scholarly journals Dietary Antiplatelets: A New Perspective on the Health Benefits of the Water-Soluble Tomato Concentrate Fruitflow®

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2184
Author(s):  
Niamh O’Kennedy ◽  
Ruedi Duss ◽  
Asim K Duttaroy
Keyword(s):  
Immune Responses ◽  
Cardiovascular Health ◽  
Water Soluble ◽  
Health Conditions ◽  
Specific Reference ◽  
Clinical Settings ◽  
Future Developments ◽  
Tomato Extract ◽  
New Perspective ◽  
Exercise Induced

Our understanding of platelet functionality has undergone a sea change in the last decade. No longer are platelets viewed simply as regulators of haemostasis; they are now acknowledged to be pivotal in coordinating the inflammatory and immune responses. This expanded role for platelets brings new opportunities for controlling a range of health conditions, targeting platelet activation and their interactions with other vascular cells. Antiplatelet drugs may be of wider utility than ever expected but often cause platelet suppression too strong to be used out of clinical settings. Dietary antiplatelets represent a nutritional approach that can be efficacious while safe for general use. In this review, we discuss potential new uses for dietary antiplatelets outside the field of cardiovascular health, with specific reference to the water-soluble tomato extract Fruitflow®. Its uses in different aspects of inflammation and immune function are discussed, highlighting exercise-induced inflammation, mediating the effects of air pollution, and controlling thrombotic aspects of the immune response. Potential future developments in women’s health, erectile dysfunction, and the allergic response indicate how broad the utility of dietary antiplatelets can be.

scholarly journals Dietary antiplatelets: a new perspective on the health benefits of the water-soluble tomato concentrate Fruitflow®

2021 ◽  
Author(s):  
Niamh O’Kennedy ◽  
Ruedi Duss ◽  
Asim K Duttaroy
Keyword(s):  
Immune Responses ◽  
Cardiovascular Health ◽  
Water Soluble ◽  
Health Conditions ◽  
Specific Reference ◽  
Clinical Settings ◽  
Future Developments ◽  
Tomato Extract ◽  
New Perspective ◽  
Exercise Induced

Understanding platelet functionality has undergone a sea change in the last decade. No longer are platelets viewed simply as regulators of haemostasis; they are now acknowledged to be pivotal in coordinating the inflammatory and immune responses. This expanded role for platelets brings new opportunities for controlling a range of health conditions, targeting platelet activation and their interactions with other vascular cells. Antiplatelet drugs may be of wider utility than ever expected but often cause too strong a platelet suppression to be used out of clinical settings. Dietary antiplatelets represent a nutritional approach that can be efficacious while safe for general use. Here we review potential new uses for dietary antiplatelets outside the field of cardiovascular health, with specific reference to the water-soluble tomato extract Fruitflow®. Uses in different aspects of inflammation and immune function are discussed, highlighting exercise-induced inflammation, mediating the effects of air pollution, and controlling thrombotic aspects of the immune response. Potential future developments in women’s health, erectile dysfunction, and the allergic response give an indication of how wide-ranging the utility of dietary antiplatelets can possibly be.

Insights from Exercise-induced Cardioprotection-from Clinical Application to Basic Research

2019 ◽  
Vol 25 (35) ◽  
pp. 3751-3761 ◽  
Author(s):  
Hao Jiang ◽  
Beijian Zhang ◽  
Daile Jia ◽  
Wenlong Yang ◽  
Aijun Sun ◽  
...  
Keyword(s):  
Cardiovascular Health ◽  
Vascular System ◽  
Basic Research ◽  
Coronary Intervention ◽  
Clinical Findings ◽  
Central Component ◽  
Health It ◽  
Coronary Syndrome ◽  
Percutaneous Coronary ◽  
Exercise Induced

Exercise has long been recognized as a beneficial living style for cardiovascular health. It has been applied to be a central component of cardiac rehabilitation for patients with chronic heart failure (CHF), coronary heart disease (CHD), post-acute coronary syndrome (ACS) or primary percutaneous coronary intervention (PCI), post cardiac surgery or transplantation. Although the effect of exercise is multifactorial, in this review, we focus on the specific contribution of regular exercise on the heart and vascular system. We will summarize the known result of clinical findings and possible mechanisms of chronic exercise on the cardiovascular system.

