scholarly journals Intestinal Production of Anti-Tissue Transglutaminase 2 Antibodies in Patients with Diagnosis Other Than Celiac Disease

Nutrients ◽  
2017 ◽  
Vol 9 (10) ◽  
pp. 1050 ◽  
Author(s):  
Mariantonia Maglio ◽  
Fabiana Ziberna ◽  
Rosita Aitoro ◽  
Valentina Discepolo ◽  
Giuliana Lania ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Transglutaminase 2

scholarly journals Utility of Tissue Transglutaminase Immunohistochemistry in Pediatric Duodenal Biopsies: Patterns of Expression and Role in Celiac Disease—A Clinicopathologic Review

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Saeeda Almarzooqi ◽  
Ronald H. Houston ◽  
Vinay Prasad
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Transglutaminase 2 ◽  
Surface Epithelium ◽  
Multifunctional Protein ◽  
Cellular Processes ◽  
Significant Difference ◽  
Villous Surface ◽  
Inflammatory Bowel ◽  
Duodenal Biopsies

Tissue transglutaminase (tTG) is a ubiquitous multifunctional protein. It has roles in various cellular processes. tTG is a major target of autoantibodies in celiac disease, and its expression by immunohistochemistry in pediatric celiac disease has not been fully examined. We studied tTG expression in 78 pediatric duodenal biopsies by utilizing an antibody to transglutaminase 2. Serum tTG was positive in all celiac cases evaluated. Serum antiserum endomysial antibody (EMA) and tTG were negative in all control subjects and in inflammatory bowel disease and eosinophilic gastroenteritis. There was a statistically significant difference between cases of celiac disease and normal controls in terms of tTG immunohistochemical staining in duodenal biopsies surface epithelium ( value = 0.0012). There was no significant statistical difference in terms of staining of the villous surface or crypt between the cases of celiac disease and cases with IBD ( value = 0.5970 and 0.5227, resp.). There was no detected correlation between serum tTG values and immunohistochemical positivity on duodenal biopsy in cases of celiac disease ( value = 1). There was no relationship between Marsh classification and positivity of villous surface for tTG ( value = 0.4955). We conclude that tTG has limited utility in diagnosis of celiac disease in pediatric duodenal biopsies.

scholarly journals Celiac Disease and IgA Deficiency: Complications of Serological Testing Approaches Encountered in the Clinic

2008 ◽  
Vol 54 (7) ◽  
pp. 1203-1209 ◽  
Author(s):  
Kelly E McGowan ◽  
Martha E Lyon ◽  
J Decker Butzner
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
False Negative ◽  
Transglutaminase 2 ◽  
Iga Deficiency ◽  
Intestinal Biopsy ◽  
Serological Testing ◽  
Gastrointestinal Pathology ◽  
Serum Iga ◽  
Testing Algorithms

AbstractBackground: IgA deficiency causes false-negative IgA-based celiac serology results in patients with celiac disease. Using a case-finding strategy, we examined the prevalence of IgA deficiency, physician evaluation, and management of IgA deficiency during serological testing for celiac disease.Methods: We reviewed consecutive IgA-endomysial antibody (EMA) and serum IgA results from the laboratory database over 17 months. We cross-referenced seronegative patients with IgA deficiency (IgA <0.06 g/L) to the pathology database to evaluate intestinal biopsy results. Ordering physicians received a questionnaire regarding the management of seronegative patients with IgA deficiency who had no biopsy record.Results: Among the 9533 patients tested for IgA-EMA, 4698 (49%) were tested for IgA deficiency. IgA deficiency occurred in 35 of 4698 (0.75%) patients screened for IgA deficiency. Only 19 of 35 (54%) IgA-deficient patients were diagnosed appropriately with either intestinal biopsy (17 patients) or measurement of IgG-tissue transglutaminase (2 patients). Thirteen (76%) of the 17 IgA-deficient patients who underwent upper endoscopy with or without colonoscopy displayed gastrointestinal pathology on biopsies, including 3 (18%) with celiac disease. No further evaluation to exclude celiac disease was performed for the remaining 16 of 35 (46%) IgA-deficient, EMA-negative patients because of inappropriate management (6 patients), administrative error (7 patients), or patient/physician refusal (3 patients).Conclusions: IgA deficiency occurred in 1:131 patients tested for celiac disease, and celiac disease occurred in 1:6 of those properly evaluated. Inadequate evaluation of IgA deficiency while testing for celiac disease occurred frequently and resulted in the underdiagnosis of both. Changes in testing algorithms and reporting of results were made to improve testing for celiac disease and IgA deficiency.

Mo1991 – Co-Localisation of Iga and Igg Anti-Tissue Transglutaminase 2 Antibodies is a Reliable Method of Diagnosing Extraintestinal Celiac Disease

2019 ◽  
Vol 156 (6) ◽  
pp. S-914
Author(s):  
Rimlee Dutta ◽  
Alka Singh ◽  
Asif Iqbal ◽  
Siddhartha Datta Gupta ◽  
Govind K. Makharia ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Reliable Method ◽  
Tissue Transglutaminase ◽  
Transglutaminase 2

Tissue transglutaminase, the celiac disease autoantigen, preferentially generates antigenic neoepitopes in γ and γ but not in α gliadins

2001 ◽  
Vol 120 (5) ◽  
pp. A684-A684
Author(s):  
D TRAPP ◽  
W DIETERICH ◽  
H WIESER ◽  
M LEIDENBERGER ◽  
D SEILMEIER ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase

245 THE ORAL TISSUE TRANSGLUTAMINASE INHIBITOR ZED1227 PREVENTS GLUTEN-INDUCED ENTEROPATHY IN A TRANSGENIC MOUSE MODEL OF CELIAC DISEASE

2021 ◽  
Vol 160 (6) ◽  
pp. S-53-S-54
Author(s):  
Manuel A. Encalada Ventura ◽  
Martin Hils ◽  
Bernhard Tewes ◽  
Ralf Pasternack ◽  
Roland Greinwald ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Tissue Transglutaminase ◽  
Transgenic Mouse Model ◽  
Oral Tissue

Tu1386 Susceptibility for Celiac Disease Based on Tissue Transglutaminase Seroprevalence and HLA Genotype in a Community Study

2016 ◽  
Vol 150 (4) ◽  
pp. S891
Author(s):  
Michael D. Potter ◽  
Gregory Brogan ◽  
Marjorie M. Walker ◽  
Mark McEvoy ◽  
Elizabeth Holliday ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Community Study ◽  
Hla Genotype

scholarly journals Comparison of tissue transglutaminase 2 and bone biological markers osteocalcin, osteopontin and sclerostin expression in human osteoporosis and osteoarthritis

Amino Acids ◽  
2016 ◽  
Vol 49 (3) ◽  
pp. 683-693 ◽  
Author(s):  
Chiara Tarquini ◽  
Rosanna Mattera ◽  
Francesca Mastrangeli ◽  
Sara Agostinelli ◽  
Amedeo Ferlosio ◽  
...  
Keyword(s):  
Biological Markers ◽  
Tissue Transglutaminase ◽  
Transglutaminase 2
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