scholarly journals Dysmagnesemia Is the Most Common Disturbance of the Calcium–Magnesium–Phosphorous Balance among Older Hospitalized People in Warsaw

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3395
Author(s):  
Justyna Malinowska ◽  
Milena Małecka-Giełdowska ◽  
Olga Ciepiela
Keyword(s):  
Vitamin D ◽  
The Elderly ◽  
Hospitalized Patients ◽  
Magnesium Phosphate ◽  
Magnesium Concentration ◽  
Hypervitaminosis D ◽  
Age Dependent ◽  
Life Threatening ◽  
Calcium Magnesium

The elderly are at great risk of developing life-threatening disturbances in calcium–magnesium–phosphate homeostasis because of comorbidities, long-term medication use, and dietary deficiencies, but it is still not known how often they occur in this group of patients. This study aimed to assess the prevalence of these disturbances in a group of hospitalized patients over 65 years of age according to age and sex. The study was conducted between January 2018 and September 2020 at the Central Clinical Hospital in Warsaw. A total of 66,450 calcium, magnesium, phosphate, and vitamin D concentration results were included in the analysis. Dysmagnesemia was present in 33% of the calcium results, dyscalcemia, dysphosphatemia, and dysvitaminosis D—in 23.5%, 26%, and 70% of the results, respectively. The magnesium concentration was found to be age-dependent, and older people were found to be at higher risk of developing abnormal magnesium concentrations (p < 0.001). Sex influenced the occurrence of abnormal magnesium (p < 0.001), vitamin D (p < 0.001), and calcium (p < 0.00001) concentrations, with hypercalcemia and hypervitaminosis D disorders being significantly more common in women (p < 0.0001). In conclusion, disorders of the calcium–magnesium–phosphate metabolism are common in hospitalized patients over 65 years of age, and the concentrations of these substances should be routinely monitored in this group.

scholarly journals Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Emanuel J. Novais ◽  
Victoria A. Tran ◽  
Shira N. Johnston ◽  
Kayla R. Darris ◽  
Alex J. Roupas ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Chronic Back Pain ◽  
The Elderly ◽  
Term Treatment ◽  
Specific Effects ◽  
Long Term Treatment ◽  
Age Dependent

AbstractIntervertebral disc degeneration is highly prevalent within the elderly population and is a leading cause of chronic back pain and disability. Due to the link between disc degeneration and senescence, we explored the ability of the Dasatinib and Quercetin drug combination (D + Q) to prevent an age-dependent progression of disc degeneration in mice. We treated C57BL/6 mice beginning at 6, 14, and 18 months of age, and analyzed them at 23 months of age. Interestingly, 6- and 14-month D + Q cohorts show lower incidences of degeneration, and the treatment results in a significant decrease in senescence markers p16INK4a, p19ARF, and SASP molecules IL-6 and MMP13. Treatment also preserves cell viability, phenotype, and matrix content. Although transcriptomic analysis shows disc compartment-specific effects of the treatment, cell death and cytokine response pathways are commonly modulated across tissue types. Results suggest that senolytics may provide an attractive strategy to mitigating age-dependent disc degeneration.

scholarly journals Keep Moving Toward Recovery! Function-Focused Care in Hospitalized Stroke and Geriatric Patients

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 629-629
Author(s):  
Janneke de Man-van Ginkel ◽  
Carolien Verstraten ◽  
Marieke Schuurmans ◽  
Silke Metzelthin ◽  
Johannes Reitsma ◽  
...  
Keyword(s):  
Functional Status ◽  
Mixed Model ◽  
The Elderly ◽  
Hospitalized Patients ◽  
Term Care ◽  
Level Method ◽  
Level Of Significance ◽  
Elderly Mobility ◽  
Patients Experience

Abstract Many hospitalized patients experience decline in functional status. Function Focused Care (FFC) has demonstrated to improve patients’ functional status in long-term care. In a stepped wedge cluster trial in 893 hospitalized geriatric and stroke patients, we investigated the effectiveness of FFC compared to usual care (FFC: n=427, UC: n=466) on ADL and mobility. We measured the Barthel Index and the Elderly Mobility Scale, and analysed using a mixed-model multi-level method. At discharge, 3 month and 6 months, the mean difference (MD) was in favour of FFC, although at none of the time points the level of significance was reached: the MD for ADL was respectively: 0.79 (95%CI: -0.98-2.56), 0.43 (95%CI: 0.10-1.79), and 0.57 (95%CI: -1.34- 2.48). For mobility, the MD was respectively 0.89 (95%CI: -1.01-2.80), 0.78 (95%CI: -1.18; 2.75), and 1.09 (95%CI: -0.88-3.07). Although the results are inconclusive, FFC shows a tendency to improve ADL and mobility in hospitalized patients. Part of a symposium sponsored by Nursing Care of Older Adults Interest Group.

