scholarly journals Efficacy of a Fatty Acids Dietary Supplement in a Polyethylene Glycol-Induced Mouse Model of Retinal Degeneration

Nutrients ◽  
2017 ◽  
Vol 9 (10) ◽  
pp. 1079 ◽  
Author(s):  
Maurizio Cammalleri ◽  
Massimo Dal Monte ◽  
Filippo Locri ◽  
Emma Lardner ◽  
Anders Kvanta ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyethylene Glycol ◽  
Mouse Model ◽  
Retinal Degeneration ◽  
Dietary Supplement

Polyethylene glycol induced mouse model of retinal degeneration

2014 ◽  
Vol 127 ◽  
pp. 143-152 ◽  
Author(s):  
Valeriy V. Lyzogubov ◽  
Nalini S. Bora ◽  
Ruslana G. Tytarenko ◽  
Puran S. Bora
Keyword(s):  
Polyethylene Glycol ◽  
Mouse Model ◽  
Retinal Degeneration

scholarly journals Decreased docosahexaenoic acid and other specific fatty acids in a mouse model of retinal degeneration

2022 ◽  
Vol 100 (S267) ◽  
Author(s):  
María José Ruiz Pastor ◽  
Oksana Kutsyr ◽  
Henar Albertos‐Arranz ◽  
Xavier Sánchez‐Sáez ◽  
Carla Sánchez‐Castillo ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Docosahexaenoic Acid ◽  
Mouse Model ◽  
Retinal Degeneration

Assessment of inner retinal oxygen metrics and thickness in a mouse model of inherited retinal degeneration

2021 ◽  
Vol 205 ◽  
pp. 108480
Author(s):  
Mansour Rahimi ◽  
Sophie Leahy ◽  
Nathanael Matei ◽  
Norman P. Blair ◽  
Shinwu Jeong ◽  
...  
Keyword(s):  
Mouse Model ◽  
Retinal Degeneration ◽  
Inherited Retinal Degeneration

scholarly journals Critical Differences Between Dietary Supplement and Prescription Omega-3 Fatty Acids: A Narrative Review

2020 ◽  
Vol 37 (2) ◽  
pp. 656-670 ◽  
Author(s):  
Daniel E. Hilleman ◽  
Barbara S. Wiggins ◽  
Michael B. Bottorff
Keyword(s):  
Fatty Acids ◽  
Dietary Supplement ◽  
Narrative Review ◽  
Omega 3 Fatty Acids ◽  
Omega 3

scholarly journals Tart Cherry Extract and Omega Fatty Acids Reduce Behavioral Deficits, Gliosis, and Amyloid-Beta Deposition in the 5xFAD Mouse Model of Alzheimer’s Disease

2021 ◽  
Vol 11 (11) ◽  
pp. 1423
Author(s):  
Zackary Bowers ◽  
Panchanan Maiti ◽  
Ali Bourcier ◽  
Jarod Morse ◽  
Kenneth Jenrow ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Mouse Model ◽  
Neuronal Morphology ◽  
Omega Fatty Acids ◽  
Tart Cherry ◽  
Therapeutic Benefits ◽  
Model Of Alzheimer’S Disease ◽  
5Xfad Mice

Combined treatments using polyphenols and omega fatty acids provide several therapeutic benefits for a variety of age-related disorders, including Alzheimer’s disease (AD). Previously, we found a commercial product, Total Body Rhythm (TBR), consisting of tart cherry extract, a potent polyphenol, and omega fatty acids, significantly reduced memory, and neuropathological deficits in the 192 IgG-saporin mouse model of AD. The present study assessed the efficacy of TBR for treating behavioral and neuropathological deficits in the 5xFAD model of AD. Both 6- and 12-month-old 5xFAD mice and age-matched wild-type controls received TBR (60 mg/kg) or the equivalent dose of vehicle (0.5% methylcellulose) via oral administration, every other day for two months. All mice were tested in the open field (OF), novel object recognition (NOR), and the Morris water maze (MWM) tasks. In addition, neuronal morphology, neurodegeneration, Aβ plaque load, and glial activation were assessed. TBR treatment reduced memory deficits in the MWM and NOR tests and lessened anxiety levels in the OF task, mostly in the 6-month-old male mice. TBR also protected against neuron loss, reduced activation of astrocytes and microglia, primarily in 6-month-old mice, and attenuated Aβ deposition. These results suggest that the combination of tart cherry extract and omega fatty acids in TBR can reduce AD-like deficits in 5xFAD mice.

Gene Therapy in the Rd6 Mouse Model of Retinal Degeneration

2014 ◽  
pp. 711-718 ◽  
Author(s):  
Astra Dinculescu ◽  
Seok-Hong Min ◽  
Wen-Tao Deng ◽  
Qiuhong Li ◽  
William W. Hauswirth
Keyword(s):  
Gene Therapy ◽  
Mouse Model ◽  
Retinal Degeneration

scholarly journals Metabolism of propane-1:2-diol infused into the rumen of sheep

1972 ◽  
Vol 27 (3) ◽  
pp. 553-560 ◽  
Author(s):  
J. L. Clapperton ◽  
J. W. Czerkawski
Keyword(s):  
Carbon Dioxide ◽  
Fatty Acids ◽  
Acetic Acid ◽  
Lactic Acid ◽  
Polyethylene Glycol ◽  
Energy Metabolism ◽  
Heat Production ◽  
Volatile Fatty Acids ◽  
Carbon Dioxide Production ◽  
Total Volatile

1. Propane-1:2-diol (loog/d) was infused through a cannula into the rumen of sheep receiving a ration of hay and dried grass. The concentration of volatile fatty acids, propanediol, lactic acid and of added polyethylene glycol, and the pH of the rumen contents were measured. The energy metabolism of the sheep was also determined.2. Most of the propanediol disappeared from the rumen within 4 h of its infusion. The infusion of propanediol resulted in a 10% decrease in the concentration of total volatile acids; the concentration of acetic acid decreased by about 30%, that of propionic acid increased by up to 60% and there was no change in the concentration of butyric acid.3. The methane production of the sheep decreased by about 9% after the infusion of propanediol and there were increases in the oxgyen consumption, carbon dioxide production and heat production of the animals; each of these increases was equivalent to about 40% of the theoretical value for the complete metabolism of 100 g propanediol.4. It is concluded that, when propanediol is introduced into the rumen, a proportion is metabolized in the rumen and a large proportion is absorbed directly. Our thanks are due to Dr J. H. Moore for helpful discussions, to Mr D. R. Paterson, Mr J. R. McDill and Mr C. E. Park for looking after the animals and to Miss K. M. Graham, Miss A. T. McKay and Mrs C. E. Ramage for performing the analyses.

Effects of different oligosaccharides at various dosages on the composition of gut microbiota and short-chain fatty acids in mice with constipation

2017 ◽  
Vol 8 (5) ◽  
pp. 1966-1978 ◽  
Author(s):  
Linlin Wang ◽  
Lujun Hu ◽  
Shuang Yan ◽  
Tian Jiang ◽  
Shuguang Fang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Gut Microbiota ◽  
Water Content ◽  
Dietary Supplement ◽  
Transit Time ◽  
Short Chain Fatty Acids ◽  
Intestinal Transit ◽  
Short Chain ◽  
Intestinal Transit Time ◽  
Chain Fatty Acids

Oligosaccharides administered as a dietary supplement increase the water content of feces, reduce intestinal transit time, modulate the composition of the gut microbiota and increase the concentration of short-chain fatty acids in the feces of mice with constipation.

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