scholarly journals Evidence of Associations Between Feto-Maternal Vitamin D Status, Cord Parathyroid Hormone and Bone-Specific Alkaline Phosphatase, and Newborn Whole Body Bone Mineral Content

Nutrients ◽  
2012 ◽  
Vol 4 (2) ◽  
pp. 68-77 ◽  
Author(s):  
Daphna K. Dror ◽  
Janet C. King ◽  
Ellen B. Fung ◽  
Marta D. Van Loan ◽  
Erik R. Gertz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Mineral Content ◽  
Whole Body ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Specific Alkaline Phosphatase ◽  
Bone Specific Alkaline Phosphatase ◽  
Maternal Vitamin D Status ◽  
Body Bone

scholarly journals Association of maternal vitamin D status during pregnancy with bone-mineral content in offspring: a prospective cohort study

The Lancet ◽  
2013 ◽  
Vol 381 (9884) ◽  
pp. 2176-2183 ◽  
Author(s):  
Debbie A Lawlor ◽  
Andrew K Wills ◽  
Abigail Fraser ◽  
Adrian Sayers ◽  
William D Fraser ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Mineral Content ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Maternal Vitamin D Status

scholarly journals Maternal vitamin D status during pregnancy and bone-mineral content in offspring

The Lancet ◽  
2013 ◽  
Vol 382 (9894) ◽  
pp. 766 ◽  
Author(s):  
Nicholas C Harvey ◽  
M Kassim Javaid ◽  
Hazel M Inskip ◽  
Keith M Godfrey ◽  
Cyrus Cooper
Keyword(s):  
Vitamin D ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Maternal Vitamin D Status

Vitamin D Status and Indices of Bone Turnover in Older European Adults

2011 ◽  
Vol 81 (5) ◽  
pp. 277-285 ◽  
Author(s):  
Kelly M. Seamans ◽  
Tom R. Hill ◽  
Lisa Scully ◽  
Nathalie Meunier ◽  
Maude Andrillo-Sanchez ◽  
...  
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Bone Turnover ◽  
Serum Markers ◽  
Vitamin D Status ◽  
Specific Alkaline Phosphatase ◽  
Bone Specific Alkaline Phosphatase ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Elevated Rate

An increased rate of bone turnover increases risk of osteoporotic fracture later in life. The concentration of 25-hydroxyvitamin D that contributes to an elevated rate of bone turnover in older adults is unclear. The objective of this study was to investigate the associations between 25-hydroxyvitamin D and biochemical markers of bone turnover in an older, pan-European cohort. 25-hydroxyvitamin D and serum markers of bone-formation (osteocalcin and bone-specific alkaline phosphatase) were assessed by ELISA, while urinary markers of bone-resorption (pyridinoline and deoxypyridinoline) were assessed by HPLC. Six percent, 36 %, and 64 % of subjects had 25-hydroxyvitamin D concentrations < 25, < 50, and < 80 nmol/L throughout the year, respectively. 25-hydroxyvitamin D was significantly and inversely correlated with serum bone-specific alkaline phosphatase (r = 0.119; p = 0.022) and urinary pyridinoline (r = 0.207; p < 0.0001) and deoxypyridinoline (r = 0.230; p < 0.0001). Stratification on the basis of tertiles [T] of 25-hydroxyvitamin D (< 47.6 [T1]; 47.6 - 85.8 [T2]; > 85.8 [T3] nmol/L), showed that urinary pyridinoline and deoxypyridinoline were significantly lower in subjects in the 2nd and 3rd compared to the 1st tertile (p < 0.015). Low vitamin D status (< 50 nmol/L) was associated with an increased rate of bone turnover in this older pan-European cohort.

Maternal vitamin D status during pregnancy and bone-mineral content in offspring – Authors' reply

The Lancet ◽  
2013 ◽  
Vol 382 (9894) ◽  
pp. 767-768 ◽  
Author(s):  
Debbie A Lawlor ◽  
Andrew K Wills ◽  
Abigail Fraser ◽  
William D Fraser ◽  
Jonathan H Tobias
Keyword(s):  
Vitamin D ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Maternal Vitamin D Status

scholarly journals Interrelationships Among Vitamin D Status and Body Composition in Mother-Infant Dyads

2021 ◽  
Author(s):  
Maryam Razaghi ◽  
Nathalie Gharibeh ◽  
Catherine A. Vanstone ◽  
Olusola F. Sotunde ◽  
Shu Qin Wei ◽  
...  
Keyword(s):  
Vitamin D ◽  
Body Composition ◽  
Fat Mass ◽  
Weight Status ◽  
Whole Body ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Neonatal Adiposity ◽  
Maternal Vitamin D Status ◽  
Maternal Adiposity

