scholarly journals Dietary Zinc Deficiency Affects Blood Linoleic Acid: Dihomo-γ-linolenic Acid (LA:DGLA) Ratio; a Sensitive Physiological Marker of Zinc Status in Vivo (Gallus gallus)

Nutrients ◽  
2014 ◽  
Vol 6 (3) ◽  
pp. 1164-1180 ◽  
Author(s):  
Spenser Reed ◽  
Xia Qin ◽  
Rinat Ran-Ressler ◽  
James Brenna ◽  
Raymond Glahn ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Linolenic Acid ◽  
Zinc Deficiency ◽  
Gallus Gallus ◽  
Zinc Status ◽  
Dietary Zinc

Most biological effects of zinc deficiency corrected by γ-linolenic acid (18: 3ω6) but not by linoleic acid (18: 2ω6)

1982 ◽  
Vol 41 (2-3) ◽  
pp. 193-207 ◽  
Author(s):  
Y.S. Huang ◽  
S.C. Cunnane ◽  
D.F. Horrobin ◽  
J. Davignon
Keyword(s):  
Linoleic Acid ◽  
Linolenic Acid ◽  
Zinc Deficiency ◽  
Biological Effects

scholarly journals An initial evaluation of newly proposed biomarker of zinc status in humans - linoleic acid: dihomo-γ-linolenic acid (LA:DGLA) ratio

2016 ◽  
Vol 15 ◽  
pp. 85-92 ◽  
Author(s):  
Marija Knez ◽  
James C.R. Stangoulis ◽  
Manja Zec ◽  
Jasmina Debeljak-Martacic ◽  
Zoran Pavlovic ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Linolenic Acid ◽  
Initial Evaluation ◽  
Zinc Status

scholarly journals Updates on the Linoleic Acid: Dihomo-γ-Linolenic Acid Ratio (LA: DGLA)- as an Emerging Biomarker of Zinc Status (P24-019-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Elad Tako
Keyword(s):  
Linoleic Acid ◽  
Linolenic Acid ◽  
Serum Zinc ◽  
Significant Negative Correlation ◽  
Mean Value ◽  
World Health ◽  
Zn Deficiency ◽  
Acid Ratio ◽  
Zn Status

Abstract Objectives Zinc (Zn) deficiency is affecting 17% of the world's population. Although whole blood, plasma, and urine Zn decrease in severe Zn deficiency, accurate assessment of Zn status is difficult. Hence, as suggested by the World Health Organization, sensitive and specific biomarkers of Zn status are needed. Previously, we suggested the concept of the essential role of Zn for ∆6-desaturase activity. For the first time, we tested and implemented a previously unexplored biomarker of Zn status related to erythrocyte ∆6-desaturation, the LA: DGLA (linoleic acid: dihomo-γ-linolenic acid) ratio. We evaluated the sensitivity of the erythrocyte LA: DGLA ratio to changes in supplemental Zn intake. A significant negative correlation was found between dietary Zn deficiency and the LA: DGLA ratio. Our objective is to provide further and recent evidence to demonstrate that the LA: DGLA ratio is a useful and effective biomarker to assess Zn status. Methods The efficacy of the LA: DGLA ratio to predict the Zn status of subjects consuming a wheat-based diet, a representative diet of the target Zn-deficient populations, was evaluated in vivo (Gallus gallus). Two groups of birds (n = 15) were fed two different diets, a “high-Zn” diet (46.5 ppm Zn) and a “low-Zn” diet (32.8 ppm Zn), for 6 weeks. Dietary Zn intake, body weight, serum zinc, and the erythrocyte fatty acid profile were assessed. Results Serum and tissues (feather and nail) Zn concentrations were greater in the high-Zn group (P < 0.05). Duodenal expression of Zn transporters demonstrated a higher mean value in the tissues collected from the birds fed a low-Zn diet (n = 15, P < 0.05). Hepatic ∆6-desaturase expression showed a higher mean value in birds fed high-Zn diets (P < 0.05). LA: DGLA ratio was higher (P < 0.05) in the low-Zn group of birds at all-time points. Even though both groups of birds were fed Zn-deficient diets, with only 14 ppm differential in dietary Zn content, still the LA: DGLA ratio differentiated clearly between the groups, which demonstrates the sensitivity of the biomarker to change in accordance with dietary Zn intake. Conclusions Recent evidence demonstrate the potential of the LA: DGLA ratio to be used as an additional biomarker of Zn status in humans. To date, research shows that the LA: DGLA ratio corresponds to dietary Zn manipulations, both in animals and humans. Funding Sources USDA-ARS. Supporting Tables, Images and/or Graphs

