scholarly journals The Role of Nutritional Status on Polypharmacy, Cognition, and Functional Capacity of Institutionalized Elderly: A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3477
Author(s):  
Catarina Caçador ◽  
Edite Teixeira-Lemos ◽  
Sofia Oliveira Martins ◽  
Fernando Ramos
Keyword(s):  
Systematic Review ◽  
Nutritional Status ◽  
Cognitive Decline ◽  
Functional Capacity ◽  
Functional Performance ◽  
Functional Decline ◽  
Population Data ◽  
Strong Impact ◽  
Institutionalized Elderly ◽  
The Impact

Adequate nutritional status is necessary for the proper management of polypharmacy, the prevention of cognitive decline, and the maintenance of functional capacity in activities of daily living. Although several studies validate this fact for the general elderly population, data on institutionalized seniors concerning this relation are scarce. A systematic review was performed according to the PRISMA guidelines, aiming to study the potential correlation between nutritional status and polypharmacy, cognitive decline, and functional performance in institutionalized elders. The search was limited to studies in English or Portuguese in the last decade. Inclusion criteria relied on the PICO method. Five studies explored the relationship of nutritional status with cognitive performance in the institutionalized elderly, and nine prospective observational studies reported significant positive associations between appropriate nutritional status and physical abilities. Nutritional status was primarily measured by MNA. Adequate nutritional status was described as an important parameter in preventing cognitive and functional decline in the institutionalized elderly. No studies were found describing the impact of nutritional status on the prevention of polypharmacy. Given the strong impact of malnutrition found in the studies in cognition and functional abilities in the institutionalized elderly, an evaluation of nutritional status of the elders is crucial to prevent health problems and allow early intervention programs in order to further prevent health decline.

scholarly journals The Ipsilesional Upper Limb Can Be Affected following Stroke

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Gemma H. Kitsos ◽  
Isobel J. Hubbard ◽  
Alex R. Kitsos ◽  
Mark W. Parsons
Keyword(s):  
Systematic Review ◽  
Upper Limb ◽  
Functional Capacity ◽  
Control Measure ◽  
Research Question ◽  
Neurological Dysfunction ◽  
Inclusion Criteria ◽  
Data Source ◽  
The Impact ◽  
The Brain

Objective. Neurological dysfunction commonly occurs in the upper limb contralateral to the hemisphere of the brain in which stroke occurs; however, the impact of stroke on function of the ipsilesional upper limb is not well understood. This study aims to systematically review the literature relating to the function of the ipsilesional upper limb following stroke and answer the following research question: Is the ipsilesional upper limb affected by stroke?Data Source. A systematic review was carried out in Medline, Embase, and PubMed.Review Methods. All studies investigating the ipsilesional upper limb following stroke were included and analysed for important characteristics. Outcomes were extracted and summarised.Results. This review captured 27 articles that met the inclusion criteria. All studies provided evidence that the ipsilesional upper limb can be affected following stroke.Conclusion. These findings demonstrate that clinicians should consider ipsilesional upper limb deficits in rehabilitation and address this reduced functional capacity. Furthermore, the ipsilesional upper limb should not be used as a “control” measure of recovery for the contralateral upper limb.

Adverse effects of ADT on cognitive function and dementia for men with prostate cancer: A meta-analysis and systematic review.

2017 ◽  
Vol 35 (6_suppl) ◽  
pp. 150-150 ◽  
Author(s):  
Maxine Sun ◽  
Alexander Cole ◽  
Nawar Hanna ◽  
Adam S. Kibel ◽  
Toni K. Choueiri ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
English Language ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Cochrane Library ◽  
Significant Heterogeneity ◽  
The Impact

