scholarly journals Selenium, Copper, Zinc Concentrations and Cu/Zn, Cu/Se Molar Ratios in the Serum of Patients with Acute Ischemic Stroke in Northeastern Poland—A New Insight into Stroke Pathophysiology

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2139
Author(s):  
Anna Mirończuk ◽  
Katarzyna Kapica-Topczewska ◽  
Katarzyna Socha ◽  
Jolanta Soroczyńska ◽  
Jacek Jamiołkowski ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Absorption Spectrometry ◽  
Molar Ratios ◽  
Control Subjects ◽  
Mineral Components ◽  
Healthy Control ◽  
Northeastern Poland ◽  
Zinc Concentrations ◽  
Copper Zinc

Background: In recent years, trace elements (TEs) have gained considerable attention in the course of treatment and diagnosis of ischemic stroke. The purpose of the conducted research was to determine the trace mineral status (Se, Cu, Zn, Cu/Zn ratio, and Cu/Se ratio) in patients with acute ischemic stroke compared to the population of healthy people in the northeastern region of Poland. Materials and methods: 141 patients with acute ischemic stroke (AIS) and 69 healthy control subjects were examined. The serum concentrations of mineral components were assessed by the atomic absorption spectrometry method. Clinical parameters were updated based on medical records. Results: The serum Se and Zn concentrations were significantly decreased (p < 0.0001; p < 0.0001) in patients with AIS compared with healthy control subjects. However, no significant differences were revealed in terms of the serum Cu concentration (p = 0.283). As expected, we found that the serum Cu/Zn and Cu/Se molar ratios were significantly higher (p = 0.001; p < 0.0001) in patients with AIS compared with healthy control subjects. Conclusions: Disturbed metal homeostasis is a significant contributor to AIS pathogenesis. Furthermore, marked disruption of the serum Cu/Zn and Cu/Se molar ratios could serve as a valuable indicator of AIS patients’ nutritional status and oxidative stress levels.

scholarly journals The Serum High-Sensitive C Reactive Protein and Homocysteine Levels to Evaluate the Prognosis of Acute Ischemic Stroke

2007 ◽  
Vol 2007 ◽  
pp. 1-5 ◽  
Author(s):  
Tahir Yoldas ◽  
Murat Gonen ◽  
Ahmet Godekmerdan ◽  
Fulya Ilhan ◽  
Ednan Bayram
Keyword(s):  
Ischemic Stroke ◽  
Clinical Status ◽  
Elevated Serum ◽  
Short Term ◽  
Reactive Protein ◽  
Control Subjects ◽  
Common Causes ◽  
Healthy Control ◽  
The Mean ◽  
The Relationship

Ischemic stroke is one of the most common causes of death worldwide and is most often caused by thrombotic processes. We investigated the changes in hsCRP and homocysteine levels, two of these risk factors, during the acute period of ischemic stroke and evaluated the relationship between these levels and the short-term prognosis. HsCRP and homocysteine levels were measured at the 2nd, 5th, and 10th days in forty patients admitted within second of an ischemic stroke. The clinical status of the patients was simultaneously evaluated with the Scandinavian stroke scale. The results were compared with 40 healthy control subjects whose age and sex were matched with the patients. The mean hsCRP levels of the patients were9.4±7.0mg/L on the 2nd day,11.0±7.4mg/L on the 5th day, and9.2±7.0mg/L on the 10th day. The mean hsCRP level of the control subjects was1.7±2.9mg/L. The mean hsCRP levels of the patients on the 2nd, 5th, and 10th days were significantly higher than the control subjects (P<.001). The patients' mean homocysteine levels were40.6±9.6μmol/L on the 2nd day,21.7±11.1μmol/L on the 5th day, and20.7±9.2μmol/L on the 10th day. The mean homocysteine level of the control subjects was11.2±1.1μmol/L. The homocysteine levels of the patients were higher than the control subjects at all times (P<.01). In conclusion, patients with stroke have a higher circulating serum hsCRP and homocysteine levels. Short-term unfavorable prognosis seems to be associated with elevated serum hsCRP levels in patients with stroke. Although serum homocysteine was found to be higher, homocysteine seems not related to prog nosis.

scholarly journals The Prognostic Value of Homocysteine in Acute Ischemic Stroke Patients: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 14 ◽  
Author(s):  
Shengming Huang ◽  
Jirui Cai ◽  
Yuejun Tian
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Independent Predictor ◽  
Meta Analysis ◽  
Survival Outcomes ◽  
Asian Patients ◽  
Significant Difference ◽  
Healthy Control ◽  
B12 Deficiency ◽  
Review Manager

