scholarly journals Does the Combined Effect of Resistance Training with EPO and Iron Sulfate Improve Iron Metabolism in Older Individuals with End-Stage Renal Disease?

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3250
Author(s):  
Hugo de Luca Corrêa ◽  
Víctor Manuel Alfaro-Magallanes ◽  
Sting Ray Gouveia Moura ◽  
Rodrigo Vanerson Passos Neves ◽  
Lysleine Alves Deus ◽  
...  

We sought to investigate the effects of resistance training (RT) combined with erythropoietin (EPO) and iron sulfate on the hemoglobin, hepcidin, ferritin, iron status, and inflammatory profile in older individuals with end-stage renal disease (ESRD). ESRD patients (n: 157; age: 66.8 ± 3.6; body mass: 73 ± 15; body mass index: 27 ± 3), were assigned to control (CTL; n: 76) and exercise groups (RT; n: 81). The CTL group was divided according to the iron treatment received: without iron treatment (CTL—none; n = 19), treated only with iron sulfate or EPO (CTL—EPO or IRON; n = 19), and treated with both iron sulfate and EPO (CTL—EPO + IRON; n = 76). The RT group followed the same pattern: (RT—none; n = 20), (RT—EPO or IRON; n = 18), and (RT—EPO + IRON; n = 86). RT consisted of 24 weeks/3 days per week at moderate intensity of full-body resistance exercises prior to the hemodialysis section. The RT group, regardless of the iron treatment, improved iron metabolism in older individuals with ESRD. These results provide some clues on the effects of RT and its combination with EPO and iron sulfate in this population, highlighting RT as an important coadjutant in ESRD-iron deficiency.

2020 ◽  
Vol 139 ◽  
pp. 111017
Author(s):  
Sting Ray Gouveia Moura ◽  
Hugo Luca Corrêa ◽  
Rodrigo Vanerson Passos Neves ◽  
Cláudio Avelino Rodrigues Santos ◽  
Luiz Sinésio Silva Neto ◽  
...  

2016 ◽  
Vol 44 (1) ◽  
pp. 32-45 ◽  
Author(s):  
Danwin Chan ◽  
Birinder S. Cheema

Background: This systematic review provides an overview of the extant literature on progressive resistance training (PRT) in patients with end-stage renal disease (ESRD) and outlines recommendations for future trials. Methods: A systematic review of all published literature evaluating the chronic (>6 weeks) application of PRT in patients with ESRD using electronic databases. Results: The search yielded 16 clinical trials, including 11 randomized controlled trials (RCT), 4 uncontrolled trials and one trial involving a within-subjects control period plus RCT. RCT quality, assessed via the CONSORT statement, ranged from low (4/10) to high (10/10) with a mean score of 7.3/10; 7/11 RCT had a quality score ≥7.5. All trials evaluated chronic adaptation to PRT across a range of important outcomes. PRT can induce muscle hypertrophy and improve aspects of physical functioning and health-related quality of life in ESRD. There is preliminary evidence that PRT may reduce protein-energy malnutrition and cardiovascular disease risk factors, including C-reactive protein, total cholesterol, triglyceride, and measures of insulin resistance in patients with or at-risk of comorbid type 2 diabetes. The evidence base for PRT adapting some of the endpoints investigated to date remains inconsistent (e.g. physical performance tests, obesity outcomes), and many other pertinent clinical outcomes remain to be investigated. Conclusion: RCT are required to investigate a range of novel research questions related to the benefits and application of PRT in this cohort and its patient subgroups (e.g. diabetes, depression, dyslipidemia, etc.). Future studies must be of high methodological quality to inform clinical practice guidelines.


2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii678-iii679
Author(s):  
Adrian Catalin Lungu ◽  
Oana Piscoran ◽  
Ana-Maria Pop ◽  
Cristina Stoica

2006 ◽  
Vol 144 (9) ◽  
pp. 701 ◽  
Author(s):  
Chi-yuan Hsu ◽  
Carlos Iribarren ◽  
Alan S. Go

Sign in / Sign up

Export Citation Format

Share Document