scholarly journals Association of Estimated Salt and Miso Intake with the Prevalence of Obesity in People with Type 2 Diabetes: A Cross-Sectional Study

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3014
Author(s):  
Fuyuko Takahashi ◽  
Yoshitaka Hashimoto ◽  
Ayumi Kaji ◽  
Ryosuke Sakai ◽  
Akane Miki ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Salt Intake ◽  
Urinary Sodium Excretion ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Prevalence Of Obesity ◽  
The Relationship ◽  
Median Amount

Salt intake is often estimated by the amount of sodium excreted in urine, and miso has been reported to increase it. This cross-sectional study investigated the relationship between obesity and high estimated salt intake with and without habitual miso consumption. Estimates of salt intake (g/day) were calculated using urinary sodium excretion, and a high estimated intake was defined as greater than the median amount of 9.5 g/day. Participants were divided into four groups based on estimated salt intake and miso consumption. Among 300 people, the proportions of obesity were 77.8% (n = 14/18), 40.2% (n = 53/132), 26.0% (n = 33/127), and 34.8% (n = 8/23) in the (+/-), (+/+), (-/+), and (-/-) groups of high estimated salt intake/habitual miso consumption, respectively. Compared with the (+/-) group, the adjusted odds ratios for obesity were 0.07 (95% confidence interval (CI): 0.02–0.26, p < 0.001), 0.16 (95% CI: 0.03–0.76, p = 0.022), and 0.14 (95% CI: 0.04–0.51, p = 0.003) in the (-/+), (-/-), and (+/+) groups, respectively. The presence of obesity was not much higher in people with high estimated salt intake with habitual miso consumption than that in people without. Clinicians should be aware that miso consumption promotes salt excretion, which may lead to an apparently higher estimated salt intake than actual.

scholarly journals Type 2 diabetes mellitus in glucose-6-phosphate dehydrogenase deficient individuals in a Ghanaian population

2020 ◽  
Vol 8 (12) ◽  
pp. 4348
Author(s):  
Perez Quartey ◽  
Bright Afriyie Owusu ◽  
Daniel Taylor ◽  
Eliza-Bertha Adomaka
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
G6pd Deficiency ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Chi Square Analysis ◽  
The Relationship

Background: Studies in different populations have shown an association between diabetes mellitus and G6PD deficiency. This association has not been investigated in the Ghanaian population. We conducted a cross-sectional study to investigate the relationship between G6PD deficiency and type 2 diabetes mellitus in a Ghanaian population.Methods: The cross-sectional study involved 125 registered type 2 diabetes mellitus clients and 125 non-diabetic individuals. Chi-square analysis was used to assess the association between G6PD status and type 2 diabetes mellitus with statistical significance pegged at p-value<0.05.Results: The prevalence of G6PD deficiency in the study population was 24.0% and 13.6% for the diabetics and non-diabetics respectively. In terms of gender, 29.5% of the diabetic males were G6PD deficient whiles G6PD deficiency was observed in 11.1% of the non-diabetic males. Additionally, 21.0% of the diabetic females were also G6PD deficient with 15.3% of the non-diabetic females being G6PD deficient. The results showed that the overall G6PD deficiency was significantly associated with type 2 diabetes mellitus as compared to the non-diabetics. In terms of gender differences, G6PD deficiency was significantly associated with type 2 diabetes in males but, there was no significant association in females.Conclusions: The study reports the first findings of the relationship between G6PD deficiencies among type 2 diabetes patients in Ghana. The study revealed that G6PD deficiency is more prevalent among type 2 diabetics than non-diabetics. Type 2 diabetes mellitus is independently associated with G6PD deficiency in males but not females.

scholarly journals A Pilot Study on the Effect of Anti-Thrombopoietin Antibody on Platelet Count in Patients with Type 2 Diabetes

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1667
Author(s):  
Takuya Fukuda ◽  
Masahide Hamaguchi ◽  
Takafumi Osaka ◽  
Yoshitaka Hashimoto ◽  
Emi Ushigome ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Platelet Count ◽  
Cross Sectional Study ◽  
Regression Analyses ◽  
Sectional Study ◽  
Cross Sectional ◽  
Platelet Production ◽  
The Relationship

Thrombopoietin (THPO) is a circulatory cytokine that plays an important role in platelet production. The presence of anti-THPO antibody relates to thrombocytopenia and is rarely seen in hematopoietic and autoimmune diseases. To date, there had been no reports that focused on the anti-THPO antibody in patients with type 2 diabetes mellitus (T2DM). To evaluate prevalence of the anti-THPO antibody in patients with T2DM and the relationship between anti-THPO antibody and platelet count, a cross-sectional study was performed on 82 patients with T2DM. The anti-THPO antibody was measured by ELISA using preserved sera and detected in 13 patients. The average platelet count was significantly lower in patients with the anti-THPO antibody than in those without the anti-THPO antibody. Multivariate linear regression analyses showed a significant relationship between the anti-THPO antibody and platelet count, after adjusting for other variables. To our best knowledge, this was the first report on the effect of the anti-THPO antibody on platelet count in patients with T2DM. Further investigation is needed to validate the prevalence and pathological significance of the anti-THPO antibody in patients with T2DM.

scholarly journals Relationship between hemoglobin glycation index and extent of coronary heart disease in individuals with type 2 diabetes mellitus: a cross-sectional study

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3875 ◽  
Author(s):  
Po Chung Cheng ◽  
Shang Ren Hsu ◽  
Yun Chung Cheng ◽  
Yu Hsiu Liu
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Relationship ◽  
Hemoglobin Glycation

Background Individuals with type 2 diabetes (T2D) are at an increased risk of coronary heart disease (CHD). Diabetic complications have recently been associated with a measure of glucose metabolism known as the hemoglobin glycation index (HGI). Currently there is insufficient information regarding a potential link between HGI and cardiovascular disease. This study aimed to investigate the relationship between HGI and extent of CHD in individuals with T2D. Methods This cross-sectional study screened individuals visiting the endocrinology clinic between June 2012 and May 2016 for eligibility. Enrollment criteria included individuals above 21 years of age with T2D diagnosed in the preceding ten years. Candidates with hemoglobin disorders, pregnancy, and existing coronary artery disease were excluded. Fasting plasma glucose (FPG) and glycated hemoglobin A1c (HbA1c) were sampled three months prior to angiography. The regression equation of predicted HbA1c = 0.008 × FPG + 6.28 described the linear relationship between these variables. HGI was calculated as the difference between the measured HbA1c and predicted HbA1c. Participants were classified into two groups according to the presence of supranormal (≥0) or subnormal HGI (<0). Results Among 423 participants, people with supranormal HGI harbored an increased prevalence of multiple vessel disease relative to those with subnormal HGI (Odds ratio (OR): 3.9, 95% CI [2.64–5.98], P < 0.001). Moreover, individuals with supranormal HGI more frequently demonstrated lesions involving the left anterior descending artery (OR: 3.0, 95% CI [1.97–4.66], P < 0.001). The intergroup difference in mean HbA1c was statistically nonsignificant (7.5 ± 1.0% versus 7.4 ± 1.1%, P = 0.80). Discussion This study demonstrated that HGI correlated with the extent of CHD in individuals with T2D. People with supranormal HGI harbored a higher prevalence of extensive cardiovascular disease compared to those with subnormal HGI. The relationship between HGI and extent of CHD enables cardiovascular risk stratification in at risk individuals. Overall, HGI provides useful information concerning cardiovascular risk in clinical practice.

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