scholarly journals Assessment of a Nano-Docetaxel Combined Treatment for Head and Neck Cancer

Onco ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 83-94
Author(s):  
Gee Young Lee ◽  
Mohamed Mubasher ◽  
Tamra S. McKenzie ◽  
Nicole C. Schmitt ◽  
Merry E. Sebelik ◽  
...  
Keyword(s):  
Cell Death ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Dose Reduction ◽  
Neck Cancer ◽  
Combination Treatment ◽  
Therapeutic Efficacy ◽  
Combined Treatment ◽  
Effective Dosage ◽  
Improve Patient

Objective: The combination of docetaxel (DTX) with Laser-Activated NanoTherapy (LANT), as a treatment for head and neck cancer (HNC), may enhance the therapeutic efficacy of lower doses of DTX, thereby minimizing the effective dosage, side effects and treatment times. Material and methods: Three HNSCC cell lines, Detroit 562, FaDu, and CAL 27, were treated with four combinations of DTX + LANT to evaluate DTX dose reduction and cell viability. Results: The 1 nM DTX + 5 nM LANT combination was the most effective treatment, increasing cell death over its corresponding DTX monotreatment with approximately 86.6%, 80.7%, and 92.1% cell death for Detroit 562, FaDu, and CAL 27, respectively. In Detroit 562, the 1 nM DTX + 5 nM LANT combination treatment resulted in the highest percentage of DTX dose reduction at 84.6%; in FaDu and CAL 27, the 0.5 nM DTX + 5 nM LANT combination treatment resulted in the highest percentage of DTX dose reduction at 78.2% and 82.4%, respectively. Conclusion: LANT may increase the therapeutic efficacy of DTX at significantly lower doses, which could improve patient outcomes.

scholarly journals Assessment of a Nano-Docetaxel Combined Treatment for Head and Neck Cancer

2021 ◽  
Author(s):  
Gee Young Lee ◽  
Mohamed Mubasher ◽  
Tamra S. McKenzie ◽  
Nicole C. Schmitt ◽  
Merry E. Sebelik ◽  
...  
Keyword(s):  
Cell Death ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Dose Reduction ◽  
Neck Cancer ◽  
Combination Treatment ◽  
Therapeutic Efficacy ◽  
Combined Treatment ◽  
Effective Dosage ◽  
Improve Patient

Objective: The combination of docetaxel (DTX) with Laser-Activated NanoTherapy (LANT), as a treatment for head and neck cancer (HNC) may enhance the therapeutic efficacy of lower doses of DTX, thereby minimizing the effective dosage, side effects and treatment times. Material and methods: Three HNSCC cell lines, Detroit 562, FaDu, and CAL 27, were treated with four combinations of DTX + LANT to evaluate DTX dose reduction and cell viability. Results: The 1 nM DTX + 5 nM LANT combination was the most effective treatment, increasing cell death over its corresponding DTX monotreatment with approximately 86.6%, 80.7%, and 92.1% cell death for Detroit 562, FaDu, and CAL 27, respectively. In Detroit 562, the 1 nM DTX + 5 nM LANT combination treatment resulted in the highest percentage of DTX dose reduction at 84.6%; in FaDu and CAL 27, the 0.5 nM DTX + 5 nM LANT combination treatment resulted in the highest percentage of DTX dose reduction at 78.2% and 82.4%, respectively. Conclusion: LANT may increase the therapeutic efficacy of DTX at significantly lower doses, which could improve patient outcomes.

scholarly journals Anti-cancer effect of Atractylodes macrocephala extract by double induction of apoptotic and autophagic cell death in head and neck cancer cells

2017 ◽  
Vol 12 (2) ◽  
pp. 25 ◽  
Author(s):  
Ni Kou ◽  
Hyejoung Cho ◽  
Hye-Eun Kim ◽  
Qiaochu Sun ◽  
Kyuhyeon Ahn ◽  
...  
Keyword(s):  
Cell Death ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Video Clip ◽  
Head And Neck Carcinoma ◽  
Autophagic Cell Death ◽  
Apoptosis Resistance ◽  
Apoptotic Pathway ◽  
Atractylodes Macrocephala

<p class="MS">The apoptosis resistance restricts the efficacy of traditional therapies of head and neck squamous cell carcinoma (HNSCC). To overcome this problem, <em>Atractylodes macrocephala</em>, a traditional Korean and Chinese herbal medicine, has been used in clinical practice. In the present study, the anticancer effect of <em>A. macrocephala</em> extract was investigated and its underlying mechanisms using head and neck cancer KB cell line. The extract-induced cytotoxicity was mediated by autophagic cell death as well as apoptosis in HNSCC cells though extrinsic apoptotic pathway and the Akt/mTOR autophagic pathway. This study suggests that <em>A. macrocephala</em> extracts can be a potential drug to overcome side effects and susceptibility for head and neck carcinoma by double induction of apoptosis and autophagy.</p><p class="MS"><strong>Video Clip of Methodology</strong>: 6 min 27 sec  <a href="https://www.youtube.com/v/iRpGT4zpfs4">Full Screen</a>    <a href="https://www.youtube.com/watch?v=iRpGT4zpfs4">If Failed</a></p>

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