150 Background: Nearly 50% of men diagnosed with prostate cancer may receive treatment with some form of androgen deprivation therapy (ADT). While some side effects of ADT are well acknowledged, the specific impact of ADT on cognitive function is uncertain. Our objective was to perform a systematic review and meta-analysis assessing the impact of ADT on overall cognitive decline, and the risks of Alzheimers, Parkinson’s disease. Methods: Relevant studies were identified through search of English language articles indexed in PubMed Medline, PsycINFO, Cochrane Library and Web of Knowledge/Science. First, we assessed rates of cognitive decline in five cohorts from three studies. Second, we assessed rates of Alzheimer’s or Parkinson disease using three large retrospective studies. A pooled-analysis was conducted using a meta-analysis. Weighted averages were reported as odds ratios (OR) with 95% confidence intervals (CI) using RevMan and a DerSimonian and Laird random-effects model. The heterogeneity test was measured using the Q-Mantel-Haenszel ( P< 0.10 was considered of significant heterogeneity). Results: With respect to overall cognitive decline (defined as scoring 1.5 standard deviations [SD] in two or more objective cognitive tests), patients receiving ADT had higher odds of overall cognitive decline than patients with prostate cancer not treated with ADT or health controls (OR: 2.03, 95% CI: 1.42–2.90). Furthermore, men with a history of ADT for prostate cancer had higher odds of developing Alzheimer’s and Parkinson dementia compared to men with prostate cancer not treated with ADT (OR: 1.32, 95% CI: 1.27–1.37). Conclusions: Men receiving ADT for prostate cancer performed significantly worse on measures of overall cognitive function. Additionally, results from the three large observational trials included suggest men exposed to ADT for prostate cancer have higher rates of Parkinson/Alzheimer’s compared to men without ADT.

scholarly journals Functional Status in Behavioral Variant Frontotemporal Dementia: A Systematic Review

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Thais Bento Lima-Silva ◽  
Valéria Santoro Bahia ◽  
Ricardo Nitrini ◽  
Mônica Sanches Yassuda
Keyword(s):  
Systematic Review ◽  
Functional Status ◽  
Frontotemporal Dementia ◽  
Frontotemporal Lobar Degeneration ◽  
Functional Performance ◽  
Functional Decline ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Functional Activities ◽  
Bibliographic Search

The aim was to conduct a systematic review of studies that described the functional profile of patients with behavioral variant frontotemporal dementia (bvFTD), published between 2000 and 2013. The bibliographic search was conducted using the terms “frontotemporal dementia” and “frontotemporal lobar degeneration” in combination with “independence,” “functionality,” “basic activities of daily living,” “disability,” and scales that measure functional performance: “Disability Assessment for Dementia-DAD,” “Functional Activities Questionnaire (FAQ),” “Direct Assessment of Functional Status (DAFS).” To be included in the review, the study had to mention the characterization of the functional status of patients with bvFTD in the objectives of the study, using a previously validated instrument of functional assessment. Fourteen studies met this criterion. The reviewed studies suggested that individuals with bvFTD have greater functional impairment when compared to those with other subtypes of frontotemporal lobar degeneration or Alzheimer’s disease. The studies documented a significant association between cognitive impairment and measures of functionality in these patients. The cognitive profile of patients may predict faster functional decline.

scholarly journals Nutritional Perspectives On Sickle Cell Disease In Africa: A Systematic Review

2020 ◽  
Author(s):  
Eunice Berko Nartey ◽  
Jonathan Spector ◽  
Seth Adu-Afarwuah ◽  
Catherine L. Jones ◽  
Alan A. Jackson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sickle Cell Disease ◽  
Nutritional Status ◽  
Health Outcomes ◽  
Sickle Cell ◽  
Small Sample ◽  
Sub Saharan Africa ◽  
Cell Disease ◽  
Sub Saharan ◽  
The Impact