Background: This comprehensive meta-analysis aimed to assess whether an increased homocysteine (Hcy) level is an independent predictor of unfavorable outcomes in acute ischemic stroke (AIS) patients.Methods: A comprehensive literature search was conducted up to August 1, 2020 to collect studies reporting Hcy levels in AIS patients. We analyzed all the data using Review Manager 5.3 software.Results: Seventeen studies with 15,636 AIS patients were selected for evaluation. A higher Hcy level was associated with a poorer survival outcome (OR 1.43, 95% CI: 1.25–1.63). Compared with the AIS group, Hcy levels were significantly lower in the healthy control patients, with an SMD of 5.11 and 95% CI (1.87–8.35). Analysis of the different subgroups of AIS demonstrated significant associations between high Hcy levels and survival outcomes only in Caucasian and Asian patients. Moreover, whereas high Hcy levels were closely associated with gender, B12 deficiency, smoking, and patients who received tissue plasminogen activator treatment, no significant difference was found between increased Hcy levels and age, drinking, hypertension, diabetes mellitus, and hyperlipidemia. In addition, the cut-off value (20.0 μmol/L) might be an optimum cut-off index for AIS patients in clinical practice.Conclusion: This meta-analysis reveals that the Hcy level may serve as an independent predictor for unfavorable survival outcomes in AIS patients, particularly in Caucasian and Asian AIS patients. Further studies can be conducted to clarify this relationship.

scholarly journals Circulating Soluble CD163: A Potential Predictor for the Functional Outcome of Acute Ischemic Stroke

2021 ◽  
Vol 12 ◽  
Author(s):  
Houchao Sun ◽  
Xiaogang Zhang ◽  
Jingxi Ma ◽  
Zhao Liu ◽  
Yunwen Qi ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Functional Outcome ◽  
Functional Outcomes ◽  
Plasma Concentrations ◽  
Soluble Form ◽  
Soluble Cd163 ◽  
Transmembrane Glycoprotein ◽  
Potential Biomarker ◽  
Healthy Control

Background: CD163 is a transmembrane glycoprotein receptor expressed on innate immune cells that sheds from the cell membrane and circulates as a soluble form (sCD163). This study aimed to investigate the circulating levels and clinical relevance of soluble CD163 (sCD163) in acute ischemic stroke (AIS).Methods: This study recruited 300 patients with AIS and 78 healthy controls. The patients were followed up for 1 month to observe the functional outcomes. The neurological functions of the patients were assessed using the NIH Stroke Scale (NIHSS) and the modified Rankin Scale (mRS). The plasma concentrations of sCD163 at the baseline (patient admission) were determined by ELISA.Results: We found that patients with AIS had significantly higher plasma sCD163 concentrations than the healthy control. Patients with high sCD163 concentrations had better functional outcomes than patients with low sCD163 concentrations. The plasma sCD163 concentrations were positively associated with the NIHSS scores and infarction volume at the baseline. The plasma sCD163 was positively associated with the improvement of the NIHSS scores but was negatively associated with the risk of poor functional outcomes during follow-up.Conclusions: These findings indicate that circulating sCD163 is a potential biomarker that is associated with disease severity and the functional outcome of AIS.

scholarly journals Evaluation of C Reactive Protein in Acute Ischemic Stroke

2014 ◽  
Vol 30 (1) ◽  
pp. 45-49
Author(s):  
Kazi Giasuddin Ahmed ◽  
Abu Saleh Md Badrul Hasan ◽  
Biplop Kumar Roy ◽  
Md Rafiqul Islam ◽  
Md Ruhul Quddus
Keyword(s):  
Ischemic Stroke ◽  
Ischaemic Stroke ◽  
Acute Ischemic Stroke ◽  
Acute Ischaemic Stroke ◽  
Case Group ◽  
C Reactive Protein ◽  
Stroke Patients ◽  
Reactive Protein ◽  
Control Subjects ◽  
Age And Sex

