scholarly journals Effects of a Calorie-Restricted Mediterranean-Style Diet on Plasma Lipids in Hypercholesterolemic South Korean Patients

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3393
Author(s):  
Da-Hye Son ◽  
Yu-Jin Kwon ◽  
Hye Sun Lee ◽  
Hyung-Mi Kim ◽  
Ji-Won Lee
Keyword(s):  
Fatty Liver ◽  
Total Cholesterol ◽  
Plasma Lipids ◽  
Fasting Glucose ◽  
Smoking Status ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Anthropometric Parameters ◽  
Conventional Diet

The objective of this randomized cross-over trial was to evaluate the short term effects of a calorie-restricted Korean style Mediterranean diet (KMD) versus a calorie-restricted conventional diet on lipid profile and other metabolic parameters in hypercholesterolemic patients. Ninety-two patients with hypercholesterolemia were randomly assigned to two groups and switched to the other group following a 4-week intervention after a 2-week washout period. While participants during KMD intervention period received home delivery of two meals daily except for weekends, those during the control group were advised to consume a conventional diet. Total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) significantly decreased in KMD group even after adjusting for age, sex, total energy intake changes, alcohol consumption, smoking status, and physical activity changes (all p < 0.05). Anthropometric parameters, white blood cell (WBC), fasting glucose, fasting insulin, HOMA-IR, and fatty liver index (FLI) also significantly decreased after KMD intervention (all p < 0.05). In addition, WBC, fasting glucose, total cholesterol, LDL-C and FLI were significantly decreased even after adjusting for weight reduction changes. Calorie-restricted KMD not only helps to treat dyslipidemia by improving the lipid parameters but also has beneficial effects on reducing cardiovascular risk by improving chronic inflammation, insulin resistance, and fatty liver.

Abstract 155: Evaluation of Dyslipidemia Control and Its Risk Factors of Cardiac Outpatients

2016 ◽  
Vol 9 (suppl_2) ◽  
Author(s):  
Iman Nazar Talib Al-Ani ◽  
Hadeer Akram AbdulRazzaq Al-Ani ◽  
Hanan Hussein ◽  
Syed Azhar Syed Sulaiman ◽  
Aseel Hadi Abdulameer Al-Hashimi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Total Cholesterol ◽  
Smoking Status ◽  
Demographic Data ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Asian Population ◽  
Hdl Cholesterol ◽  
Optimal Level ◽  
Lipoprotein Cholesterol

Objective: is to assess the dyslipidemia control and demographic differences in lipid patterns among dyslipidemic cardiac patients. Method: data based a retrospective analysis of 504 persons (age mean 58.16 ± 11.119 years) was conducted in Malaysia which estimated the lipid abnormalities in statin-treated patients. Demographic data including age, race, alcoholic and smoking status were collected. Lipid profiles including triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured. Results: a desirable level of (TC) and (TG) were 62.2% and 54.4% respectively, optimal level of (LDL-C) was 66.5% and the normal level of (HDL-C) was 54.2%. Risk factor analysis of dyslipidemia was done with a primary focus on the possible impact of statin type, gender, race and dyslipidemia type. Atorvastatin was significantly more effective for primary dyslipidemia than simvastatin and lovastatin in HDL cholesterol ( p < 0.002), while in LDL cholesterol (p = 0.001) and total cholesterol (p < 0.03) simvastatin was significantly found more effective for primary dyslipidemia. A significant correlation emerged between gender and statin type in HDL cholesterol (p < 0.02) and total cholesterol TC (p < 0.001), atorvastatin is found more effective to be used by males than females. A correlation was also significant between gender and dyslipidemia type in HDL cholesterol (p < 0.01). Results for triglyceride reported a significant relationship between age, race and statin type (p < 0.001), atorvastatin was found to be more effective among Chinese while lovastatin was more effective among Indians. Finally 18.2% abnormality of HDL was explained by interactions of risk factors: first statin type and dyslipidemia type, second for gender and dyslipidemia type and the third was gender and statin type. Conclusions: more than 50% of cardiac outpatients were in an acceptable range of lipid profile evaluation. This could support the need for increasing attention to basic monitoring of cardiovascular risk factors in these dyslipidemic patients particularly in Asian population.

