scholarly journals Leucine Supplementation Accelerates Connective Tissue Repair of Injured Tibialis Anterior Muscle

Nutrients ◽  
2014 ◽  
Vol 6 (10) ◽  
pp. 3981-4001 ◽  
Author(s):  
Marcelo Pereira ◽  
Meiricris Silva ◽  
Eduardo Carlassara ◽  
Dawit Gonçalves ◽  
Paulo Abrahamsohn ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Tibialis Anterior ◽  
Tissue Repair ◽  
Tibialis Anterior Muscle ◽  
Leucine Supplementation ◽  
Connective Tissue Repair

scholarly journals Polymer fiber-based models of connective tissue repair and healing

Biomaterials ◽  
2017 ◽  
Vol 112 ◽  
pp. 303-312 ◽  
Author(s):  
Nancy M. Lee ◽  
Cevat Erisken ◽  
Thomas Iskratsch ◽  
Michael Sheetz ◽  
William N. Levine ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Tissue Repair ◽  
Polymer Fiber ◽  
Connective Tissue Repair

Mechanisms of TGF-beta action in connective tissue repair of rat mesenteric wounds

1995 ◽  
Vol 3 (3) ◽  
pp. 322-329 ◽  
Author(s):  
Lennart E. Franzen ◽  
Nayer Ghassemifar ◽  
Johnny Nordman ◽  
Gregory Schultz ◽  
Roger Skogman
Keyword(s):  
Connective Tissue ◽  
Tissue Repair ◽  
Tgf Beta ◽  
Connective Tissue Repair

The worsening of tibialis anterior muscle atrophy during recovery post-immobilization correlates with enhanced connective tissue area, proteolysis, and apoptosis

2012 ◽  
Vol 303 (11) ◽  
pp. E1335-E1347 ◽  
Author(s):  
Lamia Slimani ◽  
Didier Micol ◽  
Julien Amat ◽  
Geoffrey Delcros ◽  
Bruno Meunier ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Muscle Atrophy ◽  
Tibialis Anterior ◽  
Fiber Type ◽  
Tibialis Anterior Muscle ◽  
Recovery Period ◽  
Mrna Levels ◽  
Adult Rats ◽  
Extracellular Compartment ◽  
Nuclear Apoptosis

Sustained muscle wasting due to immobilization leads to weakening and severe metabolic consequences. The mechanisms responsible for muscle recovery after immobilization are poorly defined. Muscle atrophy induced by immobilization worsened in the lengthened tibialis anterior (TA) muscle but not in the shortened gastrocnemius muscle. Here, we investigated some mechanisms responsible for this differential response. Adult rats were subjected to unilateral hindlimb casting for 8 days (I8). Casts were removed at I8, and animals were allowed to recover for 10 days (R1 to R10). The worsening of TA atrophy following immobilization occurred immediately after cast removal at R1 and was sustained until R10. This atrophy correlated with a decrease in type IIb myosin heavy chain (MyHC) isoform and an increase in type IIx, IIa, and I isoforms, with muscle connective tissue thickening, and with increased collagen (Col) I mRNA levels. Increased Col XII, Col IV, and Col XVIII mRNA levels during TA immobilization normalized at R6. Sustained enhanced peptidase activities of the proteasome and apoptosome activity contributed to the catabolic response during the studied recovery period. Finally, increased nuclear apoptosis prevailed only in the connective tissue compartment of the TA. Altogether, the worsening of the TA atrophy pending immediate reloading reflects a major remodeling of its fiber type properties and alterations in the structure/composition of the extracellular compartment that may influence its elasticity/stiffness. The data suggest that sustained enhanced ubiquitin-proteasome-dependent proteolysis and apoptosis are important for these adaptations and provide some rationale for explaining the atrophy of reloaded muscles pending immobilization in a lengthened position.

scholarly journals Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Feini Qu ◽  
Julianne L. Holloway ◽  
John L. Esterhai ◽  
Jason A. Burdick ◽  
Robert L. Mauck
Keyword(s):  
Cell Migration ◽  
Connective Tissue ◽  
Tissue Repair ◽  
Direct Cell ◽  
Connective Tissue Repair
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