scholarly journals Frequency and Characteristics of Overestimated Renal Function in Japanese Patients with Chronic Liver Disease and Its Relation to Sarcopenia

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2415
Author(s):  
Sonoe Yoshida ◽  
Goki Suda ◽  
Masatsugu Ohara ◽  
Qingjie Fu ◽  
Zijian Yang ◽  
...  
Keyword(s):  
Renal Function ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Muscle Mass ◽  
High Frequency ◽  
Psoas Muscle ◽  
Japanese Patients ◽  
Multivariate Regression Analysis ◽  
Chronic Liver ◽  
Function Loss

Renal dysfunction and sarcopenia are important prognostic factors in patients with chronic liver disease (CLD). Muscle atrophy can cause the overestimation of renal function based on serum creatinine. However, the frequency of overestimated renal function in Japanese patients with CLD and its relationship with sarcopenia are unclear. In present study, we evaluated the frequency of overestimated renal function, defined as a >20% higher eGFR using creatinine than using cystatin C, in 307 patients with CLD as well as its relationship with indicators of sarcopenia. In total, 24.8% of patients had overestimated renal function. In a multivariate regression analysis, liver cirrhosis (p = 0.004) and psoas muscle mass index (p = 0.049) were significantly associated with overestimated renal function. Loss of skeletal muscle mass was significantly more frequent in both male and female patients with overestimated renal function than without. In males, the loss of muscle strength and rate of sarcopenia, defined as loss of muscle mass and strength, were significantly higher in patients with than without overestimated renal function. The high frequency of overestimated renal function in Japanese patients suggests that indicators of renal function should be carefully considered; furthermore, monitoring and interventions for both renal function and sarcopenia are needed in patients with CLD.

Prevalence of restless legs syndrome in Japanese patients with chronic liver disease

2012 ◽  
Vol 42 (12) ◽  
pp. 1221-1226 ◽  
Author(s):  
Toshihisa Matsuzaki ◽  
Tatsuki Ichikawa ◽  
Hideaki Kondo ◽  
Naota Taura ◽  
Hisamitsu Miyaaki ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chronic Liver Disease ◽  
Restless Legs Syndrome ◽  
Japanese Patients ◽  
Chronic Liver ◽  
Restless Legs

Prostaglandins: Modulators of Renal Function and Pressor Resistance in Chronic Liver Disease*

1979 ◽  
Vol 48 (6) ◽  
pp. 895-900 ◽  
Author(s):  
ROBERT D. ZIPSER ◽  
JOHN C. HOEFS ◽  
PAUL F. SPECKART ◽  
PRISCILLA K. ZIA ◽  
RICHARD HORTON
Keyword(s):  
Renal Function ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver

scholarly journals Effects of in-hospital exercise on liver function, physical ability, and muscle mass during treatment of hepatoma in patients with chronic liver disease

2016 ◽  
Vol 47 (3) ◽  
pp. E22-E34 ◽  
Author(s):  
Shunji Koya ◽  
Takumi Kawaguchi ◽  
Ryuki Hashida ◽  
Emiko Goto ◽  
Hiroo Matsuse ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Function ◽  
Chronic Liver Disease ◽  
Muscle Mass ◽  
Chronic Liver ◽  
Physical Ability

Diuretics in critical illness

2016 ◽  
Author(s):  
Marlies Ostermann ◽  
Ruth Y. Y. Wan
Keyword(s):  
Heart Failure ◽  
Chronic Kidney Disease ◽  
Congestive Heart Failure ◽  
Renal Function ◽  
Liver Disease ◽  
Kidney Disease ◽  
Chronic Liver Disease ◽  
Fluid Overload ◽  
Chronic Liver ◽  
Risk Of Death

Fluid overload and chronic hypertension are the most common indications for diuretics. The diuretic response varies between different types and depends on underlying renal function. In patients with congestive heart failure, diuretics appear to reduce the risk of death and worsening heart failure compared with placebo, but their use in acute decompensated heart failure is questionable. Diuretics are also widely used in chronic kidney disease to prevent or control fluid overload, and treat hypertension. In acute kidney injury, there is no evidence that they improve renal function, speed up recovery, or change mortality. In patients with chronic liver disease and large volume ascites, paracentesis is more effective and associated with fewer adverse events than diuretic therapy, but maintenance treatment with diuretics is indicated to prevent recurrence of ascites. Mannitol has a role in liver patients with cerebral oedema and normal renal function. The use of diuretics in rhabdomyolysis is controversial and restricted to patients who are not fluid deplete. In conditions associated with resistant oedema (chronic kidney disease, congestive heart failure, chronic liver disease), combinations of diuretics with different modes of action may be necessary. Diuresis is easier to achieve with a continuous furosemide infusion compared with intermittent boluses, but there is no evidence of better outcomes. The role of combination therapy with albumin in patients with fluid overload and severe hypoalbuminaemia is uncertain with conflicting data.

Calculated body muscle mass as a useful screening marker for low skeletal muscle mass and sarcopenia in chronic liver disease

2020 ◽  
Vol 50 (6) ◽  
pp. 704-714
Author(s):  
Tatsuki Ichikawa ◽  
Hisamitsu Miyaaki ◽  
Satoshi Miuma ◽  
Yasuhide Motoyoshi ◽  
Mio Yamashima ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Chronic Liver ◽  
Body Muscle ◽  
Screening Marker

Development of a simple predictive model for decreased skeletal muscle mass in patients with compensated chronic liver disease

2017 ◽  
Vol 47 (12) ◽  
pp. 1223-1234 ◽  
Author(s):  
Hiroki Nishikawa ◽  
Hirayuki Enomoto ◽  
Akio Ishii ◽  
Yoshinori Iwata ◽  
Yuho Miyamoto ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Predictive Model ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Chronic Liver

Hepatitis G virus infection in Japanese patients with chronic liver disease

Transfusion ◽  
1997 ◽  
Vol 37 (9) ◽  
pp. 985-986
Author(s):  
A Shimoda ◽  
S Kaneko ◽  
M Takamatsu ◽  
K Kobayashi ◽  
T Saitou ◽  
...  
Keyword(s):  
Liver Disease ◽  
Virus Infection ◽  
Chronic Liver Disease ◽  
Japanese Patients ◽  
Chronic Liver ◽  
Hepatitis G Virus ◽  
Hepatitis G

scholarly journals Tu1584 – Strong Effect of Lusutrombopag in Patients with Chronic Liver Disease and Its Relationship to Renal Function

2019 ◽  
Vol 156 (6) ◽  
pp. S-1368
Author(s):  
Hirohito Takeuchi ◽  
Yoshihiro Furuichi ◽  
Masakazu Abe ◽  
Yoshitaka Kasai ◽  
Katsutoshi Sugimoto ◽  
...  
Keyword(s):  
Renal Function ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver
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