Correlation between Serum and Tissue Levels of Adipokines in Obesity in Adult Male Rats with and without Antioxidant

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M M Elshawwa
Keyword(s):  
Insulin Resistance ◽  
Adult Male ◽  
Fasting Glucose ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Control Group ◽  
Tissue Levels ◽  
Group I

Abstract Background Obesity is associated with insulin resistance, type2 diabetes, dyslipidemia and cardiovascular diseases. Apelin and chemerin are identified as adipokines and adipose tissue markers. Several adipose-derived peptides are known to influence food intake, including apelin, whose expression is regulated by insulin and chemerin. Oxidative stress thought to be involved in the development of complications associated with obesity. Objective To study the nature of correlation between serum and liver levels of apelin, chemerin and oxidative parameters in obese rats with and without antioxidant. Aiming to clarify the pathophysiology of obesity. Material and Methods Thirty adult male albino rats, divided into three equal groups. Group I (control), group II (obese) and group III (obese and Lepidium sativum (LS) as an antioxidants). At the end of the experiment, blood samples were collected for estimation of the serum levels of chemerin, apelin, fasting glucose, insulin, insulin resistance (IR), lipid profile, reduced glutathione (GSH) and malondialdehyde (MDA). In addition to tissue homogenous extracts of liver were taken for the levels of MDA, CAT, chemerin and apelin. Results After eight weeks, high fat diet group showed a significant increase in serum levels of apelin, chemerin, fasting glucose, insulin, IR, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) & MDA and a significant decrease in high-density lipoprotein cholesterol (HDL-C) & GSH. HFD also caused a significant increase in tissue levels of MDA, CAT & chemerin and a significant decrease in apelin, compared to control group. While addition of LS to HFD caused a significant decrease in serum levels of apelin, chemerin, fasting glucose, insulin, IR, TC, TG, LDL-C & MDA and a significant increase in HDL-C & GSH. LS also caused a significant decrease in tissue levels of MDA, chemerin & insignificant decrease in CAT and a significant increase in apelin, compared to HFD group. Conclusion This study showed a significant positive correlation between liver & serum chemerin and between liver and serum MDA. On the other hand, it showed a significant negative correlation between liver and serum apelin and liver CAT and serum GSH

scholarly journals Copper bioavailability, mineral utilization, and lipid metabolism in broilers

2019 ◽  
Vol 64 (No. 12) ◽  
pp. 483-490
Author(s):  
Aiyou Wen ◽  
Sifa Dai ◽  
Xuezhuang Wu ◽  
Zhihua Cai
Keyword(s):  
Lipid Metabolism ◽  
Copper Sulphate ◽  
Plasma Lipids ◽  
Plasma Cholesterol ◽  
Average Daily Gain ◽  
Density Lipoprotein ◽  
Relative Bioavailability ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Mineral Utilization

The study was conducted to investigate the effects of copper (Cu) sources and levels on mineral utilization, tissue copper residues, and lipid metabolism in Arbor Acres broilers. A total of 640 male broilers were randomly divided into 5 groups with 8 replicates per group and 16 broilers per replicate. The experiment was used in a 2 × 2 + 1 factorial experiment design. Broilers in the control group were fed a basal diet, and animals in the other four groups were fed basal diets supplemented with Cu from copper sulphate and copper methionine. Copper concentrations of the experimental diets were 20 and 40 mg Cu/kg dry matter. A metabolism trial of 4 days was conducted during the last week of experimental feeding. Neither Cu source nor Cu level affected average daily gain, average daily feed intake or feed gain ratio (P &gt; 0.05). Broilers fed 40 mg Cu/kg diets had lower plasma cholesterol than those in the control group (P &lt; 0.05). Copper supplementation decreased (P &lt; 0.05) plasma low-density lipoprotein cholesterol but did not alter plasma high-density lipoprotein cholesterol concentrations or plasma triglyceride concentrations. Copper sulphate supplementation increased (P &lt; 0.05) liver Cu but did not alter pectorals Cu, heart Cu, tibia Cu and tibia P. Broilers fed 40 mg/kg Cu from copper sulphate had a lower (P &lt; 0.05) tibia Ca level. The concentration of liver Cu in the broilers fed copper methionine diets was higher (P &lt; 0.05) than that in those fed copper sulphate. Compared with copper sulphate (100%), the relative bioavailability value of copper methionine was 117%. In conclusion, the relative bioavailability of copper methionine obtained in this study was greater than that of copper sulphate. Copper plays an important role in plasma lipids and in the digestion of dietary Ca in broiler chickens.

