scholarly journals MgpB Types among Mycoplasma genitalium Strains from Men Who Have Sex with Men in Berlin, Germany, 2016–2018

Pathogens ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 12 ◽  
Author(s):  
Roger Dumke ◽  
Marcos Rust ◽  
Tobias Glaunsinger
Keyword(s):  
Sexually Transmitted Diseases ◽  
Mycoplasma Genitalium ◽  
Clinical Samples ◽  
Genome Region ◽  
Sexually Transmitted ◽  
Gene Coding ◽  
A Cell ◽  
Different Populations ◽  
Sex With Men

Mycoplasma genitalium is a cell wall-less bacterium causing urethritis and other sexually transmitted diseases. Despite a strongly conserved genome, strains in clinical samples can be typed by different methods. To obtain data from the risk population of men having sex with men, we analyzed the typing region in the gene coding for the MgpB adhesin of M. genitalium first in 163 and 45 follow-up samples among patients of two specialized practices in Berlin, Germany. Strains belong to 43 different mgpB types emphasizing the diversity of the genome region. With respect to 133 types previously described, 27 new types were found. However, the majority of strains (64.4%) were assigned to types 4, 6, 113, and 108, respectively. A correlation between mgpB type and the occurrence of mutations associated with macrolide and quinolone resistance was not demonstrated. Investigation of follow-up samples from 35 patients confirmed the same mgpB and, additionally, MG_309 types in 25 cases. In 10 cases, differences between types in subsequent samples indicated an infection with a genetically different strain in the period between samplings. MgpB/MG_309 typing is a useful method to compare M. genitalium strains in samples of individual patients as well as those circulating in different populations

scholarly journals Antibiotic Resistance and Genotypes of Mycoplasma genitalium during a Resistance-Guided Treatment Regime in a German University Hospital

Antibiotics ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 962
Author(s):  
Roger Dumke ◽  
Petra Spornraft-Ragaller
Keyword(s):  
Tetracycline Resistance ◽  
Mycoplasma Genitalium ◽  
University Hospital ◽  
Hiv Positive ◽  
Sexually Transmitted ◽  
Development Of Resistance ◽  
Asymptomatic Patients ◽  
Sex With Men ◽  
Guided Therapy

The treatment of infections from the sexually transmitted pathogen Mycoplasma genitalium is hampered by the rapidly increasing resistance to the recommended first- (macrolides) and second-line antibiotics (quinolones). Thus, resistance-guided therapy (RGT) is key for its successful eradication but the efficiency of this approach can be influenced by re-infections and treatment failures. The typing of strains is helpful to distinguish between ongoing colonization, re-infection or the development of resistance. In the present study, mgpB and MG_309 types as well as mutations associated with macrolide, quinolone and tetracycline resistance of strains in M. genitalium-positive samples accumulated in the years 2019 and 2020 at a university hospital were analyzed. Fifty-eight positive first and sixteen positive follow-up samples from patients (96.6% male, 84.5% men who have sex with men, 74.1% HIV-positive) were included. Twenty-three mgpB types (seven new types), nine MG_309 types and thirty-four mgpB/MG_309 types were identified. The prevalence of mutations associated with macrolide, quinolone and tetracycline resistance was 56.9%, 10.3% and 6.8%, respectively. Despite the fact that many asymptomatic patients were not treated and tests of cure were impossible in different cases, the preliminary rate of successful eradication (93.3%) in this study is promising for the continuation of the RGT strategy.

Molecular screening in a longitudinal cohort of young men who have sex with men and young transgender women: associations with focus on the emerging sexually transmitted pathogen Mycoplasma genitalium

2020 ◽  
pp. sextrans-2020-054463
Author(s):  
Erik Munson ◽  
Ethan Morgan ◽  
Laura Sienkiewicz ◽  
Yazmine Thomas ◽  
Kathleen Buehler ◽  
...  
Keyword(s):  
Trichomonas Vaginalis ◽  
Young Men ◽  
Mycoplasma Genitalium ◽  
Transgender Women ◽  
Sexual Practice ◽  
Transmitted Infection ◽  
Urine Screening ◽  
Sexually Transmitted ◽  
Sex With Men

