scholarly journals Zeolite-Containing Mixture Supplementation Ameliorated Dextran Sodium Sulfate-Induced Colitis in Mice by Suppressing the Inflammatory Bowel Disease Pathway and Improving Apoptosis in Colon Mucosa

Nutrients ◽  
2017 ◽  
Vol 9 (5) ◽  
pp. 467 ◽  
Author(s):  
Weida Lyu ◽  
Huijuan Jia ◽  
Chuanzong Deng ◽  
Kenji Saito ◽  
Seigo Yamada ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Colon Mucosa ◽  
Inflammatory Bowel

scholarly journals Acetylsalicylic Acid Reduces the Severity of Dextran Sodium Sulfate-Induced Colitis and Increases the Formation of Anti-Inflammatory Lipid Mediators

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Thomas Köhnke ◽  
Beate Gomolka ◽  
Süleyman Bilal ◽  
Xiangzhi Zhou ◽  
Yanping Sun ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Acetylsalicylic Acid ◽  
Bowel Disease ◽  
Sodium Sulfate ◽  
Lipid Mediators ◽  
Dextran Sodium Sulfate ◽  
Cyclooxygenase Inhibitors ◽  
Omega 3 ◽  
Inflammatory Bowel ◽  
Anti Inflammatory

The role of non-steroidal anti-inflammatory drugs in inflammatory bowel disease is controversial, as they have been implicated in disease aggravation. Different from other cyclooxygenase inhibitors, acetylsalicylic acid (ASA) enhances the formation of anti-inflammatory and proresolution lipoxins derived from arachidonic acid as well as resolvins from omega-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA). In this study, we examined the effect of ASA on murine dextran sodium sulfate colitis. A mouse magnetic resonance imaging (MRI) protocol and post mortem assessment were used to assess disease severity, and lipid metabolites were measured using liquid chromatography-coupled tandem mass spectrometry. Decreased colitis activity was demonstrated by phenotype and MRI assessment in mice treated with ASA, and confirmed in postmortem analysis. Analysis of lipid mediators showed sustained formation of lipoxin A4 and an increase of DHA-derived 17-hydroxydocosahexaenoic acid (17-HDHA) after treatment with ASA. Furthermore,in vitroexperiments in RAW264.7 murine macrophages demonstrated significantly increased phagocytosis activity after incubation with 17-HDHA, supporting its proresolution effect. These results show a protective effect of ASA in a murine colitis model and could give a rationale for a careful reassessment of ASA therapy in patients with inflammatory bowel disease and particularly ulcerative colitis, possibly combined with DHA supplementation.

scholarly journals Dextran Sodium Sulfate-induced Colitis as a Model for Sarcopenia in Mice

2019 ◽  
Vol 26 (1) ◽  
pp. 56-65 ◽  
Author(s):  
Dominik Saul ◽  
Robyn Laura Kosinsky
Keyword(s):  
Inflammatory Bowel Disease ◽  
Mouse Model ◽  
Muscle Mass ◽  
Bowel Disease ◽  
Sodium Sulfate ◽  
Mrna Level ◽  
Dextran Sodium Sulfate ◽  
Key Players ◽  
Fiber Size ◽  
Inflammatory Bowel

Forty-two percent of inflammatory bowel disease patients suffer from sarcopenia. We established a mouse model for this condition. Dextran sodium sulfate–induced colitis caused a severe decrease in muscle mass, fiber size, and the regulation of sarcopenia-associated key players on mRNA level.

Cottonseed Oil Protects Against Intestinal Inflammation in Dextran Sodium Sulfate-Induced Inflammatory Bowel Disease

2019 ◽  
Vol 22 (7) ◽  
pp. 672-679 ◽  
Author(s):  
Jin-Sil Park ◽  
JeongWon Choi ◽  
Sun-Hee Hwang ◽  
Jae-Kyung Kim ◽  
Eun-Kyung Kim ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Sodium Sulfate ◽  
Intestinal Inflammation ◽  
Cottonseed Oil ◽  
Dextran Sodium Sulfate ◽  
Inflammatory Bowel

scholarly journals Disturbed fibrinolysis in patients with inflammatory bowel disease. A study in blood plasma, colon mucosa, and faeces.

Gut ◽  
1989 ◽  
Vol 30 (2) ◽  
pp. 188-194 ◽  
Author(s):  
E de Jong ◽  
R J Porte ◽  
E A Knot ◽  
J H Verheijen ◽  
J Dees
Keyword(s):  
Inflammatory Bowel Disease ◽  
Blood Plasma ◽  
Bowel Disease ◽  
Colon Mucosa ◽  
Inflammatory Bowel ◽  
In Blood Plasma

scholarly journals Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease.

Gut ◽  
1996 ◽  
Vol 38 (2) ◽  
pp. 216-222 ◽  
Author(s):  
R Daig ◽  
T Andus ◽  
E Aschenbrenner ◽  
W Falk ◽  
J Scholmerich ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Interleukin 8 ◽  
Colon Mucosa ◽  
Inflammatory Bowel

TL1A as a Potential Local Inducer of IL17A Expression in Colon Mucosa of Inflammatory Bowel Disease Patients

2015 ◽  
Vol 82 (4) ◽  
pp. 352-360 ◽  
Author(s):  
T. J. Ślebioda ◽  
A. Bojarska-Junak ◽  
M. Stanisławowski ◽  
M. Cyman ◽  
P. M. Wierzbicki ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Colon Mucosa ◽  
Inflammatory Bowel
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