scholarly journals Association of CD4 count with anthropometric parameters and metabolic alterations in treatment naive human immunodeficiency virus infected patients

2019 ◽  
Vol 7 (6) ◽  
pp. 2062
Author(s):  
Arunraj C. N. ◽  
Sundeep S.
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cd4 Count ◽  
Lipoprotein Cholesterol ◽  
Anthropometric Parameters ◽  
Hiv Patients ◽  
Immunodeficiency Virus ◽  
Treatment Naïve

Background: Body fat abnormalities and metabolic derangements are well known to occur in human immunodeficiency virus (HIV) infection. The objective of present study was to evaluate the anthropometric parameters, fasting lipid profile and fasting blood sugar in treatment naïve HIV patients and to assess any relation with CD4 count.Methods: Anthropometric measurements, latest CD4 count were recorded from HIV patients. Blood was collected from patients for lipid profile and sugar measurements.Results: Anthropometric parameters showed a gradual increase in waist circumference (WC), increase in waist hip ratio (WHR) and decrease in body mass index (BMI) as CD4 count declined. Fasting lipid profile showed a gradual decrease in total cholesterol, low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) and increase in triglycerides (TG) and very low density lipoprotein cholesterol (VLDL-C) as CD4 count declined which were statistically highly significant (P<0.001). Compared to higher CD4 group (350-500/ mm3), the lower CD4 group (<50/mm3) showed a decrease in mean total cholesterol by 60 mg/dL, LDL-C by 76 mg/dL and HDL-C by 13 mg/dL. The increase in mean TG and VLDL-C were 154 mg/dL and 30 mg/dL respectively. Comparison of fating blood sugar (FBS) between CD4 groups showed a gradual rise in FBS as CD4 count declined.Conclusions: As CD4 count declines, metabolic alterations occur in treatment-naïve HIV patients with substantial decrease in serum total cholesterol, HDL-C, LDL-C and an increase in TG and VLDL-C and increased incidence of impaired FBS. Morphological alteration in advanced HIV is evidenced by increased WC, WHR and decreased BMI.

scholarly journals Association of Dyslipidemia and Hyperhomocysteinemia in epileptic patients on carbamazepine monotherapy.

2020 ◽  
Vol 27 (02) ◽  
pp. 230-236 ◽  
Author(s):  
Shazia Bano ◽  
Syed Munawar Alam ◽  
Saima Iram
Keyword(s):  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Carbamazepine Therapy ◽  
Epileptic Patients

Objectives: To observe the association between dyslipidemia and homocysteine level in epileptic patients; especially on carbamazepine monotherapy. Study Design: Cross sectional study. Setting: Neurology Department and Epilepsy Centre of Jinnah Post Graduate Medical Centre, Karachi. Period: From January 2015 – January 2016. Material & Methods: Total 300 subjects, aged more than 15 years were included and divided into three groups.  Group A (100 healthy individuals) was control group, Group B (100 newly diagnosed epileptic patients without antiepileptic therapy), Group C (100 epileptic patients on Carbamazepine therapy, which was further subdivided into C-I (n=33) had epileptic patients on Carbamazepine therapy less than 1 year, C-II (n=33) comprised of epileptic patients on Carbamazepine therapy 1-2 years and C-III (n=33) had epileptic patients on Carbamazepine therapy more than 2 years. Serum lipid profile and homocysteine levels were measured. Results: In patients with different durations of carbamazepine monotherapy; a noteworthy incremental trend in the levels of homocysteine, total cholesterol, triglyceride, low density lipoprotein cholesterol, very low density lipoprotein cholesterol was observed. Homocysteine was found positively correlated with total cholesterol, triglyceride, low density lipoprotein cholesterol, very low density lipoprotein cholesterol. Conclusion: In our study dyslipidemia was associated with hyperhomocysteinemia, which in turn was correlated with atherosclerosis in CBZ treated epileptic patients.

scholarly journals Association of Dyslipidemia and Hyperhomocysteinemia in epileptic patients on carbamazepine monotherapy.

