scholarly journals Maternal Low-Protein Diet Modulates Glucose Metabolism and Hepatic MicroRNAs Expression in the Early Life of Offspring †

Nutrients ◽  
2017 ◽  
Vol 9 (3) ◽  
pp. 205 ◽  
Author(s):  
Jia Zheng ◽  
Xinhua Xiao ◽  
Qian Zhang ◽  
Tong Wang ◽  
Miao Yu ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Early Life ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein

scholarly journals Low-Protein Diet during Early Life Causes a Reduction in the Frequency of Cells Immunopositive for Nestin and CD34 in Both Pancreatic Ducts and Islets in the Rat

Endocrinology ◽  
2004 ◽  
Vol 145 (6) ◽  
pp. 3004-3013 ◽  
Author(s):  
E. A. Joanette ◽  
B. Reusens ◽  
E. Arany ◽  
S. Thyssen ◽  
R. C. Remacle ◽  
...  
Keyword(s):  
Early Life ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Pancreatic Ducts ◽  
Low Protein

Early-life nutrition influences thymic growth in male mice that may be related to the regulation of longevity

2009 ◽  
Vol 118 (6) ◽  
pp. 429-438 ◽  
Author(s):  
Jian-Hua Chen ◽  
Jane L. Tarry-Adkins ◽  
Chantal A.A. Heppolette ◽  
Donald B. Palmer ◽  
Susan E. Ozanne
Keyword(s):  
Mitotic Activity ◽  
Early Life ◽  
Low Birthweight ◽  
Adult Life ◽  
Protein Restriction ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Nuclear Antigen ◽  
Low Protein ◽  
Maternal Protein Restriction

Nutrition and growth rate during early life can influence later health and lifespan. We have demonstrated previously that low birthweight, resulting from maternal protein restriction during pregnancy followed by catch-up growth in rodents, was associated with shortened lifespan, whereas protein restriction and slow growth during lactation increased lifespan. The underlying mechanisms by which these differences arise are unknown. In the present study, we report that maternal protein restriction in mice influences thymic growth in early adult life. Offspring of dams fed a low-protein diet during lactation (PLP offspring) had significant thymic growth from 21 days to 12 weeks of age, whereas this was not observed in control mice or offspring of dams fed a low-protein diet during pregnancy (recuperated offspring). PCNA (proliferating-cell nuclear antigen) and SIRT1 (silent information regulator 1) protein levels at 21 days of age were significantly higher in the thymus from both PLP mice (P<0.001 and P<0.05 respectively) and recuperated mice (P<0.001 and P<0.01 respectively) compared with controls. At 12 weeks, PLP mice maintained a higher SIRT1 level, whereas PCNA was decreased in the thymus from recuperated offspring. This suggests that mitotic activity was initially enhanced in the thymus from both PLP and recuperated offspring, but remained sustained into adulthood only in PLP mice. The differential mitotic activity in the thymus from PLP and recuperated mice appeared to be influenced by changes in sex hormone concentrations and the expression of p53, p16, the androgen receptor, IL-7 (interleukin-7) and the IL-7 receptor. In conclusion, differential thymic growth may contribute to the regulation of longevity by maternal diet.

scholarly journals Low protein diet in uremia: Effects on glucose metabolism and energy production rate

1997 ◽  
Vol 51 (4) ◽  
pp. 1222-1227 ◽  
Author(s):  
Vincent Rigalleau ◽  
Christian Combe ◽  
Valérie Blanchetier ◽  
Jean Aubertin ◽  
Michel Aparicio ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Production Rate ◽  
Energy Production ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein

The Effect of a Low Protein Diet with Amino Acid/Keto Acid Supplements on Glucose Metabolism in Children with Uremia*

1986 ◽  
Vol 63 (4) ◽  
pp. 985-989 ◽  
Author(s):  
ROBERT H. K. MAK ◽  
CHARLES TURNER ◽  
THEA THOMPSON ◽  
GEORGE HAYCOCK ◽  
CYRIL CHANTLER
Keyword(s):  
Amino Acid ◽  
Glucose Metabolism ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Keto Acid ◽  
Low Protein

A low-protein diet during pregnancy alters glucose metabolism and insulin secretion

2011 ◽  
Vol 30 (2) ◽  
pp. 114-121 ◽  
Author(s):  
Denise de Fátima I. Souza ◽  
Letícia M. Ignácio-Souza ◽  
Sílvia Regina de L. Reis ◽  
Marise Auxiliadora de B. Reis ◽  
Luiz Fabrizio Stoppiglia ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Glucose Metabolism ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein

Hepatic Ultrastructure Changes Induced by Lithocholic Acid

1967 ◽  
Vol 25 ◽  
pp. 162-163 ◽  
Author(s):  
F. G. Zaki
Keyword(s):  
Endoplasmic Reticulum ◽  
Lithocholic Acid ◽  
Smooth Endoplasmic Reticulum ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Electron Microscopic ◽  
Hydropic Degeneration ◽  
Hepatic Cells ◽  
Low Protein ◽  
Microscopic Studies

Addition of lithocholic acid (LCA), a naturally occurring bile acid in mammals, to a low protein diet fed to rats induced marked inflammatory reaction in the hepatic cells followed by hydropic degeneration and ductular cell proliferation. These changes were accompanied by dilatation and hyperplasia of the common bile duct and formation of “gallstones”. All these changes were reversible when LCA was withdrawn from the low protein diet except for the hardened gallstones which persisted.Electron microscopic studies revealed marked alterations in the hepatic cells. Early changes included disorganization, fragmentation of the rough endoplasmic reticulum and detachment of its ribosomes. Free ribosomes, either singly or arranged in small clusters were frequently seen in most of the hepatic cells. Vesiculation of the smooth endoplasmic reticulum was often encountered as early as one week after the administration of LCA (Fig. 1).

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