Abstract 636: Gut Microflora Influences Pathology in the Kawasaki Disease (KD) Vasculitis Mouse Model

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Daiko Wakita ◽  
Yosuke Kurashima ◽  
Yoshihiro Takasato ◽  
Youngho Lee ◽  
Kenichi Shimada ◽  
...  
Keyword(s):  
Mouse Model ◽  
Immune Responses ◽  
Critical Role ◽  
Gut Microflora ◽  
Vascular Abnormalities ◽  
Coronary Arteritis ◽  
Specific Pathogen ◽  
New Perspective ◽  
Bacteria And Fungi

Background: KD is the leading cause of acquired heart disease in the US. We have demonstrated the critical role of innate immune responses via IL-1R/MyD88 signaling in the Lactobacillus casei cell wall extract (LCWE)-induced KD mouse model. The diversity and composition of microflora (both bacterial and fungal) have been associated with the regulation and alterations of immune responses and various pathologies. However, the role of gut microbiota in immunopathology of KD has not been investigated. Objective: To evaluate the role of gut microflora in development of coronary arteritis, and vascular abnormalities in KD mouse model. Methods and Results: We investigated the role of gut microflora in the LCWE-induced KD mouse model, using Specific-Pathogen Free (SPF) and Germ Free (GF) mice (C57BL/6). GF mice showed a significant decrease of KD lesions, including coronary arteritis compared with SPF mice. The development of LCWE-induced AAA, which we recently discovered in this mouse model, was also markedly diminished in GF mice. In addition to GF mice, we also investigated the specific role of commensal bacteria and/or fungi, and determined whether altered microorganism burden in this KD mouse model contributes to disease severity. To deplete bacteria and/or fungi in the gut microflora, we exposed pregnant SPF mice and their offspring to antibiotics cocktail (Abx) or antifungal drug (fluconazole; Fluc) in their drinking water for 5 wks and induced KD. The mice treated with Abx or Fluc had significantly reduced coronary arteritis and AAA compared to controls. The Abx plus Fluc administration showed marked decrease of KD vasculitis. Conclusions: We demonstrate here that gut microflora play a critical role in the development of KD vasculitis in LCWE-induced mouse model. Our results suggest that both bacteria and fungi in the intestinal microbiota may control the induction and severity of KD vasculitis. These findings provide a new perspective on the potential role of the microbiome in KD pathogenesis and may offer new diagnostic and therapeutic strategies for KD patients.

Lungsounds@UA Interface and Multimedia Database

2014 ◽  
Vol 5 (1) ◽  
pp. 81-95 ◽  
Author(s):  
Cátia Pinho ◽  
Ana Oliveira ◽  
Daniela Oliveira ◽  
João Dinis ◽  
Alda Marques
Keyword(s):  
Pilot Study ◽  
User Interfaces ◽  
Graphical User Interfaces ◽  
Respiratory Sounds ◽  
Multimedia Database ◽  
Clinical Settings ◽  
Related Data ◽  
Future Developments ◽  
Healthcare Technologies ◽  
Available Information

The development of graphical user interfaces (GUIs) has been an emergent demand in the area of healthcare technologies. Specifically for respiratory healthcare there is a lack of tools to produce a complete multimedia database, where respiratory sounds and other clinical data are available in a single repository. This is essential for a complete patients' assessment and management in research/clinical settings. Therefore, this study aimed to develop a usable interface to collect and organise respiratory-related data in a single multimedia database. A GUI, named LungSounds@UA, composed by a multilayer of windows, was developed. The usability of the user-centred interface was assessed in a pilot study and in an evaluation session. The users testified the utility of the application and its great potential for research/clinical settings. However, some drawbacks were identified, such as a certain difficulty to intuitively navigate in the great amount of the available information, which will inform future developments.

scholarly journals Characterization of an Insoluble and Soluble Form of Melanin Produced by Streptomyces cavourensis SV 21, a Sea Cucumber Associated Bacterium

Marine Drugs ◽  
2022 ◽  
Vol 20 (1) ◽  
pp. 54
Author(s):  
Joko Tri Wibowo ◽  
Matthias Y. Kellermann ◽  
Lars-Erik Petersen ◽  
Yustian R. Alfiansah ◽  
Colleen Lattyak ◽  
...  
Keyword(s):  
Biological Properties ◽  
Water Soluble ◽  
Soluble Form ◽  
Wide Range ◽  
Biological Form ◽  
Insoluble Form ◽  
New Perspective ◽  
Living Organisms ◽  
Purification Protocol

