scholarly journals Chlamydia pecorum Ovine Abortion: Associations between Maternal Infection and Perinatal Mortality

Pathogens ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1367
Author(s):  
Cheryl Jenkins ◽  
Martina Jelocnik ◽  
Emily Onizawa ◽  
Justine McNally ◽  
Ronald Coilparampil ◽  
...  
Keyword(s):  
Perinatal Mortality ◽  
South Wales ◽  
Chlamydia Pecorum ◽  
Clinical Presentations ◽  
Broad Array ◽  
Antibody Titres ◽  
Genetic Features ◽  
Infection Parameters ◽  
Abortion Case

Chlamydia pecorum is a common gastrointestinal inhabitant of livestock but infections can manifest in a broad array of clinical presentations and in a range of host species. While C. pecorum is a known cause of ovine abortion, clinical cases have only recently been described in detail. Here, the prevalence and sequence types (STs) of C. pecorum in ewes from a property experiencing high levels of perinatal mortality (PNM) in New South Wales (NSW), Australia, were investigated using serological and molecular methods. Ewes that were PNM+ were statistically more likely to test seropositive compared to PNM− ewes and displayed higher antibody titres; however, an increase in chlamydial shedding from either the rectum, vagina or conjunctiva of PNM+ ewes was not observed. Multilocus sequence typing (MLST) indicated that C. pecorum ST23 was the major ST shed by ewes in the flock, was the only ST identified from the vaginal site, and was the same ST detected within aborted foetal tissues. Whole genome sequencing of C. pecorum isolated from one abortion case revealed that the C. pecorum plasmid (pCpec) contained a unique deletion in coding sequence 1 (CDS1) that was also present in C. pecorum ST23 shed from the ewes. A further unique deletion was noted in a polymorphic membrane protein gene (pmpG) of the C. pecorum chromosome, which warrants further investigation given the role of PmpG in host cell adherence and tissue tropism.This study describes novel infection parameters in a sheep flock experiencing C. pecorum-associated perinatal mortality, provides the first genomic data from an abortigenic C. pecorum strain, and raises questions about possible links between unique genetic features of this strain and C. pecorum abortion.

scholarly journals French recommendations for the management of Behçet’s disease

2021 ◽  
Vol 16 (S1) ◽  
Author(s):  
Isabelle Kone-Paut ◽  
◽  
Stéphane Barete ◽  
Bahram Bodaghi ◽  
Kumaran Deiva ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Initial Assessment ◽  
Diagnostic Process ◽  
Behcet's Disease ◽  
Therapeutic Modalities ◽  
Clinical Presentations ◽  
Key Points

AbstractBehçet’s disease (BD) is a systemic variable vessel vasculitis that involves the skin, mucosa, joints, eyes, arteries, veins, nervous system and gastrointestinal system, presenting with remissions and exacerbations. It is a multifactorial disease, and several triggering factors including oral cavity infections and viruses may induce inflammatory attacks in genetically susceptible individuals. BD vasculitis involves different vessel types and sizes of the vascular tree with mixed-cellular perivascular infiltrates and is often complicated by recurrent thrombosis, particularly in the venous compartment. Several new therapeutic modalities with different mechanisms of action have been studied in patients with BD. A substantial amount of new data have been published on the management of BD, especially with biologics, over the last years. These important therapeutic advances in BD have led us to propose French recommendations for the management of Behçet’s disease [Protocole National de Diagnostic et de Soins de la maladie de Behçet (PNDS)]. These recommendations are divided into two parts: (1) the diagnostic process and initial assessment; (2) the therapeutic management. Thirty key points summarize the essence of the recommendations. We highlighted the main differential diagnosis of BD according to the type of clinical involvement; the role of genetics is also discussed, and we indicate the clinical presentations that must lead to the search for a genetic cause.

