scholarly journals Inhibition of Cell Survival by Curcumin Is Associated with Downregulation of Cell Division Cycle 20 (Cdc20) in Pancreatic Cancer Cells

Nutrients ◽  
2017 ◽  
Vol 9 (2) ◽  
pp. 109 ◽  
Author(s):  
Yu Zhang ◽  
Ying-bo Xue ◽  
Hang Li ◽  
Dong Qiu ◽  
Zhi-wei Wang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Division ◽  
Cell Survival ◽  
Cancer Cells ◽  
Cell Division Cycle ◽  
Pancreatic Cancer Cells

scholarly journals Apolipoprotein C-1 maintains cell survival by preventing from apoptosis in pancreatic cancer cells

Oncogene ◽  
2007 ◽  
Vol 27 (20) ◽  
pp. 2810-2822 ◽  
Author(s):  
S Takano ◽  
H Yoshitomi ◽  
A Togawa ◽  
K Sogawa ◽  
T Shida ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Survival ◽  
Cancer Cells ◽  
Pancreatic Cancer Cells ◽  
Apolipoprotein C

Aurora A phosphorylation of the epigenetic regulator HP1γ mediates cell division in pancreatic cancer cells

Pancreatology ◽  
2013 ◽  
Vol 13 (2) ◽  
pp. e28
Author(s):  
A. Grzenda ◽  
P. Leonard ◽  
G. Urrutia ◽  
A. Mathison ◽  
M. Fernandez-Zapico ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Division ◽  
Cancer Cells ◽  
Aurora A ◽  
Pancreatic Cancer Cells ◽  
Epigenetic Regulator

scholarly journals Gli1 maintains cell survival by up-regulating IGFBP6 and Bcl-2 through promoter regions in parallel manner in pancreatic cancer cells

2009 ◽  
Vol 8 (1) ◽  
pp. 13 ◽  
Author(s):  
Xing-Peng Wang ◽  
Xuan-Fu Xu ◽  
Chuan-Yong Guo ◽  
Jun Liu ◽  
Wen-Juan Yang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Survival ◽  
Cancer Cells ◽  
Promoter Regions ◽  
Pancreatic Cancer Cells

scholarly journals Human ALKBH6 Is Required for Maintenance of Genomic Stability and Promoting Cell Survival During Exposure of Alkylating Agents in Pancreatic Cancer

2021 ◽  
Vol 12 ◽  
Author(s):  
Shengyuan Zhao ◽  
Rodan Devega ◽  
Aaliyah Francois ◽  
Dawit Kidane
Keyword(s):  
Pancreatic Cancer ◽  
Dna Damage ◽  
Cell Survival ◽  
Cancer Cells ◽  
Alkylating Agent ◽  
Alkylating Agents ◽  
The Cancer Genome Atlas ◽  
Human Pancreatic Cancer ◽  
Pancreatic Cancer Cells ◽  
Dna Repair Gene

Alpha-ketoglutarate-dependent dioxygenase (ALKBH) is a DNA repair gene involved in the repair of alkylating DNA damage. There are nine types of ALKBH (ALKBH1-8 and FTO) identified in humans. In particular, certain types of ALKBH enzymes are dioxygenases that directly reverse DNA methylation damage via transfer of a methyl group from the DNA adduct onto α-ketoglutarate and release of metabolic products including succinate and formaldehyde. Here, we tested whether ALKBH6 plays a significant role in preventing alkylating DNA damage and decreasing genomic instability in pancreatic cancer cells. Using an E. coli strain deficient with ALKB, we found that ALKBH6 complements ALKB deficiency and increases resistance after alkylating agent treatment. In particular, the loss of ALKBH6 in human pancreatic cancer cells increases alkylating agent-induced DNA damage and significantly decreases cell survival. Furthermore, in silico analysis from The Cancer Genome Atlas (TCGA) database suggests that overexpression of ALKBH6 provides better survival outcomes in patients with pancreatic cancer. Overall, our data suggest that ALKBH6 is required to maintain the integrity of the genome and promote cell survival of pancreatic cancer cells.

SHh-Gli1 signaling pathway promotes cell survival by mediating baculoviral IAP repeat-containing 3 (BIRC3) gene in pancreatic cancer cells

Tumor Biology ◽  
2016 ◽  
Vol 37 (7) ◽  
pp. 9943-9950 ◽  
Author(s):  
Huizhong Gan ◽  
Hua Liu ◽  
Hui Zhang ◽  
Yueyue Li ◽  
Xiaorong Xu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Survival ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Pancreatic Cancer Cells

scholarly journals Phillygenin, a MELK Inhibitor, Inhibits Cell Survival and Epithelial–Mesenchymal Transition in Pancreatic Cancer Cells

2020 ◽  
Vol Volume 13 ◽  
pp. 2833-2842 ◽  
Author(s):  
Hongchun Li ◽  
Miao Chen ◽  
Zhuying Yang ◽  
Qinxian Wang ◽  
Jiesheng Wang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Survival ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Pancreatic Cancer Cells
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