scholarly journals Human Folate Bioavailability

Nutrients ◽  
2011 ◽  
Vol 3 (4) ◽  
pp. 475-490 ◽  
Author(s):  
Veronica E. Ohrvik ◽  
Cornelia M. Witthoft
Keyword(s):  
Folate Bioavailability

scholarly journals Folate bioavailability from foods rich in folates assessed in a short term human study using stable isotope dilution assays

2015 ◽  
Vol 6 (1) ◽  
pp. 241-247 ◽  
Author(s):  
Sabine Mönch ◽  
Michael Netzel ◽  
Gabriele Netzel ◽  
Undine Ott ◽  
Thomas Frank ◽  
...  
Keyword(s):  
Stable Isotope ◽  
Isotope Dilution ◽  
Human Study ◽  
Short Term ◽  
Standard Definition ◽  
Stable Isotope Dilution ◽  
Stable Isotope Dilution Assays ◽  
Folate Bioavailability ◽  
Definition Of ◽  
Different Sources

Different sources of folate may have different bioavailability and hence may impact the standard definition of folate equivalents.

Folate Bioavailability

2009 ◽  
pp. 25-47 ◽  
Author(s):  
Helene McNulty ◽  
Kristina Pentieva
Keyword(s):  
Folate Bioavailability

scholarly journals Intestinal absorption of different types of folate in healthy subjects with an ileostomy

2002 ◽  
Vol 88 (3) ◽  
pp. 235-242 ◽  
Author(s):  
Erik J. M. Konings ◽  
Freddy J. Troost ◽  
Jacqueline J. M. Castenmiller ◽  
Harry H. S. Roomans ◽  
Piet A. van den Brandt ◽  
...  
Keyword(s):  
Folic Acid ◽  
Folate Intake ◽  
Limiting Factor ◽  
Short Term ◽  
Relative Absorption ◽  
Different Types ◽  
The Difference ◽  
Folate Bioavailability ◽  
Serum Response ◽  
Food Folate

Our knowledge on the absorption of folate is incomplete. The deconjugation process as a possible limiting factor in the absorption of folates was investigated. The study also attempted to validate the use of the area under the serum response curve (AUC) from food compared with folic acid as a proxy variable for food folate bioavailability. Folate absorption was determined in healthy ileostomy volunteers (n11) using a single-dose short-term protocol. In a randomised crossover design, volunteers received spinach meals and a supplement. Based on analysis of test meals and ileostomy effluents, there was no difference in folate absorption between spinach with a mono-:polyglutamate ratio 40:60 and the same spinach with a 100:0 ratio. The absolute absorption of spinach folate (79 %) calculated from the difference between folate intake and folate content of ileostomy effluents was approximately equal to the relative absorption (81 %) calculated from the AUC after consumption of spinach meals in relation to the AUC after consumption of the folic acid supplement. We conclude that the deconjugation process is not a limiting factor in the absorption of spinach folates. Comparison of AUC of food folatev.folic acid in a short-term protocol may be suitable for assessing food folate bioavailability.

Folate bioavailability: UK Food Standards Agency workshop report

2003 ◽  
Vol 90 (2) ◽  
pp. 473-479 ◽  
Author(s):  
Peter Sanderson ◽  
Helene McNulty ◽  
Pierpaolo Mastroiacovo ◽  
Ian F. W. McDowell ◽  
Alida Melse-Boonstra ◽  
...  
Keyword(s):  
Folic Acid ◽  
Weighted Average ◽  
Relative Bioavailability ◽  
Evidence Base ◽  
Future Research ◽  
Workshop Report ◽  
Food Standards ◽  
Folate Bioavailability ◽  
The Uk ◽  
Review Current

The UK Food Standards Agency convened a group of expert scientists to review current research investigating folate bioavailability. The workshop aimed to overview current research and establish priorities for future research. Discrepancies were observed in the evidence base for folate bioavailability, especially with regard to the relative bioavailability of natural folates compared with folic acid. A substantial body of evidence shows folic acid to have superior bioavailability relative to food folates; however, the exact relative bioavailability still needs to be determined, and in particular with regard to mixed diets. The bioavailability of folate in a mixed diet is probably not a weighted average of that in the various foods consumed; thus the workshop considered that assessment of folate bioavailability of whole diets should be a high priority for future research.

scholarly journals Case Study: Folate Bioavailability

2001 ◽  
Vol 131 (4) ◽  
pp. 1376S-1382S ◽  
Author(s):  
Jesse F. Gregory
Keyword(s):  
Folate Bioavailability

scholarly journals Effect of cow milk on food folate bioavailability in young women

2004 ◽  
Vol 80 (6) ◽  
pp. 1565-1569 ◽  
Author(s):  
Mary Frances Picciano ◽  
Sheila G West ◽  
Amanda L Ruch ◽  
Penny M Kris-Etherton ◽  
Guixiang Zhao ◽  
...  
Keyword(s):  
Young Women ◽  
Cow Milk ◽  
Folate Bioavailability ◽  
Food Folate

scholarly journals Is there more to folates than neural-tube defects?

2003 ◽  
Vol 62 (3) ◽  
pp. 591-598 ◽  
Author(s):  
Paul M. Finglas ◽  
Anthony J. A. Wright ◽  
Caroline A. Wolfe ◽  
David J. Hart ◽  
Dawn M. Wright ◽  
...  
Keyword(s):  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Gene Polymorphisms ◽  
Common Gene ◽  
Folate Status ◽  
Health And Disease ◽  
Precision And Accuracy ◽  
Folate Bioavailability ◽  
B Vitamin

The purpose of the present paper is to review our current understanding of the chemistry and biochemistry of folic acid and related folates, and to discuss their impact on public health beyond that already established in relation to neural-tube defects. Our understanding of the fascinating world of folates and C1metabolism, and their role in health and disease, has come a long way since the discovery of the B-vitamin folic acid by Wills (1931), and its first isolation by Mitchellet al. (1941). However, there is still much to do in perfecting methods for the measurement of folate bioavailability, and status, with a high extent of precision and accuracy. Currently, examination of the relationships between common gene polymorphisms involved in C1metabolism and folate bioavailability and folate status, morbidity, mortality and longevity is evaluated as a series of individual associations. However, in the future, examination of the concurrent effects of such common gene polymorphisms may be more beneficial.

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