scholarly journals Gut Microbiota as Potential Therapeutic Target for the Treatment of Cow’s Milk Allergy

Nutrients ◽  
2013 ◽  
Vol 5 (3) ◽  
pp. 651-662 ◽  
Author(s):  
Roberto Canani ◽  
Margherita Di Costanzo
Keyword(s):  
Gut Microbiota ◽  
Therapeutic Target ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Potential Therapeutic Target ◽  
Cow's Milk ◽  
Cow's Milk Allergy

scholarly journals Gut microbiota from infant with cow’s milk allergy promotes clinical and immune features of atopy in a murine model

Allergy ◽  
2019 ◽  
Vol 74 (9) ◽  
pp. 1790-1793
Author(s):  
Aurélie Mauras ◽  
Harm Wopereis ◽  
Intan Yeop ◽  
Nathalie Esber ◽  
Johanne Delannoy ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Murine Model ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy

scholarly journals Gut microbiota composition and butyrate production in children affected by non-IgE-mediated cow’s milk allergy

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Roberto Berni Canani ◽  
Francesca De Filippis ◽  
Rita Nocerino ◽  
Lorella Paparo ◽  
Carmen Di Scala ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Microbiota Composition ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Ige Mediated ◽  
Butyrate Production ◽  
Gut Microbiota Composition

scholarly journals Three Candidate Probiotic Strains Impact Gut Microbiota and Induce Anergy in Mice with Cow's Milk Allergy

2020 ◽  
Vol 86 (21) ◽  
Author(s):  
Nathalie Esber ◽  
Aurélie Mauras ◽  
Johanne Delannoy ◽  
Chantal Labellie ◽  
Camille Mayeur ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Content Type ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Probiotic Strains

ABSTRACT Cow’s milk allergy is a worldwide public health issue, especially since there is no effective treatment, apart from milk and dairy product avoidance. The aim of this study was to assess the beneficial role of three probiotic strains previously selected for their prophylactic properties in a mouse model of β-lactoglobulin allergy. Administration of Lactobacillus rhamnosus LA305, L. salivarius LA307, or Bifidobacterium longum subsp. infantis LA308 for 3 weeks post–sensitization and challenge modified the composition of the gut microbiota, with an increase in the Prevotella NK3B31 group and a decrease in Marvinbryantia, belonging to the Lachnospiraceae family. Although no impact on markers of sensitization was detected, modifications of foxp3, tgfβ, and il10 ileal gene expression, as well as plasma metabolomic alterations in the tryptophan pathway, were observed. Moreover, ex vivo studies showed that all probiotic strains induced significant decreases in cytokine production by β-lactoglobulin-stimulated splenocytes. Taken together, these results suggest that the three probiotic strains tested lead to alterations in immune responses, i.e., induction of a tolerogenic anergy and anti-inflammatory responses. This anergy could be linked to cecal microbiota modifications, although no impact on fecal short-chain fatty acid (SCFA) concentrations was detected. Anergy could also be linked to a direct impact of probiotic strains on dendritic cells, since costimulatory molecule expression was decreased following coincubation of these strains with bone marrow-derived dendritic cells (BMDCs). To conclude, all three candidate probiotic strains induced strain-specific gut microbiota and metabolic changes, which could potentially be beneficial for general health, as well as anergy, which could contribute to oral tolerance acquisition. IMPORTANCE We showed previously that three probiotic strains, i.e., Lactobacillus rhamnosus LA305, L. salivarius LA307, and Bifidobacterium longum subsp. infantis LA308, exerted different preventive effects in a mouse model of cow’s milk allergy. In this study, we evaluated their potential benefits in a curative mouse model of cow’s milk allergy. When administered for 3 weeks after the sensitization process and a first allergic reaction, none of the strains modified the levels of sensitization and allergic markers. However, all three strains affected gut bacterium communities and modified immune and inflammatory responses, leading to a tolerogenic profile. Interestingly, all three strains exerted a direct effect on dendritic cells, which are known to play a major role in food sensitization through their potentially tolerogenic properties and anergic responses. Taken together, these data indicate a potentially beneficial role of the probiotic strains tested in this model of cow’s milk allergy with regard to tolerance acquisition.

scholarly journals Infant gut microbiota is protective against cow's milk allergy in mice despite immature ileal T-cell response

2011 ◽  
Vol 79 (1) ◽  
pp. 192-202 ◽  
Author(s):  
Bertrand Rodriguez ◽  
Guenolée Prioult ◽  
Feriel Hacini-Rachinel ◽  
Deborah Moine ◽  
Anne Bruttin ◽  
...  
Keyword(s):  
T Cell ◽  
Gut Microbiota ◽  
Cell Response ◽  
T Cell Response ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy

scholarly journals Gut Microbiota Profile in Children with IgE-Mediated Cow’s Milk Allergy and Cow’s Milk Sensitization and Probiotic Intestinal Persistence Evaluation

2021 ◽  
Vol 22 (4) ◽  
pp. 1649
Author(s):  
Maurizio Mennini ◽  
Sofia Reddel ◽  
Federica Del Chierico ◽  
Simone Gardini ◽  
Andrea Quagliariello ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Bifidobacterium Longum ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Therapeutic Effects ◽  
Milk Allergy ◽  
Functional Changes ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Ige Mediated

Food allergy (FA) and, in particular, IgE-mediated cow’s milk allergy is associated with compositional and functional changes of gut microbiota. In this study, we compared the gut microbiota of cow’s milk allergic (CMA) infants with that of cow’s milk sensitized (CMS) infants and Healthy controls. The effect of the intake of a mixture of Bifidobacterium longum subsp. longum BB536, Bifidobacterium breve M-16V and Bifidobacterium longum subsp. infantis M-63 on gut microbiota modulation of CMA infants and probiotic persistence was also investigated. Gut microbiota of CMA infants resulted to be characterized by a dysbiotic status with a prevalence of some bacteria as Haemophilus, Klebsiella, Prevotella, Actinobacillus and Streptococcus. Among the three strains administered, B.longum subsp. infantis colonized the gastrointestinal tract and persisted in the gut microbiota of infants with CMA for 60 days. This colonization was associated with perturbations of the gut microbiota, specifically with the increase of Akkermansia and Ruminococcus. Multi-strain probiotic formulations can be studied for their persistence in the intestine by monitoring specific bacterial probes persistence and exploiting microbiota profiling modulation before the evaluation of their therapeutic effects.

Effect of lactose on gut microbiota and metabolome of infants with cow’s milk allergy

2012 ◽  
Vol 23 (5) ◽  
pp. 420-427 ◽  
Author(s):  
Ruggiero Francavilla ◽  
Maria Calasso ◽  
Laura Calace ◽  
Sonya Siragusa ◽  
Maurice Ndagijimana ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy

MARKERS OF COW’S MILK ALLERGY PERSISTENCE: RESULTS OF A 5-YEAR FOLLOW-UP

2020 ◽  
Vol 99 (2) ◽  
pp. 88-95
Author(s):  
S.G. Makarova ◽  
◽  
A.A. Galimova ◽  
A.P. Fisenko ◽  
O.A. Ereshko ◽  
...  
Keyword(s):  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy
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