ObjectivesThis investigation sought to characterise risk factors associated with acquisition of traditional and emerging agents of sexually transmitted infection (STI) in a cohort of young men who have sex with men and transgender women.Methods917 participants provided urine and rectal swab submissions assessed by transcription-mediated amplification (TMA)-based assays for Chlamydia trachomatis and Neisseria gonorrhoeae and by off-label TMA-based Trichomonas vaginalis and Mycoplasma genitalium testing. A subset provided specimens at 6-month and 12-month follow-up visits.ResultsPrevalence of M. genitalium from rectal and urine specimens (21.7% and 8.9%, respectively) exceeded that of C. trachomatis (8.8% and 1.6%) and other STI agents. Black participants yielded higher prevalence of M. genitalium (30.6%) than non-black participants (17.0%; χ²=22.39; p<0.0001). M. genitalium prevalence from rectal specimens was 41.5% in HIV-positive participants vs 16.3% in HIV-negative participants (χ²=57.72; p<0.0001). Participant age, gender identity, condomless insertive anal/vaginal sexual practice and condomless receptive anal sexual practice were not associated with rectal C. trachomatis (p≥0.10), N. gonorrhoeae (p≥0.29), T. vaginalis (p≥0.18) or M. genitalium (p≥0.20) detection. While prevalence of T. vaginalis was calculated at ≤1.0%, baseline rectal and urine screening status was predictive of detection/non-detection at follow-up. A non-reactive M. genitalium baseline rectal or urine screening result was less predictive of non-reactive follow-up versus C. trachomatis, N. gonorrhoeae and T. vaginalis.ConclusionsRectal M. genitalium detection is associated with black race and HIV seropositivity. Baseline M. genitalium infection influences subsequent detection of the organism.

scholarly journals Does Penis Size Influence Sexual Behaviour of Men who Have Sex with Men?

2018 ◽  
Vol 35 (4) ◽  
pp. 311-319
Author(s):  
Milan Bjekić ◽  
Sandra Šipetić-Grujičić ◽  
Hristina Vlajinac ◽  
Ivana Dunić
Keyword(s):  
Sexually Transmitted Diseases ◽  
Sexual Behaviour ◽  
Body Part ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Sexual Role ◽  
Sexually Transmitted ◽  
Penis Size ◽  
Sex With Men ◽  
The City

Abstract Penis size is a major body image concern for the majority of men in western nations, while in gay culture the penis has become a body part linked to sexual attractiveness and viability. The aim of this study was to reveal influence of the perceived penis size on sexual behaviour, condom use, sexually transmitted infections and men’s sexual positioning among men who have sex with men. In this cross-sectional study, the data were collected from consecutive men who have sex with men who attended Counselling for Sexually Transmitted Diseases at the City Institute for Skin and Venereal Diseases in Belgrade, Serbia. Out of 319 participants, 6.6% perceived their penis as "below average", 71.5% as "average", and 21.9% as "above average". In comparison with men with an average penis, men with below average penis were more frequently unsatisfied with their penis size (p < 0.05), more frequently lied to others about their penis size (p < 0.001) and took more frequently the passive sexual role (p < 0.05). Men with above average penis were more frequently satisfied with their penis size (p < 0.001), took more frequently the active sexual role (p < 0.01), they had more sexual partners (p < 0.05), more problems with a tight condom (p < 0.001) and more gonorrhoea/Chlamydia infections (p < 0.001) than men with an average penis. Perception of one’s penis size was associated with some aspects of sexual behaviour and the frequency of sexually transmitted diseases.

scholarly journals Men treated for syphilis in Białystok, Poland, 2014-2018

2019 ◽  
pp. 329-335
Author(s):  
Agnieszka Beata Serwin ◽  
Adriana Grochowska ◽  
Iwona Flisiak
Keyword(s):  
Urban Areas ◽  
Partner Notification ◽  
Secondary Syphilis ◽  
Contact Tracing ◽  
Professional Activity ◽  
Symptomatic Infection ◽  
Sexually Transmitted ◽  
Sexual Contacts ◽  
Sex With Men

INTRODUCTION. Incidence of syphilis is increasing in Europe in recent years, mainly due to high incidence in men, especially men who have sex with men (MSM). AIM. To analyse sociodemographic, epidemiological and clinical characteristics of men treated for syphilis in Bialystok in 2014 – 2018, to compare these of MSM and men who have sex with women (MSW). MATERIAL AND METHODS. Analysis of age, residency, professional activity, type of sexual contacts (steady vs. casual), marital status, stage of syphilis diagnosed, concomitant sexually transmitted infections (STIs), treatment, partner notification and follow-up attendance. RESULTS. Of 49 male patients with syphilis 26 (53.06%) were MSM and 23 (46.94%) – MSW. The average age was 33.67 and 35.87 years in MSM and MSW patients, respectively. Majority of patients in both groups were residents of urban areas. Tradesmen and those unemployed constituted the highest proportion in MSM and MSW group, respectively. MSM were in majority single and had only casual contacts while MSW, mostly married or engaged in steady relationship, had also casual contacts. Secondary syphilis was most frequently diagnosed in MSM and late latent syphilis - in MSW. Eight patients (16.32%) had concomitant HIV infection, in all diagnosed before syphilis. Contact tracing was successful in 26.92% of MSM and 39.13% of MSW. Follow-up was not done or not completed in half of MSM and more than half of MSW. CONCLUSIONS. Results confirm that MSM play a crucial role in the current epidemics of syphilis. They have mainly casual sexual contacts and have symptomatic infection. In both MSM and MSW contact tracing and follow-up attendance is suboptimal.

