scholarly journals The Associations of Dietary Iron Intake and the Transferrin Receptor (TFRC) rs9846149 Polymorphism with the Risk of Gastric Cancer: A Case–Control Study Conducted in Korea

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2600
Author(s):  
Tao Thi Tran ◽  
Madhawa Gunathilake ◽  
Jeonghee Lee ◽  
Il Ju Choi ◽  
Young-Il Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transferrin Receptor ◽  
Case Control Study ◽  
Positive Association ◽  
Case Control ◽  
Nonheme Iron ◽  
Dietary Iron ◽  
Protective Effects ◽  
Iron Intake ◽  
Control Study

Background: A positive association between a high iron intake and colorectal cancer has been identified; however, the effect of dietary iron on gastric cancer (GC) remains unclear. Here, we investigate whether dietary iron is related to GC risk and whether the transferrin receptor (TFRC) rs9846149 polymorphism modifies this association. Methods: A case–control study was designed to assess this association among 374 GC patients and 754 healthy controls. A self-administered questionnaire was used to collect information on demographics, medical history and lifestyle. Dietary iron intake was assessed using a semi-quantitative food frequency questionnaire. TFRC rs9846149 was genetically analyzed using the Affymetrix Axiom Exom 319 Array platform. Results: A higher total dietary iron was significantly associated with decreased GC risk [OR = 0.65 (0.45–0.94), p for trend = 0.018]. A similar association was observed with nonheme iron [OR = 0.64 (0.44–0.92), p for trend = 0.018]. Individuals with a major allele of TFRC rs9846149 (CC/GC) and higher intake of total iron had a significantly lower GC risk than those with a lower intake [OR = 0.60 (0.41–0.88), p interaction = 0.035]. Conclusion: Our findings show the protective effects of total dietary iron, especially nonheme iron, against GC risk, and this association can be modified by TFRC rs9846149.

scholarly journals The association between dietary inflammatory index and gastric cancer: A case control study

2020 ◽  
Author(s):  
Ahmad Mujtaba Barekzai ◽  
Azadeh Aminianfar ◽  
Seyed Mohammad Mousavi ◽  
Ahmad Esmaillzadeh
Keyword(s):  
Gastric Cancer ◽  
Case Control Study ◽  
Dietary Assessment ◽  
Positive Association ◽  
Case Control ◽  
Dietary Inflammatory Index ◽  
Significant Positive Association ◽  
Inflammatory Index ◽  
Gastric Cancer Patients ◽  
Control Study

Abstract Background No report is available about diet-disease associations in the understudied region of Afghanistan. Although inflammatory potential of diet has been linked with several cancers, information about gastric cancer is scarce. This study aimed to investigate the relationship between dietary inflammatory index (DII) and odds of gastric cancer in Afghanistan. Methods In this hospital-based case-control study, we enrolled 90 newly-diagnosed cases of gastric cancer and 180 age (± 5) and sex-matched controls. All cases were pathologically confirmed gastric cancer patients, with no history of any type of other pathologically confirmed cancers. Controls were healthy individuals and relatives of patients in the hospital. Dietary assessment was done by a pre-tested food frequency questionnaire. DII was calculated based on energy-adjusted amounts of several foods and nutrients with inflammatory or anti-inflammatory potential, as introduced by earlier studies. Results Mean age of study participants was 54 years, of them 73% were males. After adjustment for age and sex, individuals in the highest tertile of DII were 2.47 times (95% CI: 1.31–4.66) more likely to have gastric cancer compared with those in the lowest tertile. Further adjustment for other potential confounders did not substantially affect the association; such that participants with the greatest DII had approximately 3.59 times (95% CI: 1.16, 11.02) increased odds of gastric cancer than those with the lowest adherence. Additional adjustment for BMI strengthened the association (OR: 3.75; 95% CI: 1.14–12.30). Conclusion We found a significant positive association between inflammatory potential of diet and risk of gastric cancer. Further studies with prospective nature are required to confirm this association.

scholarly journals Dietary Iron Intake and Risk of Endometrial Cancer: A Population-Based Case-Control Study in Shanghai, China

2009 ◽  
Vol 62 (1) ◽  
pp. 40-50 ◽  
Author(s):  
Asha R. Kallianpur ◽  
Sang-Ah Lee ◽  
Wang-Hong Xu ◽  
Wei Zheng ◽  
Yu-Tang Gao ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Dietary Iron ◽  
Iron Intake ◽  
Control Study

Verification of the Utility of Palliative Radiotherapy for Hemostasis of Gastric Cancer Bleeding: a Case Control Study

