scholarly journals Early Life and Nutrition and Allergy Development

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 282
Author(s):  
Yvan Vandenplas
Keyword(s):  
Allergic Disease ◽  
Early Life

Much evidence has been accumulated over recent years on the importance of the first 1000 days of a child’s life, starting from conception to the postnatal age of two years, with regard to the risk of developing allergic disease [...]

scholarly journals Ratio of Klebsiella/Bifidobacterium in early life correlates with later development of paediatric allergy

2017 ◽  
Vol 8 (5) ◽  
pp. 681-695 ◽  
Author(s):  
J.S.Y. Low ◽  
S.-E. Soh ◽  
Y.K. Lee ◽  
K.Y.C. Kwek ◽  
J.D. Holbrook ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Allergic Disease ◽  
Early Life ◽  
16S Rrna Gene Sequencing ◽  
Early Infancy ◽  
Rrna Gene ◽  
Microbial Composition ◽  
Healthy Infants ◽  
Increased Risk ◽  
Paediatric Allergy

Several studies have reported that intestinal microbial colonisation patterns differ between non-allergic and allergic infants. However, the microbial signature underlying the pathogenesis of allergies remains unclear. We aim to gain insight into the development of the intestinal microbiota of healthy infants and infants who develop allergy in early life, and identify potential microbiota biomarkers of later allergic disease. Using a case-control design in a Chinese sub-cohort of a Singaporean birth cohort (GUSTO), we utilised 16S rRNA gene sequencing to assess intestinal microbial composition and diversity of 21 allergic and 18 healthy infants at 3 weeks, 3 months and 6 months of age, and correlated the microbiota with allergy at ages 18 and 36 months. Pronounced differences in intestinal microbiota composition between allergic and healthy infants were observed at 3 months of age. The intestine of healthy infants was colonised with higher abundance of commensal Bifidobacterium. Conversely, Klebsiella, an opportunistic pathogen, was significantly enriched in the allergic infants. Interestingly, infants with a high Klebsiella/Bifidobacterium (K/B) ratio (above the population median K/B ratio) at age 3 months had an odds ratio of developing allergy by 3 years of age of 9.00 (95% confidence interval 1.46-55.50) compared to those with low K/B ratio. This study demonstrated a relationship between the ratio of genera Klebsiella and Bifidobacterium during early infancy and development of paediatric allergy in childhood. Our study postulates that an elevated K/B ratio in early infancy could be a potential indicator of an increased risk of allergy development. This line of research might enable future intervention strategies in early life to prevent or treat allergy. Our study provides new insights into microbial signatures associated with childhood allergy, in particular, suggests that an elevated K/B ratio could be a potential early-life microbiota biomarker of allergic disease.

TLR Activation and Allergic Disease: Early Life Microbiome and Treatment

2018 ◽  
Vol 18 (11) ◽  
Author(s):  
Kathryn R. Michels ◽  
Nicholas W. Lukacs ◽  
Wendy Fonseca
Keyword(s):  
Allergic Disease ◽  
Early Life

scholarly journals The Role of the Early-Life Environment in the Development of Allergic Disease

2015 ◽  
Vol 35 (1) ◽  
pp. 1-17 ◽  
Author(s):  
Ganesa Wegienka ◽  
Edward Zoratti ◽  
Christine Cole Johnson
Keyword(s):  
Allergic Disease ◽  
Early Life ◽  
Early Life Environment

Prenatal and early-life predictors of atopy and allergic disease in Canadian children: results of the Family Atherosclerosis Monitoring In earLY life (FAMILY) Study

2016 ◽  
Vol 7 (6) ◽  
pp. 665-671 ◽  
Author(s):  
T. Batool ◽  
P. L. Reece ◽  
K. M. Schulze ◽  
K. M. Morrison ◽  
S. A. Atkinson ◽  
...  
Keyword(s):  
Food Allergy ◽  
Birth Cohort ◽  
Allergic Disease ◽  
Early Life ◽  
Skin Prick Testing ◽  
Allergic Diseases ◽  
Population Based ◽  
Life Study ◽  
The Family ◽  
Study Population

Prenatal and early-life environmental exposures play a key role in the development of atopy and allergic disease. The Family Atherosclerosis Monitoring In earLY life Study is a general, population-based Canadian birth cohort that prospectively evaluated prenatal and early-life traits and their association with atopy and/or allergic disease. The study population included 901 babies, 857 mothers and 530 fathers. Prenatal and postnatal risk factors were evaluated through questionnaires collected during the antenatal period and at 1 year. The end points of atopy and allergic diseases in infants were evaluated through questionnaires and skin prick testing. Key outcomes included atopy (24.5%), food allergy (17.5%), cow’s milk allergy (4.8%), wheezing (18.6%) and eczema (16%). The association between infant antibiotic exposure [odds ratio (OR): 2.04, 95% confidence interval (CI): 1.45–2.88] and increased atopy was noted in the multivariate analysis, whereas prenatal maternal exposure to dogs (OR: 0.60, 95% CI: 0.42–0.84) and acetaminophen (OR: 0.68, 95% CI: 0.51–0.92) was associated with decreased atopy. This population-based birth cohort in Canada demonstrated high rates of atopy, food allergy, wheezing and eczema. Several previously reported and some novel prenatal and postnatal exposures were associated with atopy and allergic diseases at 1 year of age.

scholarly journals Effects of Early Life Paracetamol Use on the Incidence of Allergic Disease and Sensitization: 5 Year Follow-Up of an Ethiopian Birth Cohort

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e93869 ◽  
Author(s):  
Alemayehu Amberbir ◽  
Girmay Medhin ◽  
Charlotte Hanlon ◽  
John Britton ◽  
Gail Davey ◽  
...  
Keyword(s):  
Birth Cohort ◽  
Allergic Disease ◽  
Early Life
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