scholarly journals A Network Analysis of Sexually Transmitted Diseases and Online Hookup Sites Among Men Who Have Sex With Men

2018 ◽  
Vol 45 (7) ◽  
pp. 462-468 ◽  
Author(s):  
Philip A. Chan ◽  
Christina Crowley ◽  
Jennifer S. Rose ◽  
Trace Kershaw ◽  
Alec Tributino ◽  
...  
Keyword(s):  
Network Analysis ◽  
Sexually Transmitted Diseases ◽  
Sexually Transmitted ◽  
Sex With Men

Epididymo-orchitis

2019 ◽  
pp. 193-200
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract Infection ◽  
Differential Diagnosis ◽  
Partner Notification ◽  
Mycoplasma Genitalium ◽  
Older Men ◽  
Sexually Transmitted ◽  
Testicular Pain ◽  
Younger Men

Epididymo-orchitis is inflammation of the epididymis +/– testes, usually caused by sexually transmitted pathogens in younger men (<35) and urinary pathogens in older men. Symptoms include testicular pain and swelling, often in combination with symptoms of urethritis (e.g. discharge, dysuria) or urinary tract infection (e.g. dysuria, frequency). Complications can include chronic epididymitis, abscess, hydrocele. and infertility. Common sexually transmitted pathogens include chlamydia, gonorrhoea, and Mycoplasma genitalium, while non-sexually acquired organisms include coliforms such as Escherichia coli. This chapter details diagnosis, and differential diagnosis of testicular pain and swelling, as well as investigations, and management of epididymo-orchitis, including partner notification and follow up.

Sexually transmissible infections and characteristics of men aged 60 years and over attending a public sexually transmitted diseases (STD) clinic in South Australia

Sexual Health ◽  
2015 ◽  
Vol 12 (5) ◽  
pp. 460
Author(s):  
Carole Khaw ◽  
Bin Li ◽  
Russell Waddell
Keyword(s):  
Retrospective Study ◽  
Sexually Transmitted Diseases ◽  
South Australia ◽  
Older Men ◽  
Sexually Transmitted ◽  
Social Burden ◽  
Sexually Transmissible Infections ◽  
Younger Men ◽  
Health Related ◽  
Sex With Men

Background With society ageing, sexually transmissible infections (STIs) in the older population are of interest from an economic, health-related and social burden perspective. Few studies on STIs in men older than 60 years of age exist. Methods: A retrospective study was performed looking at characteristics of, and STIs in, 29 106 men (of which 689 were older than 60 years of age), at first presentation, visiting the only South Australian public sexually transmitted diseases (STD) clinic over a 13-year period. Results: Older men [men who have sex with men (MSM) and men who have sex with women (MSW)] were less likely than younger men to have been tested for HIV. Conclusion: There is a need for increased HIV testing in older men.

scholarly journals Mycoplasma genitalium Detection in Urogenital Specimens from Symptomatic and Asymptomatic Men and Women by Use of the cobas TV/MG Test

2020 ◽  
Vol 58 (6) ◽  
Author(s):  
Barbara Van Der Pol ◽  
Ken B. Waites ◽  
Li Xiao ◽  
Stephanie N. Taylor ◽  
Arundhati Rao ◽  
...  
Keyword(s):  
United States ◽  
Trichomonas Vaginalis ◽  
Mycoplasma Genitalium ◽  
The United States ◽  
Clinical Samples ◽  
Men And Women ◽  
Content Type ◽  
Sexually Transmitted ◽  
Asymptomatic Individuals ◽  
Asymptomatic Men

ABSTRACT Mycoplasma genitalium (MG) infections are a growing concern within the field of sexually transmitted infections. However, diagnostic assays for M. genitalium have been limited in the United States. As most infections are asymptomatic, individuals can unknowingly pass the infection on, and the prevalence is likely to be underestimated. Diagnosis of M. genitalium infection is recommended using a nucleic acid test. This multicenter study assessed the performance of the cobas Trichomonas vaginalis (TV)/MG assay (cobas) for the detection of M. genitalium, using 22,150 urogenital specimens from both symptomatic and asymptomatic men and women collected at geographically diverse sites across the United States. The performance was compared to a reference standard of three laboratory-developed tests (LDTs). The specificity of the cobas assay for M. genitalium ranged from 96.0% to 99.8% across symptomatic and asymptomatic men and women. The sensitivities in female vaginal swabs and urine samples were 96.6% (95% confidence interval [CI], 88.5 to 99.1%) and 86.4% (95% CI, 75.5 to 93.0%), respectively. The sensitivities in male urine and meatal swab samples were 100% (95% CI, 94.0 to 100%) and 85.0% (95% CI, 73.9 to 91.9%), respectively. This study demonstrated that the cobas assay was highly sensitive and specific in all relevant clinical samples for the detection of M. genitalium.

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