2021 ◽  
Author(s):  
Hirofumi Sugita ◽  
Shinichi Sakuramoto ◽  
Yoshiaki Mihara ◽  
Kazuaki Matsui ◽  
Keiji Nishibeppu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Control Study ◽  
Palliative Radiotherapy ◽  
Case Control ◽  
Control Study

Ethnicity and H. Pylori as Risk Factors for Gastric Cancer in Malaysia: A Prospective Case Control Study

2007 ◽  
Vol 102 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Khean-Lee Goh ◽  
Phaik-Leng Cheah ◽  
Noorfaridah Md ◽  
Kia-Fatt Quek ◽  
Navaratnam Parasakthi
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Case Control Study ◽  
Case Control ◽  
H Pylori ◽  
Control Study ◽  
Prospective Case Control Study

scholarly journals Anti-CCP Antibody Levels Are Not Associated with MS: Results from a Case-Control Study

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Mahmut Alpayci ◽  
Aysel Milanlioglu ◽  
Veysel Delen ◽  
Mehmet Nuri Aydin ◽  
Huseyin Guducuoglu ◽  
...  
Keyword(s):  
Case Control Study ◽  
Critical Role ◽  
Positive Association ◽  
Case Control ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Controls ◽  
Citrullinated Proteins ◽  
Antibody Levels ◽  
Citrullinated Peptide ◽  
Control Study

Citrullinated proteins have been suggested to play a critical role in the pathogenesis of multiple sclerosis (MS). Anticyclic citrullinated peptide (anti-CCP) antibody is used in the early diagnosis of rheumatoid arthritis (RA). The objective of this study was to investigate the presence of anti-CCP antibody in patients with MS compared to RA patients and healthy controls. Fifty patients with MS (38 females, 12 males; mean age 36.72 ± 8.82 years), 52 patients with RA (40 females, 12 males; mean age 40.87 ± 10.17 years), and 50 healthy controls (32 females, 18 males; mean age 38.22 ± 11.59 years) were included in this study. The levels of serum anti-CCP antibody were measured using an enzyme-linked immunosorbent assay (ELISA). The results of the study showed that anti-CCP antibody levels were significantly higher in RA patients versus MS or healthy controls(P<0.001). Moreover, anti-CCP antibody was positive in 43 (83%) patients with RA, while it was negative in all MS patients as well as in all healthy controls. Also, no significant correlation was found between the anti-CCP levels and EDSS scores(r=-0.250). In conclusion, the results of this study did not support a positive association between serum anti-CCP antibody and MS.

scholarly journals Determinants of stillbirths among women who gave birth at Hawassa university comprehensive specialized hospital, Hawassa, Sidama, Ethiopia 2019: a case-control study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Rekiku Fikre ◽  
Samuel Ejeta ◽  
Taye Gari ◽  
Akalewold Alemayhu
Keyword(s):  
Case Control Study ◽  
Sampling Technique ◽  
Positive Association ◽  
Simple Random Sampling ◽  
Case Control ◽  
Obstructed Labor ◽  
Specialized Hospital ◽  
Prolonged Labor ◽  
Hawassa University ◽  
Control Study

Abstract Background Globally over 2.6 million pregnancy ends with stillbirth annually. Despite this fact, only a few sherds of evidence were available about factors associated with stillbirth in Ethiopia. Therefore, the study aimed to spot factors related to stillbirth among women who gave birth at Hawassa University Comprehensive Specialized Hospital Hawassa, Sidama Ethiopia, 2019. Methods Facility-based unmatched case-control study was conducted at Hawassa University Comprehensive Specialized Hospital. Cases were selected using simple random sampling technique and controls were recruited to the study consecutively after every case selection with case to control ratio of 1 to 3. Data were coded and entered into Epi-data version 3.1 and exported to SPSS version 24 for analysis. Results A total of 106 cases and 318 controls were included in the study. Number of antenatal care visit [AOR = 0.38, 95% CI (0.15, 0.95)], lack of partograph utilization [AOR = 4.1 95% CI (2.04, 10.5)], prolonged labor [AOR = 6.5, 95% CI (2.9, 14.4)], obstructed labor [AOR = 3.5, 95% CI (1.5, 9.4)], and congenital defect [AOR = 9.7, 95% CI (4.08, 23.0)] were significantly associated with stillbirth. Conclusion Absence of partograph utilization, prolonged labor, obstructed labor, antepartum hemorrhage and congenital anomaly were found to have positive association with stillbirth.

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