scholarly journals In vivo Oxidation of .ALPHA.-Linolenic Acid and Linoleic Acid in Rats.

1996 ◽  
Vol 49 (6) ◽  
pp. 360-362
Author(s):  
Kenichi INUI ◽  
Hirotaka CHAKI ◽  
Yasuhiko FUKUTA ◽  
Yukifumi KOKUBA ◽  
Mikiko KATAOKA
Keyword(s):  
Linoleic Acid ◽  
Linolenic Acid ◽  
Alpha Linolenic Acid

Use of Serum Zinc Concentration as an Indicator of Population Zinc Status

2007 ◽  
Vol 28 (3_suppl3) ◽  
pp. S403-S429 ◽  
Author(s):  
Sonja Y. Hess ◽  
Janet M. Peerson ◽  
Janet C. King ◽  
Kenneth H. Brown
Keyword(s):  
Zinc Deficiency ◽  
Zinc Concentration ◽  
Zinc Supplementation ◽  
Serum Zinc ◽  
Interindividual Variation ◽  
Zinc Status ◽  
Dietary Zinc ◽  
Serum Zinc Concentration ◽  
Zinc Concentrations ◽  
Intervention Trials

Assessing the prevalence and severity of zinc deficiency in populations is critical to determine the need for and appropriate targeting of zinc intervention programs and to assess their effectiveness for improving the health and well-being of high-risk populations. However, there is very little information on the zinc status of populations worldwide due to the lack of consensus on appropriate biochemical indicators of zinc status. The objective of this review was to evaluate the use of serum zinc concentration as an indicator of population zinc status. We have reviewed the response of serum zinc concentration to dietary zinc restriction and zinc supplementation. In addition, we completed pooled analyses of nine zinc intervention trials in young children to assess the relations between serum zinc concentration of individuals before treatment and their responses to zinc supplementation. Also, in updated combined analyses of previously published data, we investigated the relation between the mean initial serum zinc concentration of a study population and their mean growth responses to zinc supplementation in randomized intervention trials among children. The results from depletion/repletion studies indicate that serum zinc concentrations respond appreciably to severe dietary zinc restriction, although there is considerable interindividual variation in these responses. There is also clear evidence that both individual and population mean serum zinc concentrations increase consistently during zinc supplementation, regardless of the initial level of serum zinc concentration. By contrast, an individual's serum zinc concentration does not reliably predict that person's response to zinc supplementation. Serum zinc concentration can be considered a useful biomarker of a population's risk of zinc deficiency and response to zinc interventions, although it may not be a reliable indicator of individual zinc status.

ALPHA-LINOLENIC ACID AND LINOLEIC ACID IN SERUM AND TISSUES AFTER FLAXSEED (Linum usitatissimum) OIL IN VIVO ADMINISTRATION

2009 ◽  
Vol 16 (3) ◽  
pp. 287-296 ◽  
Author(s):  
ROSSELLA AVALLONE ◽  
CECILIA RUSTICHELLI ◽  
ENRICO CAMPIOLI ◽  
FRANCESCA MARIA PIA NOTARANGELO ◽  
DANIELA BRAGHIROLI ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Linolenic Acid ◽  
Linum Usitatissimum ◽  
Alpha Linolenic Acid ◽  
In Vivo Administration
Sign in / Sign up

Export Citation Format

Share Document