Psychiatry trainees’ views and educational needs regarding the care of patients with a life-limiting illness

2016 ◽  
Vol 15 (2) ◽  
pp. 231-241 ◽  
Author(s):  
Benjamin C. Forster ◽  
Helen Proskurin ◽  
Brian Kelly ◽  
Melanie R. Lovell ◽  
Ralf Ilchef ◽  
...  
Keyword(s):  
New South ◽  
Psychiatric Morbidity ◽  
Educational Needs ◽  
Physical Illness ◽  
South Wales ◽  
Dying Patients ◽  
Semistructured Interviews ◽  
Case Based Learning ◽  
Psychiatric Intervention

AbstractObjective:People with a life-limiting physical illness experience high rates of significant psychological and psychiatric morbidity. Nevertheless, psychiatrists often report feeling ill-equipped to respond to the psychiatric needs of this population. Our aim was to explore psychiatry trainees’ views and educational needs regarding the care of patients with a life-limiting physical illness.Method:Using semistructured interviews, participants’ opinions were sought on the role of psychiatrists in the care of patients with a life-limiting illness and their caregivers, the challenges faced within the role, and the educational needs involved in providing care for these patients. Interviews were audiotaped, fully transcribed, and then subjected to thematic analysis.Results:A total of 17 psychiatry trainees were recruited through two large psychiatry training networks in New South Wales, Australia. There were contrasting views on the role of psychiatry in life-limiting illness. Some reported that a humanistic, supportive approach including elements of psychotherapy was helpful, even in the absence of a recognizable mental disorder. Those who reported a more biological and clinical stance (with a reliance on pharmacotherapy) tended to have a nihilistic view of psychiatric intervention in this setting. Trainees generally felt ill-prepared to talk to dying patients and felt there was an educational “famine” in this area of psychiatry. They expressed a desire for more training and thought that increased mentorship and case-based learning, including input from palliative care clinicians, would be most helpful.Significance of Results:Participants generally feel unprepared to care for patients with a life-limiting physical illness and have contrasting views on the role of psychiatry in this setting. Targeted education is required for psychiatry trainees in order to equip them to care for these patients.

scholarly journals Sustainable Energy Development under Climate Change

2018 ◽  
Vol 10 (9) ◽  
pp. 3269 ◽  
Author(s):  
Chih-Chun Kung ◽  
Bruce McCarl
Keyword(s):  
Climate Change ◽  
Sustainable Energy ◽  
Energy Development ◽  
Future Climate ◽  
Policy Implications ◽  
Future Climate Change ◽  
Human Society ◽  
Energy Needs ◽  
Broad Array

The world faces unprecedented threats from climate change and increasing variability, which severely impacts human society and the natural environment. To reduce future climate change and ensure our economies can grow in a sustainable way, sustainable energy development is considered to be an effective approach. In this context, sustainable energy development involves augmenting our energy supplies and managing demands in a fashion that societal energy needs are met with a minimal effect on greenhouse gas emissions and a nominal resultant contribution to future climate change. In this Special Issue, research papers focus on the role of sustainable energy development (while addressing important dimensions of sustainability), which mandates an inter-disciplinary perspective in all articles. We collected 11 such papers that have analyzed a broad array of topics related to bioenergy, wind power, industrial innovation, and climate change mitigation. These papers show the varied application of renewable energy and climate change energy responses, while providing meaningful decision-making information and policy implications.

scholarly journals The Role of Multimodality Imaging in Left-Sided Prosthetic Valve Dysfunction

2022 ◽  
Vol 9 (1) ◽  
pp. 12
Author(s):  
Manuela Muratori ◽  
Laura Fusini ◽  
Maria Elisabetta Mancini ◽  
Gloria Tamborini ◽  
Sarah Ghulam Ali ◽  
...  
Keyword(s):  
Prosthetic Valve ◽  
Multimodality Imaging ◽  
Integrated Approach ◽  
Advanced Imaging ◽  
Valve Dysfunction ◽  
Clinical Presentations ◽  
Imaging Approach ◽  
Treatment Administration ◽  
Life Threatening

Prosthetic valve (PV) dysfunction (PVD) is a complication of mechanical or biological PV. Etiologic mechanisms associated with PVD include fibrotic pannus ingrowth, thrombosis, structural valve degeneration, and endocarditis resulting in different grades of obstruction and/or regurgitation. PVD can be life threatening and often challenging to diagnose due to the similarities between the clinical presentations of different causes. Nevertheless, identifying the cause of PVD is critical to treatment administration (thrombolysis, surgery, or percutaneous procedure). In this report, we review the role of multimodality imaging in the diagnosis of PVD. Specifically, this review discusses the characteristics of advanced imaging modalities underlying the importance of an integrated approach including 2D/3D transthoracic and transesophageal echocardiography, fluoroscopy, and computed tomography. In this scenario, it is critical to understand the strengths and weaknesses of each modality according to the suspected cause of PVD. In conclusion, for patients with suspected or known PVD, this stepwise imaging approach may lead to a simplified, more rapid, accurate and specific workflow and management.

