scholarly journals Probiotics Prevent Late-Onset Sepsis in Human Milk-Fed, Very Low Birth Weight Preterm Infants: Systematic Review and Meta-Analysis

Nutrients ◽  
2017 ◽  
Vol 9 (8) ◽  
pp. 904 ◽  
Author(s):  
Arianna Aceti ◽  
Luca Maggio ◽  
Isadora Beghetti ◽  
Davide Gori ◽  
Giovanni Barone ◽  
...  
Keyword(s):  
Systematic Review ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Preterm Infants ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Meta Analysis ◽  
Late Onset Sepsis

scholarly journals A Systematic Review and Meta-Analysis of Human Milk Feeding and Short-Term Growth in Preterm and Very Low Birth Weight Infants

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2089
Author(s):  
Machiko Suganuma ◽  
Alice R. Rumbold ◽  
Jacqueline Miller ◽  
Yan Fong Chong ◽  
Carmel T. Collins
Keyword(s):  
Systematic Review ◽  
Birth Weight ◽  
Human Milk ◽  
Preterm Infants ◽  
Very Low Birth Weight ◽  
Meta Analysis ◽  
Poor Quality ◽  
Low Birth Weight Infants ◽  
Preterm Formula ◽  
Meta Analyses

Human milk (HM) is the gold standard for feeding infants but has been associated with slower growth in preterm infants compared with preterm formula. This systematic review and meta-analysis summarises the post-1990 literature to examine the effect of HM feeding on growth during the neonatal admission of preterm infants with birth weight ≤1500 g and/or born ≤28 weeks’ gestation. Medline, PubMed, CINAHL, and Scopus were searched, and comparisons were grouped as exclusive human milk (EHM) vs. exclusive preterm formula (EPTF), any HM vs. EPTF, and higher vs. lower doses of HM. We selected studies that used fortified HM and compared that with a PTF; studies comparing unfortified HM and term formula were excluded. Experimental and observational studies were pooled separately. The GRADE system was used to evaluate risk of bias and certainty of evidence. Forty-four studies were included with 37 (n = 9963 infants) included in the meta-analyses. In general, due to poor quality studies, evidence of the effect of any HM feeds or higher versus lower doses of HM was inconclusive. There was a possible effect that lower doses of HM compared with higher doses of HM improved weight gain during the hospital admission, and separately, a possible effect of increased head circumference growth in infants fed EPTF vs. any HM. The clinical significance of this is unclear. There was insufficient evidence to determine the effects of an exclusive HM diet on any outcomes.

64 PROCALCITONIN AS A SCREENING TEST IN LATE ONSET SEPSIS IN VERY LOW BIRTH WEIGHT PRETERM INFANTS.

2004 ◽  
Vol 52 (Suppl 2) ◽  
pp. S356.5-S356
Author(s):  
R. Vazzalwar ◽  
E. Pina-Rodriques ◽  
B. Puppala ◽  
P. Krieger ◽  
D. Angst ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Preterm Infants ◽  
Screening Test ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Late Onset Sepsis

scholarly journals Practices related to late‐onset sepsis in very low‐birth weight preterm infants

2015 ◽  
Vol 91 (2) ◽  
pp. 168-174
Author(s):  
Maria Regina Bentlin ◽  
Ligia M.S.S. Rugolo ◽  
Ligia S.L. Ferrari
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Preterm Infants ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Late Onset Sepsis

scholarly journals Practices related to late-onset sepsis in very low-birth weight preterm infants

2015 ◽  
Vol 91 (2) ◽  
pp. 168-174 ◽  
Author(s):  
Maria Regina Bentlin ◽  
Ligia M.S.S. Rugolo ◽  
Ligia S.L. Ferrari
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Preterm Infants ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Late Onset Sepsis

scholarly journals Human milk oligosaccharides and their association with late-onset neonatal sepsis in Peruvian very-low-birth-weight infants

2020 ◽  
Vol 112 (1) ◽  
pp. 106-112
Author(s):  
Victor D Torres Roldan ◽  
Meritxell Urtecho S ◽  
Julia Gupta ◽  
Chloe Yonemitsu ◽  
Cesar P Cárcamo ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Neonatal Sepsis ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Human Milk Oligosaccharides ◽  
Low Birth Weight Infants ◽  
Milk Samples ◽  
Late Onset Sepsis

ABSTRACT Background Oligosaccharides are the third most abundant component in human milk. They are a potential protective agent against neonatal sepsis. Objectives We aimed to explore the association between human milk oligosaccharides (HMOs) and late-onset sepsis in very-low-birth-weight infants, and to describe the composition and characteristics of HMOs in Peruvian mothers of these infants. Methods This is a secondary data analysis of a randomized clinical trial. We conducted a retrospective cohort study of mothers and their very-low-birth-weight (<1500 g) infants with ≥1 milk sample and follow-up data for >30 d. HMOs were measured by high performance liquid chromatography (HPLC). We used factor analysis and the Mantel–Cox test to explore the association between HMOs and late-onset neonatal sepsis. Results We included 153 mother–infant pairs and 208 milk samples. Overall, the frequency of the secretor phenotype was 93%. Secretors and nonsecretors were defined by the presence and near-absence of α1-2-fucosylated HMOs, respectively. The most abundant oligosaccharides were 2'-fucosyllactose, lacto-N-fucopentaose (LNFP) I, and difucosyllacto-N-tetraose in secretors and lacto-N-tetraose and LNFP II in nonsecretors. Secretors had higher amounts of total oligosaccharides than nonsecretors (11.45 g/L; IQR: 0.773 g/L compared with 8.04 g/L; IQR: 0.449 g/L). Mature milk samples were more diverse in terms of HMOs than colostrum (Simpson's Reciprocal Diversity Index). We found an association of factor 3 in colostrum with a reduced risk of late-onset sepsis (HR: 0.63; 95% CI: 0.41, 0.97). Fucosyl-disialyllacto-N-hexose (FDSLNH) was the only oligosaccharide correlated to factor 3. Conclusions These findings suggest that concentrations of different HMOs vary from one individual to another according to their lactation period and secretor status. We also found that FDSLNH might protect infants with very low birth weight from late-onset neonatal sepsis. Confirming this association could prove 1 more mechanism by which human milk protects infants against infections and open the door to clinical applications of HMOs. This trial was registered at clinicaltrials.gov as NCT01525316.

scholarly journals Higher risk of late-onset sepsis in very low birth weight male preterm infants

2019 ◽  
Vol 20 (3) ◽  
Author(s):  
David Ramiro-Cortijo ◽  
Carlos Zozaya-Nieto ◽  
Ángel L. López de Pablo ◽  
M. Rosario López-Giménez ◽  
Miguel Saenz de Pipaon ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Preterm Infants ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Late Onset Sepsis
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