scholarly journals Gelidium elegans Regulates the AMPK-PRDM16-UCP-1 Pathway and Has a Synergistic Effect with Orlistat on Obesity-Associated Features in Mice Fed a High-Fat Diet

Nutrients ◽  
2017 ◽  
Vol 9 (4) ◽  
pp. 342 ◽  
Author(s):  
Jia Choi ◽  
Kui-Jin Kim ◽  
Eun-Jeong Koh ◽  
Boo-Yong Lee
Keyword(s):  
Synergistic Effect ◽  
High Fat Diet ◽  
High Fat ◽  
Gelidium Elegans

Synergistic effect of sea cucumber saponins and EPA-enriched phospholipids on insulin resistance in high-fat diet-induced obese mice

2019 ◽  
Vol 10 (7) ◽  
pp. 3955-3964 ◽  
Author(s):  
Xiu-Qing Han ◽  
Ling-Yu Zhang ◽  
Lin Ding ◽  
Hao-Hao Shi ◽  
Chang-Hu Xue ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Synergistic Effect ◽  
High Fat Diet ◽  
Sea Cucumber ◽  
Insulin Response ◽  
Obese Mice ◽  
High Fat

The combination of sea cucumber saponins (SCS) and EPA-PL contributed to a synergistic effect on alleviating the obesity-related insulin resistance due to the amelioration of an inflammation centric peripheral insulin response.

scholarly journals IRAK inhibitor can improve insulin sensitivity in insulin-resistant mice fed with a high-fat diet

2020 ◽  
Vol 14 (6) ◽  
pp. 253-260
Author(s):  
Mostafa Allahyari ◽  
Athena Rajaie ◽  
Hossein Fallah
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Synergistic Effect ◽  
High Fat Diet ◽  
Interleukin 1 ◽  
Model Assessment ◽  
High Fat ◽  
Tissue Samples ◽  
Insulin Resistant ◽  
Glucose Levels

AbstractBackgroundObesity and the inflammation associated with it, play a key role in the development of insulin resistance through the release of inflammatory cytokines and free fatty acids and the stimulation of toll-like receptors (TLR). Interleukin-1 receptor-associated kinase (IRAK), which mediates the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway, is an important molecule in TLR signaling. The NF-κB pathway can reduce insulin efficacy by increasing the expression of proinflammatory cytokines. There is no safe inhibitor for the NF-κB pathway, and for this reason, the upper mediator of this pathway was selected for investigation.ObjectivesTo determine the effects of an IRAK inhibitor on insulin resistance and serum biochemical factors in high-fat-fed insulin-resistant mice.MethodsInsulin resistance was developed in C57BL/6J mice by 12 weeks of a high-fat diet. Subsequently, the IRAK 1/4 inhibitor 1-(2-(4-morpholinyl)ethyl)-2-(3-nitrobenzoylamino)benzimidazole (IRAKi)/or pioglitazone, or both, were administered for a further 2 weeks. After 12 h fasting, blood and tissue samples were collected, insulin and glucose levels were assayed, and the homeostatic model assessment was used to quantify insulin resistance (HOMA-IR).ResultsThe IRAKi decreased blood glucose levels significantly (253 ± 14.3 mg/dL vs 390.1 ± 16.6 mg/dL) and increased insulin sensitivity compared with untreated controls. However, we did not find a synergistic effect of IRAKi with pioglitazone in increasing insulin sensitivity.ConclusionIRAKis can increase insulin sensitivity and their efficacy is comparable to pioglitazone. However, combined administration of pioglitazone and IRAKi had no synergistic effect compared with monotherapy.

Effects of Maternal Flaxseed Supplementation on Female Offspring of Diabetic Rats in Serum Concentration of Glucose, Insulin, and Thyroid Hormones

2019 ◽  
Vol 89 (1-2) ◽  
pp. 45-54
Author(s):  
Akemi Suzuki ◽  
André Manoel Correia-Santos ◽  
Gabriela Câmara Vicente ◽  
Luiz Guillermo Coca Velarde ◽  
Gilson Teles Boaventura
Keyword(s):  
Thyroid Hormones ◽  
High Fat Diet ◽  
Female Offspring ◽  
Flaxseed Oil ◽  
Diabetic Rats ◽  
High Fat ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Flaxseed Flour ◽  
Maternal Consumption

Abstract. Objective: This study aimed to evaluate the effect of maternal consumption of flaxseed flour and oil on serum concentrations of glucose, insulin, and thyroid hormones of the adult female offspring of diabetic rats. Methods: Wistar rats were induced to diabetes by a high-fat diet (60%) and streptozotocin (35 mg/kg). Rats were mated and once pregnancy was confirmed, were divided into the following groups: Control Group (CG): casein-based diet; High-fat Group (HG): high-fat diet (49%); High-fat Flaxseed Group (HFG): high-fat diet supplemented with 25% flaxseed flour; High-fat Flaxseed Oil group (HOG): high-fat diet, where soya oil was replaced with flaxseed oil. After weaning, female pups (n = 6) from each group were separated, received a commercial rat diet and were sacrificed after 180 days. Serum insulin concentrations were determined by ELISA, the levels of triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) were determined by chemiluminescence. Results: There was a significant reduction in body weight at weaning in HG (−31%), HFG (−33%) and HOG (44%) compared to CG (p = 0.002), which became similar by the end of 180 days. Blood glucose levels were reduced in HFG (−10%, p = 0.044) when compared to CG, and there was no significant difference between groups in relation to insulin, T3, T4, and TSH after 180 days. Conclusions: Maternal severe hyperglycemia during pregnancy and lactation resulted in a microsomal offspring. Maternal consumption of flaxseed reduces blood glucose levels in adult offspring without significant effects on insulin levels and thyroid hormones.

Topical Application of Capsaicin Reduces Visceral Adipose Fat by Affecting Adipokine Levels in High-Fat Diet-Induced Obese Mice

Obesity ◽  
2012 ◽  
Author(s):  
Gong-Rak Lee ◽  
Mi Kyung Shin ◽  
Dong-Joon Yoon ◽  
Ah-Ram Kim ◽  
Rina Yu ◽  
...  
Keyword(s):  
Topical Application ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Visceral Adipose

POCU1b reverses diabesity induced in rats fed a high-fat diet

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
J Kim ◽  
H Kim ◽  
IH Jeong ◽  
DS Jang ◽  
JS Kim
Keyword(s):  
High Fat Diet ◽  
High Fat

A new model of synergistic effects of alcohol and high-fat diet on hepatic injury

2010 ◽  
Vol 48 (01) ◽  
Author(s):  
E Gäbele ◽  
K Dostert ◽  
C Dorn ◽  
C Hellerbrand
Keyword(s):  
High Fat Diet ◽  
Hepatic Injury ◽  
Synergistic Effects ◽  
High Fat ◽  
New Model

The role of rice bran extract on acetyl CoA carboxylase in liver of rats fed a high-fat diet

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
C Charkhonpunya ◽  
S Sireeratawong ◽  
S Komindr ◽  
N Lerdvuthisopon
Keyword(s):  
Rice Bran ◽  
High Fat Diet ◽  
Acetyl Coa Carboxylase ◽  
High Fat ◽  
Acetyl Coa ◽  
Rice Bran Extract
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