scholarly journals The role of masks in reducing the risk of new waves of COVID-19 in low transmission settings: a modeling study

2020 ◽  
Author(s):  
Robyn M Stuart ◽  
Romesh G Abeysuriya ◽  
Cliff C Kerr ◽  
Dina Mistry ◽  
Daniel J Klein ◽  
...  
Keyword(s):  
Initial Conditions ◽  
High Mobility ◽  
Baseline Scenario ◽  
New Wave ◽  
Policy Environment ◽  
Agent Based ◽  
Low Transmission ◽  
South Wales ◽  
Community Transmission

Objectives: To evaluate the risk of a new wave of coronavirus disease 2019 (COVID-19) in a setting with ongoing low transmission, high mobility, and an effective test-and-trace system, under different assumptions about mask uptake. Design: We used a stochastic agent-based microsimulation model to create multiple simulations of possible epidemic trajectories that could eventuate over a five-week period following prolonged low levels of community transmission. Setting: We calibrated the model to the epidemiological and policy environment in New South Wales, Australia, at the end of August 2020. Participants: None Intervention: From September 1, 2020, we ran the stochastic model with the same initial conditions (i.e., those prevailing at August 31, 2020), and analyzed the outputs of the model to determine the probability of exceeding a given number of new diagnoses and active cases within five weeks, under three assumptions about future mask usage: a baseline scenario of 30% uptake, a scenario assuming no mask usage, and a scenario assuming mandatory mask usage with near-universal uptake (95%). Main outcome measure: Probability of exceeding a given number of new diagnoses and active cases within five weeks. Results: The policy environment at the end of August is sufficient to slow the rate of epidemic growth, but may not stop the epidemic from growing: we estimate a 20% chance that NSW will be diagnosing at least 50 new cases per day within five weeks from the date of this analysis. Mandatory mask usage would reduce this to 6-9%. Conclusions: Mandating the use of masks in community settings would significantly reduce the risk of epidemic resurgence.

scholarly journals Historical, Socio-cultural and International Political Preconditions for the Emergence and Formation of the Australian Union

2020 ◽  
pp. 68-90
Author(s):  
I. Vietrynskyi
Keyword(s):  
Industrial Revolution ◽  
Political Processes ◽  
Early Stages ◽  
South Wales ◽  
Australian Continent ◽  
Colonial Empire ◽  
The Status ◽  
The Creation ◽  
British Colonies

The article examines the prerequisites for the creation and early stages of development of the Commonwealth of Australia from the founding of the first European colonies prior to the legal formalization of the federation. Also mentioned are the variability of approaches to the development of Australia’s historiography, in particular from the positions of classical English and modern Australian views. Also, the early stages of the development of the continent that preceded the discovery of Australia by Europeans are considered. It analyzes the wide context of geopolitical processes in Europe in the era of imperialism (XVI-XIX centuries), as well as the circumstances of the formation of large colonial empires. In particular, features of the status, place and role of England in the international political processes of the XVIІ and XVIII centuries are shown, and the stages of the formation of the British colonial empire are also considered. The complex of internal socio-economic as well as foreign policy prerequisites for the beginning of the colonization of Australia by Great Britain is analyzed, in particular the attention paid to the consequences of the British Industrial Revolution XVIII. The stages of formation of the British colonies in Australia, as well as the development of the mainland from the establishment of the first settlement - New South Wales until full control of the continent are investigated. The characteristics of the economic, social, political, demographic and other aspects of the development of Australian colonies are analyzed. The article discusses the evolution of trade and administrative relations between individual colonies, as well as the stages of preparation for the creation of a federation, which was called the Commonwealth of Australia and changed the country's colonial position to the dominion status in the British Empire. Particular attention is paid to the international political processes that accompanied the development of the Australian continent, as well as the role of colonial administrations in regional geopolitical processes, in particular the colonization of New Guinea.

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