scholarly journals Hepatoprotective Effect of Opuntia robusta and Opuntia streptacantha Fruits against Acetaminophen-Induced Acute Liver Damage

Nutrients ◽  
2016 ◽  
Vol 8 (10) ◽  
pp. 607 ◽  
Author(s):  
Herson González-Ponce ◽  
María Martínez-Saldaña ◽  
Ana Rincón-Sánchez ◽  
María Sumaya-Martínez ◽  
Manon Buist-Homan ◽  
...  
Keyword(s):  
Liver Damage ◽  
Hepatoprotective Effect ◽  
Acute Liver Damage

The hepatoprotective effect of the probiotic Clostridium butyricum against carbon tetrachloride-induced acute liver damage in mice

2017 ◽  
Vol 8 (11) ◽  
pp. 4042-4052 ◽  
Author(s):  
Jiaming Liu ◽  
Yaoyang Fu ◽  
Hao Zhang ◽  
Jindan Wang ◽  
Jing Zhu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Alcoholic Liver Disease ◽  
Clostridium Butyricum ◽  
Hepatoprotective Effect ◽  
Acute Liver Damage

Previous studies have revealed that the probioticClostridium butyricum(C. butyricum) can attenuate cirrhosis in chronic non-alcoholic liver disease.

scholarly journals Hepatoprotective effect of Opuntia dillenii seed oil on CCl4 induced acute liver damage in rat

2018 ◽  
Vol 8 (5) ◽  
pp. 254 ◽  
Author(s):  
Mohamed Bnouham ◽  
Mohamed Bouhrim ◽  
Hayat Ouassou ◽  
Mohamed Choukri ◽  
Hassane Mekhfi ◽  
...  
Keyword(s):  
Liver Damage ◽  
Seed Oil ◽  
Hepatoprotective Effect ◽  
Acute Liver Damage ◽  
Opuntia Dillenii

scholarly journals 1H-NMR Based Serum Metabolomics Study to Investigate Hepatoprotective Effect of Qin-Jiao on Carbon Tetrachloride-Induced Acute Hepatotoxicity in Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Zeyun Li ◽  
Ying Li ◽  
Lingpan Lu ◽  
Zhiheng Yang ◽  
Wenhua Xue ◽  
...  
Keyword(s):  
Protective Effect ◽  
Liver Damage ◽  
Ketone Bodies ◽  
Histopathological Examination ◽  
Tca Cycle ◽  
Underlying Mechanism ◽  
Positive Control ◽  
Hepatoprotective Effect ◽  
Acute Liver Damage ◽  
H Nmr

Gentiana macrophylla Radix, commonly known as Qin-Jiao (QJ), was recorded alone to treat jaundice in Compendium of Materia Medica and has been frequently prescribed for treatment of liver disease in China. However, the underlying mechanism remains unknown. In the present work, QJ of 1,2 g/kg or silybin of 40 mg/kg (positive control) was orally given to rats for 7 days to verify the protective effect on acute liver damage induced by tetrachloride (CCl4). Together with serum biochemistry and histopathological examination,1H-NMR based metabolomics work was carried out to investigate the efficacy. It turned out that QJ of 2 g/kg exerted comparable protective effect with positive control and partially recovered disturbed metabolism by CCl4. Multivariate analysis was conducted and metabolites altered significantly among groups were assigned and discussed, including betaine, glucose, lactate, creatine, and LDL/VLDL. Metabolic regulations involved in QJ or silybin treatment were as follows: tricarboxylic acid (TCA) cycle, synthesis of LDL/VLDL, and gluconeogenesis were enhanced, while betaine metabolism, glycolysis, creatine metabolism, synthesis of ketone bodies, amino acids metabolism, andβ-oxidation of fatty acids were suppressed. For the first time hepatoprotective effect of QJ on acute liver damage was revealed by1H-NMR based metabolomics, prompting understanding of the underlying mechanism.

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