scholarly journals (Preventing) two birds with one stone: improving vitamin D levels in the elderly

2011 ◽  
Vol 3 (2) ◽  
pp. 150 ◽  
Author(s):  
Susie Lawless ◽  
Phil White ◽  
Prue Murdoch ◽  
Sharon Leitch
Keyword(s):  
Vitamin D ◽  
Vaccination Campaign ◽  
Fragility Fractures ◽  
The Elderly ◽  
Vitamin D Supplementation ◽  
Adverse Outcomes ◽  
Flu Vaccination ◽  
Increased Risk ◽  
Vitamin D Levels

BACKGROUND AND CONTEXT: A majority of adults have sub-optimal vitamin D levels in the winter in southern New Zealand. This is associated with an increased risk of falls and fragility fractures in the elderly, with long-term adverse outcomes likely. Vitamin D supplementation decreases the risks of both falls and fractures. ASSESSMENT OF PROBLEM: An intervention was undertaken by a small urban general practice to increase the number of elderly patients receiving vitamin D supplementation by linking vitamin D prescription to the annual flu vaccination campaign. RESULTS: Uptake of the supplementation was high and costs to the practice low. Thirty-eight patients were identified for whom long-term supplementation with vitamin D was indicated. STRATEGIES FOR IMPROVEMENT: The study could have been strengthened by incorporating a more formal method of evaluating uptake. LESSONS: Encouraging patients to take supplements as a population-based strategy is a realistic intervention, and linking it to the flu vaccination campaign is both seasonally appropriate and efficient. KEYWORDS: Vitamin D deficiency; elderly; vitamin D supplementation; cholecalciferol; prevention; fragility fractures; intervention

scholarly journals Targeting Age-Dependent Functional and Metabolic Decline of Human Skeletal Muscle: The Geroprotective Role of Exercise, Myokine IL-6, and Vitamin D

2020 ◽  
Vol 21 (3) ◽  
pp. 1010 ◽  
Author(s):  
Clara Crescioli
Keyword(s):  
Skeletal Muscle ◽  
Vitamin D ◽  
The Elderly ◽  
Whole Body ◽  
Nutrient Level ◽  
Tissue Mass ◽  
Age Related ◽  
Current Perspective ◽  
Age Dependent ◽  
Distant Organ

In the elderly, whole-body health largely relies on healthy skeletal muscle, which controls body stability, locomotion, and metabolic homeostasis. Age-related skeletal muscle structural/functional deterioration is associated with a higher risk of severe comorbid conditions and poorer outcomes, demanding major socioeconomic costs. Thus, the need for efficient so-called geroprotective strategies to improve resilience and ensure a good quality of life in older subjects is urgent. Skeletal muscle senescence and metabolic dysregulation share common cellular/intracellular mechanisms, potentially representing targets for intervention to preserve muscle integrity. Many factors converge in aging, and multifaceted approaches have been proposed as interventions, although they have often been inconclusive. Physical exercise can counteract aging and metabolic deficits, not only in maintaining tissue mass, but also by preserving tissue secretory function. Indeed, skeletal muscle is currently considered a proper secretory organ controlling distant organ functions through immunoactive regulatory small peptides called myokines. This review provides a current perspective on the main biomolecular mechanisms underlying age-dependent and metabolic deterioration of skeletal muscle, herein discussed as a secretory organ, the functional integrity of which largely depends on exercise and myokine release. In particular, muscle-derived interleukin (IL)-6 is discussed as a nutrient-level biosensor. Overall, exercise and vitamin D are addressed as optimal geroprotective strategies in view of their multi-target effects.