2020 ◽  
Vol 27 (02) ◽  
pp. 230-236
Author(s):  
Shazia Bano ◽  
Syed Munawar Alam ◽  
Saima Iram
Keyword(s):  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Carbamazepine Therapy ◽  
Epileptic Patients

Objectives: To observe the association between dyslipidemia and homocysteine level in epileptic patients; especially on carbamazepine monotherapy. Study Design: Cross sectional study. Setting: Neurology Department and Epilepsy Centre of Jinnah Post Graduate Medical Centre, Karachi. Period: From January 2015 – January 2016. Material & Methods: Total 300 subjects, aged more than 15 years were included and divided into three groups.  Group A (100 healthy individuals) was control group, Group B (100 newly diagnosed epileptic patients without antiepileptic therapy), Group C (100 epileptic patients on Carbamazepine therapy, which was further subdivided into C-I (n=33) had epileptic patients on Carbamazepine therapy less than 1 year, C-II (n=33) comprised of epileptic patients on Carbamazepine therapy 1-2 years and C-III (n=33) had epileptic patients on Carbamazepine therapy more than 2 years. Serum lipid profile and homocysteine levels were measured. Results: In patients with different durations of carbamazepine monotherapy; a noteworthy incremental trend in the levels of homocysteine, total cholesterol, triglyceride, low density lipoprotein cholesterol, very low density lipoprotein cholesterol was observed. Homocysteine was found positively correlated with total cholesterol, triglyceride, low density lipoprotein cholesterol, very low density lipoprotein cholesterol. Conclusion: In our study dyslipidemia was associated with hyperhomocysteinemia, which in turn was correlated with atherosclerosis in CBZ treated epileptic patients.

scholarly journals Decreased Serum Lipids in Patients with Probable Alzheimer´s Disease

2009 ◽  
Vol 9 (3) ◽  
pp. 215-220 ◽  
Author(s):  
Orhan Lepara ◽  
Amina Valjevac ◽  
Azra Alajbegović ◽  
Asija Zaćiragić ◽  
Emina Nakaš-Ićindić
Keyword(s):  
Total Cholesterol ◽  
Serum Lipids ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Epidemiologic Studies ◽  
Lipoprotein Cholesterol ◽  
Initial Assessment ◽  
Control Group ◽  
Cross Sectional ◽  
Control Subjects

Alzheimer’s disease (AD) is a multifactorial disease but its aetiology and pathophisiology are still not fully understood. Epidemiologic studies examining the association between lipids and dementia have reported conflicting results. High total cholesterol has been associated with both an increased, and decreased, risk of AD and/or vascular dementia (VAD), whereas other studies found no association. The aim of this study was to investigate the serum lipids concentration in patients with probable AD, as well as possible correlation between serum lipids concentrations and cognitive impairment.Our cross-sectional study included 30 patients with probable AD and 30 age and sex matched control subjects. The probable AD was clinically diagnosed by NINCDS-ADRDA criteria. Serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels were determined at the initial assessment using standard enzymatic colorimetric techniques. Low-den- sity lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) levels were calculated. Subjects with probable AD had significantly lower serum TG (p<0,01), TC (p<0,05), LDL-C (p<0,05) and VLDL-C (p<0,01) compared to the control group. We did not observe signifi-cant difference in HDL-C level between patients with probable AD and control subjects. Negative, although not significant correlation between TG, TC and VLDL-C and MMSE in patients with AD was observed. In the control group of subjects there was a negative correlation between TC and MMSE but it was not statistically significant (r = -0,28). Further studies are required to explore the possibility for serum lipids to serve as diagnostic and therapeutic markers of AD.

scholarly journals Diagnostic and pathogenetic significance of apolipoprotein disorders in patients with alcoholic fatty liver

2017 ◽  
Vol 74 (2) ◽  
pp. 133-137
Author(s):  
Bojan Mladenovic ◽  
Vesna Brzacki ◽  
Daniela Benedeto-Stojanov ◽  
Nikola Mladenovic
Keyword(s):  
Fatty Liver ◽  
Daily Intake ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Alcoholic Beverages ◽  
Control Group ◽  
Albumin Concentration ◽  
Apo B ◽  
Alcoholic Fatty Liver ◽  
Significant Difference

