scholarly journals Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease

Nutrients ◽  
2015 ◽  
Vol 7 (4) ◽  
pp. 2485-2498 ◽  
Author(s):  
Jiying Wang ◽  
Shishi Lv ◽  
Guo Chen ◽  
Chenlin Gao ◽  
Jianhua He ◽  
...  
Keyword(s):  
Vitamin D ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Autoimmune Thyroid

scholarly journals Meta-Analysis of the Association between Vitamin D Receptor Polymorphisms and the Risk of Autoimmune Thyroid Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Xue-Ren Gao ◽  
Yong-Guo Yu
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Autoimmune Thyroid ◽  
Asian Populations ◽  
Increased Risk ◽  
African Populations ◽  
Reduced Risk

The association between vitamin D receptor (VDR) polymorphisms (rs731236, rs1544410, rs2228570, and rs7975232) and the risk of autoimmune thyroid disease (AITD) had been investigated in previous studies. However, the results of these studies remained controversial. Thus, a meta-analysis was performed to derive a more precise conclusion. All related articles were systematically searched by PubMed, Embase, Google Scholar, and Chinese National Knowledge Infrastructure (CNKI). The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of association. The overall results indicated thatVDRrs731236 and rs2228570 polymorphisms were significantly associated with a reduced risk of AITD. However, a stratification analysis based on clinical types showed thatVDRrs731236 and rs2228570 polymorphisms were associated only with a reduced risk of HT. A stratification analysis by ethnicity showed thatVDRrs731236 polymorphism was significantly associated with a reduced risk of AITD in Asian and African populations.VDRrs2228570 polymorphism was associated with a reduced risk of AITD in Asian populations.VDRrs1544410 polymorphism was associated with a reduced risk of AITD in European and African populations, but with an increased risk of AITD in Asian populations.VDRrs7975232 polymorphism was significantly associated with an increased risk of AITD in African populations. In conclusion, the present study suggested thatVDRrs731236, rs1544410, rs2228570, and rs7975232 polymorphisms were significantly associated with AITD risk. However, more well-designed studies should be performed to verify the current results.

Vitamin D Receptor Gene (VDR) Polymorphisms Are Not Associated with Autoimmune Thyroid Disease Risk in Turner Syndrome Patients

2011 ◽  
pp. P3-594-P3-594
Author(s):  
Bianca Bianco ◽  
Ieda Therezinha do Nascimento Verreschi ◽  
Kelly Cristina Oliveira ◽  
Alexis Dourado Guedes ◽  
Caio Parente Barbosa ◽  
...  
Keyword(s):  
Vitamin D ◽  
Turner Syndrome ◽  
Vitamin D Receptor ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Disease Risk ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Autoimmune Thyroid ◽  
Vdr Polymorphisms

Association of serum IL-21 and vitamin D concentrations in Chinese children with autoimmune thyroid disease

2020 ◽  
Vol 507 ◽  
pp. 194-198
Author(s):  
Yaling Feng ◽  
Ting Qiu ◽  
Huijuan Chen ◽  
Yarong Wei ◽  
Xinye Jiang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Chinese Children ◽  
Autoimmune Thyroid

scholarly journals The proportion of peripheral blood Tregs among the CD4+ T cells of autoimmune thyroid disease patients: a meta-analysis

2020 ◽  
Vol 67 (3) ◽  
pp. 317-326 ◽  
Author(s):  
Ziyi Chen ◽  
Yue Wang ◽  
Xi Ding ◽  
Meng Zhang ◽  
Mingqian He ◽  
...  
Keyword(s):  
T Cells ◽  
Peripheral Blood ◽  
Thyroid Disease ◽  
Cd4 T Cells ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Autoimmune Thyroid

scholarly journals Vitamin D and Autoimmune Thyroid Disease—Cause, Consequence, or a Vicious Cycle?

