scholarly journals Dietary Interventions and Changes in Cardio-Metabolic Parameters in Metabolically Healthy Obese Subjects: A Systematic Review with Meta-Analysis

Nutrients ◽  
2016 ◽  
Vol 8 (8) ◽  
pp. 455 ◽  
Author(s):  
Marta Stelmach-Mardas ◽  
Jarosław Walkowiak
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Metabolic Parameters ◽  
Dietary Interventions ◽  
Metabolically Healthy Obese ◽  
Obese Subjects ◽  
Healthy Obese ◽  
Metabolically Healthy

Abstract 17843: Visceral Adipose Tissue Secretion of Adiponectin Decreases with Increased Body Mass Index

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Lenore R Rengel ◽  
Brittaney Obi ◽  
Jon Gould ◽  
Matthew Goldblatt ◽  
Andrew Kastenmeier ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Metabolic Health ◽  
Metabolically Healthy Obese ◽  
Obese Subjects ◽  
Healthy Obese ◽  
Metabolically Healthy ◽  
Visceral Adipose ◽  
Subcutaneous Adipose

Introduction: Peripheral adiposity is associated with better metabolic health and higher plasma adiponectin (ADPN) levels. Since ADPN is secreted mainly by adipose tissue (AT), it is intriguing that higher visceral adipose tissue (VAT) is associated with lower ADPN levels and poor metabolic health. Hypothesis: We hypothesized that various AT depots differ in their ability to secrete ADPN. Methods: Paired AT samples (VAT and subcutaneous adipose tissue (SAT)) were collected from 19 subjects (10 women, 15 obese) undergoing elective abdominal surgery. The samples were cultured and the supernatant was collected after 24 hours. ADPN levels released into the supernatant from VAT and SAT were measured using multiplex methods. Subjects were defined as obese or non-obese (NO) based on BMI > or ≤ 30kg/m2 respectively. Obese subjects were further classified as metabolically unhealthy obese (MUO) or metabolically healthy obese (MHO) based on presence or absence of type 2 diabetes mellitus, hypertension, or cardiovascular disease at the time of surgery. Results: Mean ADPN secretion levels from SAT and VAT were similar in NO subjects (17.3 ± 3.4 vs. 9.8 ± 13.0 ng/mL/mg, p=0.5) whereas the mean ADPN secretion was lower from VAT among obese subjects (15.9 ± 0.8 vs. 4.5 ± 0.2 ng/mL/mg, p=0.0002). ADPN secretion decreased from VAT (r=-0.16) and increased from SAT (r=0.33) with increased BMI (Fig.1). When MHO and MUO were compared, ADPN secretion from VAT in MHO was reduced only slightly (16.1 ± 8.2 vs. 4.0 ± 2.0 ng/mL/mg, p=0.07) whereas ADPN secretion was significantly reduced in MUO (15.9 ± 5.3 vs. 4.7 ± 4.6 ng/mL/mg, p=0.003). Conclusions: Reduced ADPN secretion from VAT in subjects with increasing BMI may explain lower circulating ADPN levels in obese individuals. Higher ADPN production from SAT and the relatively preserved secretion of ADPN from VAT may explain metabolic health in some obese individuals. Futures studies will help identify factors that control ADPN secretion from AT.

scholarly journals Visceral and subcutaneous adipose tissue FDG uptake by PET/CT in metabolically healthy obese subjects

Obesity ◽  
2014 ◽  
Vol 23 (2) ◽  
pp. 286-289 ◽  
Author(s):  
Adriana L. Oliveira ◽  
Debora C. Azevedo ◽  
Miriam A. Bredella ◽  
Takara L. Stanley ◽  
Martin Torriani
Keyword(s):  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Fdg Uptake ◽  
Metabolically Healthy Obese ◽  
Pet Ct ◽  
Obese Subjects ◽  
Healthy Obese ◽  
Metabolically Healthy ◽  
Subcutaneous Adipose

scholarly journals Metabolically healthy obese subjects and metabolic signs of obesity in subjects with normal body weight: what is behind?

2010 ◽  
Vol 56 (3) ◽  
pp. 47-51 ◽  
Author(s):  
L M Bershteĭn ◽  
I G Kovalenko
Keyword(s):  
Body Weight ◽  
Normal Weight ◽  
Metabolic Disturbances ◽  
Normal Body ◽  
Metabolically Healthy Obese ◽  
Metabolically Obese Normal Weight ◽  
Normal Body Weight ◽  
Obese Subjects ◽  
Healthy Obese ◽  
Metabolically Healthy

The current concept of obesity as a heterogeneous condition is discussed. Such interpretation provides a basis for distinguishing a group of obese subjects without metabolic disturbances (metabolically healthy obese (MHO) subjects) and another one including subjects with normal body weight and signs of hormonal and metabolic disorders (metabolically obese normal weight (MONW) subjects). A separate subgroup is represented by obese patients with deficit of muscular mass and force (sarcopenic obesity). Potential mechanisms underlying development of these conditions are considered along with selected applied aspects of this problem.

scholarly journals Circulating Adipokines in Healthy versus Unhealthy Overweight and Obese Subjects

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Assim A. Alfadda
Keyword(s):  
Hdl Cholesterol ◽  
Metabolic Health ◽  
Bioactive Substances ◽  
Metabolically Healthy Obese ◽  
Cholesterol Levels ◽  
Increased Risk ◽  
Obese Subjects ◽  
Healthy Obese ◽  
Metabolically Healthy

It is now well established that not all obese subjects are at increased risk of cardiometabolic complications; such patients are termed the metabolically healthy obese. Despite their higher-than-normal body fat mass, they are still insulin sensitive, with a favorable inflammatory and lipid profile and no signs of hypertension. It remains unclear which factors determine an individual's metabolic health. Adipose tissue is known to secrete multiple bioactive substances, called adipokines, that can contribute to the development of obesity-associated complications. The goal of this study was to determine whether the circulating adipokine profiles differs between metabolically healthy and metabolically unhealthy overweight and obese subjects, thereby obtaining data that could help to explain the link between obesity and its related cardiometabolic complications. We defined metabolic health in terms of several metabolic and inflammatory risk factors. The serum adiponectin levels were higher in the healthy group and showed a positive correlation with HDL cholesterol levels in the unhealthy group. There were no differences between the two groups in the levels of serum leptin, chemerin and orosomucoid. Accordingly, adiponectin might play a role in protecting against obesity-associated cardiometabolic derangements. More studies are needed to clarify the role of different chemerin isoforms in this system.

Higher mortality in metabolically obese normal-weight people than in metabolically healthy obese subjects in elderly Koreans

2013 ◽  
Vol 79 (3) ◽  
pp. 364-370 ◽  
Author(s):  
Kyung Mook Choi ◽  
Hyun Joo Cho ◽  
Hae Yoon Choi ◽  
Sae Jeong Yang ◽  
Hye Jin Yoo ◽  
...  
Keyword(s):  
Normal Weight ◽  
Metabolically Healthy Obese ◽  
Metabolically Obese Normal Weight ◽  
Obese Subjects ◽  
Healthy Obese ◽  
Metabolically Healthy ◽  
Elderly Koreans
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