Long-term hypervitaminosis D-induced hypercalcaemia treated with glucocorticoids and bisphosphonates

2020 ◽  
Vol 13 (4) ◽  
pp. e233853 ◽  
Author(s):  
Chase C Houghton ◽  
Susie Q Lew
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Additional Treatment ◽  
Long Term Effects ◽  
Over The Counter ◽  
Hypervitaminosis D ◽  
Vitamin D Intoxication ◽  
Common Diagnosis ◽  
Vitamin D Supplement

Hypercalcaemia is a common diagnosis with the majority of cases resulting from hyperparathyroidism or malignancy. We report a rare case of persistent symptomatic hypervitaminosis D-induced hypercalcaemia in an individual taking 50 000 IU of vitamin D supplement daily for several months following a diagnosis of vitamin D deficiency. His hypercalcaemia was initially treated with calcitonin and intravenous fluids, but due to recurrent symptomatic hypercalcaemia after discharge, additional treatment with glucocorticoids and bisphosphonates was warranted during his second admission. The pathophysiology of hypercalcaemia from vitamin D intoxication results from the long-term effects of vitamin D storage in adipose tissue. In the present case, we discuss this pathophysiology and treatment approaches in the context of increasing awareness of and testing for vitamin D deficiency, and growing access to over-the-counter supplements.

scholarly journals Utilizing the Crosstalk Among Minocycline, Chicoric Acid, 13-Cis Retinoic Acid(Aerosolized) and Vitamin D as a Potent Quadrate Therapy for treating coinfection with Multidrug-resistant TB and COVID-19 . A double-edged sword Clinical Study

2021 ◽  
Author(s):  
Mahmoud Ramadan Elkazzaz ◽  
Amr Ahmed
Keyword(s):  
Vitamin D ◽  
Mycobacterium Tuberculosis ◽  
Retinoic Acid ◽  
The Elderly ◽  
Multidrug Resistant ◽  
Severe Form ◽  
Hospitalized Patients ◽  
The Body ◽  
Chicoric Acid ◽  
Mdr Tb

Abstract Tuberculosis (TB) is a major infectious disease killer globally. It affected 10 million and killed 1.4 million people in 2019 alone. TB is considered a disease caused by a bacterium—Mycobacterium tuberculosis—that usually attacks the lungs, but can attack any part of the body. But TB has a worrisome connection to the novel coronavirus.. Both diseases are airborne and spread when people cough or sneeze. The predicted impact of the COVID-19 pandemic is an additional 190,000 TB deaths in 2020, and it is expected in the next 5 y that there will be up to a 20% increase in the global TB disease burden, stressing the critical need for new safe and effective drugs against Mycobacterium tuberculosis (Mtb). In addition, controlling multidrug-resistant TB (MDR-TB) presents a huge public health challenge. Recently it was showed that hospitalized patients with Tuberculosis are more susceptible to COVID-19 infection and complication. Furthermore, hospitalized patients with MDR-TB are increasingly vulnerable to COVID-19 complications than patients with non-resistant tuberculosis.. For someone with latent TB, contracting COVID-19 could activate the bacterium, potentially leading to an accelerated and more severe form of the disease WHO estimates that these COVID-19 related disruptions in access to TB care could cause an additional half a million TB deaths. Older age, especially >65 years, may be a risk factor for death from COVID-TB, consistent with previous findings indicating that the mortality rate from COVID-19 increases exponentially with age. Thus, the elderly should be the primary focus of both COVID-19 and COVID-TB mitigation efforts due to its much higher mortality risk in that group. COVID-TB patients had a much higher rate of comorbidities than COVID-19 patients At present, evidence suggests that the main transmission route of both COVID-19 and TB is via respiratory droplets, and their main target are the lungs, which can lead to a worse outcome among COVID-19 and TB coinfection patients (aptly abbreviated COVID-TB). As a result, coinfections with common viral and bacterial (COVID-TB) pathogens among hospitalized patients are a severe concern that will likely worsen patient outcomes and pose a real challenge for treating those patients.ConclusionsNew drug discovery could require several years with no guarantee but repurposing established drugs may be useful to treat confection with COVID-19 and Nonresistant Strains of Mycobacterium tuberculosis: or resistant Strains of Mycobacterium tuberculosis . Here we demonstrate that we could utilize the crosstalk among Chicoric Acid, 13-Cis Retinoic Acid, Minocycline and vitamin D as a novel quadrate therapy against Multidrug-resistant TB and COVID-19 coinfection.

scholarly journals Assessment of the contribution of calcium and vitamin D in the diet of the elderly