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2791
Author(s):  
Inês Henriques Vieira ◽  
Dírcea Rodrigues ◽  
Isabel Paiva
Keyword(s):  
Vitamin D ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Minor Role ◽  
Vicious Cycle ◽  
Autoimmune Process ◽  
Autoimmune Thyroid ◽  
A Minor ◽  
Pleiotropic Expression ◽  
The Relationship

Vitamin D is a steroid hormone traditionally connected to phosphocalcium metabolism. The discovery of pleiotropic expression of its receptor and of the enzymes involved in its metabolism has led to the exploration of the other roles of this vitamin. The influence of vitamin D on autoimmune disease—namely, on autoimmune thyroid disease—has been widely studied. Most of the existing data support a relationship between vitamin D deficiency and a greater tendency for development and/or higher titers of antibodies linked to Hashimoto’s thyroiditis, Graves’ disease, and/or postpartum thyroiditis. However, there have also been some reports contradicting such relationships, thus making it difficult to establish a unanimous conclusion. Even if the existence of an association between vitamin D and autoimmune thyroid disease is assumed, it is still unclear whether it reflects a pathological mechanism, a causal relationship, or a consequence of the autoimmune process. The relationship between vitamin D’s polymorphisms and this group of diseases has also been the subject of study, often with divergent results. This text presents a review of the recent literature on the relationship between vitamin D and autoimmune thyroid disease, providing an analysis of the likely involved mechanisms. Our thesis is that, due to its immunoregulatory role, vitamin D plays a minor role in conjunction with myriad other factors. In some cases, a vicious cycle is generated, thus contributing to the deficiency and aggravating the autoimmune process.

Prevalence of Celiac Disease in Patients with Autoimmune Thyroid Disease: A Meta-Analysis

Thyroid ◽  
2016 ◽  
Vol 26 (7) ◽  
pp. 880-890 ◽  
Author(s):  
Abhik Roy ◽  
Monika Laszkowska ◽  
Johan Sundström ◽  
Benjamin Lebwohl ◽  
Peter H.R. Green ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Autoimmune Thyroid

SUN-P299: Assessment of Vitamin D Level in Autoimmune Thyroid Disease in Turkish Population

2017 ◽  
Vol 36 ◽  
pp. S164
Author(s):  
B.P. Sarer-Yurekli ◽  
E. Bellikci-Koyu ◽  
H. Ozisik ◽  
D. Ongan ◽  
G. Ozgen
Keyword(s):  
Vitamin D ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Turkish Population ◽  
Autoimmune Thyroid

scholarly journals The association of autoimmune thyroid disease (AITD) with psoriatic disease: a prospective cohort study, systematic review and meta-analysis

2017 ◽  
Vol 177 (4) ◽  
pp. 347-359 ◽  
Author(s):  
Samer R Khan ◽  
Arjola Bano ◽  
Marlies Wakkee ◽  
Tim I M Korevaar ◽  
Oscar H Franco ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Thyroid Disease ◽  
Prospective Cohort ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Autoimmune Thyroid ◽  
Psoriatic Disease ◽  
Disease Definition

ObjectiveAutoimmune thyroid disease (AITD) and psoriatic disease share auto-immunological components. Few studies have investigated the link between both, yielding inconclusive results.DesignWe assessed the association of AITD with psoriatic disease in a prospective cohort study and performed a systematic review and meta-analysis.Methods8214 participants of the Rotterdam Study (RS) with thyroid peroxidase antibodies (TPO-Abs), thyroid-stimulating hormone (TSH) and/or free thyroxine (FT4) measurements and information on psoriatic disease were included. We performed logistic and Cox regression analyses and a systematic literature search in several electronic databases on AITD and psoriatic disease. We pooled odds ratios (ORs) of included studies using the Mantel-Haenszel method, while adding RS data on prevalent psoriatic disease.ResultsWithin the RS, we found no association between TPO-Ab positivity and psoriatic disease. There was a positive trend between TSH and prevalent psoriatic disease, and between FT4 and incident psoriatic disease, although not significant. Out of 1850 articles identified, seven were included in the systematic review and four in the meta-analysis. The risk of psoriatic disease (pooled OR) was 1.71 (confidence interval (CI): 1.27–2.31) for TPO-Ab positivity, 1.25 (CI: 1.14–1.37) for AITD and 1.34 (CI: 1.16–1.54) respectively, and 1.17 (CI: 1.03–1.32) for hypothyroidism and hyperthyroidism.ConclusionsOur meta-analysis suggests that TPO-Ab positivity, hypothyroidism and hyperthyroidism might be associated with prevalent psoriatic disease. However, there are only few studies with large heterogeneity regarding psoriatic disease definition and indication of publication bias. Additional prospective data are needed to assess the association of AITD with incident psoriatic disease.

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