scholarly journals Association between Caffeine Intake and All-Cause and Cause-Specific Mortality: An Analysis of the National Health and Nutrition Examination Survey (NHANES) 1999–2014 Database

2021 ◽  
Vol 11 (4) ◽  
pp. 901-912
Author(s):  
Juan Feng ◽  
Jing Wang ◽  
Mini Jose ◽  
Yaewon Seo ◽  
Li Feng ◽  
...  
Keyword(s):  
National Health ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Caffeine Intake ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
Hazard Ratios ◽  
All Cause Mortality ◽  
Specific Mortality ◽  
Cvd Mortality

Sixty-four percent of adults in America drink coffee daily, and caffeine is the main reason people tend to drink coffee habitually. Few studies have examined the association between caffeine and all-cause and cause-specific mortality. The objective of this study was to examine the association between caffeine and all-cause and cause-specific mortality using the National Health and Nutrition Examination Survey (NHANES) 1999–2014 database. The multivariate Cox proportional hazards regression model was used to examine 23,878 individuals 20 years and older. Daily caffeine intake was measured once at baseline. A total of 2206 deaths occurred, including 394 cardiovascular (CVD) deaths and 525 cancer deaths. Compared to those with a caffeine intake of <100 mg/day, the hazard ratios (HRs) for CVD mortality were significantly lower in the participants with a caffeine intake of 100–200 mg/day (HR, 0.63; 95% confidence interval [CI], 0.45–0.88), and those with a caffeine intake of >200 mg/day (HR, 0.67; 95% CI, 0.50–0.88) after adjusting for potential confounders. The HRs for all-cause mortality were significantly lower in the participants with a caffeine intake of 100–200 mg/day (HR, 0.78; 95% CI, 0.67–0.91), and those with a caffeine intake of >200 mg/day (HR, 0.68; 95% CI, 0.60–0.78). Subgroup analyses showed that caffeine may have different effects on all-cause mortality among different age and body mass index (BMI) groups. In conclusion, higher caffeine intake was associated with lower all-cause and CVD mortality.

Association between selenium intake, diabetes, and mortality in adults: findings from National Health and Nutrition Examination Survey (NHANES) 2003-2014

2021 ◽  
pp. 1-24
Author(s):  
Bushra Hoque ◽  
Zumin Shi
Keyword(s):  
National Health ◽  
Cox Regression ◽  
Inverse Association ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
Hazard Ratios ◽  
The Us ◽  
All Cause Mortality ◽  
Cvd Mortality

Abstract Selenium (Se) is a trace mineral that has antioxidant and anti-inflammatory properties. This study aimed to investigate the association between Se intake, diabetes, all-cause and cause-specific mortality in a representative sample of US adults. Data from 18,932 adults who attended the 2003-2014 National Health and Nutrition Examination Survey (NHANES) were analysed. Information on mortality was obtained from the US mortality registry updated to 2015. Multivariable logistic regression and Cox regression were used. Cross-sectionally, Se intake was positively associated with diabetes. Comparing extreme quartiles of Se intake, the odds ratio (OR) for diabetes was 1.44 (95% CI: 1.09–1.89). During a mean of 6.6 years follow-up, there were 1627 death (312 CVD, 386 cancer). High intake of Se was associated with a lower risk of all-cause mortality. When comparing the highest with the lowest quartiles of Se intake, the hazard ratios (HRs) for all-cause, CVD mortality, cancer mortality and other mortality were: 0.77 (95% CI 0.59-1.01), 0.62 (95% CI, 0.35-1.13), 1.42 (95% CI, 0.78-2.58) and 0.60 (95% CI,0.40-0.80), respectively. The inverse association between Se intake and all-cause mortality was only found among white participants. In conclusion, Se intake was positively associated with diabetes but inversely associated with all-cause mortality. There was no interaction between Se intake and diabetes in relation to all-cause mortality.

scholarly journals The association of energy and macronutrients intake at dinner versus breakfast with disease-specific and all-cause mortality among people with diabetes: the US National Health and Nutrition Examination Survey, 2003-2014

2020 ◽  
Author(s):  
Tianshu Han ◽  
Jian Gao ◽  
Lihong Wang ◽  
Chao Li ◽  
Lu Qi ◽  
...  
Keyword(s):  
Total Energy ◽  
National Health ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Nutrition Examination Survey ◽  
Dietary Recall ◽  
Health And Nutrition ◽  
All Cause Mortality ◽  
Total Fat ◽  
Disease Specific