Melanin is a widely distributed and striking dark-colored pigment produced by countless living organisms. Although a wide range of bioactivities have been recognized, there are still major constraints in using melanin for biotechnological applications such as its fragmentary known chemical structure and its insolubility in inorganic and organic solvents. In this study, a bacterial culture of Streptomyces cavourensis SV 21 produced two distinct forms of melanin: (1) a particulate, insoluble form as well as (2) a rarely observed water-soluble form. The here presented novel, acid-free purification protocol of purified particulate melanin (PPM) and purified dissolved melanin (PDM) represents the basis for an in-depth comparison of their physicochemical and biological properties, which were compared to the traditional acid-based precipitation of melanin (AM) and to a synthetic melanin standard (SM). Our data show that the differences in solubility between PDM and PPM in aqueous solutions may be a result of different adjoining cation species, since the soluble PDM polymer is largely composed of Mg2+ ions and the insoluble PPM is dominated by Ca2+ ions. Furthermore, AM shared most properties with SM, which is likely attributed to a similar, acid-based production protocol. The here presented gentler approach of purifying melanin facilitates a new perspective of an intact form of soluble and insoluble melanin that is less chemical altered and thus closer to its original biological form.

scholarly journals A New Perspective for Prevention and to Cure COVID-19 Patients: Encouraging Medical Teams to Contact Healed People Treated with Chlorine Dioxide in Solution (CDS)

2020 ◽  
Vol 7 ◽  
Author(s):  
Enrique Martinez
Keyword(s):  
Chlorine Dioxide ◽  
Health Conditions ◽  
Healthcare Environments ◽  
The World ◽  
New Perspective ◽  
Medical Teams ◽  
Local Healthcare ◽  
Actual Health

This article is written to encourage medical teams from all over the world to contact the patients already treated with this soluble gas. To contact also their medical teams accompanying the study cases as to verify the actual health conditions of patients. Finally, the invitation is to question whether CDS should be tried in their respective local healthcare environments.

scholarly journals Leptin and Immunological Profile in Obesity and Its Associated Diseases in Dogs

2019 ◽  
Vol 20 (10) ◽  
pp. 2392 ◽  
Author(s):  
Laura Cortese ◽  
Giuseppe Terrazzano ◽  
Alessandra Pelagalli
Keyword(s):  
Immune Responses ◽  
Scientific Evidence ◽  
Health Conditions ◽  
Leptin Resistance ◽  
Peripheral Tissues ◽  
Chronic Inflammatory Response ◽  
Immunological Status ◽  
Associated Diseases ◽  
Immunological Profile ◽  
Inflammatory State

Growing scientific evidence has unveiled increased incidences of obesity in domestic animals and its influence on a plethora of associated disorders. Leptin, an adipokine regulating body fat mass, represents a key molecule in obesity, able to modulate immune responses and foster chronic inflammatory response in peripheral tissues. High levels of cytokines and inflammatory markers suggest an association between inflammatory state and obesity in dogs, highlighting the parallelism with humans. Canine obesity is a relevant disease always accompanied with several health conditions such as inflammation, immune-dysregulation, insulin resistance, pancreatitis, orthopaedic disorders, cardiovascular disease, and neoplasia. However, leptin involvement in many disease processes in veterinary medicine is poorly understood. Moreover, hyperleptinemia as well as leptin resistance occur with cardiac dysfunction as a consequence of altered cardiac mitochondrial metabolism in obese dogs. Similarly, leptin dysregulation seems to be involved in the pancreatitis pathophysiology. This review aims to examine literature concerning leptin and immunological status in obese dogs, in particular for the aspects related to obesity-associated diseases.

scholarly journals Criteria and Applications of the MK Classification System

1979 ◽  
Vol 47 ◽  
pp. 23-30
Author(s):  
R. F. Garrison
Keyword(s):  
Present State ◽  
Classification System ◽  
Visual Inspection ◽  
Higher Dimensions ◽  
Variable Stars ◽  
Specific Reference ◽  
The Sun ◽  
The Third ◽  
Future Developments ◽  
Inspection Techniques

AbstractA review is given of the present state of MK classification, with a view to future developments in techniques and instrumentation. The principle of the complementarity of quantitative and visual inspection techniques is stressed.Included in the discussion are examples of problems which are currently outstanding. Among these are variable stars, marginal peculiarities, fundamental standards (with specific reference to the Sun), and representation of the third and higher dimensions.

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