scholarly journals Supplementation of Antipsychotic Treatment with the Amino Acid Sarcosine Influences Proton Magnetic Resonance Spectroscopy Parameters in Left Frontal White Matter in Patients with Schizophrenia

Nutrients ◽  
2015 ◽  
Vol 7 (10) ◽  
pp. 8767-8782 ◽  
Author(s):  
Dominik Strzelecki ◽  
Michał Podgórski ◽  
Olga Kałużyńska ◽  
Oliwia Gawlik-Kotelnicka ◽  
Ludomir Stefańczyk ◽  
...  
Keyword(s):  
Amino Acid ◽  
White Matter ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Antipsychotic Treatment ◽  
Resonance Spectroscopy ◽  
Frontal White Matter

IMPROVEMENT AFTER CEREBROSPINAL FLUID DRAINAGE IS RELATED TO LEVELS OF N-ACETYL-ASPARTATE IN IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS

Neurosurgery ◽  
2008 ◽  
Vol 62 (1) ◽  
pp. 135-142 ◽  
Author(s):  
Niklas Lenfeldt ◽  
Jon Hauksson ◽  
Richard Birgander ◽  
Anders Eklund ◽  
Jan Malm
Keyword(s):  
Cerebrospinal Fluid ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Normal Pressure Hydrocephalus ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Normal Pressure ◽  
Idiopathic Normal Pressure Hydrocephalus ◽  
Resonance Spectroscopy ◽  
Frontal White Matter

AbstractOBJECTIVEThis study uses proton magnetic resonance spectroscopy to investigate whether or not idiopathic normal pressure hydrocephalus is associated with neuronal dysfunction or ischemia in the brain. We evaluate whether or not proton magnetic resonance spectroscopy is useful for predicting improvement after long-term external lumbar drainage (ELD) of cerebrospinal fluid.METHODSEighteen patients (mean age, 73 yr; six women) and 10 matching controls participated. Participants were characterized by clinical features, cognitive and motor function tests, and cerebrospinal fluid hydrodynamics (patients only). Signals from N-acetyl-aspartate (NAA), choline, lactate, and creatine (Cr) (reference) were sampled once in controls and twice in patients (before and after a 3-day ELD of ∼ 135 mL/24 h) by proton magnetic resonance spectroscopy (1.5 T) from a 7.2-mL volume in the frontal white matter. Improvement was defined by video recordings of the patients' gait.RESULTSSixteen patients finished the ELD (one patient had meningitis, and one patient had catheter insertion failure) with a mean drain volume of 395 mL. NAA/Cr ratios were lower in patients than in controls (1.60 versus 1.84, P = 0.02), but no difference was found for choline/Cr ratios. No lactate signals were detected. Fifty percent of patients improved after ELD. They had higher NAA/Cr ratios than nonimproved patients (1.70 versus 1.51, P = 0.01), but no differences were found in choline/Cr ratios or drain volume.CONCLUSIONNAA/Cr ratios were decreased in patients with idiopathic normal pressure hydrocephalus, which is consistent with neuronal dysfunction in the frontal white matter. Improved patients had NAA/Cr ratios close to normal, indicating that enough functional neurons are a prerequisite for the cerebrospinal fluid drainage to have an effect.

Proton Magnetic Resonance Spectroscopy Changes After Antipsychotic Treatment

2013 ◽  
Vol 20 (3) ◽  
pp. 414-427 ◽  
Author(s):  
Agata Szulc ◽  
Beata Galinska-Skok ◽  
Napoleon Waszkiewicz ◽  
Daniel Bibulowicz ◽  
Beata Konarzewska ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Antipsychotic Treatment ◽  
Resonance Spectroscopy
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