2018 ◽  
Vol 128 (4) ◽  
pp. 156-159
Author(s):  
Wioletta Samolińska ◽  
Bożena Kiczorowska ◽  
Renata Klebaniuk
Keyword(s):  
Vitamin D ◽  
Elderly Population ◽  
Dietary Supplementation ◽  
Calcium Content ◽  
Food Products ◽  
The Elderly ◽  
Daily Food ◽  
Age Dependent ◽  
The Impact ◽  
Dietary Interview

Abstract Introduction. The rate of aging and the possible coexistence of diet-related diseases are largely determined by the nutrition and lifestyle of the elderly. Therefore, it is important to assess the degree of coverage of organism demand for such nutrients as calcium and vitamin D in the elderly population. Aim. The aim of the study was to determine the impact of age on calcium and vitamin D supply in daily alimentary rations of the elderly as well as their nutritional behaviour in terms of consumption of products which are the source of these nutrients. Material and methods. The study involved 42 subjects aged from 60 to 85 years. The vitamin D and calcium content in daily food rations was assessed with the method of a 24-hour dietary interview carried out in triplicate. Results. The nutrition of the elderly turned out to be inappropriate in terms of supplying the organism with calcium and vitamin D, and this was not age dependent. The average calcium and vitamin D supply in the daily food rations was estimated at 455.53 mg/day and 2.31 μg/day, respectively. The demand for calcium was covered in the range of 31-60% of RDA in over 60% of the elderly and the vitamin D demand was met in 30% of AI in over 80% of the subjects. Conclusions. The assessment of the daily food rations indicates a necessity for increasing the intake of calcium- and vitamin D-rich food products and dietary supplementation with these components.

scholarly journals Hyper-Vitaminosis D

2019 ◽  
Vol 4 (9) ◽  
Keyword(s):  
Vitamin D ◽  
Biological Effects ◽  
Serum Vitamin ◽  
Kidney Injury ◽  
Serum Vitamin D ◽  
Hypervitaminosis D ◽  
Vitamin D Intoxication ◽  
Status Assessment ◽  
Calcium Magnesium ◽  
25 Oh Vitamin D

Vitamin D is a group of fat-soluble molecules responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and multiple other biological effects [1]. High levels of 25(OH) vitamin D can therefore cause refractory hypercalcemia. Suboptimal levels of serum Vitamin D are a global healthcare issue. Recently, Vitamin D has increasingly been recognised to have healthcare benefits beyond Calcium metabolism and bone health. As a result, Vitamin D status assessment and over-thecounter consumption has exponentially increased. However indiscriminate consumption can lead to hypervitaminosis D and its associated complication. This report reviews a case of a patient with hypercalcaemia and Acute Kidney injury as result of Vitamin D intoxication.

scholarly journals Challenges of Longevity: Safety of Vaginal and Laparoscopic Urogynecological Procedures in Septuagenarians and Older Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
R. Joukhadar ◽  
A. Wöckel ◽  
D. Herr ◽  
V. Paulus ◽  
J. Radosa ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Older Patients ◽  
Intraoperative Complications ◽  
Operation Time ◽  
The Elderly ◽  
Pelvic Organ ◽  
Younger Patients ◽  
Long Term Study ◽  
Life Threatening

Introduction. Pelvic organ prolapse (POP) and urinary incontinence (UI) have increasing prevalence in the elderly population. The aim of this study was to compare the comorbidities of these procedures between <70 y/o and ≥70 y/o patients.Materials and Methods. In our retrospective study over a period of 2.5 years, 407 patients had received an urogynecological procedure. All patients with POP were treated by reconstructive surgery. Complications were reported using the standardized classification of Clavien-Dindo (CD). The study can be assigned to stage 2b Exploration IDEAL (Idea, Development, Exploration, Assessment, Long-term study)-system of surgical innovation.Results. Operation time, blood loss, and intraoperative complications have not been more frequent in the elderly, whereas hospital stay was significantly longer in ≥70 y/o patients. Regarding postoperative complications, we noticed that ≥70 y/o patients had an almost threefold risk to develop mild early postoperative complications compared to younger patients (OR: 2.86; 95% CI: 1.76–4.66). On the contrary, major complications were not more frequent. No case of life-threatening complication or the need for blood transfusion was reported.Conclusion. After urogynecological procedures, septuagenarians and older patients are more likely to develop mild postoperative complications but not more intraoperative or severe postoperative complications compared to younger patients.

Sign in / Sign up

Export Citation Format

Share Document