Background: Stroke is a dreadful health hazard all over the world as well as in our country. The relationship between serum C-reactive protein (CRP) level and acute ischaemic stroke is not well studied especially in Bangladesh. Aims and Objectives: To evaluate the association of C-reactive protein (CRP) in acute ischemic stroke .Materials and Methods: This case-control study was carried out in the Department of Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka during the period from January 2006 to December 2007. A total of 30 acute ischaemic stroke patients were included in the case group. Another 30 age and sex matched and apparently healthy persons without any stroke were taken as controls. Results: The stroke patients [21 (70.0%) male; mean age, 56.3 (SD±13.7) years] and control subjects [25 (83.3%) male; mean age, 53.4 (SD ± 9.9) years] were similar in age and sex (p>0.05 each). CRP level was significantly higher in acute ischaemic stroke patients than that of control [42.06 (SD ± 21.26) mg/L; vs 4.30 (SD ± 0.072) mg/L; p<0.001]. CRP was found positive in 28 (93.7%) stroke patients and none of the control subjects. CRP was 16 times significantly higher in stroke patients than that of control subjects (OR=16.00; 95% CI=4.18-61.22; p<0.001).Conclusion: This study confirms that CRP is elevated in acute ischaemic stroke. More local studies are required regarding the significance of CRP as a risk factor for acute ischemic stroke. Bangladesh Journal of Neuroscience 2014; Vol. 30 (1): 45-49

Single nucleotide polymorphisms in the VKORC1 gene and the risk of stroke in the Southern German population

2008 ◽  
Vol 100 (10) ◽  
pp. 614-617 ◽  
Author(s):  
Christoph Lichy ◽  
Inge Werner ◽  
Alexander Radbruch ◽  
Simone Wagner ◽  
Caspar Grond-Ginsbach ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
German Population ◽  
Nucleotide Polymorphisms ◽  
Young Population ◽  
Northern Germany ◽  
Single Nucleotide ◽  
Control Subjects ◽  
Epoxide Reductase ◽  
Healthy Control ◽  
Vkorc1 Gene

SummaryVariation in the gene that encodes the vitamin K epoxide reductase subunit 1 (VKORC1) was recently proposed as a genetic risk factor for stroke in a Chinese population. In this ethnic group, only two common haplotypes were observed, with the C-allele of the polymorphism rs2359612 (VKORC1: c.283+837C>T) associated with stroke and other cardiovascular diseases. Recently, the influence of VKORC1 haplotypes on venous thrombosis and coronary heart disease was analyzed in study populations from France and Northern Germany. We studied the frequencies of theVKORC1 haplotypes in a series of young (<50 years, n = 158) patients with ischemic stroke from Southern Germany. The data were compared with findings from age-matched healthy control subjects from the same population (n = 213). In a replica study we also analysed older stroke patients (>50 years, n = 135) and matched control subjects (n = 113). Neither in the young population, nor in the replica study, we observed significant differences in VKORC1 haplotype distributions between healthy control subjects and patients with ischemic stroke. Our data do not confirm the association between polymorphism in the VKORC1 gene and stroke in the German population.

scholarly journals Copeptin: a potential blood biomarker for acute ischemic stroke

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Mohammed I. Oraby ◽  
Rasha H. Soliman ◽  
Rehab M. Abd Elkareem ◽  
Amna I. Mohammed
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Inflammatory Responses ◽  
Unfavorable Outcome ◽  
P Value ◽  
Severe Stroke ◽  
Blood Biomarker ◽  
Copeptin Level ◽  
Healthy Control ◽  
And Control

Abstract Background Copeptin is a new blood biomarker for acute ischemic stroke which emerged to assist clinicians with decision-making. Serum copeptin can accurately reflect vasopressin concentration, which plays a role in aggravation of inflammatory responses, ions and neurotransmitters dysfunctions. The objective of this work was to investigate the relation between copeptin level as a blood biomarker and the short-term prognosis of acute ischemic stroke after 3 months. The current study included 45 patients with first ever acute ischemic stroke and 45 healthy volunteers as a control. Clinical evaluation, CT and MRI of the brain, NIHSS on admission, and mRS after 3 months were done for the patients, and all the patients and control were subjected to assessment of serum level of copeptin by ELISA technique. Results Copeptin level was significantly higher in patients with acute ischemic stroke compared to healthy control subjects (p-value = 0.001). Also, copeptin level was significantly higher in patients with severe stroke (NIHSS > 16) than in those with mild-to-moderate stroke (NIHSS 0–15) at presentation and in patients with unfavorable outcome (mRS 3–6) when compared to patients with favorable outcome (mRS 0–2) (p-value = 0.003 and 0.001, respectively). Copeptin level was significantly lower in patients who received thrombolytic therapy with rTPA (p-value = 0.049). Conclusion Copeptin has an interesting potential as a new prognostic biomarker for patients with acute ischemic stroke as its level was significantly higher in patients with severe stroke and in patients with unfavorable outcome.

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