Abstract Background Sickle Cell Disease (SCD) is an inherited blood disorder and mostly affects individuals living in sub-Saharan Africa. Whilst there is an established link between its pathophysiology and nutritional status, research in this area in Africa is limited and evidence-based nutritional guidelines lacking. This systematic review aimed to evaluate studies in sub-Saharan Africa focused on nutritional aspects of SCD, codify results, and highlight gaps in knowledge that could inform priority-setting for future research. Methods The study was conducted using the Preferred Reporting items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We sought to include all studies involving original research of nutritional status of individuals (children and adults) with SCD in Africa. ‘Nutritional status’ was defined as topics related to dietary intake, measurements of growth or anthropometry, and nutritional-related biomarkers. Studies of anemia alone in non-SCD individuals were excluded as well as studies that assessed individuals with sickle cell trait (i.e., carriers). The databases used were Ovid Embase, Medline, Biosis and Web of Science. Studies conducted between 1995 and 2018 were included in the analyses. Results The search returned 366 articles from which 66 studies were included in the final analyses. Most investigations (70%) were conducted in Nigeria. Studies were categorized into one of three main categories: descriptive studies of anthropometric characteristics (47% of studies), descriptive studies of macro- or micronutrient levels (36% of studies), and interventional studies (14% of studies). There were fairly uniform findings that demonstrate that the growth of SCD patients in sub-Saharan Africa was impaired, especially in childhood and adolescence. Studies assessing macro- and micro-nutrients generally had small sample sizes and were exploratory in nature. Only two randomized, placebo-controlled trials were identified, which measured the impact of fatty acid supplementation and lime juice on health outcomes. Conclusions The findings of this review are consistent with data from other regional settings that describe a significant risk of malnutrition in individuals with SCD. There appears to be a substantial unmet need for clinical research to better understand the potential utility of nutritional-related interventions for patients with SCD in sub-Saharan Africa, to promote optimal growth and improve health outcomes.

Fish intake, n-3 fatty acid body status, and risk of cognitive decline: a systematic review and a dose–response meta-analysis of observational and experimental studies

2021 ◽  
Author(s):  
Rena I Kosti ◽  
Maria I Kasdagli ◽  
Andreas Kyrozis ◽  
Nicola Orsini ◽  
Pagona Lagiou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fatty Acid ◽  
Executive Functions ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Dose Response ◽  
Experimental Studies ◽  
Fish Intake ◽  
Risk Of Bias ◽  
The Impact

Abstract Context Randomized controlled trials (RCTs) testing supplementation with eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids have failed to provide evidence supporting a suggested inverse association between fish intake and dementia risk. Objective Dose–response analyses were conducted to evaluate associations between fish intake, all-cause dementia or Alzheimer’s Disease (AD), and the effect of EPA/DHA supplementation on cognitive performance. Data Sources PubMed, Scopus and Web of Science databases were searched for original research evaluating either associations between fish intake and dementia or AD, or the impact of EPA and/or DHA supplementation on the risk of cognitive decline. Data Extraction Data were collected on study characteristics and methods; number of cases/deaths (for observational studies); categories of exposure; model covariates; risk estimates from the most-adjusted model; type and dosage of supplementation (from RCTs); fatty acid levels in blood; and differences in cognition test results before and after supplementation. Risk of bias was assessed through the ROBINS-E and RoB2.0 tools for observational and experimental studies, respectively. Data Analysis Weighted mixed-effects models were applied, allowing for the inclusion of studies with 2 levels of exposure. Based on findings with low/moderate risk of bias, fish intake of up to 2 portions (250 g) per week was associated with a 10% reduction (95% confidence interval [CI]: 0.79, 1.02, Ν = 5) in all-cause dementia and a 30% reduction (95% CI: 0.54, 0.89, Ν = 3) in AD risk. Changes in EPA and DHA body status had a positive impact on participants’ executive functions, but not on their overall cognitive performance. Conclusion The protection offered by fish intake against cognitive decline levels off at intakes higher than 2 portions/week and likely relates to the impact of EPA and DHA on the individual’s executive functions, although there remain questions about the mechanisms linking the short- and long-term effects. Systematic Review Registration PROSPERO registration no. CRD42019139528.