<b>Objective </b>This study aims<b> </b>to evaluate the association of energy and macronutrients intake at dinner vs. breakfast with disease-specific and all-cause mortality in people with diabetes. <div><p><b>Methods </b>4699 peoples with diabetes who enrolled in the National Health and Nutrition Examination Survey from 2003 to 2014 were recruited for this study. Energy and macronutrients intake were measured by a 24h dietary-recall. The Differences(△) in energy and macronutrients intake between dinner and breakfast (△=dinner minus breakfast) were categorized into quintiles. Death information was obtained from the National Death Index until 2015. Cox proportional hazards regression models were developed to evaluate the survival relationship between △ and diabetes, cardiovascular-disease (CVD) and all-cause mortality. </p> <p><b>Results</b> Of the 4699 participants, 913 deaths, including 269 deaths due to diabetes and 314 deaths due to CVD, were documented. After adjusting for potential confounders, compared with participants in the lowest quintile of Δ in terms of total energy and protein, participants in the highest quintile were more likely to die due to diabetes (HR<sub>Δenergy</sub>=1.92, 99% CI:1.08-3.42; HR<sub>Δprotein</sub>=1.92, 99% CI:1.06-3.49) and CVD (HR<sub>Δenergy</sub>=1.69, 99% CI:1.02-2.80; HR<sub>Δprotein</sub>=1.96, 99% CI:1.14-3.39). The highest quintile of Δ from total-fat was related with CVD mortality (HR=1.67, 99% CI: 1.01-2.76). Isocalorically replacing 5% of total-energy at dinner with breakfast was associated with 4% and 5% lower risk of diabetes (HR=0.96, 95% CI: 0.94-0.98) and CVD (HR=0.95, 95% CI: 0.93-0.97) mortality.</p> <p><b>Conclusions</b> Higher intake of energy, total-fat and protein from dinner than breakfast was associated with greater diabetes, CVD and all-cause mortality in people with diabetes. <b></b></p><b></b></div>

scholarly journals Association of serum levels of antioxidant micronutrients with mortality in US adults: National Health and Nutrition Examination Survey 1999–2002

2020 ◽  
pp. 1-10
Author(s):  
Noah C Peeri ◽  
Weiwen Chai ◽  
Robert V Cooney ◽  
Meng-Hua Tao
Keyword(s):  
Vitamin E ◽  
National Health ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
All Cause Mortality ◽  
Specific Mortality ◽  
Race Ethnicity ◽  
Risk Of Cancer ◽  
Reduced Risk ◽  
Cvd Mortality

Abstract Objective: To examine associations between serum antioxidant levels and mortality (all-cause, cancer and CVD) among US adults. Design: We examined the risk of death from all-cause and cause-specific mortality associated with serum antioxidant (vitamin E and carotenoids) and vitamin A levels using Cox regression models to estimate hazards ratios (HR) and 95 % CI. Setting: The National Health and Nutrition Examination Survey (NHANES) 1999–2002 was followed up through 31 December 2015. Participants: The NHANES 1999–2002 cohort included 8758 participants aged ≥ 20 years. Serum carotenoid levels were only assessed for the 1999–2000 cycle. Therefore, sample size for each assessed antioxidant ranged from 4633 to 8758. Results: Serum vitamin E level was positively associated with all-cause mortality (HR = 1·22, 95 % CI 1·04, 1·43, highest v. lowest quartile). No other antioxidants were associated with mortality in overall analysis. In race/ethnicity-specific analyses, high vitamin E and α-tocopherol levels were associated with increased risk of all-cause mortality among non-Hispanic Whites. Among non-Hispanic Blacks, serum α-tocopherol level was associated with decreased risk of cancer mortality (HR = 0·30, 95 % CI 0·12, 0·75, third v. first quartile) and total carotenoid levels with reduced risk of CVD mortality (HR = 0·26; 95 % CI 0·07, 0·97, second v. lowest quartile). Hispanics with high β-carotene levels had reduced risk of CVD mortality. Conclusions: Serum antioxidant levels may be related to mortality; these associations may differ by race/ethnicity and appeared to be non-linear for all-cause and cause-specific mortality. Further studies are needed to confirm our results.