Background/Aim. Alcohol is the most common cause of fatty liver. Alcohol metabolism takes place in the liver by alcohol dehydrogenase, to toxic acetaldehyde, with fatty acids accumulation in the liver as a consequence. By daily intake of the amount greater than 80 g/day for men and 20 g for women, there is the risk for developing the alcoholic fatty liver (AFLD). The aim of this study was to determine the profile of atherogenic factors in plasma of patients with AFLD compared to patients with non-alcoholic fatty liver (NAFLD) and determine its diagnostic significance. Methods. The study included 74 patients with AFLD who consumed alcoholic beverages daily in large quantities and over 80 g [for men: 3?4 units (U) of alcohol and for women 2?3 U]; the control group consisted of 70 patients with NAFLD verified with ultrasound. A total holesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and apoliporoteins (ApoA1 and ApoB) were determined and the ratios TC/HDL-C, ApoB/ApoA1 and LDL-C/HDL-C were calculated. Results. The study included two group: 74 AFLD patients (21% of women and 79% of men), mean age 42.65 ? 9.73 years, who consumed alcoholic beverages daily in the amounts of 80 g, or greter, during the average 2.31 ? 0.96 years and 70 patients with NAFLD (37.5% of women and 63.5% of men) with the average 41.3 ? 4.1 years. There was no significant difference in gender distribution and the average age between the examined groups. Higher values of TG ? 9.94 ? 2.94 mmol/L, TC 14.53 ? 2.81 mmol/L, LDL-C 8.57 ? 2.15 mmol/L and ApoB 3.97 ? 0.28 g/L and lower values of HDL-C 0.43 ? 0.11 mmol/L, Apo A1 0.49 ? 0.09 g/L and ApoB/ApoA1 ratio 2.43 ? 1.27 were registered in the AFLD group compared to those registered in the NAFLD group, (TG 8.74 ? 2.54 mmol/L TC 9.87 ? 2.36, LDL-C 6.72 ? 1.98 mmol/L, Apo B 2.38 ? 0.16 g/L, HDL-C 0.78 ? 0.09 mmol/L, Apo A1 0.98 ? 0.04 g/L and ApoB/ApoA1 ratio 7.81?1.42). There were no differences in albumin concentration, international normalized ratio (INR) and values of haemoglobin and haematocrit between the groups. Conclusion. Lipids and the ApoB/ApoA1 ratio, besides markers of hepatocelular damage, can serve as a diagnostic criteria for the presence of AFLD, and as a better indicator of atherogenic risk.

Influence of plasma and erythrocyte factors on red blood cell aggregation in survivors of acute myocardial infarction

2004 ◽  
Vol 91 (02) ◽  
pp. 354-359 ◽  
Author(s):  
Cristina Falcó ◽  
Edelmiro Réganon ◽  
Virtudes Vila ◽  
Vicenta Martínez-Sales ◽  
Dolores Corella ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Sialic Acid ◽  
Plasma Lipids ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Erythrocyte Aggregation ◽  
Phospholipid Content ◽  
Control Group

SummaryIncreased erythrocyte aggregation (EA) has been observed in patients with ischaemic heart disease (IHD), although most of these studies have been performed in the acute phase when reactant proteins may account for this increase. Little is known about the role played by the erythrocyte itself in this aggregation process. To ascertain the contribution of both plasma and erythrocyte factors to EA in IHD, we investigated the following parameters in 78 survivors of acute myocardial infarction (AMI) and in a well-matched control group of 98 subjects: EA, glucose, total cholesterol (T-Chol), low-density lipoprotein-cholesterol (LDL-Chol), high-density lipoprotein–cholesterol (HDL-Chol), triglycerides, apolipoproteins A1 and B, protein and functional fibrinogen, plasma sialic acid, membrane sialic acid, and the cholesterol and phospholipid content of the erythrocyte membrane. AMI survivors showed higher glucose (p<0.001), a borderline increase in triglycerides (p= 0.043), and a statistical decrease in Apo A1 (p= 0.003) relative to controls. EA, functional fibrinogen, and plasma sialic acid were statistically higher in AMI survivors than in controls (p= 0.001; p<0.001; p= 0.011, respectively). Membrane sialic acid content was statistically lower in AMI patients than in controls (p= 0.026). No differences were observed in either membrane cholesterol or phospholipids. Multivariate logistic regression analysis, in which EA was dichotomized as higher or lower than 8.7, demonstrated that triglyceride levels higher than 175 mg/dL (OR= 7.7, p= 0.001) and functional fibrinogen levels higher than 320 mg/dL (OR= 3.7, p= 0.004) were independently associated with a greater risk of erythrocyte hyperaggregability. Our results suggest that plasma lipids, predominantly triglycerides, and fibrinogen may not only enhance the development of ischaemic events by their recognized atherogenic mechanisms, but also by increasing EA.

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