A multicentric study on cognitive functions in a large sample of patients with schizophrenia and their unaffected first-degree relatives

2016 ◽  
Vol 33 (S1) ◽  
pp. s244-s244
Author(s):  
M. Chieffi ◽  
A. Mucci ◽  
A. Rossi ◽  
P. Rocca ◽  
A. Bertolino ◽  
...  
Keyword(s):  
Social Cognition ◽  
Functional Outcome ◽  
Social Functioning ◽  
Functional Capacity ◽  
Real Life ◽  
Strong Impact ◽  
Specific Level ◽  
Multicentric Study ◽  
First Degree Relatives ◽  
The Impact

IntroductionNeurocognition may represent an indicator of genetic risk and poor outcome in schizophrenia patients (SCZ) predicting real life functioning.ObjectivesAs cognitive performance of unaffected first-degree relatives (UR) is intermediate between SCZ and healthy controls (HC), neurocognitive impairment may represent a marker of vulnerability to schizophrenia.AimsTo investigate social and neurocognition in all subjects and their impact on functional capacity of patients as markers of vulnerability.MethodsSample: 922 SCZ, 379 UR and 780 HC. Assessment: MATRICS Consensus Cognitive Battery (neurocognition), Facial Emotion Identification Test and Awareness of Social Inference Test (social cognition) and Specific Level of Functioning Scale (social functioning). Analyses: Structural Equation Model (SEM) analyses to model the impact of all variables on functional outcome.ResultsSCZ scored worse in all domains than UR and HC. UR had significant impairments in all cognitive domains with respect to HC. Cognitive functioning had direct and indirect impacts on functional outcome mainly through social cognition and functional capacity. Social cognition had a direct impact on outcome, independent of neurocognition.ConclusionSCZ and UR display similar patterns of social and neurocognition deficits. Our results confirm a strong impact of neurocogniton on functional outcome. Social cognition has become an interesting object of study and its conceptualization as trait variable and the existence of a continuum between SCZ and UR are hypotheses for further research.AcknowledgementsThe study was carried out within the project “Multicenter study on factors influencing real-life social functioning of people with a diagnosis of schizophrenia” of the Italian Network for Research on Psychoses.Disclosure of interestThe authors have not supplied their declaration of competing interest.

[P4-370]: COMPARISON OF NUTRITIONAL STATUS AND FUNCTIONAL CAPACITY AMONG INSTITUTIONALIZED AND NON-INSTITUTIONALIZED ELDERLY

2017 ◽  
Vol 13 (7S_Part_29) ◽  
pp. P1433-P1434
Author(s):  
Fernanda Nascimento Costa ◽  
Alessandro Ferrari Jacinto ◽  
Kaoana Maria Vieira de Almeida ◽  
Evelise Saia Rodolpho ◽  
Marcelo Piovezan
Keyword(s):  
Nutritional Status ◽  
Functional Capacity ◽  
Institutionalized Elderly

scholarly journals Anxiety and depressive symptomatology among children and adolescents exposed to the COVID-19 pandemic - meta-analysis

2021 ◽  
pp. 92-92
Author(s):  
Sanja Djurdjevic ◽  
Ghigliazza Conde ◽  
Vesna Dukanac ◽  
Ana Djurdjevic
Keyword(s):  
Mental Health ◽  
Systematic Review ◽  
Depressive Symptoms ◽  
Children And Adolescents ◽  
Depressive Symptomatology ◽  
Well Being ◽  
Anxiety Symptoms ◽  
Strong Impact ◽  
Positive Correlations ◽  
The Impact