Self-reported cataract surgery and 10-year all-cause and cause-specific mortality: findings from the National Health and Nutrition Examination Survey

2021 ◽  
pp. bjophthalmol-2021-319678
Author(s):  
Yifan Chen ◽  
Wei Wang ◽  
Huan Liao ◽  
Danli Shi ◽  
Zachary Tan ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
National Health ◽  
Large Scale ◽  
Proportional Hazards ◽  
Statistical Significance ◽  
Cox Proportional Hazards ◽  
Mortality Data ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
Specific Mortality

PurposeTo investigate the association of self-reported cataract surgery with all-cause and cause-specific mortality using a large-scale population-based sample.MethodsData from the 1999–2008 cycles of the National Health and Nutrition Examination Survey were used. A self-reported history of cataract surgery was considered a surrogate for the presence of clinically significant cataract surgery. Mortality data were ascertained from National Death Index records. Hazard ratios (HRs) and 95% confidence intervals (CIs) for survival were estimated using Cox proportional hazards regression models.ResultsA total of 14 918 participants were included in the analysis. During a median follow-up of 10.8 (Interquartile range, IQR, 8.25–13.7) years, 3966 (19.1%) participants died. Participants with self-reported cataract surgery were more likely to die from all causes and specific causes (vascular disease, cancer, accident, Alzheimer’s disease, respiratory disease, renal disease and others) compared with those without (all Ps <0.05). The association between self-reported cataract surgery and all-cause mortality remained significant after multiple adjustments (HR=1.13; 95% CI 1.01 to 1.26). For cause-specific mortality, multivariable Cox models showed that self-reported cataract surgery predicted a 36% higher risk of vascular-related mortality (HR=1.36; 95% CI 1.01 to 1.82). The association with other specific causes of mortality did not reach statistical significance after multiple adjustments.ConclusionsThis study found significant associations of self-reported cataract surgery with all-cause and vascular mortalities. Our findings provide potential insights into the pathogenic pathways underlying cataract.

scholarly journals The association of energy and macronutrients intake at dinner versus breakfast with disease-specific and all-cause mortality among people with diabetes: the US National Health and Nutrition Examination Survey, 2003-2014

2020 ◽  
Author(s):  
Tianshu Han ◽  
Jian Gao ◽  
Lihong Wang ◽  
Chao Li ◽  
Lu Qi ◽  
...  
Keyword(s):  
Total Energy ◽  
National Health ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Nutrition Examination Survey ◽  
Dietary Recall ◽  
Health And Nutrition ◽  
All Cause Mortality ◽  
Total Fat ◽  
Disease Specific

<b>Objective </b>This study aims<b> </b>to evaluate the association of energy and macronutrients intake at dinner vs. breakfast with disease-specific and all-cause mortality in people with diabetes. <div><p><b>Methods </b>4699 peoples with diabetes who enrolled in the National Health and Nutrition Examination Survey from 2003 to 2014 were recruited for this study. Energy and macronutrients intake were measured by a 24h dietary-recall. The Differences(△) in energy and macronutrients intake between dinner and breakfast (△=dinner minus breakfast) were categorized into quintiles. Death information was obtained from the National Death Index until 2015. Cox proportional hazards regression models were developed to evaluate the survival relationship between △ and diabetes, cardiovascular-disease (CVD) and all-cause mortality. </p> <p><b>Results</b> Of the 4699 participants, 913 deaths, including 269 deaths due to diabetes and 314 deaths due to CVD, were documented. After adjusting for potential confounders, compared with participants in the lowest quintile of Δ in terms of total energy and protein, participants in the highest quintile were more likely to die due to diabetes (HR<sub>Δenergy</sub>=1.92, 99% CI:1.08-3.42; HR<sub>Δprotein</sub>=1.92, 99% CI:1.06-3.49) and CVD (HR<sub>Δenergy</sub>=1.69, 99% CI:1.02-2.80; HR<sub>Δprotein</sub>=1.96, 99% CI:1.14-3.39). The highest quintile of Δ from total-fat was related with CVD mortality (HR=1.67, 99% CI: 1.01-2.76). Isocalorically replacing 5% of total-energy at dinner with breakfast was associated with 4% and 5% lower risk of diabetes (HR=0.96, 95% CI: 0.94-0.98) and CVD (HR=0.95, 95% CI: 0.93-0.97) mortality.</p> <p><b>Conclusions</b> Higher intake of energy, total-fat and protein from dinner than breakfast was associated with greater diabetes, CVD and all-cause mortality in people with diabetes. <b></b></p><b></b></div>

scholarly journals The association of energy and macronutrients intake at dinner versus breakfast with disease-specific and all-cause mortality among people with diabetes: the US National Health and Nutrition Examination Survey, 2003-2014