Abstract Background: Vitamin D status of pregnant women is associated with body composition of the offspring. The objective of this study was to assess whether the association between maternal vitamin D status and neonatal adiposity is modified by maternal adiposity preconception.Methods: Healthy mothers and their term appropriate weight for gestational age (AGA) infants (n=142; 59% male, Greater Montreal, March 2016-2019) were studied at birth and 1 month postpartum (2-6 weeks). Newborn (24-36 hour) serum was collected to measure total 25-hydroxyvitamin D [25(OH)D] (immunoassay); maternal pre-pregnancy BMI was obtained from the medical record. Anthropometry, body composition (dual-energy X-ray absorptiometry) and serum 25(OH)D were measured at 2-6 weeks postpartum in mothers and infants. Mothers were grouped into 4 categories based on their vitamin D status (sufficient 25(OH)D ≥50 nmol/L vs. at risk of being insufficient <50 nmol/L) and pre-pregnancy BMI (<25 vs. ≥25 kg/m2): insufficient-recommended weight (I-RW, n=24); insufficient-overweight/obese (I-OW/O, n=21); sufficient-recommended weight (S-RW, n=69); and sufficient-overweight/obese (S-OW/O, n=28). Partial correlation and mixed model ANOVA were used while adjusting for covariates.Results: At birth, infant serum 25(OH)D mean concentrations were below the cut-point for sufficiency of 50 nmol/L for both maternal pre-pregnancy BMI categories; 47.8 [95%CI: 43.8, 51.9] nmol/L if BMI <25 kg/m2 and 38.1 [95%CI: 33.5, 42.7] nmol/L if BMI ≥25 kg/m2. Infant serum 25(OH)D concentrations at birth (r=0.77; p<0.0001) and 1 month (r=0.59, p<0.0001) were positively correlated with maternal postpartum serum 25(OH)D concentrations. Maternal serum 25(OH)D concentration was inversely associated with maternal percent whole body fat mass (r=-0.26, p=0.002). Infants of mothers in I-OW/O had higher fat mass versus those of mothers in S-OW/O (914.0 [95%CI: 766.4, 1061.6] vs. 780.7 [95%CI: 659.3, 902.0] g; effect size [Hedges' g: 0.42]; p=0.04) with magnitude of difference of 220.4 g or ~28% difference (adjusting for covariates). Conclusions: Maternal vitamin D status is positively correlated with neonatal vitamin D. In this study, maternal adiposity and serum 25(OH)D <50 nmol/L are dual exposures for neonatal adiposity. These findings reinforce the importance of vitamin D supplementation early in infancy irrespective of vitamin D stores acquired in utero and maternal weight status.

scholarly journals Maternal Vitamin D Status Determines Bone Variables in the Newborn

2010 ◽  
Vol 95 (4) ◽  
pp. 1749-1757 ◽  
Author(s):  
H. T. Viljakainen ◽  
E. Saarnio ◽  
T. Hytinantti ◽  
M. Miettinen ◽  
H. Surcel ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Mineral ◽  
Mineral Content ◽  
First Trimester ◽  
Vitamin D Status ◽  
Mineral Density ◽  
Cross Sectional ◽  
Maternal Vitamin ◽  
The Mean ◽  
Maternal Vitamin D Status

Abstract Context: Vitamin D regulates 3% of the human genome, including effects on bone health throughout life. Maternal vitamin D status may program neonatal skeletal development. The objective here was to determine the association of mothers’ vitamin D status with bone variables of their newborns. Subjects and Methods: In a birth hospital, pregnant women (n = 125) participated in a cross-sectional study with a longitudinal follow-up of the pregnancy. The mean (sd) values for age, body mass index before pregnancy, pregnancy weight gain, and total vitamin D intake in mothers were 31 (4) yr, 23.5 (3.7) kg/m2, 13.1 (4.3) kg, and 14.3 (5.8) μg, respectively. All newborns were full-term, 99% were appropriate for gestational age, and 53% were boys. Blood samples were collected from mothers during the first trimester and 2 d postpartum and from umbilical cords at birth for analysis of serum 25-hydroxyvitamin D (S-25-OHD), PTH, and bone remodeling markers. Bone variables were measured by pQCT at the 20% site of the newborn tibia on an average of 10 (11) d postpartum. Bone contour was analyzed with a single threshold of 180 mg/mm3 for the detection of total bone mineral density (BMD), bone mineral content (BMC), and cross-sectional area (CSA). Results: Mean S-25-OHD was 41.0 (13.6), 45.1 (11.9), and 50.7 (14.9) nmol/liter during the first trimester, postpartum, and in the umbilical cord, respectively. The median value of the individual means for first trimester and the 2-d postpartum S-25-OHD was 42.6 nmol/liter, which was used as cutoff to define two equal-sized groups. Groups are called below median and above median in the text. Newborns below median were heavier (P = 0.05), and 60% were boys. Tibia bone mineral content was 0.047 (95% confidence interval, 0.011–0.082) g/cm higher (P = 0.01), and cross-sectional area was 12.3 (95% confidence interval, 2.0–22.6) mm2 larger (P = 0.02), but no difference in bone mineral density was observed, above median compared with below median group. These results were adjusted for newborn Z-score birth weight, maternal height, and newborn age at the measurement. A positive, significant correlation was observed between remodeling markers in mothers at different time points and above median group in the cord. Conclusions: Although the mean total intake of vitamin D among mothers met current Nordic recommendations, 71% of women and 15% of newborns were vitamin D deficient during the pregnancy. Our results suggest that maternal vitamin D status affects bone mineral accrual during the intrauterine period and influences bone size. More efforts should be made to revise current nutrition recommendations for pregnant women that may have permanent effects on the well-being of children.

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