Background/Aim: Children and adolescents are the sensitive groups for the development of mental disorders during the crisis. The aim of this systematic review is to assess the impact of the COVID-19 pandemic regarding anxiety and depressive symptomatology in this population. Method: Investigation is based on a Systematic Review followed by PRISMA protocol including Ovid MEDLINE, Embase, Global Health and APA Psyc Info data bases to identify relevant studies reporting anxiety and depressive symptoms among children and adolescents during the COVID-19 pandemic. 27 articles were included. Results: Anxiety symptoms increased from 28.3% before the pandemic to 49.5% during confinement (GAD-7 ? 11) (McNemar test p <0.0001). More depression symptomatology was found as well; weight and sleep changes are disturbances in children and adolescents? mental health. Additionally, female teenagers were experiencing grater declines in mood disorders than male teenagers during the COVID-19 crisis. On one hand, different positive correlations between anxiety and other variables, were found, such as clinical depressive symptoms and anxiety (3/14), smartphone and internet addiction (2/14), lower levels of family income (2/14), perceived threats (2/14), higher grades at school (2/14), loneliness (1/14). On the other hand, positive correlations were reported between depression and children and adolescents that were socially disconnected (3/17). Finally, mothers with higher levels of education and income were associated with more happiness (2/17). Conclusions: COVID-19 has a strong impact in children?s and adolescents? mental health regarding depression and anxiety symptoms. Prevention programs focused on coping strategies should also be considered to be delivered in elementary schools, middle schools and high schools. Mental health should become a priority matter for governments and the current pandemic could be an opportunity to highlight the importance of mental well-being and to invest in the betterment of clinical trainings, treatments and mental health research.

scholarly journals The effectiveness of interventions on nutrition social behaviour change communication in improving child nutritional status within the first 1000 days: Evidence from a systematic review and meta-analysis

2021 ◽  
Author(s):  
Rashidul Alam Mahumud ◽  
Sophiya Uprety ◽  
Nidhi Wali ◽  
Andre M.N. Renzaho ◽  
Stanley Chitekwe
Keyword(s):  
Systematic Review ◽  
Nutritional Status ◽  
Dietary Diversity ◽  
Meta Analysis ◽  
Grey Literature ◽  
Child Feeding ◽  
Random Effects Models ◽  
Young Child Feeding ◽  
Child Nutritional Status ◽  
The Impact

Abstract This systematic review and meta-analysis aimed to assess the robustness of designs and tools used in NSBCC interventions and establish their effectiveness. EBSCOhost as an umbrella database including Medline (Ovid) and CINAHL, EMBASE and ProQUEST databases were searched for peer-reviewed articles from January 1960 to October 2018. Additional sources were searched to identify all relevant studies including grey literature. Studies’ biases were assessed according to Cochrane handbook. Pooled estimate of effectiveness of interventions on infant and young child feeding (IYCF) practices and child nutritional status with 95% confidence intervals were measured using random-effects models. Eighty studies were included in this review: Fifty-one (64%) were cluster randomised trials (RCTs), 13 (16%) were RCTs and 16 (20%) quasi-experimental. Of the included studies, 22 (27%) measured early initiation of breastfeeding, 38 (47%) measured exclusive breastfeeding, 29 (36%) measured minimum dietary diversity, 21 (26%) measured minimum meal frequency, 26 (32%) measured HAZ, 23 (29%) measured WHZ, 27 (34%) measured WAZ, 20 (25%) measured stunting, 14 (17%) measured wasting, and 11 (14%) measured underweight. The overall intervention’s effect was significant for EBF (OR = 1.73; 95% CI: 1.35–2.11, p < 0.001), HAZ (Standardized Mean Differences, SMD = 0.19; 95% CI: 0.17–0.21; p < 0.001), WHZ (SMD = 0.02; 95% CI: 0.004 to 0.04; p < 0.001), and WAZ (SMD = 0.04; 95% CI: 0.02 to 0.06; p < 0.001). Evidence shows the effectiveness of NSBCC in improving EBF and child anthropometric outcomes. Further research should test the impact on child nutritional status with clearly specified and detailed NSBCC interventions.

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