2020 ◽  
Author(s):  
Tianshu Han ◽  
Jian Gao ◽  
Lihong Wang ◽  
Chao Li ◽  
Lu Qi ◽  
...  
Keyword(s):  
Total Energy ◽  
National Health ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Nutrition Examination Survey ◽  
Dietary Recall ◽  
Health And Nutrition ◽  
All Cause Mortality ◽  
Total Fat ◽  
Disease Specific

<b>Objective </b>This study aims<b> </b>to evaluate the association of energy and macronutrients intake at dinner vs. breakfast with disease-specific and all-cause mortality in people with diabetes. <div><p><b>Methods </b>4699 peoples with diabetes who enrolled in the National Health and Nutrition Examination Survey from 2003 to 2014 were recruited for this study. Energy and macronutrients intake were measured by a 24h dietary-recall. The Differences(△) in energy and macronutrients intake between dinner and breakfast (△=dinner minus breakfast) were categorized into quintiles. Death information was obtained from the National Death Index until 2015. Cox proportional hazards regression models were developed to evaluate the survival relationship between △ and diabetes, cardiovascular-disease (CVD) and all-cause mortality. </p> <p><b>Results</b> Of the 4699 participants, 913 deaths, including 269 deaths due to diabetes and 314 deaths due to CVD, were documented. After adjusting for potential confounders, compared with participants in the lowest quintile of Δ in terms of total energy and protein, participants in the highest quintile were more likely to die due to diabetes (HR<sub>Δenergy</sub>=1.92, 99% CI:1.08-3.42; HR<sub>Δprotein</sub>=1.92, 99% CI:1.06-3.49) and CVD (HR<sub>Δenergy</sub>=1.69, 99% CI:1.02-2.80; HR<sub>Δprotein</sub>=1.96, 99% CI:1.14-3.39). The highest quintile of Δ from total-fat was related with CVD mortality (HR=1.67, 99% CI: 1.01-2.76). Isocalorically replacing 5% of total-energy at dinner with breakfast was associated with 4% and 5% lower risk of diabetes (HR=0.96, 95% CI: 0.94-0.98) and CVD (HR=0.95, 95% CI: 0.93-0.97) mortality.</p> <p><b>Conclusions</b> Higher intake of energy, total-fat and protein from dinner than breakfast was associated with greater diabetes, CVD and all-cause mortality in people with diabetes. <b></b></p><b></b></div>

NHSR 155: Comparative Analysis of the National Health and Nutrition Examination Survey Public-Use and Restricted-Use Linked Mortality Files - Production Schedule

2021 ◽  
Author(s):  
Lisa Mirel
Keyword(s):  
Comparative Analysis ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
The Public ◽  
Health And Nutrition ◽  
Cox Proportional Hazards Models ◽  
Hazard Ratios ◽  
Specific Mortality ◽  
Standard Set ◽  
Restricted Use

This report describes a comparative analysis of the public-use and restricted-use NHANES LMFs. Cox proportional hazards models were used to estimate relative hazard ratios for a standard set of sociodemographic covariates for all-cause as well as cause-specific mortality, using the public-use and restricted-use NHANES LMFs.

scholarly journals U-shaped Association Between Apolipoprotein B and All-Cause Mortality: Results from the National Health and Nutrition Examination Surveys

2021 ◽  
Author(s):  
mengqi yan ◽  
Xiaocong Liu ◽  
Yuqing Huang ◽  
Yuling Yu ◽  
Dan Zhou ◽  
...  
Keyword(s):  
National Health ◽  
Cardiovascular Mortality ◽  
Proportional Hazards ◽  
Piecewise Linear ◽  
Cardiovascular Death ◽  
Cox Proportional Hazards ◽  
Health And Nutrition ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Non Linear

Abstract BackgroundApolipoprotein B (apoB), a significant component directly reflecting the number of atherogenic lipoprotein particles, gradually becomes a more conducive indicator to control blood lipids. However, epidemiological evidence on its relationship with mortality is limited, especially with all-cause mortality. MethodsParticipants from the National Health and Nutrition Examination Survey during 2007-2014 were grouped according to the apoB quartiles (15-76, 77-92, 93-110, 111-345mg/dL). We performed Cox proportional hazards models and Kaplan-Meier survival curves to evaluate the relationships of apoB with all-cause and cardiovascular mortality. Restricted cubic spline and piecewise linear regression were performed to detect their non-linear relationships. ResultsIn general, we enrolled 10375 participants among United States adults (mean age 46.3 ± 16.9, 47.88% men). On average, participants were followed up for 69.2 months, among whom 533 (5.14%) and 91 (0.88%) deaths were observed due to all -causes and cardiovascular diseases, respectively. After adjusting for confounders, apoB was independently associated with an elevated risk of cardiovascular death (hazard ratio [HR], 1.13; 95% confidence interval [CI], 1.03-1.24). However, in the third quartile of apoB, the risk of all-cause death decreased significantly (HR, 0.71; 95% CI, 0.56-0.91). Moreover, the non-linear relationship between apoB and all-cause death demonstrated an increased risk at both low and high level apoB concentrations, divided by the threshold point of 108 mg/dl. ConclusionElevated apoB was significantly associated with an increased risk for cardiovascular mortality, while its association with all-cause mortality was non-linear correlated, with an increased risk at both low and high apoB levels.

