scholarly journals Serum Parathyroid Hormone Responses to Vitamin D Supplementation in Overweight/Obese Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Nutrients ◽  
2017 ◽  
Vol 9 (3) ◽  
pp. 241 ◽  
Author(s):  
Ashley Lotito ◽  
Masaru Teramoto ◽  
May Cheung ◽  
Kendra Becker ◽  
Deeptha Sukumar
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Clinical Trials ◽  
Parathyroid Hormone ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Serum Parathyroid Hormone ◽  
Obese Adults ◽  
Hormone Responses

scholarly journals Vitamin D Supplementation and Breast Cancer Prevention: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e69269 ◽  
Author(s):  
Francesca Sperati ◽  
Patrizia Vici ◽  
Marcello Maugeri-Saccà ◽  
Saverio Stranges ◽  
Nancy Santesso ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Vitamin D ◽  
Clinical Trials ◽  
Cancer Prevention ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Breast Cancer Prevention

scholarly journals Vitamin D supplementation and incident preeclampsia: A systematic review and meta-analysis of randomized clinical trials

2020 ◽  
Vol 39 (6) ◽  
pp. 1742-1752 ◽  
Author(s):  
Silvia Fogacci ◽  
Federica Fogacci ◽  
Maciej Banach ◽  
Erin D. Michos ◽  
Adrian V. Hernandez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Vitamin D Supplementation

scholarly journals Determinants of parathyroid hormone response to vitamin D supplementation: a systematic review and meta-analysis of randomised controlled trials

2015 ◽  
Vol 114 (9) ◽  
pp. 1360-1374 ◽  
Author(s):  
Nazanin Moslehi ◽  
Sakineh Shab-Bidar ◽  
Parvin Mirmiran ◽  
Farhad Hosseinpanah ◽  
Fereidoun Azizi
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Parathyroid Hormone ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Controlled Trials ◽  
Significant Heterogeneity ◽  
Randomised Controlled ◽  
Pth Level

AbstractThis systematic review aimed to assess the determinants of the parathyroid hormone (PTH) level response to vitamin D supplementation. We searched Medline, Google Scholar and the reference lists of previous reviews. All randomised controlled trials (RCT) on vitamin D supplementation that involved apparently healthy human subjects with a report of PTH were selected. Potential studies were screened independently and in duplicate. Results are summarised as mean differences with 95 % confidence intervals. Quality assessment, subgroup analysis, meta-analysis and meta-regression analysis were carried out. Thirty-three vitamin D supplementation RCT were included. Vitamin D supplementation significantly raised circulating 25-hydroxyvitamin D (25(OH)D) with significant heterogeneity among studies with a pooled mean difference (PMD) of 15.5 ng/ml (test for heterogeneity: P<0·001 and I2=97·3 %). Vitamin D supplementation significantly reduced PTH level with PMD of −8·0 pg/ml, with significant heterogeneity ((test for heterogeneity: P<0·001) and the I2 value was 97·3 %). In the subgroup analyses, the optimum treatment effect for PTH was observed with Ca doses of 600–1200 mg/d (−22·48 pg/ml), after the duration of a >12-month trial (−18·36 pg/ml), with low baseline 25(OH)D concentration of <20 ng/ml (−16·70 pg/ml) and in those who were overweight and obese (−18·11 pg/ml). Despite the present meta-analysis being hindered by some limitations, it provided some interesting evidence, suggesting that suppression of PTH level needs higher vitamin D intake (75 μg/d) than the current recommendations and longer durations (12 months), which should be taken into account for nutritional recommendations.

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