scholarly journals Esophageal Eosinophilia and Eosinophilic Esophagitis in Celiac Children: A Ten Year Prospective Observational Study

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3755
Author(s):  
Fernanda Cristofori ◽  
Fulvio Salvatore D’Abramo ◽  
Vincenzo Rutigliano ◽  
Vanessa Nadia Dargenio ◽  
Stefania Castellaneta ◽  
...  
Keyword(s):  
Celiac Disease ◽  
General Population ◽  
Observational Study ◽  
Eosinophilic Esophagitis ◽  
Odds Ratio ◽  
Prospective Observational Study ◽  
Disease Diagnosis ◽  
International Consensus ◽  
Esophageal Eosinophilia ◽  
Celiac Disease Diagnosis

The association between eosinophilic esophagitis and celiac disease is still controversial and its prevalence is highly variable. We aimed to investigate the prevalence of esophageal eosinophilia and eosinophilic esophagitis in a large group of children with celiac disease, prospectively followed over 11 years. Methods: Prospective observational study performed between 2008 and 2019. Celiac disease diagnosis was based on ESPGHAN criteria. At least four esophageal biopsies were sampled in patients who underwent endoscopy. The presence of at least 15 eosinophils/HPF on esophageal biopsies was considered suggestive of esophageal eosinophilia; at the same time, eosinophilic esophagitis was diagnosed according to the International Consensus Diagnostic Criteria for Eosinophilic Esophagitis. Results: A total of 465 children (M 42% mean age 7.1 years (range: 1–16)) were diagnosed with celiac disease. Three hundred and seventy patients underwent endoscopy, and esophageal biopsies were available in 313. The prevalence of esophageal eosinophilia in children with celiac disease was 1.6% (95% CI: 0.54–2.9%). Only one child was diagnosed as eosinophilic esophagitis; we calculated a prevalence of 0.3% (95% CI: 0.2–0.5%). The odds ratio for an association between eosinophilic esophagitis and celiac disease was at least 6.5 times higher (95% CI: 0.89–47.7%; p = 0.06) than in the general population. Conclusion: The finding of an increased number of eosinophils (>15/HPF) in celiac patients does not have a clinical implication or warrant intervention, and therefore we do not recommend routine esophageal biopsies unless clinically indicated.

scholarly journals LOW BONE MINERAL DENSITY IN BRAZILIAN PATIENTS AT DIAGNOSIS OF CELIAC DISEASE

2015 ◽  
Vol 52 (3) ◽  
pp. 176-179 ◽  
Author(s):  
Joyce Timmermans Pires da SILVA ◽  
Renato M NISIHARA ◽  
Luís Roberto KOTZE ◽  
Márcia OLANDOSKI ◽  
Lorete Maria da Silva KOTZE
Keyword(s):  
Bone Mineral Density ◽  
Celiac Disease ◽  
Bone Mineral ◽  
Disease Diagnosis ◽  
Bone Fragility ◽  
Mineral Density ◽  
X Ray ◽  
Low Bone Mineral Density ◽  
Celiac Disease Diagnosis ◽  
Male Subjects

BackgroundLow bone mineral density is considered an extra-intestinal manifestation of celiac disease with reduced bone mass, increased bone fragility, and risk of fractures. Celiac disease is considered a condition at high risk for secondary osteoporosis and the evaluation of bone density is very important in the clinical management of these patients.ObjectiveThe present study aimed to investigate bone alterations in celiac patients from Curitiba, South Region of Brazil at diagnosis, correlating the findings with age and gender.MethodsPatients who were included in the study were attended to in a private office of the same physician from January 2009 to December 2013. The diagnosis of celiac disease was done through clinical, serological and histological findings. All data were collected from the medical charts of the patients. After the diagnosis of celiac disease, evaluation for low bone mineral density was requested by dual-energy X-ray absorptiometry (DEXA). DEXA bone densitometer was used to estimate low bone mineral density at the lumbar spine and femur.ResultsA total of 101 patients, 82 (81.2%) female and 19 (18.8%) male subjects, with mean age of 39.0±3.03 years were included. At celiac disease diagnosis, 36 (35.6%) were younger than 30 years, 41 (40.6%) were between 31 and 50 years, and 24 (23.8%) were older than 50 years. Among the evaluated patients, 69 (68.3%) presented low bone mineral density, being 47% with osteopenia and 32% with osteoporosis. Patients who were older than 51 years and diagnosed with celiac disease presented low bone mineral density in 83.3% (20/24) of the cases. As expected, age influenced significantly the low bone mineral density findings. Among women, low bone mineral density was present with high frequency (60%) from 30 to 50 years. In patients diagnosed older than 60 years (n=8), all the women (n=5) and two of the three men had osteoporosis.ConclusionThis study demonstrated that 69% of Brazilian patients with celiac disease at diagnosis had low bone mineral density, being more frequent in women older than 50 years.

OC3.05.1 CELIAC DISEASE DIAGNOSIS: HAS THE TIME COME TO CHANGE THE GOLD STANDARD?

2008 ◽  
Vol 40 ◽  
pp. S48-S49
Author(s):  
A. Picarelli ◽  
M. Greco ◽  
G. Donato ◽  
D. De Nitto ◽  
V. Libanori ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Gold Standard ◽  
Disease Diagnosis ◽  
Celiac Disease Diagnosis

scholarly journals Computer-aided texture analysis combined with experts' knowledge: Improving endoscopic celiac disease diagnosis

2016 ◽  
Vol 22 (31) ◽  
pp. 7124 ◽  
Author(s):  
Michael Gadermayr ◽  
Hubert Kogler ◽  
Maximilian Karla ◽  
Dorit Merhof ◽  
Andreas Uhl ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Texture Analysis ◽  
Disease Diagnosis ◽  
Computer Aided ◽  
Celiac Disease Diagnosis

scholarly journals Serum transglutaminase 3 antibodies correlate with age at celiac disease diagnosis

2016 ◽  
Vol 48 (6) ◽  
pp. 632-637 ◽  
Author(s):  
Teea T. Salmi ◽  
Kalle Kurppa ◽  
Kaisa Hervonen ◽  
Kaija Laurila ◽  
Pekka Collin ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Disease Diagnosis ◽  
Celiac Disease Diagnosis ◽  
Transglutaminase 3

scholarly journals Smoking in pregnancy, cord blood cotinine and risk of celiac disease diagnosis in offspring

2019 ◽  
Vol 34 (7) ◽  
pp. 637-649 ◽  
Author(s):  
Karl Mårild ◽  
German Tapia ◽  
Øivind Midttun ◽  
Per M. Ueland ◽  
Maria C. Magnus ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Cord Blood ◽  
Disease Diagnosis ◽  
Smoking In Pregnancy ◽  
Celiac Disease Diagnosis ◽  
In Pregnancy
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