scholarly journals Ultra-processed food intake and mortality in the USA: results from the Third National Health and Nutrition Examination Survey (NHANES III, 1988–1994)

2019 ◽  
Vol 22 (10) ◽  
pp. 1777-1785 ◽  
Author(s):  
Hyunju Kim ◽  
Emily A Hu ◽  
Casey M Rebholz
Keyword(s):  
Food Intake ◽  
National Health ◽  
Representative Sample ◽  
Nhanes Iii ◽  
Nutrition Examination Survey ◽  
Processed Food ◽  
The Third ◽  
Health And Nutrition ◽  
All Cause Mortality ◽  
Cvd Mortality

AbstractObjectiveTo evaluate the association between ultra-processed food intake and all-cause mortality and CVD mortality in a nationally representative sample of US adults.DesignProspective analyses of reported frequency of ultra-processed food intake in 1988–1994 and all-cause mortality and CVD mortality through 2011.SettingThe Third National Health and Nutrition Examination Survey (NHANES III, 1988–1994).ParticipantsAdults aged ≥20 years (n11898).ResultsOver a median follow-up of 19 years, individuals in the highest quartile of frequency of ultra-processed food intake (e.g. sugar-sweetened or artificially sweetened beverages, sweetened milk, sausage or other reconstructed meats, sweetened cereals, confectionery, desserts) had a 31% higher risk of all-cause mortality, after adjusting for demographic and socio-economic confounders and health behaviours (adjusted hazard ratio=1·31; 95% CI 1·09, 1·58;P-trend = 0·001). No association with CVD mortality was observed (P-trend=0·86).ConclusionsHigher frequency of ultra-processed food intake was associated with higher risk of all-cause mortality in a representative sample of US adults. More longitudinal studies with dietary data reflecting the modern food supply are needed to confirm our results.

Diet quality and all-cause mortality among US adults, estimated from National Health and Nutrition Examination Survey (NHANES), 2003–2008

2021 ◽  
pp. 1-11
Author(s):  
Selma Gicevic ◽  
Emin Tahirovic ◽  
Sabri Bromage ◽  
Walter Willett
Keyword(s):  
National Health ◽  
Diet Quality ◽  
Total Mortality ◽  
Healthy Eating Index ◽  
Cox Proportional Hazards ◽  
Mortality Data ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
The Us ◽  
All Cause Mortality

Abstract Objective: We assessed the ability of the Prime Diet Quality Score (PDQS) to predict mortality in the US population and compared its predictiveness with that of the Healthy Eating Index-2015 (HEI-2015). Design: PDQS and HEI-2015 scores were derived using two 24-h recalls and converted to quintiles. Mortality data were obtained from the 2015 Public-Use Linked Mortality File. Associations between diet quality and all-cause mortality were evaluated using multivariable Cox proportional hazards models, and predictive performance of the two metrics was compared using a Wald test of equality of coefficients with both scores in a single model. Finally, we evaluated associations between individual metric components and mortality. Setting: A prospective analysis of the US National Health and Nutrition Examination Survey (NHANES) data. Participants: Five-thousand five hundred and twenty-five participants from three survey cycles (2003–2008) in the NHANES aged 40 years and over. Results: Over the 51 248 person-years of follow-up (mean: 9·2 years), 767 deaths were recorded. In multivariable models, hazard ratios between the highest and lowest quintiles of diet quality scores were 0·70 (95 % CI 0·51, 0·96, Ptrend = 0·03) for the PDQS and 0·77 (95 % CI 0·57, 1·03, Ptrend = 0·20) for the HEI-2015. The PDQS and HEI-2015 were similarly good predictors of total mortality (Pdifference = 0·88). Conclusion: Among US adults, better diet quality measured by the PDQS was associated with reduced risk of all-cause mortality. Given that the PDQS is simpler to calculate than the HEI-2015, it should be evaluated further for use as a diet quality metric globally.

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