scholarly journals Very Low-Protein Diet (VLPD) Reduces Metabolic Acidosis in Subjects with Chronic Kidney Disease: The “Nutritional Light Signal” of the Renal Acid Load

Nutrients ◽  
2017 ◽  
Vol 9 (1) ◽  
pp. 69 ◽  
Author(s):  
Biagio Di Iorio ◽  
Lucia Di Micco ◽  
Stefania Marzocco ◽  
Emanuele De Simone ◽  
Antonietta De Blasio ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Metabolic Acidosis ◽  
Kidney Disease ◽  
Light Signal ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
Acid Load ◽  
Very Low Protein Diet

scholarly journals The Effect of Ketoanalogues on Chronic Kidney Disease Deterioration: A Meta-Analysis

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 957 ◽  
Author(s):  
Albert Li ◽  
Hsiang-Yen Lee ◽  
Yen-Chung Lin
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Meta Analysis ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
Randomized Control ◽  
Very Low Protein Diet ◽  
Restricted Protein Diet

The effects of ketoanalogues (KA) on chronic kidney disease (CKD) deterioration have not yet been fully confirmed. To strengthen the evidence of the role of KA in CKD, PubMed and Embase were searched for studies published through February 2019. Effect sizes from ten randomized control trials (RCTs) and two non-RCTs comprising a total of 951 patients were pooled and analyzed. A restricted protein diet supplemented with ketoanalogues (RPKA) was found to significantly delay the progression of CKD (p = 0.008), particularly in patients with an estimated glomerular filtration rate (eGFR) > 18 mL/min/1.73 m2 (p < 0.0001). No significant change in eGFR was found when comparing a very-low-protein diet and a low-protein diet (p = 0.10). In addition, compared with the placebo, RPKA did not cause malnutrition (albumin: p = 0.56; cholesterol: p = 0.50). Moreover, RPKA significantly decreased phosphorous levels (p = 0.001), increased calcium levels (p = 0.04), and decreased parathyroid hormone (PTH) levels (p = 0.05) in patients with eGFR < 18 mL/min/1.73 m2. In conclusion, RPKA could slow down the progression of CKD in patients with eGFR > 18 mL/min/1.73 m2 without causing malnutrition and reverse CKD-MBD in patients with eGFR < 18 mL/min/1.73 m2.

scholarly journals Very low protein diet supplemented with ketoanalogs improves blood pressure control in chronic kidney disease

2007 ◽  
Vol 71 (3) ◽  
pp. 245-251 ◽  
Author(s):  
V. Bellizzi ◽  
B.R. Di Iorio ◽  
L. De Nicola ◽  
R. Minutolo ◽  
P. Zamboli ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Blood Pressure Control ◽  
Pressure Control ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
Very Low Protein Diet

scholarly journals Very Low Protein Diet for Patients with Chronic Kidney Disease: Recent Insights

2019 ◽  
Vol 8 (5) ◽  
pp. 718 ◽  
Author(s):  
Lucia Di Micco ◽  
Luca Di Lullo ◽  
Antonio Bellasi ◽  
Biagio R. Di Iorio
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Nutritional Therapy ◽  
Sodium Content ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Phosphate Binders ◽  
Beneficial Effects ◽  
Low Protein ◽  
Very Low Protein Diet

Use of nutritional therapy (NT) in chronic kidney disease (CKD) patients is still debated among nephrologists, but it represents a fundamental point in the conservative treatment of CKD. It has been used for years and it has new goals today, such as (1) the reduction of edema, diuretics, and blood pressure values with a low sodium-content diet; (2) the dose reduction of phosphate levels and phosphate binders; (3) the administration of bicarbonate with vegetables in order to correct metabolic acidosis and delay CKD progression; (4) the reduction of the number and the doses of drugs and chemical substances; and (5) the lowering of urea levels, the cure of intestinal microbioma, and the reduction of cyanates levels (such as indoxyl-sulphate and p-cresol sulphate), which are the most recent known advantages achievable with NT. In conclusion, NT and especially very low protein diet (VLPD) have several beneficial effects in CKD patients and slows the progression of CKD.

Very Low Protein Diet Reduces Indoxyl Sulfate Levels in Chronic Kidney Disease

2013 ◽  
Vol 35 (1-3) ◽  
pp. 196-201 ◽  
Author(s):  
Stefania Marzocco ◽  
Fabrizio Dal Piaz ◽  
Lucia Di Micco ◽  
Serena Torraca ◽  
Maria Luisa Sirico ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Indoxyl Sulfate ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
Very Low Protein Diet

scholarly journals Nutritional Approaches for the Management of Metabolic Acidosis in Chronic Kidney Disease

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2534
Author(s):  
Annalisa Noce ◽  
Giulia Marrone ◽  
Georgia Wilson Jones ◽  
Manuela Di Lauro ◽  
Anna Pietroboni Zaitseva ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Metabolic Acidosis ◽  
Kidney Disease ◽  
Alkali Treatment ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Nutritional Treatment ◽  
Low Protein ◽  
Profile Control ◽  
The Mediterranean

Metabolic acidosis is a severe complication of chronic kidney disease (CKD) which is associated with nefarious impairments such as bone demineralization, muscle wasting, and hormonal alterations, for example, insulin resistance. Whilst it is possible to control this condition with alkali treatment, consisting in the oral administration of sodium citrate or sodium bicarbonate, this type of intervention is not free from side effects. On the contrary, opting for the implementation of a targeted dietetic-nutritional treatment for the control of CKD metabolic acidosis also comes with a range of additional benefits such as lipid profile control, increased vitamins, and antioxidants intake. In our review, we evaluated the main dietary-nutritional regimens useful to counteract metabolic acidosis, such as the Mediterranean diet, the alkaline diet, the low-protein diet, and the vegan low-protein diet, analyzing the potentialities and limits of every dietary-nutritional treatment. Literature data suggest that the Mediterranean and alkaline diets represent a valid nutritional approach in the prevention and correction of metabolic acidosis in CKD early stages, while the low-protein diet and the vegan low-protein diet are more effective in CKD advanced stages. In conclusion, we propose that tailored nutritional approaches should represent a valid therapeutic alternative to counteract metabolic acidosis.

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