer good prospects for malaria vaccine development.

scholarly journals In silico Identification and Validation of a Linear and Naturally Immunogenic B-Cell Epitope of the Plasmodium vivax Malaria Vaccine Candidate Merozoite Surface Protein-9

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0146951 ◽  
Author(s):  
Rodrigo Nunes Rodrigues-da-Silva ◽  
João Hermínio Martins da Silva ◽  
Balwan Singh ◽  
Jianlin Jiang ◽  
Esmeralda V. S. Meyer ◽  
...  
Keyword(s):  
B Cell ◽  
Malaria Vaccine ◽  
Vaccine Candidate ◽  
Cell Epitope ◽  
Surface Protein ◽  
Merozoite Surface Protein ◽  
B Cell Epitope ◽  
Plasmodium Vivax Malaria ◽  
Malaria Vaccine Candidate ◽  
In Silico Identification
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